Patients & Visitors ›

Profile

Profile
Research

William C. Little, M.D.

Professor, Cardiology

Clinical Specialties

Cardiac Catheterization, Cardiology (clinical), Cardiology (interventional)

Contact Information

New Patient Appointments: 336-716-WAKE
Returning Patient Appointments: 336-716-6674
Department: 336-716-7631

Insurance Accepted »

Education & Training

B.A., Oberlin College , 1972
M.D., Ohio State University College of Medicine , 1975
Residency, Medicine, Univ Of Virginia Hospitals, 1978
Fellowship, University of Alabama-Birmingham, 1980

Board Certifications

American Board of Internal Medicine, Cardiovascular Disease
American Board of Internal Medicine, Interventional Cardiology
American Board of Internal Medicine, Internal Medicine

Memberships

Am Board Of Internal Medicine
American College of Cardiology
Am Heart Association
Am Soc Of Clinical Investigati
Assn Of University Cardiologis
Assn of Prof of Cardiology
Cardiovascular Systems Dynamic

NPI Number

1568447852

William C. Little, M.D.

Professor, Cardiology

Contact Information

Academic: 336-716-4342 | Department: 336-716-7631

Recent Publications

Anderson J, Sacrinty M, Turner S, Gandhi S, Santos R, Kutcher M, Little W, Applegate R. Gender differences in vascular complications associated with transfemoral and transradial cardiac catheterization and PCI: a single-center experience [abstract]. J Am Coll Cardiol. 2013;61(10 Suppl):E77.

Applegate RJ, Sacrinty M, Gandhi S, Kutcher M, Santos R, Little W. Cost effectiveness of Everolimus-eluting compared to propensity score matched bare metal stenting: an analysis of a selected stent strategy [abstract]. J Am Coll Cardiol. 2013;61(10 Suppl):E1505.

Butler M, Sacrinty M, Little W, Applegate R, Kutcher M, Santos R, Gandhi S. Peak troponin I greater than 5 times the 99th percentile after PCI does not define a high-risk group [abstract]. J Am Coll Cardiol. 2013;61(10 Suppl):E1879.

Little WC, Oh JK. Pericardial diseases In: Goldman L, Schafer AI, eds. Goldman's Cecil medicine, vol 1. 24th ed. Philadelphia: Elsevier/Saunders;2012: 473-481.

Kitzman DW, Little WC. Left ventricle diastolic dysfunction and prognosis [editorial]. Circulation. 2012;125(6):743-745.

Zile MR, Little WC. Effects of autonomic modulation [editorial comment]. J Am Coll Cardiol. 2012;59(10):910-912.

Ohara T, Ohte N, Little WC. Pulmonary hypertension in heart failure with preserved left ventricular ejection fraction: diagnosis and management. Curr Opin Cardiol. 2012;27(3):281-287.

Jeevanantham V, Chughtai H, Little WC, Morgan T, Kitzman DW, Hamilton CA, Hundley WG. Aging reduces left atrial performance during adrenergic stress in middle aged and older patients. Cardiol J. 2012;19(1):45-52.

Schafer P, Sacrinty MT, Smith JW, Little W, Gandhi S, Kutcher M, Santos R, Smith T, Cecile AC, Applegate R. Cost-effectiveness analysis of propensity matched radial and femoral cardiac catheterization and coronary intervention [abstract]. J Am Coll Cardiol. 2012;59(13 Suppl):E72.

Lam CSP, Little WC. Sex and cardiovascular risk: are women advantaged or men disadvantaged? [editorial]. Circulation. 2012;126(8):913-915.

Turner S, Sacrinty M, Manogue M, Little W, Gandhi S, Kutcher M, Santos R, Applegate R. Transitioning to the radial artery as the preferred access site for cardiac catheterization: an academic medical center experience. Catheter Cardiovasc Interv. 2012;80(2):247-257.

Ohara T, Niebel CL, Stewart KC, Charonko JJ, Pu M, Vlachos PP, Little WC. Loss of adrenergic augmentation of diastolic intra-LV pressure difference in patients with diastolic dysfunction: evaluation by color M-mode echocardiography. JACC Cardiovasc Imaging. 2012;5(9):861-870.

Little WC, Vasu S. Heart failure: not just the heart but also the lungs [editorial]. Circ Cardiovasc Imaging. 2012;5(6):689-690.

Stewart KC, Charonko JC, Niebel CL, Little WC, Vlachos PP. Left ventricular vortex formation is unaffected by diastolic impairment. Am J Physiol Heart Circ Physiol. 2012;303(10):H1255-62.

Cheng H-J, Zhou P, Shao Q, Kitzman DW, Kritchevsky SB, Sane DC, Little WC, Cheng CP. Upregulation of cardiac beta3-adrenergic receptor-activated inducible nitric oxide synthase promotes cardiac aging: role of oxidant stress [abstract]. Circulation. 2012;126(21 Suppl):A11645.

Cheng CP, Zhou P, Cheng H-J, Shao Q, Sane DC, Little WC. Chronic urotensin II receptor blockade causes regression of heart failure: beneficial effects on neurohormonal activation, cardiomyocyte contractile function [Ca2+]i regulation and beta-adrenergic modulation [abstract]. Circulation. 2012;126(21 Suppl):A9932.

Applegate R, Sacrinty M, Allem J, Gandhi S, Kutcher M, Santos R, Smith T, Little W. Contrast use and acute kidney injury in contemporary clinical practice [abstract]. J Am Coll Cardiol. 2012;60(17 Suppl B):B39-B40.

Applegate R, Sacrinty M, Gandhi S, Kutcher M, Santos R, Smith T, Little W. Cost effectiveness of Everolimus-eluting stents compared to first generation drug-eluting stents in contemporary clinical practice [abstract]. J Am Coll Cardiol. 2012;60(17 Suppl B):B185.

Little WC, Zile MR. HFpEF: cardiovascular abnormalities not just comorbidities [editorial]. Circ Heart Fail. 2012;5(6):669-671.

Ohara T, Anzai T, Yasuda S, Ogawa H, Applegate R, Little W. Diastolic function at rest determines the prognosis of myocardial infarction [abstract]. J Card Fail. 2012;18(10 Suppl 1):S190.

Stewart KC, Kumar R, Charonko JJ, Ohara T, Vlachos PP, Little WC. Evaluation of LV diastolic function from color M-mode echocardiography. JACC Cardiovasc Imaging. 2011;4(1):37-46.

Charoenpanichkit C, Little WC, Mandapaka S, Dall'Armellina E, Morgan TM, Hamilton CA, Hundley WG. Impaired left ventricular stroke volume reserve during clinical dobutamine stress predicts future episodes of pulmonary edema. J Am Coll Cardiol. 2011;57(7):839-848.

Kumar R, Charonko J, Hundley WG, Hamilton CA, Stewart KC, McNeal GR, Vlachos PP, Little WC. Assessment of left ventricular diastolic function using 4-dimensional phase-contrast cardiac magnetic resonance. J Comput Assist Tomogr. 2011;35(1):108-112.

Little WC, Ohara T. Left atrial emptying reserve: a mirror of LV diastolic function that predicts prognosis? [editorial comment]. JACC Cardiovasc Imaging. 2011;4(4):389-391.

Georgakopoulos D, Little WC, Abraham WT, Weaver FA, Zile MR. Chronic baroreflex activation: a potential therapeutic approach to heart failure with preserved ejection fraction. J Card Fail. 2011;17(2):167-178.

Masutani S, Cheng H-J, Tachibana H, Little WC, Cheng C-P. Levosimendan restores the positive force-frequency relation in heart failure. Am J Physiol Heart Circ Physiol. 2011;301(2):H488-496.

Schafer PE, Sacrinty MT, Cohen DJ, Kutcher MA, Gandhi SK, Santos RM, Little WC, Applegate RJ. Cost-effectiveness of drug-eluting stents versus bare metal stents in clinical practice. Circ Cardiovasc Qual Outcomes. 2011;4(4):408-415.

Manogue MR, Sacrinty MT, Little WC, Gandhi SK, Kutcher MA, Santos RM, Turner SJ, Applegate RJ. Bleeding avoidance strategy: transition from femoral to radial artery as the preferred access for cardiac procedures. The Wake Forest academic medical center experience [abstract]. J Am Coll Cardiol. 2011;57(14 Suppl 1):E1057.

Ohara T, Niebel CL, Stewart KC, Kumar R, Charonko JJ, Pu M, Vlachos PP, Little WC. Aging impairs dobutamine augmentation of early diastolic intraventricular pressure gradient [abstract]. J Am Coll Cardiol. 2011;57(17 Suppl):E332.

Ohara T, Niebel CL, Stewart KC, Kumar R, Charonko JJ, Pu M, Vlachos PP, Little WC. Left ventricular dilation decreases the convective component of the early diastolic intraventricular pressure [abstract]. J Am Coll Cardiol. 2011;57(17 Suppl):E379.

Schafer P, Sacrinty MT, Kutcher MA, Santos RM, Gandhi SK, Little WC, Applegate RJ. Cost effectiveness of drug-eluting stents versus bare metal stents in clinical practice: effect of stent length and diameter [abstract]. J Am Coll Cardiol. 2011;57(14 Suppl 1):E1184.

Turner S, Sacrinty MT, Little WC, Gandhi SK, Kutcher MA, Santos RM, Manogue MR, Applegate RJ. Cath lab utilization during transition to the radial artery as preferred access: the Wake Forest academic medical center experience [abstract]. J Am Coll Cardiol. 2011;57(14 Suppl):E1269.

Ohara T, Niebel CL, Stewart KC, Charonko JJ, Burgess PR, Pu M, Vlachos PP, Little WC. Impaired dobutamine augmentation of early diastolic suction in diastolic dysfunction [abstract]. J Card Fail. 2011;17(8 Suppl 1):S7.

Wajih N, Cheng H-J, Zhou P, Daunais JB, Friedman DP, Little WC, Grant KA, Cheng CP. Downregulation of SR Ca2+-ATPase as a contributing cause of impaired cardiomyocyte basal and beta-adrenergic regulation of [Ca2+]i with myocyte dysfunction in monkeys with chronic heavy alcohol consumption [abstract]. Circulation. 2011;124(21 Suppl):A9254.

Cheng H-J, Zhou P, Zhao W, Wajih N, Han Q-H, Little WC, Cheng CP. Upregulation of cardiac urotensin II (UII) exacerbates UII stimulation-induced negative modulation on myocyte contractile function and Ca2+ current in streptozotocin-induced diabetic rats [abstract]. Circulation. 2011;124(21 Suppl):A9259.

Cheng CP, Cheng H-J, Zhou P, Masutani S, Callahan MF, Cline JM, Little WC. Is beta3-adrenoceptor (AR) a target for heart failure therapy? Evidence from beta3-AR knockout mice [abstract]. Circulation. 2011;124(21 Suppl):A12986.

Schafer PE, Sacrinty MT, Little WC, Gandhi SK, Kutcher MA, Santos RM, Cecile AC, Applegate RJ. Resource utilization for propensity matched radial and femoral catheterization and intervention [abstract]. J Am Coll Cardiol. 2011;58(20 Suppl B):B146-B147.

Ohara T, Niebel CL, Stewart KC, Charonko JJ, Burgess PR, Pu M, Vlachos PP, Little WC. Diastolic function determines the adrenergic augmentation of early diastolic intra-ventriclular pressure gradient and its spatial distribution [abstract]. Circulation. 2011;124(21 Suppl):A9356.

Chaosuwannakit N, D'Agostino R Jr, Hamilton CA, Lane KS, Ntim WO, Lawrence J, Melin SA, Ellis LR, Torti FM, Little WC, Hundley WG. Aortic stiffness increases upon receipt of anthracycline chemotherapy. J Clin Oncol. 2010;28(1):166-172.

Zile MR, Gaasch WH, Anand IS, Haass M, Little WC, Miller AB, Lopez-Sendon J, Teerlink JR, White M, McMurray JJ, et al. Mode of death in patients with heart failure and a preserved ejection fraction: results from the Irbesartan in Heart Failure With Preserved Ejection Fraction Study (I-Preserve) trial. Circulation. 2010;121(12):1393-1405.

Hayes KR, Applegate RJ, Sacrinty MT, Kutcher MA, Gandhi SK, Santos RM, Little WC. Target lesion revascularization after bare-metal or drug-eluting stents: clinical presentations and outcomes. J Invasive Cardiol. 2010;22(6):266-270.

Cheng H-J, Grant KA, Han Q-H, Daunais JB, Friedman DP, Masutani S, Little WC, Cheng C-P. Up-regulation and functional effect of cardiac beta(3)-adrenoreceptors in alcoholic monkeys. Alcohol Clin Exp Res. 2010;34(7):1171-1181.

Kitzman DW, Hundley WG, Brubaker PH, Morgan TM, Moore JB, Stewart KP, Little WC. A randomized double-blind trial of enalapril in older patients with heart failure and preserved ejection fraction: effects on exercise tolerance and arterial distensibility. Circ Heart Fail. 2010;3(4):477-485.

Ohara T, Little WC. Evolving focus on diastolic dysfunction in patients with coronary artery disease. Curr Opin Cardiol. 2010;25(6):613-621.

Little WC, Ohara T. Equilibrium volume and suction [letter]. J Appl Physiol. 2010;109(2):614.

Kitzman DW, Brubaker PH, Morgan TM, Stewart KP, Little WC. Exercise training in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial. Circ Heart Fail. 2010;3(6):659-667.

Cheng C-P, Han Q-H, Cheng H-J, Onishi K, Ukai T, Ohte N, Little WC. Is up-regulation of beta3-adrenergic receptor (AR) in the failing myocardium detrimental or beneficial?--Effect on chronic beta3-AR blockade in pacing-induced heart failure [abstract]. Circulation. 2010;122(21 Suppl):A17062.

Cheng H-J, Zhou P, Kitzman DW, Kritchevsky SB, Sane DC, Little WC, Cheng C-P. Reversal of aging-induced upregulation of cardiac inducible nitric oxide synthase and beta-adrenergic desensitization in mice lacking the beta3-adrenoreceptor [abstract]. Circulation. 2010;122(21 Suppl):A13008.

Zhou P, Cheng H-J, Zhang Z-S, Little WC, Cheng C-P. Inducible nitric oxide synthase stimulation depresses cardiomyocyte basal and beta-adrenergic response of L-type calcium current in heart failure: insights into the underlying electrophysiological mechanism [abstract]. Circulation. 2010;122(21 Suppl):A15884.

Georgakopoulos D, Kroon A, Bach DS, Kaufman CL, Abraham WT, Little WC, Zile MR. Improved left ventricular end-systolic myocardial wall stress following chronic Baroreflex Activation with the Rheos System in resistant hypertension [abstract]. J Card Fail. 2010;16(8 Suppl 1):S25.

Georgakopoulos D, Kroon A, Bach DS, Kaufman CL, Abraham WT, Little WC, Zile MR. Improved ventricular-arterial elastance following chronic treatment using the Rheos System implantable device in resistant hypertension [abstract]. J Card Fail. 2010;16(8 Suppl 1):S27.

Twomley K, D'Agostino R Jr, Lawrence J, Melin S, Ellis LR, Stacey B, Hamilton CA, Torti F, Little W, Hundley W. Early and persistent evidence of subclinical cardiovascular injury after receipt of anthracycline chemotherapy [abstract]. Circulation. 2010;122(21 Suppl):A12766.

Thohan V, Little WC. Is a higher blood pressure better in heart failure? [editorial]. Heart. 2009;95(1):4-5.

Applegate RJ, Sacrinty MT, Kutcher MA, Santos RM, Gandhi SK, Little WC. Effect of length and diameter of drug-eluting stents versus bare-metal stents on late outcomes. Circ Cardiovasc Interv. 2009;2():35-42.

Applegate RJ, Sacrinty MT, Kutcher MA, Santos RM, Gandhi SK, Little WC. 3-year comparison of drug-eluting versus bare-metal stents. J Am Coll Cardiol Intv. 2009;2(3):231-239.

Applegate RJ, Sacrinty MT, Kutcher MA, Santos RM, Gandhi SK, Little WC. Three-year comparison of drug-eluting versus bare metal stents [abstract]. J Am Coll Cardiol. 2009;53(10 Suppl 1):A353.

Hayes KR, Applegate RJ, Sacrinty MT, Kutcher MA, Gandhi SK, Santos RM, Little WC. Clinical outcomes of bare metal stents versus drug-eluting stents target vessel revascularization: evidence for a high-risk bare metal stent cohort [abstract]. J Am Coll Cardiol. 2009;53(10 Suppl 1):A317-A318.

Santos RM, Sacrinty MJ, Kutcher MA, Gandhi SK, Little WC, Applegate RJ. Drug-eluting stent versus bare metal stent use in patients with chronic kidney disease [abstract]. J Am Coll Cardiol. 2009;53(10 Suppl 1):A393-A394.

Applegate R, Sacrinty M, Little W, Gandhi S, Kutcher M, Santos R. Prognostic implications of vascular complications following PCI. Catheter Cardiovasc Interv. 2009;74(1):64-73.

Ohte N, Miyoshi I, Sane DC, Little WC. Zebrafish with antisense-knockdown of cardiac troponin C as a model of hereditary dilated cardiomyopathy [editorial]. Circ J. 2009;73(9):1595-1596.

Little WC, Kirkman PM. Moving beyond angiotensin II to also target aldosterone? [editorial]. J Am Coll Cardiol. 2009;54(6):513-514.

Little WC, Oh JK. Echocardiographic evaluation of diastolic function can be used to guide clinical care. Circulation. 2009;120(9):802-809.

Zile MR, Barst RJ, Bourge R, Redfield MM, Little WC. A phase 2 randomized, double-blind, placebo-controlled exploratory efficacy study of sitaxsentan sodium to improve impaired exercise tolerance in subjects with diastolic heart failure [abstract]. J Card Fail. 2009;15(6 Suppl 1):S63.

Cheng C-P, Cheng H-J, Hasegawa H, Morimoto A, Zhou P, Cross M, Little WC. Na+-H+ exchange inhibition by cariporide enhances cardiac positive inotropic and lusitropic responses to dobutamine in heart failure: assessment by pressure-volume analysis [abstract]. Circulation. 2009;120(18 Suppl):S733-S734.

Zhou P, Cheng H-J, Cross M, Little WC, Cheng C-P. Modulation of cardiac L-type Ca2+ current by angiotensin-(1-7): normal vs heart failure [abstract]. Circulation. 2009;120(18 Suppl):S694.

Cheng H-J, Zhou P, Cross M, Kitzman D, Kritchevsky S, Sane DC, Little WC, Cheng C-P. Upregulation of cardiac SERCA 2a by chronic beta3-adrenergic receptor (AR) deficiency: a key molecular mechanism of the protective effect of beta3-AR deficiency on myocardial aging [abstract]. Circulation. 2009;120(18 Suppl):S584-S585.

Jeevanantham V, Chughtai HL, Little WC, Morgan TM, Kitzman DW, Ntim WO, Hamilton CA, Hundley WG. Aging affects the response of the left atrium to adrenergic stress [abstract]. Circulation. 2009;120(18 Suppl):S493.

Chaosuwannakit N, D'Agostino R Jr, Hamilton CA, Lane KS, Ntim WO, Lawrence J, Melin SA, Ellis LR, Torti FM, Little WC, Hundley WG. Subclinical cardiovascular toxicity of anthracyclines identified with cardiovascular magnetic resonance imaging [abstract]. Circulation. 2009;120(18 Suppl):S299.

Little WC, Pu M. Left ventricular-arterial coupling [editorial comment]. J Am Soc Echocardiogr. 2009;22(11):1246-1248.

Wells GL, Little WC. Role of neurohormones and peripheral vasculature In: Smiseth OA, Tendera M, eds. Diastolic heart failure. London (UK): Springer;2008: 71-79.

Fukuta H, Little WC. Diastolic versus systolic heart failure In: Smiseth OA, Tendera M, eds. Diastolic heart failure. London (UK): Springer;2008: 119-133.

Kumar R, Gandhi SK, Little WC. Acute heart failure with preserved systolic function. Crit Care Med. 2008;36(1 Suppl):S52-S56.

Applegate RJ, Sacrinty MT, Kutcher MA, Santos RM, Gandhi SK, Baki TT, Little WC. 'Off-label' stent therapy: 2-year comparison of drug-eluting versus bare-metal stents. J Am Coll Cardiol. 2008;51(6):607-614.

Wells GL, Little WC. Peripartum cardiomyopathy presenting as diastolic heart failure. Congest Heart Fail. 2008;14(1):52-54.

Fukuta H, Little WC. The cardiac cycle and the physiologic basis of left ventricular contraction, ejection, relaxation, and filling. Heart Fail Clin. 2008;4(1):1-11.

Masutani S, Cheng H-J, Hyttila-Hopponen M, Levijoki J, Heikkila A, Vuorela A, Little WC, Cheng C-P. Orally available levosimendan dose-related positive inotropic and lusitropic effect in conscious chronically instrumented normal and heart failure dogs. J Pharmacol Exp Ther. 2008;325(1):236-247.

Masutani S, Little WC, Hasegawa H, Cheng H-J, Cheng C-P. Restrictive left ventricular filling pattern does not result from increased left atrial pressure alone. Circulation. 2008;117(12):1550-1554.

Applegate RJ, Graham SH, Gandhi SK, Kutcher MA, Sacrinty MT, Santos RM, Little WC. Culprit vessel PCI versus traditional cath and PCI for STEMI. J Invasive Cardiol. 2008;20(5):224-228.

Fukuta H, Little WC. Observational studies of statins in heart failure with preserved systolic function. Heart Fail Clin. 2008;4(2):209-216.

Applegate RJ, Sacrinty MT, Kutcher MA, Gandhi SK, Santos RM, Little WC. Drug-eluting stents versus bare metal stents in saphenous vein grafts at 2 years [abstract]. J Am Coll Cardiol. 2008;51(10 Suppl B):B78.

Gandhi SK, Kay JD, Applegate RJ, Sacrinty MT, Kutcher MA, Santos RM, Little WC. Drug-eluting stents for ST elevation myocardial infarction: evidence for benefit at two years [abstract]. J Am Coll Cardiol. 2008;51(10 Suppl B):B1.

Graham SH, Applegate RJ, Gandhi SK, Sacrinty MT, Baki TT, Santos RM, Little WC, Kutcher MA. Culprit vessel primary percutaneous coronary intervention for ST elevation myocardial infarction shorter door to balloon time [abstract]. J Am Coll Cardiol. 2008;51(10 Suppl B):B61.

Fukuta H, Little WC. General principles, clinical definition, and epidemiology In: Klein AL, Garcia MJ, eds. Diastology: clinical approach to diastolic heart failure. Philadelphia: Saunders/Elsevier;2008: 63-72.

Applegate RJ, Sacrinty MT, Kutcher MA, Kahl FR, Gandhi SK, Santos RM, Little WC. Trends in vascular complications after diagnostic cardiac catheterization and percutaneous coronary intervention via the femoral artery, 1998 to 2007. J Am Coll Cardiol Intv. 2008;1(3):317-326.

Cheng C-P, Masutani S, Cheng H-J, Morimoto A, Hasegawa H, Little WC. Cardiac beta3-adrenergic receptor: a new target for the treatment of exercise intolerance in heart failure [abstract]. J Card Fail. 2008;14(6 Suppl 1):S12.

Cheng C-P, Masutani S, Cheng H-J, Little WC, Hyttila-Hopponen M, Levijoki J, Heikkila A, Vuorela A. Use of oral levosimendan to treat congestive heart failure: a pharmacodynamic versus pharmacokinetic relationship study [abstract]. J Card Fail. 2008;14(6 Suppl 1):S79.

Applegate RJ, Sacrinty M, Kutcher M, Santos R, Gandhi S, Little W. Late outcomes of drug-eluting versus bare meta stents in saphenous vein grafts: propensity score analysis. Catheter Cardiovasc Interv. 2008;72(1):7-12.

Masutani S, Little WC, Hasegawa H, Cheng H-J, Cheng C-P. Response to letter regarding article, 'Restrictive left ventricular filling pattern does not result from increased left atrial pressure alone' [reply to letter]. Circulation. 2008;118(3):e506.

Applegate RJ, Sacrinty MT, Little WC, Santos RM, Gandhi SK, Kutcher MA. Incidence of coronary stent thrombosis based on academic research consortium definitions. Am J Cardiol. 2008;102(6):683-688.

Little WC. Diastolic dysfunction heart failure [abstract]. J Card Fail. 2008;14(7 Suppl):S132.

Kumar R, McNeal GR, Stewart KC, Charonko JJ, Pierrakos O, Vlachos PP, Ntim WO, Hundley G, Hamilton CA, Little WC. Phase contrast imaging: a novel way of assessing left ventricular diastolic function [abstract]. J Cardiovasc Magn Reson. 2008;10(Suppl 1):Abstr 225.

Zhou P, Cheng H-J, Cross M, Callahan MF, Brosnihan B, Little WC, Cheng C-P. Functional effect of chronic urotensin II receptor antagonist on L-type Ca2+ current in mouse model of progressive heart failure [abstract]. Circulation. 2008;118(18 Suppl 2):S398.

Cheng H-J, Masutani S, Zhang C-X, Cross M, Little WC, Cheng C-P. Upregulation of beta3-adrenoceptors (AR) as a contributing cause of reduced positive modulation of adrenergic signaling in aged hearts: evidence from beta3-AR knockout mice [abstract]. Circulation. 2008;118(18 Suppl 2):S425.

Cheng C-P, Zhou P, Cheng H-J, Cross M, Little WC. Direct cardiac effect and cellular mechanism of angiotensin-(1-7) in heart failure [abstract]. Circulation. 2008;118(18 Suppl 2):S513.

Kumar R, Stewart KC, Charonko JJ, Vlachos PP, Little WC. Diastolic intraventricular pressure gradients assessed by color M-mode echocardiography [abstract]. Circulation. 2008;118(18 Suppl 2):S602.

Mandapaka S, Little W, Dall'Armelina E, Morgan T, Bertoni A, Hamilton C, Hundley WG. Is heightened vascular stiffness a predictor of future acute pulmonary edema [abstract]. Circulation. 2008;118(18 Suppl 2):S691.

Lingle KC, Lohman K, Goff DC Jr, Little WC, Carr J, Bluemke DA, Szklo M, Ding J. Pericardial fat and left ventricular end diastolic volume, a subclinical marker of heart failure with normal ejection fraction: the Multi-Ethnic Study of Atherosclerosis [abstract]. Circulation. 2008;118(18 Suppl 2):S725.

Cheng H-J, Zhou P, Cross M, Callahan MF, Little WC, Cheng C-P. Normalization of beta adrenergic receptor signaling improves left ventricular myocyte function with urotensin II receptor blockade in murine heart failure [abstract]. Circulation. 2008;118(18 Suppl 2):S797.

Masutani S, Cheng H-J, Han Q-H, Ohte N, Suzuki M, Little WC, Cheng C-P. Vasopressin V1 receptor improves left ventricular systolic and diastolic performance at rest and during exercise after heart failure [abstract]. Circulation. 2008;118(18 Suppl 2):S954.

Little WC. Hypertension, heart failure, and ejection fraction [editorial]. Circulation. 2008;118(22):2223-2224.

Applegate RJ, Sacrinty MT, Kutcher MA, Gandhi SK, Santos RM, Little WC. Prognostic implications of post percutaneous coronary intervention vascular complications [abstract]. Am J Cardiol. 2008;102(8A Suppl):9i.

Fukuta H, Ohte N, Brucks S, Carr JJ, Little WC. Contribution of right-sided heart enlargement to cardiomegaly on chest roentgenogram in diastolic and systolic heart failure. Am J Cardiol. 2007;99(1):62-67.

Fukuta H, Little WC. Contribution of systolic and diastolic abnormalities to heart failure with a normal and a reduced ejection fraction. Prog Cardiovasc Dis. 2007;49(4):229-240.

Applegate RJ, Sacrinty MT, Kutcher MA, Baki TT, Gandhi SK, Santos RM, Little WC. Comparison of drug-eluting versus bare metal stents on later frequency of acute myocardial infarction and death. Am J Cardiol. 2007;99(3):333-338.

Applegate RJ, Sacrinty MT, Kutcher MA, Baki TT, Gandhi SK, Santos RM, Kahl FR, Little WC. Propensity score analysis of vascular complications after diagnostic cardiac catheterization and percutaeous coronary intervention using thrombin hemostatic patch-facilitated manual compression. J Invasive Cardiol. 2007;19(4):164-170.

Applegate RJ, Sacrinty MT, Kutcher MA, Baki TT, Gandhi SK, Santos RM, Little WC. Vascular complications following cardiac catheterization and coronary intervention 1998-2005: influence of gender [abstract]. J Am Coll Cardiol. 2007;49(9 Suppl):193A.

Fukuta H, Little WC. Diagnosis of diastolic heart failure. Curr Cardiol Rep. 2007;9(3):224-228.

Cheng CP, Masutani S, Cheng HJ, Cross M, Hyttila-Hopponen M, Levijoki J, Heikkila A, Vuorela A, Little WC. Oral levosimendan enhances left ventricular systolic and diastolic performance prior to and after pacing-induced heart failure in dogs [abstract]. J Vet Intern Med. 2007;21(3):632-633.

Gaasch WH, Little WC. Assessment of left ventricular diastolic function and recognition of diastolic heart failure [editorial]. Circulation. 2007;116(6):591-593.

Fukuta H, Little WC. Elevated left ventricular filling pressure after maximal exercise predicts increased plasma B-type natriuretic peptide levels in patients with impaired relaxation pattern of diastolic filling. J Am Soc Echocardiogr. 2007;20(7):832-837.

Applegate RJ, Sacrinty MT, Kutcher MA, Baki TT, Gandhi SK, Kahl FR, Santos RM, Little WC. Vascular complications in women after catheterization and percutaneous coronary intervention 1998-2005. J Invasive Cardiol. 2007;19(9):369-374.

Cheng C-P, Masutani S, Cheng H-J, Cross M, Zhang C-X, Zhou P, Cann J, Cline JM, Little WC, Kuo S-R, et al. Progressive left ventricle, myocyte dysfunction, and heart failure in the lethality of anthrax toxin in conscious dogs [abstract]. Circulation. 2007;116(16 Suppl II):II-758.

Cheng H-J, Han Q-H, Zhou P, Morimoto A, Masutani S, Little WC, Cheng C-P. Coordinated upregulation of cardiomyocyte urotensin II (U-II) and its receptor (UT) exhibits enhanced inhibition of L-type calcium current in heart failure [abstract]. Circulation. 2007;116(16 Supp II):II-148.

Cheng H-J, Cunningham CC, Zhang ZS, Shihabi ZK, Sane DC, Wannenburg T, Masutani S, Little WC, Cheng C-P. Upregulation of cardiac AT1 receptor signaling inhibits myocyte contractile performance, [Ca2+]i transient, and Ca2+ current in alcoholic dogs: insights into the underlying molecular mechanism [abstract]. Circulation. 2007;116(16 Suppl II):II-311.

Zhou P, Zhang Z-S, Cheng H-J, Masutani S, Cross M, Little WC, Cheng C-P. Electrophysiological effects of endothelin-1: altered inotropic response of left ventricle in heart failure [abstract]. Circulation. 2007;116(16 Suppl II):II-12.

Applegate RJ, Sacrinty MT, Kutcher MA, Gandhi SK, Santos RM, Little WC. Vascular complications 1998-2007: evidence for better outcomes [abstract]. Am J Cardiol. 2007;100(8 Suppl 1):6L.

Applegate RJ, Sacrinty MT, Kutcher MA, Santos RM, Baki TT, Gandhi SK, Little WC. Off-label DES vs. BMS treatment: outcomes at 2 years [abstract]. Am J Cardiol. 2007;100(8 Suppl 1):159L.

Little WC, Zile MR, Klein A, Appleton CP, Kitzman DW, Wesley-Farrington DJ. Effect of losartan and hydrochlorothiazide on exercise tolerance in exertional hypertension and left ventricular diastolic dysfunction. Am J Cardiol. 2006;98(3):383-385.

Call J, Sacrinty M, Applegate R, Little W, Santos R, Baki T, Gandhi S, Kahl F, Kutcher M. Automated contrast injection in contemporary practice during cardiac catheterization and PCI: effects on contrast-induced nephropathy. J Invasive Cardiol. 2006;18(10):469-474.

Applegate RJ, Upadhya B, Little WC, Xenakis M, Gandhi SK, Baki TT, Kahl FR, Kutcher MA. Late outcomes after intervention of vein grafts in diabetics with abciximab use. Int J Cardiol. 2006;111(1):136-141.

Cheng C-P, Cheng H-J, Cunningham C, Shihabi ZK, Sane DC, Wannenburg T, Little WC. Angiotensin II type 1 receptor blockade prevents alcoholic cardiomyopathy. Circulation. 2006;114(3):226-236.

Rassi A Jr, Rassi A, Little WC, Xavier SS, Rassi SG, Rassi AG, Rassi GG, Hasslocher-Moreno A, Sousa AS, Scanavacca MI. Development and validation of a risk score for predicting death in Chagas' heart disease. N Engl J Med. 2006;355(8):799-808.

Masutani S, Little WC, Hasegawa H Cheng H-J, Cheng C-P. Restrictive left ventricular filling pattern does not result from increased left atrial pressure alone [abstract]. Circulation. 2006;114(18 Suppl):II-134.

Applegate RJ, Kutcher MA, Little WC, Sacrinty MT, Gandhi SK, Baki TT, Santos RM. Vascular complications after cath and percutaneous coronary intervention: thrombin hemostatic patch versus manual compression [abstract]. Circulation. 2006;114(18 Suppl):II-392.

Rassi A Jr, Rassi A, Little WC. A risk score for predicting death in Chagas' heart disease [reply to letter]. N Engl J Med. 2006;355(23):2490.

Applegate RJ, Grabarczyk MA, Sane DC, Sacrinty MT, Goodin JE, Statonk GS, Baki TT, Gandhi SK, Kutcher MA, Little WC. PCI with and without abciximab after upstream eptifibatide use: outcomes in high-risk patients. J Invasive Cardiol. 2006;18(12):604-613.

Applegate RJ, Kutcher MA, Little WC, Sacrinty MT, Gandhi SK, Baki TT, Santos RM. Drug-eluting stent treatment of patients with myocardial infarction--efficacy and safety at nine months [abstract]. Am J Cardiol. 2006;98(8A Suppl):75M.

Leonard JC, Sacrinty MT, Applegate RJ, Little WC, Baki TT, Gandhi SK, Santos RM, Kutcher MA. Timing of intervention in non-ST-segment elevation myocardial infarctions: nine month outcomes [abstract]. Am J Cardiol. 2006;98(8A Suppl):80M-81M.