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David R. Riddle, Ph.D.

David R. Riddle, Ph.D.

Professor, Neurobiology & Anatomy
Comprehensive Cancer Center
Brain Tumor Center of Excellence
Sticht Center on Aging

Contact Information

Academic: 336-716-4677 | Department: 336-716-4677

Email: driddle@wakehealth.edu

Education & Training

  • Ph.D., University of Michigan/Ann Arbor , 1990
  • B.S., University of North Carolina-Chapel Hill , 1984
  • Fellowship, Duke University Medical Center, 1996

Related Links

David R. Riddle, Ph.D.

David R. Riddle, Ph.D.

Professor, Neurobiology & Anatomy Comprehensive Cancer Center
Brain Tumor Center of Excellence
Sticht Center on Aging

Research Interests

cognition/learning

Contact Information

Academic: 336-716-4677 | Department: 336-716-4677

Email: driddle@wakehealth.edu

Recent Publications

Lee TC, Greene-Schloesser D, Payne V, Diz DI, Hsu F-C, Kooshki M, Mustafa R, Riddle DR, Zhao W, Chan MD, Robbins ME. Chronic administration of the angiotensin-converting enzyme inhibitor, ramipril, prevents fractionated whole-brain irradiation-induced perirhinal cortex-dependent cognitive impairment. Radiat Res. 2012;178(1):46-56.

Riddle DR, Forbes ME, Paitsel M. Radiation-induced changes in the growth hormone/IGF-1 axis in adult and aging rats [abstract]. Soc Neurosci Abstr. 2012;2012(Neuroscience Meeting Planner):.

Willard SL, Riddle DR, Forbes ME, Hemby SE, McIntosh S, Uberseder B, Shively CA. Cellular and molecular factors contributing to hippocampus size in an adult female monkey model of depression [abstract]. Soc Neurosci Abstr. 2012;2012(Neuroscience Meeting Planner):.

Hua K, Schindler MK, McQuail JA, Forbes ME, Riddle DR. Regionally distinct responses of microglia and glial progenitor cells to whole brain irradiation in adult and aging rats. PLoS One. 2012;7(12):e52728.

Sergeant S, McQuail JA, Riddle DR, Chilton FH, Ortmeier SB, Jessup JA, Groban L, Nicolle MM. Dietary fish oil modestly attenuates the effect of age on diastolic function but has no effect on memory or brain inflammation in aged rats. J Gerontol A Biol Sci Med Sci. 2011;66(5):521-533.


Schindler MK, Bourland JD, Forbes ME, Hua K, Riddle DR. Neurobiological responses to stereotactic focal irradiation of the adult rodent hippocampus. J Neurol Sci. 2011;306(1-2):129-137.

McQuail JA, Riddle DR, Nicolle MM. Neuroinflammation not associated with cholinergic degeneration in aged-impaired brain. Neurobiol Aging. 2011;32(12):2322.e1-4.

Willard SL, Riddle DR, Forbes ME, Shively CA. Effects of behavioral depression on cell number, size and density in the hippocampus of adult female cynomolgus macaques [abstract]. Soc Neurosci Abstr. 2011;2011(Neuroscience Meeting Planner):.

Riddle DR, Forbes ME, Paitsel M. Sustained performance in memory tasks in old rats [abstract]. Soc Neurosci Abstr. 2011;2011(Neuroscience Meeting Planner):.

Ramanan S, Zhao W, Riddle DR, Robbins ME. Role of PPARs in radiation-induced brain injury. PPAR Res. 2010;2010():art.234975.

Conner KR, Payne VS, Forbes ME, Robbins ME, Riddle DR. Effects of the AT1 receptor antagonist L-158,809 on microglia and neurogenesis after fractionated whole-brain irradiation. Radiat Res. 2010;173(1):49-61.

Hua K, Forbes ME, Riddle DR. Effects of long-term, adult-onset growth hormone/IGF-I deficiency on oligodendrocyte turnover and adult neurogenesis [abstract]. Soc Neurosci Abstr. 2010;2010(Neuroscience Meeting Planner):.

Riddle DR, Forbes ME, Paitsel M, Shi L, Linville MC, Brunso-Bechtold JK. Chronic alterations in microglia and cell proliferation in the adult rat hippocampus following fractionated whole-brain irradiation at middle age [abstract]. Soc Neurosci Abstr. 2010;2010(Neuroscience Meeting Planner):.

Adams MM, Forbes ME, Linville MC, Riddle DR, Sonntag WE, Brunso-Bechtold JK. Stability of local brain levels of insulin-like growth factor-I in two well-characterized models of decreased plasma IGF-I. Growth Factors. 2009;27(3):181-188.

Hua K, Forbes ME, Lichtenwalner RJ, Sonntag WE, Riddle DR. Adult-onset deficiency in growth hormone and insulin-like growth factor-I alters oligodendrocyte turnover in the corpus callosum. Glia. 2009;57(10):1062-1071.

McQuail JA, Riddle DR, Nicolle MM. Microglial activation but no loss of cholinergic neurons in basal forebrain of aged-impaired F344 x Brown Norway F1 rats [abstract]. Soc Neurosci Abstr. 2009;2009(Neuroscience Meeting Planner):.

Riddle DR, Nieves-Martinez E, Wilson A, Sonntag WE, Nicolle MM. Acute growth hormone administration shows no benefits on spatial retention memory in aged Fisher 344 x BN F1 rats [abstract]. Soc Neurosci Abstr. 2009;2009(Neuroscience Meeting Planner):.

Ramanan S, Kooshki M, Zhao W, Hsu F-C, Riddle DR, Robbins ME. The PPARalpha agonist fenofibrate preserves hippocampal neurogenesis and inhibits microglial activation after whole-brain irradiation. Int J Radiat Oncol Biol Phys. 2009;75(3):870-877.

Wiant D, Atwood TF, Olson J, Papagikos M, Forbes ME, Riddle DR, Bourland JD. Gamma knife radiosurgery treatment planning for small animals using high-resolution 7T micro-magnetic resonance imaging. Radiat Res. 2009;172(5):625-631.

Ingraham JP, Forbes ME, Riddle DR, Sonntag WE. Aging reduces hypoxia-induced microvascular growth in the rodent hippocampus. J Gerontol A Biol Sci Med Sci. 2008;63(1):12-20.

Schindler MK, Forbes ME, Robbins ME, Riddle DR. Aging-dependent changes in the radiation response of the adult rat brain. Int J Radiat Oncol Biol Phys. 2008;70(3):826-834.

Adams MM, Shi L, Linville MC, Forbes ME, Long AB, Bennett C, Newton IG, Carter CS, Riddle DR, Brunso-Bechtold JK, et al. Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability. Exp Neurol. 2008;211(1):141-149.

Newton IG, Forbes ME, Linville MC, Pang H, Tucker EW, Riddle DR, Brunso-Bechtold JK. Effects of aging and caloric restriction on dentate gyrus synapses and glutamate receptor subunits. Neurobiol Aging. 2008;29(9):1308-1318.

Conner KR, Forbes ME, Lee WH, Lee YW, Riddle DR. Angiotensin type 1 receptor blockade and radiation-induced brain injury [abstract]. Soc Neurosci Abstr. 2008;2008(Neuroscience Meeting Planner):.

Riddle DR, Schindler MK, Forbes ME, Hua K, Bourland JD. Low dose Gamma Knife irradiation of the adult rodent hippocampus: aging affects the development of in- and out-of-field effects [abstract]. Soc Neurosci Abstr. 2008;2008(Neuroscience Meeting Planner):.

Hua K, Schindler MK, Forbes ME, Robbins ME, Riddle DR. Aging alters the response of oligodendrocyte precursor cells and microglia to whole brain irradiation [abstract]. Soc Neurosci Abstr. 2008;2008(Neuroscience Meeting Planner):.

McQuail JA, Schindler MK, Riddle DR. The neuroinflammatory response of the adult rat hippocampus to whole brain irradiation is age-dependent and sub-region specific [abstract]. Soc Neurosci Abstr. 2008;2008(Neuroscience Meeting Planner):.

Linville C, Forbes E, Riddle D, Sonntag W, Adams M, Brunso-Bechtold JK. Plasma and hippocampal levels of insulin-like growth factor-1 (IGF-1) differ in rodent models of caloric restriction and adult-onset growth hormone deficiency [abstract]. Soc Neurosci Abstr. 2008;2008(Neuroscience Meeting Planner):.

Riddle DR. In: Brain aging models, methods, and mechanisms. Boca Raton (FL): CRC Press;2007: .

Riddle DR, Lichtenwalner RJ. Neurogenesis in the adult and aging brain In: Riddle DR, ed. Brain aging models, methods, and mechanisms. Boca Raton (FL): CRC Press;2007: 127-157.

Sonntag WE, Eckman DM, Ingraham J, Riddle DR. Regulation of cerebrovascular aging In: Riddle DR, ed. Brain aging models, methods, and mechanisms. Boca Raton (FL): CRC Press;2007: 279-304.

Shi L, Adams MM, Linville MC, Newton IG, Forbes ME, Long AB, Riddle DR, Brunso-Bechtold JK. Caloric restriction eliminates the aging-related decline in NMDA and AMPA receptor subunits in the rat hippocampus and induces homeostasis. Exp Neurol. 2007;206(1):70-79.

Riddle DR, Schindler MK. Brain aging research. Rev Clin Gerontol. 2007;17(4):225-239.

Sonntag WE, Bennett C, Ingram R, Donahue A, Ingraham J, Chen H, Moore T, Brunso-Bechtold JK, Riddle D. Growth hormone and IGF-I modulate local cerebral glucose utilization and ATP levels in a model of adult-onset growth hormone deficiency. Am J Physiol Endocrinol Metab. 2006;291(3):E604-E610.

Shan HQ, Riddle DR. Effects of decreased IGF-1 signaling on dendritic spine development [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

Ingraham J, Ingram R, Forbes E, Riddle DR, Sonntag WE. Effect of aging and growth hormone administration on basal and hypoxia-stimulated hippocampal vascular growth factor expression, microvascular density, and angiogenesis [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

Conner KR, Forbes ME, Gallagher PE, Robbins ME, Riddle DR. Assessing the effects of AT1 receptor blockade on WBI-induced brain damage [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

Schindler MK, Robbins ME, Riddle DR. Assessing the effects of aging on radiation-induced brain injury [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

Hua K, Forbes ME, Sonntag WE, Riddle DR. Effects of adult-onset growth hormone/IGF-I deficiency on oligodendrocyte turnover [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Neurobiology & Anatomy

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