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Research

Wendy C. Moore, M.D.

Associate Professor, Pulmonary, Critical Care, Allergy, and Immunologic Medicine
Center for Genomics and Personalized Medicine Research
Center for Genomics and Personalized Medicine Research

Clinical Specialties

General Pulmonary Diseases, Scleroderma, Asthma

Contact Information

Department: 336-716-2011

Insurance Accepted »

Education & Training

B.A., University of Maryland-Baltimore County , 1986
M.D., University of Maryland School of Medicine , 1991
Internship, U Maryland Medical System, 1992
Residency, Baltimore City Hosps, 1994
Fellowship, University of Maryland School of Medicine, 1997

Memberships

Maryland Thoracic Society
Amer Coll Of Chest Physicians
American Thoracic Society
Alpha Omega Alpha

NPI Number

1235112376

Wendy C. Moore, M.D.

Associate Professor, Pulmonary, Critical Care, Allergy, and Immunologic Medicine Center for Genomics and Personalized Medicine Research
Center for Genomics and Personalized Medicine Research

Contact Information

Academic: 336-713-7520 | Department: 336-716-2011

Recent Publications

Holguin F, Comhair SA, Hazen SL, Powers RW, Khatri SS, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Moore WC, Peters SP, Teague WG, Chung KF, Erzurum SC, Wenzel SE. An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype. Am J Respir Crit Care Med. 2013;187(2):153-159.

Romeo J, Hastie AT, Foster S, Moore W, Peters SP, Bleecker ER, Dykewicz MS. LIGHT is associated with increased cellular infiltrate and levels of TH1 cytokines as well as well as [sic] reduced lung function in human asthma [abstract]. J Allergy Clin Immunol. 2013;131(2 Suppl):AB203.

Li X, Ampleford EJ, Howard TD, Moore WC, Li H, Busse WW, Castro M, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Teague WG, Wenzel SE, Hawkins GA, Bleecker ER, Meyers DA. The C11orf30-LRRC32 region is associated with total serum IgE levels in asthmatic patients [letter]. J Allergy Clin Immunol. 2012;129(2):575-578.

Hartman JM, Hastie A, Moore WC, Rector B, Peters SP, Bleecker ER, Dykewicz MS. Thioredoxin is positively associated with eosinophils in induced sputum from patients with asthma [abstract]. J Allergy Clin Immunol. 2012;129(2 Suppl):AB209.

Jarjour NN, Erzurum SC, Bleecker ER, Calhoun WJ, Castro M, Comhair SAA, Chung KF, Curran-Everett D, Dweik RA, Fain SB, Fitzpatrick AM, Gaston BM, Israel E, Hastie A, Hoffman EA, Holguin F, Levy BD, Meyers DA, Moore WC, Peters SP,. Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. Am J Respir Crit Care Med. 2012;185(4):356-362.

Ortega VE, Hawkins G, Moore WC, Sadeghnejad A, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Characterization of rare variants in the Adam33 gene in asthma cases from two ethnic groups [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A5609.

Bellinger C, Pascual R, Krings J, Smith R, Burmudez R, Peters SP, Bleecker ER, Moore WC. Similar decrements in FEV1 and FVC in not severe and severe asthma subjects following investigative bronchoscopy [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A4178.

Li X, Moore WC, Li H, Ampleford EJ, Busse WW, Erzurum SC, Wenzel SE, Howard TD, Hawkins GA, Meyers DA, Bleecker ER. Phenotype determinants for asthma severity clusters and genetic association for cluster-based asthma severity in Severe Asthma Research Program (SARP) [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A2501.

Slager RE, Moore WC, Peters SP, Busse WW, Erzurum SC, Wenzel SE, Meyers DA, Bleecker ER. Rare TH1 and TH2 pathway genetic variants contribute to severe allergic asthma [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A2509.

Hawkins G, Li X, Slager R, Moore WC, Peters SP, Bleecker ER, Meyers DA. Exome sequencing of asthma candidate genes in chromosome 2q11-12 and 2q33 [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A4904.

Moore WC, Hastie AT, Li H, Li X, Busse WW, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. The addition of sputum inflammatory cell counts to the SARP cluster analysis results in similar clinical asthma phenotypes with biologic heterogeneity [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A3625.

Ortega VE, Hawkins G, Hastie AT, Moore WC, Sadeghnejad A, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Effects of rare beta2-adrenergic receptor gene variants and long-acting beta agonists on healthcare utilization and corticosteroid use in two multi-ethnic asthma populations [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A2514.

Hastie AT, Moore WC, Li H, Rector BM, Pascual RM, Peters SP, Meyers DA, Bleecker ER. Blood eosinophils, exhaled nitric oxide, and IGE do not accurately predict sputum eosinophils [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A3926.

Bellinger C, Bowers B, Pascual R, Chin R Jr, Moore W, Conforti J. Bronchoscopy in patients with asthma. Clin Pulm Med. 2012;19(1):1-4.

Hawkins GA, Robinson MB, Hastie AT, Li X, Li H, Moore WC, Howard TD, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. The IL6R variation Asp358 Ala is a potential modifier of lung function in subjects with asthma. J Allergy Clin Immunol. 2012;130(2):510-515.

Calhoun WJ, Ameredes BT, King TS, Icitovic N, Bleecker ER, Castro M, Cherniack RM, Chinchilli VM, Craig T, Denlinger L, DiMango EA, Engle LL, Fahy JV, Grant JA, Israel E, Jarjour N, Kazani SD, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF,. Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial. JAMA. 2012;308(10):987-997.

Torgerson DG, Capurso D, Ampleford EJ, Li X, Moore WC, Gignoux CR, Hu D, Eng C, Mathias RA, Busse WW, Castro M, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Teague WG, Wenzel SE, Rodriguez-Santana JR,. Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects. J Allergy Clin Immunol. 2012;130(3):622-629.

Li X, Ampleford EJ, Howard TD, Moore WC, Torgerson DG, Li H, Busse WW, Castro M, Erzurum SC, Israel E, Nicolae DL, Ober C, Wenzel SE, Hawkins GA, Bleecker ER, Meyers DA. Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases. J Allergy Clin Immunol. 2012;130(4):861-868.

Busse WW, Peters SP, Fenton MJ, Mitchell H, Bleecker ER, Castro M, Wenzel S, Erzurum SC, Fitzpatrick AM, Moore WC, et al. Vaccination of patients with mild and severe asthma with a 2009 pandemic H1N1 influenza virus vaccine. J Allergy Clin Immunol. 2011;127(1):130-137.

Fitzpatrick AM, Teague WG, Meyers DA, Peters SP, Li X, Li H, Wenzel SE, Aujla S, Bleecker ER, Moore WC, et al. Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. J Allergy Clin Immunol. 2011;127(2):382-389.

Liu L, Teague WG, Erzurum S, Fitzpatrick A, Mantri S, Dweik RA, Bleecker ER, Meyers D, Moore W, Peters SP, et al. Determinants of exhaled breath condensate pH in a large population with asthma. Chest. 2011;139(2):328-336.

Ortega VE, Hastie A, Sadeghnejad A, Moore W, Hawkins GA, Peters SP, Busse WW, Calhoun WJ, Meyers DA, Bleecker ER, et al. Rare beta2-adrenergic receptor gene polymorphisms in asthma cases and controls from the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med. 2011;183(Meeting Abstracts):A1357.

Holguin F, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Erzurum SC, Fitzpatrick AM, Gaston B, Moore WC, Peters SP, et al. Obesity and asthma: an association modified by age of asthma onset. J Allergy Clin Immunol. 2011;127(6):1486-1493.

Li X, Howard TD, Moore WC, Ampleford EJ, Li H, Busse WW, Peters SP, Hawkins GA, Bleecker ER, Meyers DA, et al. Importance of hedgehog interacting protein and other lung function genes in asthma. J Allergy Clin Immunol. 2011;127(6):1457-1465.

Comhair SAA, Gaston BM, Ricci KS, Hammel J, Dweik RA, Meyers D, Ampleford EJ, Bleecker ER, Moore W, Peters SP, et al. Detrimental effects of environmental tobacco smoke in relation to asthma severity. PLoS ONE. 2011;6(5):e18574.

Slager RE, Li H, Moore W, Hawkins G, Peters SP, Busse WW, Chung K, Erzurum SC, Meyers DA, Bleecker ER, et al. Predictive model of severe atopic asthma phenotypes using interleukin 4/13 pathway polymorphisms [abstract]. Am J Respir Crit Care Med. 2011;183():A1332.

Moore WC, Evans MD, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Chung KF, Erzurum SC, Pascual RM, Peters SP, et al. Safety of investigative bronchoscopy in the Severe Asthma Research Program. J Allergy Clin Immunol. 2011;128(2):328-336.

Hawkins GA, Robinson MB, Moore W, Hastie A, Pascual RM, Peters SP, Meyers DA, Bleecker ER. Correlation of serum IL6 with lung function and phenotypic asthma clusters: data from the Severe Asthma Research Program (SARP) [abstract]. Am J Respir Crit Care Med. 2011;183(Meeting Abstracts):A6169.

Hatzis CE, Hastie A, Moore W, Rector B, Sousa A, Knowles R, Peters SP, Meyers DA, Bleecker ER. BAL cell lysate IL1b synthesis and processing correlates with blood eosinophil levels in subjects with asthma [abstract]. Am J Respir Crit Care Med. 2011;183(Meeting Abstracts):A4453.

Holguin F, Moore W, Peters SP, Wenzel SE. Obesity and asthma, an association modified by age of asthma onset [abstract]. Am J Respir Crit Care Med. 2011;183(Meeting Abstracts):A2662.

Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, D'Agostino R Jr, Castro M, Peters SP, Bleecker ER, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med. 2010;181(4):315-323.

Hastie AT, Moore WC, Meyers DA, Vestal PL, Li H, Peters SP, Bleecker ER. Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes. J Allergy Clin Immunol. 2010;125(5):1028-1036.

Dweik RA, Sorkness RL, Wenzel S, Hammel J, Curran-Everett D, Comhair SAA, Bleecker E, Busse W, Moore W, Peters S, et al. Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma. Am J Respir Crit Care Med. 2010;181(10):1033-1041.

Moore WC, Pascual RM. Update in asthma 2009. Am J Respir Crit Care Med. 2010;181(11):1181-1187.

Hawkins GA, Moore WC, Robinson MB, Peters SP, Meyers D, Bleecker ER. IL6R polymorphisms predict measures of lung function in caucasian asthmatics: data from the Severe Asthma Research Program (SARP) [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A1298.

Slager RE, Pascual RM, Moore WC, Hawkins GA, Peters SP, Meyers D, Bleecker ER. GATA3 polymorphisms are predictors of steroid use and atopic asthma in the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A1301.

Ortega VE, Hawkins GA, Montealegre F, Chardon D, Sadeghnejad A, Moore WC, Peters SP, Meyers D, Bleecker ER. Rare beta2 adrenergic receptor gene polymorphisms in asthma cases and controls from different ethnic groups [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A1316.

Ortega VE, Liggett SB, Pascual R, Diallo A, Moore WC, Meyers D, Bleecker ER, Hawkins GA. Epigenetics of the beta2-adrenergic receptor gene [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A1306.

Ortega VE, Hawkins GA, Sadeghnejad A, Moore WC, Meyers D, Bleecker ER. Characterization of asthma cases and controls with rare ADAM33 gene polymorphisms in a multi-ethnic population [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A1315.

Hastie AT, Albon D, Moore WC, Krings J, Smith RV, Meyers DA, Peters SP, Bleecker ER. Inflammatory protein microarray analysis of sputum from obese subjects with asthma compared with nonobese subjects with asthma [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A6801.

Pascual RM, Moore WC, Peters SP, Li H, Wenzel SE, Meyers DA, Weiss ST, Litonjua AA, Bleecker ER. Serum vitamin D levels are inversely correlated with FEV1 and FVC in asthma [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A6800.

Djukanovic R, Wilson SJ, Moore WC, Koenig SM, Laviolette M, Bleecker ER, Davis WB, Doherty DE, Olivenstein R, Israel E, et al. Montelukast added to fluticasone propionate does not alter inflammation or outcomes. Respir Med. 2010;104(10):1425-1435.

Bhatti SK, Hastie AT, Moore WC, Peters SP, Dykewicz MS, Bleecker ER. Increased numbers of macrophages and neutrophils are associated with decreased interleukin-33 (IL-33) levels in asthmatic sputum [abstract]. J Allergy Clin Immunol. 2010;125(2 Suppl 1):AB109.

Hawkins GA, Robinson MB, Moore WC, Hastie AT, Peters SP, Meyers DA, Bleecker ER. Serum levels of soluble IL6R are genetically regulated and correlate with lung function in asthmatics: Severe Asthma Research Program (SARP) [abstract]. J Allergy Clin Immunol. 2010;125(2 Suppl 1):AB357.

Peters SP, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, Boushey HA, Calhoun WJ, Meyers DA, Bleecker ER, et al. Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med. 2010;363(18):1715-1726.

Hastie AT, Moore WC, Meyers DA, Vestal PL, Krings JO, Smith RA, Li H, Peters SP, Bleecker ER. Inflammatory protein analyses of sputum from human subjects with severe or nonsevere asthma [abstract]. Am J Respir Crit Care Med. 2009;179(Online Abstr Issue):A3925.

Breit JS, Hastie AT, Vestal PL, Moore WC, Peters SP, Bleecker ER. Stem cell factor and cKit from asthmatic and normal subjects' epithelial cells and fibroblasts in response to inflammatory mediators [abstract]. Am J Respir Crit Care Med. 2009;179(Online Abstr Issue):A5444.

Moore WC. Update in asthma 2008. Am J Respir Crit Care Med. 2009;179(10):869-874.

Moore WC, Meyers DA, Li H, D'Agostino R, Peters SP, Bleecker ER. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med. 2009;179(1 Meeting Abstracts):A2522.

Crowley MB, Moore WC, Smith RV, Meyers DA, Peters SP, Bleeker ER [sic] [Bleecker ER]. The effect of specific air pollutants on FEV1 variability in the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med. 2009;179(1 Meeting Abstracts):A1291.

Moore WC, Meyers DA, Li H, Peters SP, Bleecker ER. The importance of the 3rd controller medication in the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med. 2009;179(1 Meeting Abstracts):A2806.

Pascual RM, Slager RE, Li H, Hawkins GA, Peters SP, Moore WC, Meyers DA, Bleecker ER. GATA3 polymorphisms are associated with baseline and maximal post-bronchodilator FEV1 in Severe Asthma Research Program (SARP) asthmatics [abstract]. Am J Respir Crit Care Med. 2009;179(1 Meeting Abstracts):A2449.

Sorkness RL, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Chung KF, Curran-Everett D, Erzurum SC, Moore WC, Peters SP, et al. Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation. J Appl Physiol. 2008;104(2):394-403.

Moore WC. Update in asthma 2007. Am J Respir Crit Care Med. 2008;177(10):1068-1073.

Hite RD, Hastie AT, Seeds MC, Grier BL, Peters SP, Moore WC, Bleecker ER. Surfactant alterations in asthmatics from the Wake Forest Severe Asthma Research Program Center [abstract]. Am J Respir Crit Care Med. 2008;177(Abstr Issue):A100.

Lara A, Khatri SB, Wang Z, Comhair SAA, Xu W, Dweik RA, Bodine M, Bleecker E, Moore W, Peters SP, et al. Alterations of the arginine metabolome in asthma. Am J Respir Crit Care Med. 2008;178(7):673-681.

McCallister JW, Moore WC. Hydrofluoroalkane preparations of fluticasone propionate. Expert Rev Resp Med. 2008;2(4):433-442.

Perry CD, Hawkins GA, Hastie AT, Cauthen CG, Diallo A, Li H, Moore WC, Meyers DA, Peters SP, Bleecker ER. Genetic variation in pulmonary and activation-regulated chemokine (PARC/CCL18) in asthma [abstract]. Am J Respir Crit Care Med. 2008;177(Online Abstr Issue):A338.

Cauthen CG, Hastie AT, Wu M, Vestal PL, Moore WC, Krings J, Smith RV, Bleecker ER, Peters SP. Collagen type I fragments associate with cytokines and cell counts in sputum of severe and nonsevere asthmatics [abstract]. Am J Respir Crit Care Med. 2008;177(Online Abstr Issue):A813.

Hastie AT, Vestal PL, Moore WC, Krings J, Smith RV, Peters SP, Bleecker ER. Proteomic microarray analyses of sputum from subjects with asthma compared to subjects with chronic obstructive pulmonary disease (COPD) [abstract]. Am J Respir Crit Care Med. 2008;177(Online Abstr Issue):A960.

Moore WC, Bleecker ER, Curran-Everett D, Erzurum SC, Ameredes BT, Bacharier L, Calhoun WJ, Castro M, Peters SP, Meyers DA, et al. Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol. 2007;119(2):405-413.

Moore WC, Peters SP. Update in asthma 2006. Am J Respir Crit Care Med. 2007;175(7):649-654.

Smith RS, Meyers DA, Peters SP, Moore WC, Wenzel SA, Bleecker ER, Hawkins GA. Sequence analysis of HSPA1A and HSPA1B in a multi-ethnic study population. DNA Seq. 2007;18(1):47-53.

Surka AE, Hastie AT, Moore WC, Wu M, Krings J, Smith R, Peters SP, Bleecker ER. Corticosteroid effect on brain derived neurotrophic factor (BDNF) in serum and sputum of asthmatics in vivo, and in asthmatic sputum cells and airway fibroblasts in vitro [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A56.

McCallister JW, Moore WC, Hastie AT, Vestal PL, Ampleford EJ, Hawkins GA, Wenzel SE, Meyers DA, Bleecker ER. Association of polymorphisms in the tumor necrosis factor-alpha (TNFalpha) gene with levels of TNFalpha and pulmonary function in asthma [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A462.

Surka AE, McCallister JW, Hastie AT, Moore WC, Vestel [sic] PL [Vestal PL], Krings J, Smith R, Peters SP, Bleecker ER. Levels of tumor necrosis factor alpha (TNFa) and brain derived neurotrophic factor (BDNF) correlate in sputum but not in serum [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A681.

McCallister JW, Hastie AT, Moore WC, Vestal PL, Krings JO, Smith RV, Peters SP, Bleecker ER. Lack of correlation between sputum, exhaled breath condensate and serum levels of tumor necrosis factor-alpha (TNFalpha) in asthma [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A684.

Moore WC, Everett DC, Bleecker ER, Wenzel SE. Racial differences in health care utilization in the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A829.

Smith RS, Li H, Ampleford EA, Peters SP, Moore WC, Meyers DA, Bleecker ER, Hawkins GA. Steroid complex immunophilia FKBP4 is associated with severe asthma [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A833.

Jarjour NN, Wilson SJ, Koenig SM, Laviolette M, Moore WC, Davis WB, Doherty DE, Hamid Q, Israel E, Kavuru MS, et al. Control of airway inflammation maintained at a lower steroid dose with 100/50 mu g of fluticasone propionate/salmeterol. J Allergy Clin Immunol. 2006;118(1):44-52.

Hawkins GA, Tantisira K, Meyers DA, Ampleford EJ, Moore WC, Klanderman B, Liggett SB, Peters SP, Weiss ST, Bleecker ER. Sequence, haplotype and association analysis of ADRbeta2 in a multiethnic asthma case-control study. Am J Respir Crit Care Med. 2006;174(10):1101-1109.