Profile

Mark A. Espeland, Ph.D.Wake Forest Baptist Health

Education & Training

  • Ph.D., University of Rochester , 1981
  • B.S., Arizona State University-Tempe Campps , 1974
  • M.A., University of Rochester , 1981

Memberships

  • Am Academy Of Neurology
  • Am Assn Of Advancement Of Scie
  • Soc Clin Trials
  • Am Diabetes Assn
  • Am Statistical Assn
  • Biometric Society
Mark A. Espeland, Ph.D.Wake Forest Baptist Health

Mark A. Espeland, Ph.D.

Professor, Department of Biostatistics
Translational Science Institute
Office of Women in Medicine and Science
Sticht Center on Aging
Center for Diabetes Research
WFU Primate Center
Center for Integrative Medicine
Translational Science Institute

Research Interests

aging, cognition/learning, diabetes, drugs/therapeutic agents pharm, environmental sciences, epidemiology, fitness/physical, nutrition

Contact Information

Academic: 336-716-2826 | Department: 336-716-2011

Email: mespelan@wakehealth.edu

Recent Publications

Coker LH, Espeland MA, Hogan PE, Resnick SM, Bryan RN, Robinson JG, Goveas JS, Davatzikos C, Kuller LH, Williamson JD, Bushnell CD, Shumaker SA. Change in brain and lesion volumes after CEE therapies: The WHIMS-MRI studies. Neurology. 2014;82(5):427-434.

Klepin HD, Geiger AM, Bandos H, Costantino JP, Rapp SR, Sink KM, Lawrence JA, Atkinson HH, Espeland MA. Cognitive factors associated with adherence to oral antiestrogen therapy: results from the cognition in the study of tamoxifen and raloxifene (Co-STAR) study. Cancer Prev Res (Phila Pa). 2014;7(1):161-168.

Pottala JV, Yaffe K, Robinson JG, Espeland MA, Wallace R, Harris WS. Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI Study. Neurology. 2014;82(5):435-442.

Fitzpatrick SL, Jeffery R, Johnson KC, Roche CC, Van Dorsten B, Gee M, Dotson K, Walkup MP, Espeland MA, Bahnson JL, Wagenknecht LE, Reboussin D, Rejeski WJ, Bertoni AG, Lang W, Lawlor MS, Lefkowitz D, Miller GD, Reynolds PS, Ribisl PM,. Baseline predictors of missed visits in the Look AHEAD study. Obesity (Silver Spring). 2014;22(1):131-140.

Espeland MA, Bryan RN, Goveas JS, Robinson JG, Siddiqui MS, Liu S, Hogan PE, Casanova R, Coker LH, Yaffe K, Masaki K, Rossom R, Resnick SM. Influence of type 2 diabetes on brain volumes and changes in brain volumes: results from the Women's Health Initiative magnetic resonance imaging studies. Diabetes Care. 2013;36(1):90-97.

Kostis WJ, Cabrera J, Hooper WC, Whelton PK, Espeland MA, Cosgrove NM, Cheng JQ, Deng Y, De Staerck C, Pyle M, Maruthur N, Reyes I, Anderson CA, Liu J, Kostis JB. Relationships between selected gene polymorphisms and blood pressure sensitivity to weight loss in elderly persons with hypertension. Hypertension. 2013;61(4):857-863.

Vaughan L, Espeland MA, Snively B, Shumaker SA, Rapp SR, Shupe J, Robinson JG, Sarto GE, Resnick SM. The rationale, design, and baseline characteristics of the Women's Health Initiative Memory Study of Younger Women (WHIMS-Y). Brain Res. 2013;1514():3-11.

Sophonsritsuk A, Appt SE, Clarkson TB, Shively CA, Espeland MA, Register TC. Differential effects of estradiol on carotid artery inflammation when administered early versus late after surgical menopause. Menopause. 2013;20(5):540-547.

Wilson V, Espeland M, Rapp S, Oles K, Gass M, Thomas A, Sherwin B, Sink K. Prevalence of anticholinergic drug use and impact on cognition in older women: results from the Women's Health Initiative Memory Study (WHIMS) [abstract]. J Am Geriatr Soc. 2013;61(Suppl 1):S14.

Kavanagh K, Espeland MA, Sutton-Tyrrell K, Barinas-Mitchell E, Khoudary SR, Wildman RP. Liver fat and SHBG affect insulin resistance in midlife women: the Study of Women's Health Across the Nation (SWAN). Obesity (Silver Spring). 2013;21(5):1031-1038.

Espeland MA, Pettinger M, Falkner KL, Shumaker SA, Limacher M, Thomas F, Weaver KE, Stefanick ML, McQuellon C, Hunt JR, Johnson KC. Demographic and health factors associated with enrollment in posttrial studies: the Women's Health Initiative Hormone Therapy Trials. Clin Trials. 2013;10(3):463-472.

Rubin RR, Peyrot M, Gaussoin SA, Espeland MA, Williamson D, Faulconbridge LF, Wadden TA, Ewing L, Safford M, Evans-Hudnall G, Wing RR, Knowler WC. Four-year analysis of cardiovascular disease risk factors, depression symptoms, and antidepressant medicine use in the Look AHEAD (Action for Health in Diabetes) clinical trial of weight loss in diabetes. Diabetes Care. 2013;36(5):1088-1094.

Espeland MA, Rejeski WJ, West DS, Bray GA, Clark JM, Peters AL, Chen H, Johnson KC, Horton ES, Hazuda HP. Intensive weight loss intervention in older individuals: results from the Action for Health in Diabetes Type 2 diabetes mellitus trial. J Am Geriatr Soc. 2013;61(6):912-922.

Rossom RC, Espeland MA, Manson JE, Dysken MW, Johnson KC, Lane DS, LeBlanc ES, Lederle FA, Masaki KH, Margolis KL. Response to Annweiler and Beauchet [letter]. J Am Geriatr Soc. 2013;61(6):1050-1051.

Wing RR, Bolin P, Brancati FL, Bray GA, Clark JM, Coday M, Crow RS, Curtis JM, Egan CM, Espeland MA, Evans M, Foreyt JP, Ghazarian S, Gregg EW, Harrison B, Hazuda HP, Hill JO, Horton ES, Hubbard VS, Jakicic JM,. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med. 2013;369(2):145-154.

Ammann EM, Pottala JV, Harris WS, Espeland MA, Wallace R, Denburg NL, Carnahan RM, Robinson JG. Omega-3 fatty acids and domain-specific cognitive aging: secondary analyses of data from WHISCA. Neurology. 2013;81(17):1484-1491.

Espeland MA, Katula JA, Rushing J, Kramer AF, Jennings JM, Sink KM, Nadkarni NK, Reid KF, Castro CM, Church T, Kerwin DR, Williamson JD, Marottoli RA, Rushing S, Marsiske M, Rapp SR. Performance of a computer-based assessment of cognitive function measures in two cohorts of seniors. Int J Geriatr Psychiatry. 2013;28(12):1239-1250.

Casanova R, Hsu FC, Sink KM, Rapp SR, Williamson JD, Resnick SM, Espeland MA. Alzheimer's disease risk assessment using large-scale machine learning methods. PLoS One. 2013;8(11):e77949.

Espeland MA, Shumaker SA, Leng I, Manson JE, Brown CM, LeBlanc ES, Vaughan L, Robinson J, Rapp SR, Goveas JS, Wactawski-Wende J, Stefanick ML, Li W, Resnick SM. Long-term effects on cognitive function of postmenopausal hormone therapy prescribed to women aged 50 to 55 years. JAMA Intern Med. 2013;173(15):1429-1436.

Vaughan L, Leng I, Dagenbach D, Resnick SM, Rapp SR, Jennings JM, Brunner RL, Simpson SL, Beavers DP, Coker LH, Gaussoin SA, Sink KM, Espeland MA. Intraindividual variability in domain-specific cognition and risk of mild cognitive impairment and dementia. Curr Gerontol Geriatr Res. 2013;():495793.

Sink KM, Corbett M, Dugan E, Espeland MA, Hogan P, Rapp S, Vaughan L, Shumaker SA. (CNS) prevalence and predictors of driving among cognitively impaired older adults: the Women's Health Initiative Memory Study-epidemiology of cognitive health outcomes (WHIMS-ECHO) [abstract]. Gerontologist. 2013;53(Suppl 1):7.

Espeland MA, Brancati FL, Evans M, Gregg E, Kahn SE, Lewis CE, Pi-Sunyer X, Wing R. Design and primary findings of the action for health in diabetes trial [abstract]. Gerontologist. 2013;53(Suppl 1):388.

Marx N, Rosenstock J, Kahn SE, Zinman B, Kastelein JJ, Lachin J, Espeland MA, Bluhmki E, Mattheus M, Patel S, Johansen O, Woerle HJ. Baseline characteristics of participants enrolled in the cardiovascular outcome study of linagliptin versus glimepiride in early type 2 diabetes (CAROLINA) [abstract]. Diabetologia. 2013;56(Suppl 1):S36-S37.

Miller ME, Walkup MP, Barnes DE, Johnson KC, Lopez OL, Williamson JD, Pahor M, Espeland MA. Using external data to project the incidence of dementia in the life cohort [abstract]. Gerontologist. 2013;53(Suppl 1):549.

Rapp SR, Espeland MA, Manson JE, Resnick SM, Bryan NR, Smoller S, Coker LH, Phillips LS, Stefanick ML, Sarto GE. Educational attainment, MRI changes, and cognitive function in older postmenopausal women from the Women's Health Initiative Memory Study. Int J Psychiatry Med. 2013;46(2):121-143.

McCaffery JM, Papandonatos GD, Huggins GS, Peter I, Kahn SE, Knowler WC, Hudnall GE, Lipkin EW, Kitabchi AE, Wagenknecht LE, Espeland MA, Bahnson JL, Reboussin D, Rejeski WJ, Bertoni A,. FTO predicts weight regain in the Look AHEAD clinical trial. Int J Obes (Lond). 2013;37(12):1545-1552.

McDermott MM, Applegate WB, Bonds DE, Buford TW, Church T, Espeland MA, Gill TM, Guralnik JM, Haskell W, Lovato LC, Pahor M, Pepine CJ, Reid KF, Newman A. Ankle brachial index values, leg symptoms, and functional performance among community-dwelling older men and women in the lifestyle interventions and independence for elders study. J Am Heart Assoc. 2013;2(6):e000257.


Casanova R, Whitlow CT, Wagner B, Espeland MA, Maldjian JA. Combining graph and machine learning methods to analyze differences in functional connectivity across sex. Open Neuroimag J. 2012;6():1-9.

Mount DL, Davis C, Kennedy B, Raatz S, Dotson K, Gary-Webb TL, Thomas S, Johnson KC, Espeland MA, Bahnson J, Wagenknecht L, Reboussin D, Rejeski WJ, Lang W, Bertoni A, Vitolins M, Miller G, Ribisl P, Hodges A,. Factors influencing enrollment of African Americans in the Look AHEAD trial. Clin Trials. 2012;9(1):80-89.

Phelan S, Kanaya AM, Subak LL, Hogan PE, Espeland MA, Wing RR, Burgio KL, DiLillo V, Gorin AA, West DS, Brown JS. Weight loss prevents urinary incontinence in women with type 2 diabetes: results from the Look AHEAD trial. J Urol. 2012;187(3):939-944.

Haan M, Espeland MA, Klein BE, Casanova R, Gaussoin SA, Jackson RD, Millen AE, Resnick SM, Rossouw JE, Shumaker SA, Wallace R, Yaffe K. Cognitive function and retinal and ischemic brain changes: the Women's Health Initiative. Neurology. 2012;78(13):942-949.

Crane MM, Tate DF, LaRose JG, Wing RR, Espeland M. Randomized comparison of messages for recruiting men into a weight gain prevention trial [abstract]. Ann Behav Med. 2012;43(Suppl 1):S191.

Faulconbridge LF, Wadden TA, Rubin RR, Wing RR, Walkup MP, Fabricatore AN, Coday M, Van Dorsten B, Mount DL, Ewing LJ, Espeland MA, Bahnson JL, Wagenknecht L, Reboussin D, Rejeski WJ, Bertoni A, Lang W, Miller G, Lefkowitz D,. One-year changes in symptoms of depression and weight in overweight/obese individuals with type 2 diabetes in the Look AHEAD study. Obesity (Silver Spring). 2012;20(4):783-793.

Schwartz AV, Johnson KC, Kahn SE, Shepherd JA, Nevitt MC, Peters AL, Walkup MP, Hodges A, Williams CC, Bray GA, Espeland MA, Bahnson JL, Wagenknecht L, Reboussin D, Rejeski WJ, Bertoni A, Lang W, Miller G, Lefkowitz D, Reynolds PS,. Effect of 1 year of an intentional weight loss intervention on bone mineral density in type 2 diabetes: results from the Look AHEAD randomized trial. J Bone Miner Res. 2012;27(3):619-627.

Tate DF, LaRose JG, Espeland M, Bahnson J, Ferguson E, Erickson KE, Perdue L, Wing RR. Recruitment of young adults for weight gain prevention [abstract]. Ann Behav Med. 2012;43(Suppl 1):S240.

Bertoni AG, Wagenknecht LE, Kitzman DW, Marcovina SM, Rushing JT, Espeland MA. Impact of the Look AHEAD intervention on NT-pro brain natriuretic peptide in overweight and obese adults with diabetes. Obesity (Silver Spring). 2012;20(7):1511-1518.

Goveas JS, Hogan PE, Kotchen JM, Smoller JW, Denburg NL, Manson JE, Tummala A, Mysiw WJ, Ockene JK, Woods NF, Espeland MA, Wassertheil-Smoller S. Depressive symptoms, antidepressant use, and future cognitive health in postmenopausal women: the Women's Health Initiative Memory Study. Int Psychogeriatr. 2012;24(8):1252-1264.

Neiberg RH, Wing RR, Bray GA, Reboussin DM, Rickman AD, Johnson KC, Kitabchi AE, Faulconbridge LF, Kitzman DW, Espeland MA. Patterns of weight change associated with long-term weight change and cardiovascular disease risk factors in the Look AHEAD Study. Obesity (Silver Spring). 2012;20(10):2048-2056.

Pottala JV, Espeland MA, Polreis J, Robinson J, Harris WS. Correcting the effects of -20 degrees C storage and aliquot size on erythrocyte fatty acid content in the Women's Health Initiative. Lipids. 2012;47(9):835-846.

Rapp SR, Legault C, Espeland MA, Resnick SM, Hogan PE, Coker LH, Dailey M, Shumaker SA. Validation of a cognitive assessment battery administered over the telephone. J Am Geriatr Soc. 2012;60(9):1616-1623.


Woods NF, Cochrane BB, LaCroix AZ, Seguin RA, Zaslavsky O, Liu J, Beasley JM, Brunner RL, Espeland MA, Goveas JS, Lane DS, Manson JE, Mouton CP, Robinson JG, Tinker LF. Toward a positive aging phenotype for older women: observations from the Women's Health Initiative. J Gerontol A Biol Sci Med Sci. 2012;67(11):1191-1196.

Rossom RC, Espeland MA, Manson JE, Dysken MW, Johnson KC, Lane DS, LeBlanc ES, Lederle FA, Masaki KH, Margolis KL. Calcium and vitamin D supplementation and cognitive impairment in the Women's Health Initiative. J Am Geriatr Soc. 2012;60(12):2197-2205.

Espeland MA, Castro CM, Jennings JM, Katula JA, Kerwin DR, Kramer A, Rushing J. Performance of a computer-based assessment of cognitive function in two cohorts of seniors [abstract]. Gerontologist. 2012;52(Suppl 1):304.

Espeland MA, Rapp SR, Katula JA, Andrews LA, Felton D, Gaussoin SA, Dagenbach D, Legault C, Jennings JM, Sink KM. Telephone interview for cognitive status (TICS) screening for clinical trials of physical activity and cognitive training: the Seniors Health and Activity Research Program pilot (SHARP-P) study. Int J Geriatr Psychiatry. 2011;26(2):135-143.

Goveas JS, Espeland MA, Woods NF, Wassertheil-Smoller S, Kotchen JM. Depressive symptoms and incidence of mild cognitive impairment and probable dementia in elderly women: the Women's Health Initiative Memory Study. J Am Geriatr Soc. 2011;59(1):57-66.

Kerwin DR, Gaussoin SA, Chlebowski RT, Kuller LH, Vitolins M, Coker LH, Kotchen JM, Nicklas BJ, Wassertheil-Smoller S, Espeland MA, et al. Interaction between body mass index and central adiposity and risk of incident cognitive impairment and dementia: results from the Women's Health Initiative Memory Study. J Am Geriatr Soc. 2011;59(1):107-112.

Casanova R, Espeland MA, Goveas JS, Davatzikos C, Gaussoin SA, Maldjian JA, Brunner RL, Kuller LH, Johnson KC, Wagner B, et al. Application of machine learning methods to describe the effects of conjugated equine estrogens therapy on region-specific brain volumes. Magn Reson Imaging. 2011;29(4):546-553.

Legault C, Jennings JM, Katula JA, Dagenbach D, Gaussoin SA, Sink KM, Rapp SR, Rejeski WJ, Shumaker SA, Espeland MA. Designing clinical trials for assessing the effects of cognitive training and physical activity interventions on cognitive outcomes: the Seniors Health and Activity Research Program Pilot (SHARP-P) Study, a randomized controlled trial. BMC Geriatr. 2011;11(1):article 27.

Katula JA, Lucas A, Jennings JM, Legault C, Gaussoin S, Yamamoto K, Dagenbach D, Sink K, Rapp S, Rejeski J, Espeland M. The role of executive function in 400 M walk performance: the Senior'S Health & Activity Research Program-Pilot (Sharp-P) [abstract]. Ann Behav Med. 2011;41(Suppl 1):s113.

Goveas JS, Espeland MA, Hogan P, Dotson V, Tarima S, Coker LH, Ockene J, Brunner R, Woods NF, Wassertheil-Smoller S, et al. Depressive symptoms, brain volumes and subclinical cerebrovascular disease in postmenopausal women: the Women's Health Initiative MRI Study. J Affect Disord. 2011;132(1-2):275-284.

Belalcazar LM, Ballantyne CM, Lang W, Rushing J, Espeland MA, Bahnson JL, Wagenknecht L, Reboussin D, Rejeski WJ, Bertoni A, Miller G, Lefkowitz D, Reynolds PS, Ribisl P, Vitolins M, Booth M, Dotson KM, Hodges A, Williams CC,. Metabolic factors, adipose tissue, and plasminogen activator inhibitor-1 levels in type 2 diabetes: findings from the Look AHEAD study. Arterioscler Thromb Vasc Biol. 2011;31(7):1689-1695.

Shea MK, Nicklas BJ, Houston DK, Miller ME, Davis CC, Kitzman DW, Espeland MA, Appel LJ, Kritchevsky SB. The effect of intentional weight loss on all-cause mortality in older adults: results of a randomized controlled weight-loss trial. Am J Clin Nutr. 2011;94(3):839-846.

Driscoll I, Espeland MA, Wassertheil-Smoller S, Gaussoin SA, Ding J, Granek IA, Ockene JK, Phillips LS, Yaffe K, Resnick SM. Weight change and cognitive function: findings from the Women's Health Initiative Study of Cognitive Aging. Obesity (Silver Spring). 2011;19(8):1595-1600.

Shih RA, Ghosh-Dastidar B, Margolis KL, Slaughter ME, Jewell A, Bird CE, Eibner C, Denburg NL, Ockene J, Espeland MA, et al. Neighborhood socioeconomic status and cognitive function in women. Am J Public Health. 2011;101(9):1721-1728.

Casanova R, Whitlow CT, Wagner B, Williamson J, Shumaker SA, Maldjian JA, Espeland MA. High dimensional classification of structural MRI Alzheimer's disease data based on large scale regularization. Front Neuroinform. 2011;5():article 22.

Espeland MA, Miller ME, Goveas JS, Hogan PE, Coker LH, Williamson J, Naughton M, Resnick SM. Cognitive function and fine motor speed in older women with diabetes mellitus: results from the Women's Health Initiative Study of Cognitive Aging. J Womens Health. 2011;20(10):1435-1443.

Marsh AP, Rejeski WJ, Espeland MA, Miller ME, Church TS, Fielding RA, Gill TM, Guralnik JM, Newman AB, Pahor M. Muscle strength and BMI as predictors of major mobility disability in the Lifestyle Interventions and Independence for Elders pilot (LIFE-P). J Gerontol A Biol Sci Med Sci. 2011;66(12):1376-1383.

Fielding RA, Rejeski WJ, Blair S, Church T, Espeland MA, Gill TM, Guralnik JM, Hsu F-C, Katula J, King AC, Kritchevsky SB, McDermott MM, Miller ME, Nayfield S, Newman AB, Williamson JD, Bonds D, Romashkan S, Hadley E, Pahor M. The Lifestyle Interventions and Independence for Elders Study: design and methods. J Gerontol A Biol Sci Med Sci. 2011;66(11):1226-1237.

Casanova R, Maldjian JA, Espeland MA. Evaluating the impact of different factors on Voxel-based classification methods of ADNI structural MRI brain images. Int J Biomed Data Mining. 2011;1():B110102.

Espeland MA, Miller ME, Goveas JS, Hogan PE, Coker LH, Williamson J, Naughton M, Resnick SM. Domain-specific cognitive function and fine motor speed in women 65 years and older with type 2 diabetes mellitus: results from the Women's Health Initiative Study of Cognitive Aging [abstract]. Diabetes. 2011;60(Suppl 1):A69-A70.

Shea M, Houston DK, Nicklas B, Miller ME, Messier SP, Espeland MA, Kritchevsky SB. The effect of intentional weight loss on total mortality in older adults: a pooled analysis of two randomized-controlled trials [abstract]. Gerontologist. 2011;51(Suppl 2):518.

Tooze JA, Gaussoin SA, Resnick SM, Fischbein NJ, Robinson JG, Bryan RN, An Y, Espeland MA. A uniform approach to modeling risk factor relationships for ischemic lesion prevalence and extent: the Women's Health Initiative Magnetic Resonance Imaging Study. Neuroepidemiology. 2010;34(1):55-62.

Coker LH, Espeland MA, Rapp SR, Legault C, Resnick SM, Hogan P, Gaussoin S, Dailey M, Shumaker SA. Postmenopausal hormone therapy and cognitive outcomes: the Women's Health Initiative Memory Study (WHIMS). J Steroid Biochem Mol Biol. 2010;118(4-5):304-310.

Katula JA, Vitolins MZ, Rosenberger EL, Blackwell C, Espeland MA, Lawlor MS, Rejeski WJ, Goff DC. Healthy Living Partnerships to Prevent Diabetes (HELP PD): design and methods. Contemp Clin Trials. 2010;31(1):71-81.

Atkinson HH, Rapp SR, Williamson JD, Lovato J, Absher JR, Gass M, Henderson VW, Johnson KC, Sink KM, Espeland MA, et al. The relationship between cognitive function and physical performance in older women: results from the Women's Health Initiative Memory Study. J Gerontol A Biol Sci Med Sci. 2010;65(3):300-306.

Curtis JM, Horton ES, Bahnson J, Gregg EW, Jakicic JM, Regensteiner JG, Ribisl PM, Soberman JE, Stewart KJ, Espeland MA. Prevalence and predictors of abnormal cardiovascular responses to exercise testing among individuals with type 2 diabetes: the Look AHEAD (Action for Health in Diabetes) study. Diabetes Care. 2010;33(4):901-907.

Espeland MA, Shumaker SA, Limacher M, Rapp SR, Bevers TB, Barad DH, Coker LH, Gaussoin SA, Stefanick ML, Lane DS, et al. Relative effects of tamoxifen, raloxifene, and conjugated equine estrogens on cognition. J Womens Health. 2010;19(3):371-379.

Burdette JH, Laurienti PJ, Espeland MA, Morgan A, Telesford Q, Vechlekar CD, Hayasaka S, Jennings JM, Katula JA, Kraft RA, Rejeski WJ. Using network science to evaluate exercise-associated brain changes in older adults. Front Aging Neurosci. 2010;2():article 23.

Katula JA, Vitolins MZ, Rosenberger EL, Blackwell C, Isom SP, Espeland MA, Lawlor MS, Goff DC. Correlates of health-related quality of life in overweight and obese adults with prediabetes [abstract]. Ann Behav Med. 2010;39(Suppl 1):207.

Espeland MA, Brunner RL, Hogan PE, Rapp SR, Coker LH, Legault C, Granek I, Resnick SM. Long-term effects of conjugated equine estrogen therapies on domain-specific cognitive function: results from the Women's Health Initiative study of cognitive aging extension. J Am Geriatr Soc. 2010;58(7):1263-1271.

Klepin HD, Geiger AM, Costantino JP, Sink KM, Lawrence JA, Espeland MA. Association between domain-specific cognitive function and adherence to oral anti-cancer therapy: results from Cognition in the Study of Tamoxifen and Raloxifene (Co-STAR) [abstract]. J Am Geriatr Soc. 2010;58(Suppl 1):86-87.

Kerwin DR, Zhang Y, Kotchen JM, Espeland MA, Van Horn L, McTigue KM, Robinson JG, Powell L, Kooperberg C, Coker LH, et al. The cross-sectional relationship between body mass index, waist-hip ratio, and cognitive performance in postmenopausal women enrolled in the Women's Health Initiative. J Am Geriatr Soc. 2010;58(8):1427-1432.

Casanova R, Espeland MA, Goveas J, Davatzikos C, Gaussoin SA, Wagner B, Maldjian JA, Resnick SM. Application of machine learning methods to describe the effects of conjugated equine estrogens therapy on region-specific brain volumes [abstract]. Gerontologist. 2010;50(Suppl 1):308-309.

Espeland MA. Designing clinical trials to assess the effects of behavioral interventions on cognitive outcomes in seniors [abstract]. Gerontologist. 2010;50(Suppl 1):415.

Rapp S, Espeland MA, Manson JE, Resnick S, Bryan NR, Coker LH, Phillips L, Stefanick ML. Educational attainment, MRI changes and cognitive function in postmenopausal women [abstract]. Gerontologist. 2010;50(Suppl 1):308.

Shumaker SA, Espeland MA, Leng X, Limacher M, Manson JE, Stefanick ML. Cognitive function and cognitive change on incident CCD: the WHI Memory Study (WHIMS) [abstract]. Gerontologist. 2010;50(Suppl 1):309.

Gaussion S [sic] [Gaussoin S], Espeland MA, Rapp SR, Katula JA, Andrews LA, Felton D, Dagenbach D, Legault C, Sink KM. Use of the telephone interview for cognitive status (TICS) to screen volunteers for clinical trials of physical activity and cognitive training interventions; the Seniors Health and Activity Research Program [abstract]. Clin Trials. 2010;7(4):476.

Wing RR, Bahnson JL, Bray GA, Clark JM, Coday M, Egan C, Espeland MA, Reboussin D, Rejeski WJ, Wagenknecht L, et al. Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial. Arch Intern Med. 2010;170(17):1566-1575.

Rejeski WJ, Marsh AP, Chmelo E, Prescott AJ, Dobrosielski M, Walkup MP, Espeland M, Miller ME, Kritchevsky S. The Lifestyle Interventions and Independence for Elders Pilot (LIFE-P): 2-year follow-up. J Gerontol A Biol Sci Med Sci. 2009;64(4):462-467.

Resnick SM, Espeland MA, Jaramillo SA, Hirsch C, Stefanick ML, Murray AM, Ockene J, Davatzikos C. Postmenopausal hormone therapy and regional brain volumes: the WHIMS-MRI Study. Neurology. 2009;72(2):135-142.

Vestergaard S, Patel KV, Walkup MP, Pahor M, Marsh AP, Espeland MA, Studenski S, Gill TM, Church T, Guralnik JM. Stopping to rest during a 400-meter walk and incident mobility disability in older persons with functional limitations. J Am Geriatr Soc. 2009;57(2):260-265.

Bhasin S, Espeland MA, Evans WJ, Ferrucci L, Fried LP, Gill TM, Pahor M, Studenski S, Guralnik J, Nayfi S, et al. Indications, labeling, and outcomes assessment for drugs aimed at improving functional status in older persons: a conversation between aging researchers and FDA regulators. J Gerontol A Biol Sci Med Sci. 2009;64(4):487-491.

Williamson JD, Espeland M, Kritchevsky SB, Newman AB, King AC, Pahor M, Guralnik JM, Pruitt LA, Miller ME. Changes in cognitive function in a randomized trial of physical activity: results of the Lifestyle Interventions and Independence for Elders pilot study. J Gerontol A Biol Sci Med Sci. 2009;64(6):688-694.

Alexander TH, Weisman MH, Derebery JM, Espeland MA, Gantz BJ, Gulya AJ, Hammerschlag PE, Hannley M, Hughes GB, Moscicki R, et al. Safety of high-dose corticosteroids for the treatment of autoimmune inner ear disease. Otol Neurotol. 2009;30(4):443-448.

Ding J, Hsu F-C, Harris TB, Liu Y, Kritchevsky SB, Szklo M, Ouyang P, Espeland MA, Lohman KK, Carr JJ, et al. The association of pericardial fat with incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Clin Nutr. 2009;90(3):499-504.

Espeland MA, Bray GA, Neiberg R, Rejeski WJ, Knowler WC, Lang W, Cheskin LJ, Williamson D, Lewis B, Wing R. Describing patterns of weight changes using principal components analysis: results from the Action for Health in Diabetes (Look AHEAD) Research Group. Ann Epidemiol. 2009;19(10):701-710.

Phelan S, Kanaya AM, Subak LL, Hogan PE, Espeland MA, Wing RR, Burgio KL, DiLillo V, Gorin AA, West DS, et al. Prevalence and risk factors for urinary incontinence in overweight and obese diabetic women: Action for Health in Diabetes (Look AHEAD) study. Diabetes Care. 2009;32(8):1391-1397.

Resnick SM, Espeland MA, An Y, Maki PM, Coker LH, Jackson R, Stefanick ML, Wallace R, Rapp SR. Effects of conjugated equine estrogens on cognition and affect in postmenopausal women with prior hysterectomy. J Clin Endocrinol Metab. 2009;94(11):4152-4161.

Mount DL, Feeney P, Fabricatore AN, Coday M, Bahnson J, Byington R, Phelan S, Wilmoth S, Knowler WC, Espeland MA, et al. Constructing common cohorts from trials with overlapping eligibility criteria: implications for comparing effect sizes between trials. Clin Trials. 2009;6(5):416-429.

Espeland MA, Tindle HA, Bushnell CA, Jaramillo SA, Kuller LH, Margolis KL, Mysiw WJ, Maldjian JA, Melhem ER, Resnick SM. Brain volumes, cognitive impairment, and conjugated equine estrogens. J Gerontol A Biol Sci Med Sci. 2009;64(12):1243-1250.

Bushnell C, Tindle H, Espeland M, Jamillo S, Melhem E, Resnick S. Regional brain and ischemic lesion volumes in women with cognitive impairment following exposure to conjugated equine estrogen therapies (CEE): the Women's Health Initiative Magnetic Resonance Imaging Study (WHIMS-MRI) [abstract]. Neurology. 2009;72(11 Suppl 3):A171-A172.

Bandelow S, Espeland MA, Henderson VW, Resnick SM, Wallace RB, Coker LH, Hogervorst E. Identifying risk factors for cognitive change in the Women's Health Initiative: a neural networks approach In: Hogervorst E, Henderson VW, Gibbs RB, Brinton RD, eds. Hormones, cognition and dementia: state of the art and emergent therapeutic strategies. New York: Cambridge University Press;2009: 11-24.

Espeland MA, Shumaker SA, Hogan PE, Resnick SM. Women's Health Initiative Memory Study (WHIMS) program: emerging findings In: Hogervorst E, Henderson VW, Gibbs RB, Brinton RD, eds. Hormones, cognition and dementia: state of the art and emergent therapeutic strategies. New York: Cambridge University Press;2009: 1-10.

Barad DH, Bevers TB, Coker LH, Espeland MA, Jaramillo SA, Limacher M, Lane DS, Rapp S, Maki P, Shumaker SA, et al. Relative effects of tamoxifen, raloxifene, and estrogen therapy on cognition: results from the Women's Health Initiative Memory Study (WHIMS) and the Cognition in the Study of Tamoxifen and Raloxifene (CoSTAR) clinical trials [abstract]. Reprod Sci. 2008;15(2 Suppl):309A.

Atkinson HH, Williamson JD, Rapp SR, Lovato J, Sink KM, Absher JR, Gass M, Henderson V, Johnson KC, Espeland MA, et al. Grip strength predicts dementia in 75 to 80 year-old women: the Women's Health Initiative Memory Study (WHIMS) [abstract]. J Am Geriatr Soc. 2008;56(4 Suppl):S107.

Wing RR, Wadden TA, Espeland M. Surgical vs behavioral therapy for weight loss in patients with type 2 diabetes [letter]. JAMA. 2008;299(18):2146.

Bhasin S, Cress E, Espeland MA, Evans WJ, Ferrucci L, Fried LP, Gill TM, Pahor M, Studenski S, Guralnik J, et al. Functional outcomes for clinical trials in frail older persons: time to be moving. J Gerontol A Biol Sci Med Sci. 2008;63(2):160-164.

Underhill HR, Yuan C, Terry JG, Chen H, Espeland MA, Kraft R, Carr JJ, Maldjian J, Tang R, Crouse JR III, et al. Differences in carotid arterial morphology and composition between individuals with and without obstructive coronary artery disease: a cardiovascular magnetic resonance study. J Cardiovasc Magn Reson. 2008;10(1):article 31.

Espeland MA, Regensteiner JG, Jaramillo SA, Gregg E, Knowler WC, Wagenknecht LE, Bahnson J, Haffner S, Hill J, Hiatt WR. Measurement characteristics of the ankle-brachial index: results from the Action for Health in Diabetes study. Vasc Med. 2008;13(3):225-233.

Johnson KC, Margolis KL, Espeland MA, Colenda CC, Fillit H, Manson JE, Masaki KH, Mouton CP, Prineas R, Robinson JG, et al. A prospective study of the effect of hypertension and baseline blood pressure on cognitive decline and dementia in postmenopausal women: the Women's Health Initiative Memory Study. J Am Geriatr Soc. 2008;56(8):1449-1458.

Espeland MA, Bryan NR, Coker LH, Manson J, Phillips LS, Rapp SR, Sarto GE, Stefanick ML, Wassertheil-Smoller S. Influence of educational attainment and occupation on relationships that cognitive function has with MRI-based neuropathology, mild cognitive impairment, and dementia: results from the Women's Health Initative Memory Study [abstract]. Alzheimers Dement. 2008;4(4 Suppl 1):T672.

Cann JA, Register TC, Adams MR, St. Clair RW, Espeland MA, Williams JK. Timing of estrogen replacement influences atherosclerosis progression and plaque leukocyte populations in ApoE-/- mice. Atherosclerosis. 2008;201(1):43-52.

Marsh A, Rejeski W, Espeland M, Miller M, Church T, Gill T, Guralnik J, Vestergaard S, Newman A, Pahor M. Predictors of risk for major mobility disability in the Lifestyle Interventions and Independence for Elders Pilot (Life-P) [abstract]. Gerontologist. 2008;48(Special Issue 3):197-198.

Vestergaard S, Walkup M, Pahor M, Marsh A, Espeland M, Studenski S, Gill T, Church T, M GJ [sic ] [Guralnik JM]. Stopping to rest during a 400-meter walk and incident mobility disability in older persons with functional limitations [abstract]. Gerontologist. 2008;48(Special Issue 3):198.

Chambers MS, Fleming TJ, Toth BB, Lemon JC, Craven TE, Bouwsma OJ, Garden AS, Espeland MA, Keene HJ, Martin JW, et al. Erratum to 'Clinical evaluation of the intraoral fluoride releasing system in radiation-induced xerostomic subjects. Part 2: Phase I study'. Oral Oncol. 2007;43(1):98-105.

Harper M, Dugan E, Espeland M, Martinez-Borges A, McQuellon C. Why African-American women are at greater risk for pregnancy-related death. Ann Epidemiol. 2007;17(3):180-185.

Pi-Sunyer X, Blackburn G, Brancati FL, Bray GA, Bright R, Clark JM, Curtis JM, Espeland MA, Foreyt JP, Wagenknecht L, et al. Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the Look AHEAD Trial. Diabetes Care. 2007;30(6):1374-1383.

Crouse JR, Furberg CD, Espeland MA, Riley WA. B-mode ultrasound: a noninvasive method for assessing atherosclerosis In: Willerson JT, Cohn JN, Wellens HJJ, Holmes DR Jr, eds. Cardiovascular medicine. 3rd ed. London: Springer;2007: 1783-1796.

Jaramillo SA, Felton D, Andrews L, Desiderio L, Hallarn RK, Jackson SD, Coker LH, Robinson JG, Ockene JK, Espeland MA. Enrollment in a brain magnetic resonance study: results from the Women's Health Initiative Memory Study Magnetic Resonance Imaging Study (WHIMS-MRI). Acad Radiol. 2007;14(5):603-612.

Espeland MA, Gill TM, Guralnik J, Miller ME, Fielding R, Newman AB, Pahor M. Designing clinical trials of interventions for mobility disability: results from the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) Trial. J Gerontol A Biol Sci Med Sci. 2007;62(11):1237-1243.

Espeland MA, Bahnson J, Wagenknecht, Reboussin D, Rejeski WJ, Lang W, Bertoni A, Vitolins M, Miller G, Ribisl P, Dotson K, Hodges A, Hogan P, et al. The Look AHEAD Study: a description of the lifestyle intervention and the evidence supporting it. Obesity. 2006;14(5):737-752.

Espeland MA, Dotson K, Jaramillo SA, Kahn SE, Harrison B, Montez M, Foreyt JP, Montgomery B, Knowler WC. Consent for genetics studies among clinical trial participants: findings from Action for Health in Diabetes (Look AHEAD). Clin Trials. 2006;3(5):443-456.

Espeland MA, Henderson VW. Preventing cognitive decline in usual aging [editorial]. Arch Intern Med. 2006;166(22):2433-2434.

Pahor M, Blair SN, Espeland M, Fielding R, Gill TM, Guralnik JM, Hadley EC, Kritchevsky SB, Miller ME, Rejeski WJ, et al. Effects of a physical activity intervention on measures of physical performance: results of the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) Study. J Gerontol A Biol Sci Med Sci. 2006;61A(11):1157-1165.

Underhill HR, Yuan C, Espeland MA, Chen H, Terry JG, Hatsukami TS, Saam T, Tang R, Crouse JR, et al. The composition and morphology of the carotid artery are associated with coronary artery disease: a case-control high resolution magnetic resonance imaging study [abstract]. Circulation. 2006;114(18 Suppl):823-824.

Espeland MA, Rapp SR, Robertson J, Granek I, Murphy C, Albert M, Bassford T. Benchmarks for designing two-stage studies using modified mini-mental state examinations: experience from the Women's Health Initiative Memory Study. Clin Trials. 2006;3(2):99-106.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Quick Reference

Request an Appointment
New Patients

336-716-WAKE
888-716-WAKE

Existing patients may contact the clinic directly.
Find a Doctor Ways to Give
USNWR 2013-2014Magnet Hospital RecognitionConsumer Choice2014 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.