Alan J. Townsend, Ph.D., Professor Biochemistry - Wake Forest School of Medicine

Alan J. Townsend, Ph.D.

Program Director, Comprehensive Cancer Center
Professor, Biochemistry
Comprehensive Cancer Center
Women's Health Center of Excellence for Research, Leadership, Education
Cancer Biology

Contact Information

Department: 336-713-7215

Email: atown@wakehealth.edu

Education & Training

Ph.D., University of North Carolina-Chapel Hill , 1986
B.S., University of South Florida , 1974
Fellowship, National Institutes Hlth, 1990

Memberships

Am Assn Of Advancement Of Scie
Am Assn Of Cancer Research
Soc Of Toxicology
Am Soc Of Biochem & Mol Biolog
Environmental Mutagen Society
Int'l Soc for Study of Xenobio

Alan J. Townsend, Ph.D.

Program Director, Comprehensive Cancer Center
Professor, Biochemistry Comprehensive Cancer Center
Women's Health Center of Excellence for Research, Leadership, Education
Cancer Biology

Research Interests

cancer/oncogenesis

Contact Information

Department: 336-713-7215

Email: atown@wakehealth.edu

Recent Publications

Lok HC, Rahmanto YS, Hawkins CL, Kalinowski DS, Morrow CS, Townsend AJ, Ponka P, Richardson DR. Nitric oxide storage and transport in cells are mediated by glutathione S-transferase P1-1 and multidrug resistance protein 1 via dinitrosyl iron complexes. J Biol Chem. 2012;287(1):607-618.

Rudd LP, Kabler SL, Morrow CS, Townsend AJ. Enhanced glutathione depletion, protein adduct formation, and cytotoxicity following exposure to 4-hydroxy-2-nonenal (HNE) in cells expressing human multidrug resistance protein-1 (MRP1) together with human glutathione S-transferase-M1 (GSTM1). Chem Biol Interact. 2011;194(2-3):113-119.

Kabler SL, Seidel A, Jacob J, Doehmer J, Morrow CS, Townsend AJ. Differential protection by human glutathione S-transferase P1 against cytotoxicity of benzo[a]pyrene, dibenzo[a,l]pyrene, or their dihydrodiol metabolites, in bi-transgenic cell lines that co-express rat versus human cytochrome P4501A1. Chem Biol Interact. 2009;179(2-3):240-246.

Bates DJP, Lively MO, Gorczynski MJ, King SB, Townsend AJ, Morrow CS. Noncatalytic interactions between glutathione S-transferases and nitroalkene fatty acids modulate nitroalkene-mediated activation of peroxisomal proliferator-activated receptor gamma. Biochemistry. 2009;48(19):4159-4169.

Dance-Barnes ST, Kock ND, Moore JE, Lin EY, Mosley LJ, D'Agostino RB Jr, McCoy TP, Townsend AJ, Miller MS. Lung tumor promotion by curcumin. Carcinogenesis. 2009;30(6):1016-1023.

Sibhatu MB, Smitherman PK, Townsend AJ, Morrow CS. Expression of MRP1 and GSTP1-1 modulate the acute cellular response to treatment with the chemopreventive isothiocyanate, sulforaphane. Carcinogenesis. 2008;29(4):807-815.

Miller MS, Dance ST, Kock ND, Moore JE, D'Agostino RB Jr, Mosley LJ, Townsend AJ. Lung tumor promotion by curcumin [abstract]. Toxicol Sci. 2008;102(S-1 [Toxicologist]):23.

Peklak-Scott C, Smitherman PK, Townsend AJ, Morrow CS. Role of glutathione S-transferase P1-1 in the cellular detoxification of cisplatin. Mol Cancer Ther. 2008;7(10):3247-3255.

Ahmad S, Kabler SL, Rudd L, Amin S, Doehmer J, Morrow CS, Townsend AJ. Cytotoxicity and mutagenicity of 5-methylchrysene and its 1,2-dihydrodiol in V79MZ cells modified to express human CYP1A1 or CYP1B1, in the presence or absence of human GSTP1 coexpression. Toxicol Lett. 2008;183(1-3):99-104.

Scott LM, Durant P, Leone-Kabler S, Wood CE, Register TC, Townsend A, Cline JM. Effects of prior oral contraceptive use and soy isoflavonoids on estrogen-metabolizing cytochrome P450 enzymes. J Steroid Biochem Mol Biol. 2008;112(4-5):179-185.

Kushman ME, Kabler SL, Fleming MH, Ravoori S, Gupta RC, Dochmer J, Morrow CS, Townsend AJ. Expression of human glutathione S-transferase P1 confers resistance to benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol mutagenesis, macromolecular alkylation, and formation of stable N2-Gua-BPDE adducts in stably transfected. Carcinogenesis. 2007;28(1):207-214.

Kushman ME, Kabler SL, Ahmad S, Doehmer J, Morrow CS, Townsend AJ. Protective efficacy of hGSTM1-1 against B[a]P and (+)- or (-)-B[a]P-7,8-dihydrodiol cytotoxicity, mutagenicity, and macromolecular adducts in V79 cells coexpressing hCYP1A1. Toxicol Sci. 2007;99(1):51-57.

Kushman ME, Kabler SL, Ahmad S, Doehmer J, Morrow CS, Townsend AJ. Cytotoxicity and mutagenicity of dibenzo[a,1]pyrene and (+/-)-dibenzo [a,1]pyrene-11, 12-dihydrodiol in V79MZ cells co-expressing either hCYP1A1 or hCYP1B1 together with human glutathione-S-transferase A1. Mutat Res. 2007;624(1-2):80-87.

Hu Y, Kabler SL, Tennant AH, Townsend AJ, Kligerman AD. Induction of DNA-protein crosslinks by dichloromethane in a V79 cell line transfected with the murine glutathione-S-transferase theta 1 gene. Mutat Res. 2006;607(2):231-239.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

WFBMC
All

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Biochemistry

Profile

Alan J. Townsend, Ph.D.

Contact Information

Education & Training

Memberships

Alan J. Townsend, Ph.D.

Research Interests

Contact Information

Recent Publications

All Publications

Quick Reference

Research