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Douglas S. Lyles, Ph.D.

Douglas S. Lyles, Ph.D.

Program Director, Comprehensive Cancer Center
Professor, Biochemistry
Comprehensive Cancer Center

Contact Information

Department: 336-716-4237

Email: dlyles@wakehealth.edu

Education & Training

  • B.A., University of Pennsylvania , 1972
  • Ph.D., University of Mississippi School of Medicine , 1975
  • Fellowship, Rockefeller University, 1978

Memberships

  • Am Soc Of Biochem & Mol Biolog
  • Am Soc Of Microbiology
  • Am Soc Of Virology

Related Links

Douglas S. Lyles, Ph.D.

Douglas S. Lyles, Ph.D.

Program Director, Comprehensive Cancer Center
Professor, Biochemistry Comprehensive Cancer Center

Research Interests

cancer/oncogenesis, cell growth, differentiation,d, infectious diseases, molecular biology/molecular me, vaccines

Contact Information

Department: 336-716-4237

Email: dlyles@wakehealth.edu

Recent Publications

Blackham AU, Northrup SA, Willingham M, D'Agostino RB Jr, Lyles DS, Stewart JH IV. Variation in susceptibility of human malignant melanomas to oncolytic vesicular stomatitis virus. Surgery. 2013;153(3):333-343.

Lyles DS. Assembly and budding of negative-strand RNA viruses. Adv Virus Res. 2013;85():57-90.

Rajani KR, Pettit Kneller EL, McKenzie MO, Horita DA, Chou JW, Lyles DS. Complexes of vesicular stomatitis virus matrix protein with host Rae1 and Nup98 involved in inhibition of host transcription. PLoS Pathog. 2012;8(9):e1002929.


Johnson JB, Douglas LS [sic] [Lyles DS], Martha AMA [sic] [Alexander-Miller MA], Griffith DG [sic] [Parks GD]. Virion-associated complement regulator CD55 is more potent than CD46 in mediating resistance of mumps virus and VSV to neutralization [abstract]. Immunobiology. 2012;217(11):1215-1216.


Gerlier D, Lyles DS. Interplay between innate immunity and negative-strand RNA viruses: towards a rational model. Microbiol Mol Biol Rev. 2011;75(3):468-490.

Stewart JH IV, Ahmed M, Northrup SA, Willingham M, Lyles DS. Vesicular stomatitis virus as a treatment for colorectal cancer. Cancer Gene Ther. 2011;18(12):837-849.


Johnson JB, Lyles DS, Parks GD. Complement evasion by vesicular stomatitis virus involves recruitment of host complement regulatory proteins [abstract]. Mol Immunol. 2010;47(13):2239.

Porosnicu M, Liu J, Lyles D. Susceptibility of head and neck cancer to an attenuated model of the oncolytic vesicular stomatitis virus expressing suicide genes [abstract]. J Clin Oncol. 2010;27(15 Suppl):e14604.

Ahmed M, Puckett S, Arimilli S, Braxton CL, Mizel SB, Lyles DS. Stimulation of human dendritic cells by wild-type and M protein mutant vesicular stomatitis viruses engineered to express bacterial flagellin. J Virol. 2010;84(22):12093-98.


Dancho B, McKenzie MO, Connor JH, Lyles DS. Vesicular stomatitis virus matrix protein mutations that affect association with host membranes and viral nucleocapsids. J Biol Chem. 2009;284(7):4500-4509.

Kneller ELP, Connor JH, Lyles DS. hnRNPs relocalize to the cytoplasm following infection with vesicular stomatitis virus. J Virol. 2009;83(2):770-780.


Agnihothram SS, Dancho B, Grant KW, Grimes ML, Lyles DS, Nunberg JH. Assembly of arenavirus envelope glycoprotein GPC in detergent-soluble membrane microdomains. J Virol. 2009;83(19):9890-9900.


Faul EJ, Lyles DS, Schnell MJ. Interferon response and viral evasion by members of the family Rhabdoviridae. Viruses. 2009;1(3):832-851.

Whitlow ZW, Connor JH, Lyles DS. New mRNAs are preferentially translated during vesicular stomatitis virus infection. J Virol. 2008;82(5):2286-2294.


Ahmed M, Marino TR, Puckett S, Kock ND, Lyles DS. Immune response in the absence of neurovirulence in mice infected with m protein mutant vesicular stomatitis virus. J Virol. 2008;82(18):9273-9277.


Lyles DS, Rupprecht CE. Rhabdoviridae In: Knipe DM, Howley PM, Griffin DE, Lamb RA, Straus SE, Martin MA, Roizman B, eds. Fields virology. 5th ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins;2007: 1363-1408.


Connor JH, McKenzie MO, Parks GD, Lyles DS. Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses. Virology. 2007;362(1):109-119.


All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Biochemistry

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