Yuh-Hwa Wang, Ph.D., Associate Professor Biochemistry

Yuh-Hwa Wang, Ph.D.

Associate Professor, Biochemistry
Comprehensive Cancer Center
Cancer Biology

Contact Information

Department: 336-716-6186

Email: ywang@wakehealth.edu

Education & Training

Ph.D., University of North Carolina-Chapel Hill , 1989
B.S., Natl Taiwan Univ College of Medicine-Taiwan , 1983

Memberships

Am Assn Of Advancement Of Scie
Am Soc Of Biochem & Mol Biolog
Am Soc Of Human Genetics

Yuh-Hwa Wang, Ph.D.

Associate Professor, Biochemistry Comprehensive Cancer Center
Cancer Biology

Research Interests

cancer/oncogenesis, molecular biology/molecular me, structural biology

Contact Information

Department: 336-716-6186

Email: ywang@wakehealth.edu

Recent Publications

Dillon LW, Pierce LC, Ng MCY, Wang Y-H. Role of DNA secondary structures in fragile site breakage along human chromosome 10. Hum Mol Genet. 2013;22(7):1443-1456.

Dillon LW, Lehman CE, Wang Y-H. The role of fragile sites in sporadic papillary thyroid carcinoma. J Thyroid Res. 2012;2012():927683.

Reddy K, Tam M, Bowater RP, Barber M, Tomlinson M, Edamura KN, Wang Y-H, Pearson CE. Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeats. Nucleic Acids Res. 2011;39(5):1749-1762.

Weckerle AB, Santra M, Ng MCY, Koty PP, Wang Y-H. CBFB and MYH11 in inv(16)(p13q22) of acute myeloid leukemia displaying close spatial proximity in interphase nuclei of human hematopoietic stem cells. Genes Chromosomes Cancer. 2011;50(9):746-755.

Wan C, Kulkarni A, Wang Y-H. ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment. Mutat Res. 2010;686(1-2):39-46.

Gandhi M, Dillon LW, Pramanik S, Nikiforov YE, Wang Y-H. DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells. Oncogene. 2010;29(15):2272-2280.

Burrow AA, Marullo A, Holder LR, Wang Y-H. Secondary structure formation and DNA instability at fragile site FRA16B. Nucleic Acids Res. 2010;38(9):2865-2877.

Li G, Margueron R, Hu G, Stokes D, Wang Y-H, Reinberg D. Highly compacted chromatin formed in vitro reflects the dynamics of transcription activation in vivo. Mol Cell. 2010;38(1):41-53.

Dillon LW, Burrow AA, Wang YH. DNA instability at chromosomal fragile sites in cancer. Curr Genomics. 2010;11(5):326-337.

Burrow AA, Williams LE, Pierce LCT, Wang Y-H. Over half of breakpoints in gene pairs involved in cancer-specific recurrent translocations are mapped to human chromosomal fragile sites. BMC Genomics. 2009;10():article 59.

Hagerman KA, Ruan H, Edamura KN, Matsuura T, Pearson CE, Wang Y-H. The ATTCT repeats of spinocerebellar ataxia type 10 display strong nucleosome assembly which is enhanced by repeat interruptions. Gene. 2009;434(1-2):29-34.

Kar K, Wang YH, Brodsky B. Sequence dependence of kinetics and morphology of collagen model peptide self-assembly into higher order structures. Protein Sci. 2008;17(6):1086-1095.

Ruan H, Wang Y-H. Friedreich's ataxia GAA.TTC duplex and GAA.GAA.TTC triplex structures exclude nucleosome assembly. J Mol Biol. 2008;383(2):292-300.

Trojer P, Li G, Sims RJ III, Vaquero A, Kalakonda N, Boccuni P, Lee D, Erdjument-Bromage H, Tempst P, Wang Y-H, et al. L3MBTL1, a histone-methylation-dependent chromatin lock. Cell. 2007;129(5):915-928.

Wang YH. Chromatin structure of repeating CTG/CAG and CGG/CCG sequences in human disease. Front Biosci. 2007;12():4731-4741.

Wang Y-H. Nucleosome assembly on DNA derived from rare fragile sites In: Arrieta I, Penagarikano O, Telez M, eds. Fragile sites: new discoveries and changing perspectives. New York: Nova Biomedical Books;2007: 147-165.