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Research

Griffith D. Parks, Ph.D.

Professor, Microbiology & Immunology
Translational Science Institute
Comprehensive Cancer Center
Women's Health Center of Excellence for Research, Leadership, Education
WFU Primate Center
Translational Science Institute

Contact Information

Academic: 336-716-9083 | Department: 336-716-2011

Email: gparks@wakehealth.edu

Education & Training

B.A., University of Colorado-Boulder , 1982
Ph.D., University of Wisconsin-Madison , 1987
Fellowship, Northwestern University, 1991

Griffith D. Parks, Ph.D.

Professor, Microbiology & Immunology Translational Science Institute
Comprehensive Cancer Center
Women's Health Center of Excellence for Research, Leadership, Education
WFU Primate Center
Translational Science Institute

Contact Information

Academic: 336-716-9083 | Department: 336-716-2011

Email: gparks@wakehealth.edu

Recent Publications

Briggs CM, Mayer AE, Parks GD. Mumps virus inhibits migration of primary human macrophages toward a chemokine gradient through a TNF-alpha dependent mechanism. Virology. 2012;433(1):245-252.

Whitlock PW, Seyler TM, Parks GD, Ornelles DA, Smith TL, Van Dyke ME, Poehling GG. A novel process for optimizing musculoskeletal allograft tissue to improve safety, ultrastructural properties, and cell infiltration. J Bone Joint Surg Am. 2012;94(16):1458-1467.

Johnson JB, Lyles DS, Alexander-Miller MA, Parks GD. Virion-associated complement regulator CD55 is more potent than CD46 in mediating resistance of mumps virus and vesicular stomatitis virus to neutralization. J Virol. 2012;86(18):9929-9940.

Biswas M, Johnson JB, Kumar SRP, Parks GD, Subbiah E. Incorporation of host complement regulatory proteins into Newcastle disease virus enhances complement evasion. J Virol. 2012;86(23):12708-16.

Johnson JB, Douglas LS [sic] [Lyles DS], Martha AMA [sic] [Alexander-Miller MA], Griffith DG [sic] [Parks GD]. Virion-associated complement regulator CD55 is more potent than CD46 in mediating resistance of mumps virus and VSV to neutralization [abstract]. Immunobiology. 2012;217(11):1215-1216.

Briggs CM, Holder RC, Reid SD, Parks GD. Activation of human macrophages by bacterial components relieves the restriction on replication of an interferon-inducing parainfluenza virus 5 (PIV5) P/V mutant. Microbes Infect. 2011;13(4):359-368.

Johnson JB, Aguilar HC, Lee B, Parks GD. Interactions of human complement with virus particles containing the Nipah virus glycoproteins. J Virol. 2011;85(12):5940-5948.

Clark KM, Johnson JB, Kock ND, Mizel SB, Parks GD. Parainfluenza virus 5-based vaccine vectors expressing vaccinia virus (VACV) antigens provide long-term protection in mice from lethal intranasal VACV challenge. Virology. 2011;419(2):97-106.

Manuse MJ, Parks GD. TLR3-dependent upregulation of RIG-I leads to enhanced cytokine production from cells infected with the parainfluenza virus SV5. Virology. 2010;397(1):231-241.

Arimilli S, Sharma SK, Yammani R, Reid SD, Parks GD, Alexander-Miller MA. Pivotal advance: nonfunctional lung effectors exhibit decreased calcium mobilization associated with reduced expression of ORAI1. J Leukoc Biol. 2010;87(6):977-988.

Manuse MJ, Briggs CM, Parks GD. Replication-independent activation of human plasmacytoid dendritic cells by the paramyxovirus SV5 requires TLR7 and autophagy pathways. Virology. 2010;405(2):383-389.

Johnson JB, Lyles DS, Parks GD. Complement evasion by vesicular stomatitis virus involves recruitment of host complement regulatory proteins [abstract]. Mol Immunol. 2010;47(13):2239.

Palmer EM, Holbrook BC, Arimilli S, Parks GD, Alexander-Miller MA. IFNgamma-producing, virus-specific CD8+ effector cells acquire the ability to produce IL-10 as a result of entry into the infected lung environment. Virology. 2010;404(2):225-230.

Parks GE [sic] [Parks GD], Perkins LA, Garvin AJ, Geisinger KR. Evaluation of renal neoplasms by FNA and core biopsy: benefits of a combined approach to sampling during radiofrequency ablation as demonstrated by 215 consecutive cases [abstract]. Mod Pathol. 2009;22(1 Suppl):93A.

Johnson JB, Grant K, Parks GD. The paramyxoviruses simian virus 5 and mumps virus recruit host cell CD46 to evade complement-mediated neutralization. J Virol. 2009;83(15):7602-7611.

Manuse MJ, Parks GD. Role for the paramyxovirus genomic promoter in limiting host cell antiviral responses and cell killing. J Virol. 2009;83(18):9057-9067.

Gainey MD, Dillon PJ, Clark KM, Manuse MJ, Parks GD. Paramyxovirus-induced shutoff of host and viral protein synthesis: role of the P and V proteins in limiting PKR activation. J Virol. 2008;82(2):828-839.

Johnson JB, Capraro GA, Parks GD. Differential mechanisms of complement-mediated neutralization of the closely related paramyxoviruses simian virus 5 and mumps virus. Virology. 2008;376(1):112-123.

Capraro GA, Johnson JB, Kock ND, Parks GD. Virus growth and antibody responses following respiratory tract infection of ferrets and mice with WT and P/V mutants of the paramyxovirus Simian Virus 5. Virology. 2008;376(2):416-428.

Gainey MD, Manuse MJ, Parks GD. A hyperfusogenic F protein enhances the oncolytic potency of a paramyxovirus simian virus 5 P/V mutant without compromising sensitivity to type I interferon. J Virol. 2008;82(19):9369-9380.

Arimilli S, Johnson JB, Clark KM, Graff AH, Alexander-Miller MA, Mizel SB, Parks GD. Engineered expression of the TLR5 ligand flagellin enhances paramyxovirus activation of human dendritic cell function. J Virol. 2008;82(22):10975-85.

Lamb RA, Parks GD. Paramyxoviridae: the viruses and their replication In: Knipe DM, Howley PM, Griffin DE, Lamb RA, Straus SE, Martin MA, Roizman B, eds. Fields virology. 5th ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins;2007: 1449-1496.

Connor JH, McKenzie MO, Parks GD, Lyles DS. Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses. Virology. 2007;362(1):109-119.

Pejawar-Gaddy S, Gitiban-Vaghefi N, Parks GD, Alexander-Miller MA. Distinct pathways for signaling maturation in macrophages and dendritic cells after infection with paramyxovirus simian virus 5. Viral Immunol. 2007;20(1):76-87.

Arimilli S, Johnson JB, Alexander-Miller MA, Parks GD. TLR-4 and -6 agonists reverse apoptosis and promote maturation of simian virus 5-infected human dendritic cells through NFkB-dependent pathways. Virology. 2007;365(1):144-156.

Dillon PJ, Parks GD. Role for the phosphoprotein P subunit of the paramyxovirus polymerase in limiting induction of host cell antiviral responses. J Virol. 2007;81(20):11116-27.

Dillon PJ, Wansley EK, Young VA, Alexander-Miller MA, Parks GD. Exchange of P/V genes between two non-cytopathic simian virus 5 variants results in a recombinant virus that kills cells through death pathways that are sensitive to caspase inhibitors. J Gen Virol. 2006;87(Pt 12):3643-3648.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

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For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Microbiology & Immunology

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