David Horita, Ph.D., Associate Professor Biochemistry

David Horita, Ph.D.

Associate Professor, Biochemistry
Comprehensive Cancer Center

Contact Information

Academic: 336-713-4194 | Department: 336-716-2011

Email: dhorita@wakehealth.edu

Education & Training

B.A., Carleton College , 1998
Ph.D., University of Wisconsin-Madison , 1994
Fellowship, Natl Cancer Institute (NIH), 1999

David Horita, Ph.D.

Associate Professor, Biochemistry Comprehensive Cancer Center

Research Interests

cancer/oncogenesis, diabetes, immunology/allergy/inflammatio, structural biology, vascular diseases

Contact Information

Academic: 336-713-4194 | Department: 336-716-2011

Email: dhorita@wakehealth.edu

Recent Publications

Davis NY, McPhail LC, Horita DA. The NOXO1beta PX domain preferentially targets PtdIns(4,5)P2 and PtdIns(3,4,5)P3. J Mol Biol. 2012;417(5):440-453.

O'Flaherty JT, Hu Y, Wooten RE [deceased], Horita DA, Samuel MP, Thomas MJ, Sun H, Edwards IJ. 15-Lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survival. PLoS One. 2012;7(9):e45480.

Rajani KR, Pettit Kneller EL, McKenzie MO, Horita DA, Chou JW, Lyles DS. Complexes of vesicular stomatitis virus matrix protein with host Rae1 and Nup98 involved in inhibition of host transcription. PLoS Pathog. 2012;8(9):e1002929.

Ghosh S, Salsbury FR Jr, Horita DA, Gmeiner WH. Zn2+ selectively stabilizes FdU-substituted DNA through a unique major groove binding motif. Nucleic Acids Res. 2011;39(10):4490-4498.

Davis NY, McPhail LC, Horita DA. Backbone 1H, 15N, and 13C resonance assignments for the NOXO1 beta PX domain. Biomol NMR Assign. 2011;5(2):139-141.

Lewis EM, Wilkinson AS, Davis NY, Horita DA, Wilkinson JC. Nondegradative ubiquitination of apoptosis inducing factor (AIF) by X-linked inhibitor of apoptosis at a residue critical for AIF-mediated chromatin degradation. Biochemistry. 2011;50(51):11084-96.

Hall A, Parsonage D, Horita D, Karplus PA, Poole LB, Barbar E. Redox-dependent dynamics of a dual thioredoxin fold protein: evolution of specialized folds. Biochemistry. 2009;48(25):5984-5993.

Hantgan RR, Stahle MC, Horita DA. Entropy drives integrin alpha IIb beta 3 : echistatin binding--evidence from surface plasmon resonance spectroscopy. Biochemistry. 2008;47(9):2884-2892.

Hantgan RR, Stahle MC, Grant K, Horita DA. PAC-1 binding illuminates integrin priming mechanisms [abstract]. Arterioscler Thromb Vasc Biol. 2008;28(6):e-139.

Rocco M, Rosano C, Weisel JW, Horita DA, Hantgan RR. Integrin conformational regulation: uncoupling extension/tail separation from changes in the head region by a multiresolution approach. Structure. 2008;16(6):954-964.

Shen K, Sergeant S, Hantgan RR, McPhail LC, Horita DA. Mutations in the PX-SH3A linker of p47phox decouple PI(3,4)P2 binding from NADPH oxidase activation. Biochemistry. 2008;47(34):8855-8865.

Hantgan RR, Stahle MC, Connor JH, Horita DA, Rocco M, McLane MA, Yakovlev S, Medved L. Integrin alphaIIbbeta3:ligand interactions are linked to binding-site remodeling. Protein Sci. 2006;15(8):1893-1906.