James P. Vaughn, Ph.D., Assistant Professor Cancer Biology

James P. Vaughn, Ph.D.

Assistant Professor, Cancer Biology
Comprehensive Cancer Center

Clinical Specialties

Breast Cancer

Contact Information

Academic: 336-716-7122 | Department: 336-716-7122

Email: jvaughn@wakehealth.edu

Education & Training

Ph.D., University of Virginia , 1992
B.S., Duke University , 1983
Fellowship, Biophysical Chemistry, University of Virginia, 1984
Fellowship, Surgery, Duke University School of Medicine, 1995

James P. Vaughn, Ph.D.

Assistant Professor, Cancer Biology Comprehensive Cancer Center

Research Interests

biotechnology, cancer/oncogenesis, drugs/therapeutic agents pharm

Contact Information

Academic: 336-716-7122 | Department: 336-716-7122

Email: jvaughn@wakehealth.edu

Recent Publications

Huang W, Smaldino PJ, Zhang Q, Miller LD, Cao P, Stadelman K, Wan M, Giri B, Lei M, Nagamine Y, Vaughn JP, Akman SA, Sui G. Yin Yang 1 contains G-quadruplex structures in its promoter and 5'-UTR and its expression is modulated by G4 resolvase 1. Nucleic Acids Res. 2012;40(3):1033-1049.

Kute T, Stehle Jr JR, Ornelles D, Walker N, Delbono O, Vaughn JP. Understanding key assay parameters that affect measurements of trastuzumab-mediated ADCC against Her2 positive breast cancer cells. Oncoimmunology. 2012;1(6):810-821.

Giri B, Smaldino PJ, Thys RG, Creacy SD, Routh ED, Hantgan RR, Lattmann S, Nagamine Y, Akman SA, Vaughn JP. G4 Resolvase 1 tightly binds and unwinds unimolecular G4-DNA. Nucleic Acids Res. 2011;39(16):7161-7178.

Lattmann S, Stadler MB, Vaughn JP, Akman SA, Nagamine Y. The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme. Nucleic Acids Res. 2011;39(21):9390-9404.

Lattmann S, Giri B, Vaughn JP, Akman SA, Nagamine Y. Role of the amino terminal RHAU-specific motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU. Nucleic Acids Res. 2010;38(18):6219-6233.

Kute TE, Savage L, Stehle JR Jr, Kim-Shapiro JW, Blanks MJ, Wood J, Vaughn JP. Breast tumor cells isolated from in vitro resistance to trastuzumab remain sensitive to trastuzumab anti-tumor effects in vivo and to ADCC killing. Cancer Immunol Immunother. 2009;58(11):1887-1896.

Creacy SD, Routh ED, Iwamoto F, Nagamine Y, Akman SA, Vaughn JP. G4 resolvase-1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates. J Biol Chem. 2008;283(50):34626-34.

Kute TE, Savage L, Wood J, Vaughn J. Mechanism of action of herceptin killing of HER-2+breast cancer cells under 'in vitro' and 'in vivo' conditions [abstract]. Breast Cancer Res Treat. 2007;106(Suppl 1):S123.