Profile

Carl D. Langefeld, Ph.D.Wake Forest Baptist Health

Carl D. Langefeld, Ph.D.

Section Head,
Professor,



Contact Information

Academic: 336-713-0013 | Department: 336-716-2011

Email: clangefe@wakehealth.edu

Education & Training

  • Ph.D., University of Michigan/Ann Arbor , 1999

Memberships

  • Am Diabetes Assn
  • Am Soc Of Human Genetics
  • Biometric Society
  • Int'L Genetic Epidemiology Soc
Carl D. Langefeld, Ph.D.Wake Forest Baptist Health

Carl D. Langefeld, Ph.D.

Section Head, Department of Biostatistics
Professor, Department of Biostatistics
Sticht Center on Aging
Center for Diabetes Research
WFU Primate Center

Research Interests

atherosclerosis/thrombosis, cardiac function, diabetes, epidemiology, genetics/genome, immunology/allergy/inflammatio, maternal & child health, minority health issues, obesity, statistics/mathematics, women's health issues

Contact Information

Academic: 336-713-0013 | Department: 336-716-2011

Email: clangefe@wakehealth.edu

Recent Publications

Hellwege JN, Palmer ND, Ziegler JT, Langefeld CD, Lorenzo C, Norris JM, Takamura T, Bowden DW. Genetic variants in selenoprotein P plasma 1 gene (SEPP1) are associated with fasting insulin and first phase insulin response in Hispanics. Gene. 2014;534(1):33-39.

Palmer ND, Ng MC, Hicks PJ, Mudgal P, Langefeld CD, Freedman BI, Bowden DW. Evaluation of candidate nephropathy susceptibility genes in a genome-wide association study of African American diabetic kidney disease. PLoS One. 2014;9(2):e88273.

Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI. Sclerostin is positively associated with bone mineral density in men and women and negatively associated with carotid calcified atherosclerotic plaque in men from the African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2014;99(1):315-321.

Divers J, Palmer ND, Lu L, Langefeld CD, Rocco MV, Hicks PJ, Murea M, Ma L, Bowden DW, Freedman BI. Gene-gene interactions in APOL1-associated nephropathy. Nephrol Dial Transplant. 2014;29(3):587-594.

Freedman BI, Langefeld CD, Andringa KK, Croker JA, Williams AH, Garner NE, Birmingham DJ, Hebert LA, Hicks PJ, Segal MS, Edberg JC, Brown EE, Alarcon GS, Costenbader KH, Comeau ME, Criswell LA, Harley JB, James JA, Kamen DL,. End-stage renal disease in African Americans with lupus nephritis is associated with APOL1. Arthritis Rheum. 2014;66(2):390-396.

Cox AJ, Hsu FC, Ng MC, Langefeld CD, Freedman BI, Carr JJ, Bowden DW. Genetic risk score associations with cardiovascular disease and mortality in the Diabetes Heart Study. Diabetes Care. 2014;37(4):1157-1164.

Guthridge JM, Lu R, Sun H, Sun C, Wiley GB, Dominguez N, Macwana SR, Lessard CJ, Kim-Howard X, Cobb BL, Kaufman KM, Kelly JA, Langefeld CD, Adler AJ, Harley IT, Merrill JT, Gilkeson GS, Kamen DL, Niewold TB, Brown EE, Edberg JC, Petri MA,. Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription. Am J Hum Genet. 2014;94(4):586-598.

Woo D, Falcone GJ, Devan WJ, Brown WM, Biffi A, Howard TD, Anderson CD, Brouwers HB, Valant V, Battey TW, Radmanesh F, Raffeld MR, Baedorf-Kassis S, Deka R, Woo JG, Martin LJ, Haverbusch M, Moomaw CJ, Sun G, Broderick JP, Flaherty ML,. Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage. Am J Hum Genet. 2014;94(4):511-521.

Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI. Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetes. J Clin Endocrinol Metab. 2013;98(1):E60-E65.

Ahmeti KB, Ajroud-Driss S, Al-Chalabi A, Andersen PM, Armstrong J, Birve A, Blauw HM, Brown RH, Bruijn L, Chen W, Chio A, Comeau MC, Cronin S, Diekstra FP, Soraya Gkazi A, Glass JD, Grab JD, Groen EJ, Haines JL, Hardiman O, Heller S,. Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1. Neurobiol Aging. 2013;34(1):357.e7-19.

An SS, Palmer ND, Hanley AJ, Ziegler JT, Brown WM, Haffner SM, Norris JM, Rotter JI, Guo X, Chen YD, Wagenknecht LE, Langefeld CD, Bowden DW. Estimating the contributions of rare and common genetic variations and clinical measures to a model trait: adiponectin. Genet Epidemiol. 2013;37(1):13-24.

Lipkowitz MS, Freedman BI, Langefeld CD, Comeau ME, Bowden DW, Kao WH, Astor BC, Bottinger EP, Iyengar SK, Klotman PE, Freedman RG, Zhang W, Parekh RS, Choi MJ, Nelson GW, Winkler CA, Kopp JB. Apolipoprotein L1 gene variants associate with hypertension-attributed nephropathy and the rate of kidney function decline in African Americans. Kidney Int. 2013;83(1):114-120.

Deng Y, Zhao J, Sakurai D, Kaufman KM, Edberg JC, Kimberly RP, Kamen DL, Gilkeson GS, Jacob CO, Scofield RH, Langefeld CD, Kelly JA, Ramsey-Goldman R, Petri MA, Reveille JD, Vila LM, Alarcon GS, Vyse TJ, Pons-Estel BA,. MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus. PLoS Genet. 2013;9(2):e1003336.

Molineros JE, Maiti AK, Sun C, Looger LL, Han S, Kim-Howard X, Glenn S, Adler A, Kelly JA, Niewold TB, Gilkeson GS, Brown EE, Alarcon GS, Edberg JC, Petri M, Ramsey-Goldman R, Reveille JD, Vila LM, Freedman BI, Tsao BP,. Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production. PLoS Genet. 2013;9(2):e1003222.

Ng MCY, Saxena R, Li J, Palmer ND, Dimitrov L, Xu J, Rasmussen-Torvik LJ, Zmuda JM, Siscovick DS, Patel SR, Crook ED, Sims M, Chen YD, Bertoni AG, Li M, Grant SF, Dupuis J, Meigs JB, Psaty BM, Pankow JS, Langefeld CD,. Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study. Diabetes. 2013;62(3):965-976.

Divers J, Palmer ND, Lu L, Register TC, Carr JJ, Hicks PJ, Hightower RC, Smith SC, Xu J, Cox AJ, Hruska KA, Bowden DW, Lewis CE, Heiss G, Province MA, Borecki IB, Kerr KF, Chen YD, Palmas W, Rotter JI, Wassel CL, Bertoni AG,. Admixture mapping of coronary artery calcified plaque in African Americans with type 2 diabetes mellitus. Circ Cardiovasc Genet. 2013;6(1):97-105.

Adams JN, Cox AJ, Freedman BI, Langefeld CD, Carr JJ, Bowden DW. Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the Diabetes Heart Study. Cardiovasc Diabetol. 2013;12():31.

Divers J, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Smith SC, Xu J, Langefeld CD, Freedman BI. Albuminuria associates with calcified atherosclerotic plaque in African Americans with diabetes [letter]. Diabetes Care. 2013;36(3):e34-e35.

Register TC, Divers J, Bowden DW, Carr JJ, Lenchik L, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Hruska KA, Langefeld CD, Freedman BI. Relationships between serum adiponectin and bone density, adiposity and calcified atherosclerotic plaque in the African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2013;98(5):1916-1922.

Monda KL, Chen GK, Taylor KC, Ng MCY, Liu Y, Freedman BI, Howard TD, Langefeld CD, Lohman K, Palmer ND, Shriner DA, Burke G, Ding J, et al. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet. 2013;45(6):690-696.

Cox AJ, Lehtinen AB, Xu J, Langefeld CD, Freedman BI, Carr JJ, Bowden DW. Polymorphisms in the Selenoprotein S gene and subclinical cardiovascular disease in the Diabetes Heart Study. Acta Diabetol. 2013;50(3):391-399.

Cox AJ, Hugenschmidt CE, Wang PT, Hsu FC, Kenchaiah S, Daniel K, Langefeld CD, Freedman BI, Herrington DM, Carr JJ, Stacey B, Bowden DW. Usefulness of biventricular volume as a predictor of mortality in patients with diabetes mellitus (from the Diabetes Heart Study). Am J Cardiol. 2013;111(8):1152-1158.

Ramos PS, Oates JC, Kamen DL, Williams AH, Gaffney PM, Kelly JA, Kaufman KM, Kimberly RP, Niewold TB, Jacob CO, Tsao BP, Alarcon GS, Brown EE, Edberg JC, Petri MA, Ramsey-Goldman R, Reveille JD, Vila LM, James JA,. Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry. J Rheumatol. 2013;40(6):842-849.

Raffield LM, Cox AJ, Hsu FC, Ng MC, Langefeld CD, Carr JJ, Freedman BI, Bowden DW. Impact of HDL genetic risk scores on coronary artery calcified plaque and mortality in individuals with type 2 diabetes from the Diabetes Heart Study. Cardiovasc Diabetol. 2013;12():95.

Cox AJ, Ng MC, Xu J, Langefeld CD, Koch KL, Dawson PA, Carr JJ, Freedman BI, Hsu FC, Bowden DW. Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study. Atherosclerosis. 2013;229(1):155-160.

Manku H, Langefeld CD, Guerra SG, Malik TH, Alarcon-Riquelme M, Anaya JM, Bae SC, Boackle SA, Brown EE, Criswell LA, Freedman BI, Gaffney PM, Gregersen PA, Guthridge JM, Han SH, Harley JB, Jacob CO, James JA,. Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4. PLoS Genet. 2013;9(7):e1003554.

Namjou B, Kim-Howard X, Sun C, Adler A, Chung SA, Kaufman KM, Kelly JA, Glenn SB, Guthridge JM, Scofield RH, Kimberly RP, Brown EE, Alarcon GS, Edberg JC, Kim JH, Choi J, Ramsey-Goldman R, Petri MA, Reveille JD,. PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes. PLoS One. 2013;8(8):e69404.

Hinks A, Cobb J, Marion MC, Prahalad S, Sudman M, Bowes J, Martin P, Comeau ME, Sajuthi S, Andrews R, Brown M, Chen WM, Concannon P, Deloukas P, Edkins S, Eyre S, Gaffney PM, Guthery SL, Guthridge JM, Hunt SE,. Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. Nat Genet. 2013;45(6):664-669.

Cox AJ, Lambird JE, Sandy An S, Register TC, Langefeld CD, Carr JJ, Freedman BI, Bowden DW. Variants in adiponectin signaling pathway genes show little association with subclinical CVD in the Diabetes Heart Study. Obesity (Silver Spring). 2013;21(9):E456-462.

Divers J, Palmer ND, Lu L, Langefeld CD, Rocco MV, Hicks PJ, Murea M, Ma L, Bowden DW, Freedman BI. Gene-gene interactions in APOL1-associated nephropathy [abstract]. J Am Soc Nephrol. 2013;24(Abstract Suppl):67A.

Caster DJ, Korte EA, Nanda SK, McLeish KR, Oliver RK, G'sell RT, Sheehan RM, Freeman DW, Coventry SC, Kelly JA, Guthridge JM, James JA, Sivils KL, Alarcon-Riquelme ME, Scofield RH, Adrianto I, Gaffney PM, Stevens AM,. ABIN1 dysfunction as a genetic basis for lupus nephritis. J Am Soc Nephrol. 2013;24(11):1743-1754.

Sakurai D, Zhao J, Deng Y, Kelly JA, Brown EE, Harley JB, Bae SC, Alarcon-Riquelme ME, Edberg JC, Kimberly RP, Ramsey-Goldman R, Petri MA, Reveille JD, Vila LM, Alarcon GS, Kaufman KM, Vyse TJ, Jacob CO, Gaffney PM,. Preferential binding to Elk-1 by SLE-associated IL10 risk allele upregulates IL10 expression. PLoS Genet. 2013;9(10):e1003870.

Woo D, Rosand J, Kidwell C, McCauley JL, Osborne J, Brown MW, West SE, Rademacher EW, Waddy S, Roberts JN, Koch S, Gonzales NR, Sung G, Kittner SJ, Birnbaum L, Frankel M, Testai FD, Hall CE, Elkind MS,. The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study protocol. Stroke. 2013;44(10):e120-e125.

Clancy RM, Buyon JP, Costedoat-Chalumeau N, Brucato A, Levesque K, Ramoni V, Marion MC, Comeau M, Sajuthi S, Ramos PS, Kimberly RP, Howard TD, Langefeld CD. Accounting for parental load and identification of multiple risk variants for anti-Ro congenital heart block through high-density genotyping of immune-related loci [abstract]. Arthritis Rheum. 2013;65(Suppl 10):S1226.

Dumancas G, Lin CP, Adrianto I, Kelly JA, Glenn SB, Anderson J, Harley JB, Vyse TJ, Kimberly RP, Alarcon-Riquelme ME, Langefeld CD, Tsao BP, Criswell LA, Jacob CO, Gaffney PM, Sivilis K, James JA, Montgomery C. Identification of novel genetic associations within major histocompatibility complex (MHC) class I and class II in systemic lupus erythematosus (SLE) patients: an examination of epitopes of early autoimmunity [abstract]. Arthritis Rheum. 2013;65(Suppl 10):S693-S694.

Hinks A, Cobb J, Han B, Marion MC, Sudman M, Martin P, Bohnsack JF, Wedderburn LR, Haas JP, de Bakker P, Langefeld CD, Raychaudhuri S, Prahalad S, Thompson SD, Thomson W. Analysis of the MHC region In a large cohort of juvenile idiopathic arthritis cases identifies independent effects at HLA-DRB1 [abstract]. Arthritis Rheum. 2013;65(Suppl 10):S937-S938.

Kariuki S, Ghodke Y, Dorschner JM, Chrabot B, Kelly JA, Tsao BP, Kimberly RP, Alarcon-Riquelme ME, Jacob CO, Criswell LA, Sivils KL, Langefeld CD, Harley JB, Skol AD, Niewold TB. Sub-phenotype mapping in systemic lupus erythematosus identifies multiple novel loci associated with circulating interferon alpha [abstract]. Arthritis Rheum. 2013;65(Suppl 10):S693.

Langefeld CD, Sajuthi S, Divers J, Huang YQ, Nayak U, Chen WM, Hunt KJ, Kamen DL, Gikeson GS, Fernandes JK, Spruill IJ, Garvey WT, Sale MM, Ramos PS. Identification of autoimmune disease risk alleles that are under recent selection in the Sea Island Gullah African Americans [abstract]. Arthritis Rheum. 2013;65(Suppl 10):S60-S61.

Lessard CJ, Sajuthi S, Bang SY, Lee HS, Kang YM, Suh CH, Chung WT, Lee SK, Choe JY, Shim SC, Lee SS, Oh JH, Kim YJ, Lee JY, Han BG, Gaffney PM, Vyse Slegen TJ, Harley JB, Langefeld CD, Bae SC, Sivils KL, Tsao BP. Identification of a novel systemic lupus erythematosus risk locus between FCHSD2 and P2RY2 in Koreans [abstract]. Arthritis Rheum. 2013;65(Suppl 10):S692-S693.

Ombrello MJ, Remmers EF, Tachmazidou I, Grom AA, Foll D, Martini A, Gattorno M, Ozen S, Prahalad S, Bohnsack JF, Ilowite NT, Mellins ED, Russo RAG, Len CA, Yeung RSM, Wedderburn LR, Anton J, Langefeld CD, Thompson SD,. Genome wide association meta-analysis implicates HLA-DRB1, the BTNL2/HLA-DRA region, and a novel susceptibility locus on chromosome 1 in systemic juvenile idiopathic arthritis [abstract]. Arthritis Rheum. 2013;65(Suppl 10):S937.

Ramos PS, Titus N, Sajuthi S, Divers J, Huang YQ, Nayak U, Chen WM, Hunt KJ, Kamen DL, Gikeson GS, Fernandes JK, Spruill IJ, Garvey WT, Sale MM, Langefeld CD. Identification of autoimmune disease genes in regions under selection in the Gullah African American population of South Carolina [abstract]. Arthritis Rheum. 2013;65(Suppl 10):S61.

Riquelme MEA, Ziegler JT, Comeau ME, Sanchez E, Pons-Estel B, Acevedo E, Cucho JM, de la Torre IG, Cardiel MH, Miranda P, Cattogio L, Maradiaga M, Esquivel-Valerio J, Moctezuma JF, Garcia M, Berbotto G, Babini A,. GWAS in Hispanic and Latin American individuals enriched for Amerindian ancestry identifies a new locus associated with systemic lupus erythematosus [abstract]. Arthritis Rheum. 2013;65(Suppl 10):S695.

Woo D, Deka R, Falcone GJ, Flaherty ML, Haverbusch M, Martini SR, Greenberg SM, Ayres AM, Sauerbeck L, Kissela BM, Kleindorfer DO, Moomaw CJ, Anderson CD, Broderick JP, Rosand J, Langefeld CD, Woo JG. Apolipoprotein E, statins, and risk of intracerebral hemorrhage. Stroke. 2013;44(11):3013-3017.

Zhao J, Giles BM, Taylor RL, Yette GA, Lough KM, Abraham LJ, Wu H, Gaffney PM, Kelly JA, Kaufman KM, Harley JB, Langefeld CD, Brown EE, Edberg JC, Kimberly RP, Ulgiati D, Tsao BP, Boackle SA. An intronic CR2 polymorphism associated with systemic lupus erythematosus alters CTCF binding and CR1 expression [abstract]. Arthritis Rheum. 2013;65(Suppl 10):S1155.

Divers J, Nunez M, High KP, Murea M, Rocco MV, Ma L, Bowden DW, Hicks PJ, Spainhour M, Ornelles DA, Kleiboeker SB, Duncan K, Langefeld CD, Turner J, Freedman BI. JC polyoma virus interacts with APOL1 in African Americans with nondiabetic nephropathy. Kidney Int. 2013;84(6):1207-1213.

Thameem F, Igo RP Jr, Freedman BI, Langefeld C, Hanson RL, Schelling JR, Elston RC, Duggirala R, Nicholas SB, Goddard KA, Divers J, Guo X, Ipp E, Kimmel PL, Meoni LA, Shah VO, Smith MW, Winkler CA, Zager PG, Knowler WC, Nelson RG,. A genome-wide search for linkage of estimated glomerular filtration rate (eGFR) in the family investigation of nephropathy and diabetes (FIND). PLoS One. 2013;8(12):e81888.

Sandy An S, Palmer ND, Hanley AJ, Ziegler JT, Mark Brown W, Freedman BI, Register TC, Rotter JI, Guo X, Ida Chen YD, Wagenknecht LE, Langefeld CD, Bowden DW. Genetic analysis of adiponectin variation and its association with type 2 diabetes in African Americans. Obesity (Silver Spring). 2013;21(12):E721-E729.

Zhang W, Langefeld CD, Grunwald GK, Fingerlin TE. Testing gene-environment interactions in family-based association studies using trait-based ascertained samples. Stat Med. 2013;33(2):304-318.

Cooke Bailey JN, Lu L, Chou JW, Xu J, McWilliams DR, Howard TD, Freedman BI, Bowden DW, Langefeld CD, Palmer ND. The role of copy number variation in African Americans with Type 2 diabetes-associated end stage renal disease. J Mol Genet Med. 2013;7(2):61.

Palmer ND, Musani SK, Yerges-Armstrong LM, Feitosa MF, Bielak LF, Hernaez R, Kahali B, Carr JJ, Harris TB, Jhun MA, Kardia SL, Langefeld CD, Mosley TH Jr, Norris JM, Smith AV, Taylor HA, Wagenknecht LE, Liu J, Borecki IB, Peyser PA, Speliotes EK. Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent. Hepatology. 2013;58(3):966-975.

Sandholm N, McKnight AJ, Salem RM, Brennan EP, Forsblom C, Harjutsalo V, Makinen VP, McKay GJ, Sadlier DM, Williams WW, Martin F, Panduru NM, Tarnow L, Tuomilehto J, Tryggvason K, Zerbini G, Comeau ME, Langefeld CD, Godson C,. Chromosome 2q31.1 associates with ESRD in women with type 1 diabetes. J Am Soc Nephrol. 2013;24(10):1537-1543.

Sergeant S, Hugenschmidt CE, Rudock ME, Ziegler JT, Ivester P, Ainsworth HC, Vaidya D, Case LD, Langefeld CD, Freedman BI, Bowden DW, Mathias RA, Chilton FH. Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome. Br J Nutr. 2012;107(4):547-555.

Ng MCY, Hester JM, Wing MR, Li J, Xu J, Hicks PJ, Roh BH, Lu L, Divers J, Langefeld CD, Freedman BI, Palmer ND, Bowden DW. Genome-wide association of BMI in African Americans. Obesity (Silver Spring). 2012;20(3):622-627.

Rao M, Mottl AK, Cole SA, Umans JG, Freedman BI, Bowden DW, Langefeld CD, Fox CS, Yang Q, Cupples A, Iyengar SK, Hunt SC, Trikalinos TA. Meta-analysis of genome-wide linkage scans for renal function traits. Nephrol Dial Transplant. 2012;27(2):647-656.

Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS, Hester JM, Cooke JN, Bostrom MA, Rudock ME, Talbert ME, Lewis JP, Lu L, Ziegler JT, Divers J, Ng MCY, Langefeld CD, Freedman BI, Bowden DW, et al. A genome-wide association search for type 2 diabetes genes in African Americans. PLoS ONE. 2012;7(1):e29202.

Cooke JN, Ng MCY, Palmer ND, An SS, Hester JM, Freedman BI, Langefeld CD, Bowden DW. Genetic risk assessment of type 2 diabetes-associated polymorphisms in African Americans. Diabetes Care. 2012;35(2):287-292.

Sheth K, Koch S, Elkind M, Sung G, Kittner S, Frankel M, Rosand J, Langefeld C, Comeau M, Waddy S, Osborne J, Woo D. Anti-epileptic drug use and outcome in the Ethnic and Racial Variations in Intracerebral Hemorrhage (ERICH) study [abstract]. Neurology. 2012;78(Suppl 1):S23005.

Bostrom MA, Kao WHL, Li M, Abboud HE, Adler SG, Iyengar SK, Kimmel PL, Hanson RL, Nicholas SB, Rasooly RS, Lu L, Hicks PJ, Langefeld CD, Bowden DW, Freedman BI, et al. Genetic association and gene-gene interaction analyses in African American dialysis patients with nondiabetic nephropathy. Am J Kidney Dis. 2012;59(2):210-221.

Jacob CO, Eisenstein M, Dinauer MC, Ming W, Liu Q, John S, Quismorio FP Jr, Reiff A, Myones BL, Kaufman KM, McCurdy D, Harley JB, Silverman E, Kimberly RP, Vyse TJ, Gaffney PM, Langefeld CD, et al. Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase. Proc Natl Acad Sci U S A. 2012;109(2):E59-E67.

Hughes T, Adler A, Kelly JA, Kaufman KM, Williams AH, Langefeld CD, Brown EE, Alarcon GS, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Boackle SA, Stevens AM, Reveille JD, Sanchez E, Martin J, Niewold TB, Vila LM, Scofield RH,. Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus. Arthritis Rheum. 2012;64(2):485-492.

Hester JM, Wing MR, Li J, Palmer ND, Xu J, Hicks PJ, Roh BH, Norris JM, Wagenknecht LE, Langefeld CD, Freedman BI, Bowden DW, Ng MCY. Implication of European-derived adiposity loci in African Americans. Int J Obes (Lond). 2012;36(3):465-473.

Cooke JN, Bostrom MA, Hicks PJ, Ng MCY, Hellwege JN, Comeau ME, Divers J, Langefeld CD, Freedman BI, Bowden DW. Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans. Nephrol Dial Transplant. 2012;27(4):1505-1511.

Freedman BI, Langefeld CD. The new era of APOL1-associated glomerulosclerosis. Nephrol Dial Transplant. 2012;27(4):1288-1291.

Keys T, Gorbachinsky I, Mckenzie P, Campeau L, Rohozinski J, Andersson K-E, Langefeld C, Badlani G. Enhanced MMP-1 transcription: role in the development of SUI and POP [abstract]. Neurourol Urodyn. 2012;31(2):244.

Lin CP, Adrianto I, Lessard CJ, Kelly JA, Kaufman KM, Guthridge JM, Freedman BI, Anaya J-M, Alarcon-Riquelme ME, Pons-Estel BA, Martin J, Glenn S, Adler A, Bae S-C, Park S-Y, Bang S-Y, Song Y-W, Boackle SA, Brown EE, Edberg JC,. Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis. Genes Immun. 2012;13(3):232-238.

Saxena A, McDonnell E, Ramos PS, Sajuthi S, Marion MC, Langefeld CD, Buyon JP, Clancy RM. Preferential transmission of genetic risk variants of candidate loci at 6p21 from asymptomatic grandparents to mothers of children with neonatal lupus. Arthritis Rheum. 2012;64(3):931-939.

Lessard CJ, Adrianto I, Ice JA, Wiley GB, Kelly JA, Glenn SB, Adler AJ, Rasmussen A, Williams AH, Ziegler J, Comeau ME, Marion M, Wakeland BE, Liang C, Ramos PS, Grundahl KM, Gallant CJ, alarcon-Riquelme ME, Alarcon GS, Anaya J-M, Bae S-C,. Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study. Am J Hum Genet. 2012;90(4):648-660.

Gawrieh S, Marion MC, Komorowski R, Wallace J, Charlton M, Kissebah A, Langefeld CD, Olivier M. Genetic variation in the peroxisome proliferator activated receptor-gamma gene is associated with histologically advanced NAFLD. Dig Dis Sci. 2012;57(4):952-957.

Guy RT, Santago P, Langefeld CD. Bootstrap aggregating of alternating decision trees to detect sets of SNPs that associate with disease. Genet Epidemiol. 2012;36(2):99-106.

Ko K, Franek BS, Marion M, Kaufman KM, Langefeld CD, Harley JB, Niewold TB. Genetic ancestry, serum interferon-alpha activity, and autoantibodies in systemic lupus erythematosus. J Rheumatol. 2012;39(6):1238-1240.

Cobb J, Hinks A, Bowes J, Steel K, Sudman M, Marion MC, Keddache M, Wedderburn LR, Haas JP, Glass DN, Langefeld CD, Thomson W, Thompson SD. Analysis of the immunochip in a large cohort of oligo- and polyarthritis juvenile idiopathic arthritis cases confirms previous and identifies novel associations [abstract]. Rheumatology. 2012;51(Suppl 3):50-51.

Farlow J, Lin H, Hetrick K, Ling H, Lai D, Sauerbeck L, Woo D, Langefeld C, Brown R, Pugh E, Doheny K, Liu Y, Foroud T, Broderick J. The use of linkage data to prioritize results from whole exome sequencing in familial intracranial aneurysm [abstract]. Neurology. 2012;78(Suppl 1):S53001.

Hughes T, Adler A, Merrill JT, Kelly JA, Kaufman KM, Williams A, Langefeld CD, Gilkeson GS, Sanchez E, Martin J, Boackle SA, Stevens AM, Alarcon GS, Niewold TB, Brown EE, Kimberly RP, Edberg JC, Ramsey-Goldman R,. Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus. Ann Rheum Dis. 2012;71(5):694-699.

Namjou B, Choi CB, Harley IT, Alarcon-Riquelme ME, Kelly JA, Glenn SB, Ojwang JO, Adler A, Kim K, Gallant CJ, Boackle SA, Criswell LA, Kimberly RP, Brown EE, Edberg J, Alarcon GS, Stevens AM, Jacob CO, Gilkeson GS, Kamen DL,. Evaluation of TRAF6 in a large multiancestral lupus cohort. Arthritis Rheum. 2012;64(6):1960-1969.

Wang S, Adrianto I, Wiley GB, Lessard CJ, Kelly JA, Adler AJ, Glenn SB, Williams AH, Ziegler JT, Comeau ME, Marion MC, Wakeland BE, Liang C, Kaufman KM, Guthridge JM, Alarcon-Riquelme ME, Alarcon GS, Anaya J-M, Bae S-C, Kim J-H,. A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus. Genes Immun. 2012;13(5):380-387.

Hinks A, Cobb J, Sudman M, Eyre S, Martin P, Flynn E, Packham J, Barton A, Worthington J, Langefeld CD, Glass DN, Thompson SD, Thomson W. Investigation of rheumatoid arthritis susceptibility loci in juvenile idiopathic arthritis confirms high degree of overlap. Ann Rheum Dis. 2012;71(7):1117-1121.

Cooke JN, Bowden DW, Langefeld CD, Freedman BI. Association of MYH9/APOL1 with chronic kidney disease in a UK population [reply to letter]. Nephrol Dial Transplant. 2012;27(9):3660-3662.

Thompson SD, Marion MC, Sudman M, Ryan M, Tsoras M, Howard TD, Barnes MG, Ramos PS, Thomson W, Hinks A, Haas JP, Prahalad S, Bohnsack JF, Wise CA, Punaro M, Rose CD, Pajewski NM, Spigarelli M, Keddache M, Wagner M, Langefeld CD, Glass DN. Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13. Arthritis Rheum. 2012;64(8):2781-2791.

Miller MR, Pereira RI, Langefeld CD, Lorenzo C, Rotter JI, Chen Y-DI, Bergman RN, Wagenknecht LE, Norris JM, Fingerlin TE. Levels of free fatty acids (FFA) are associated with insulin resistance but do not explain the relationship between adiposity and insulin resistance in Hispanic Americans: the IRAS Family Study. J Clin Endocrinol Metab. 2012;97(9):3285-3291.

Kim K, Brown EE, Choi CB, Alarcon-Riquelme ME, Kelly JA, Glenn SB, Ojwang JO, Adler A, Lee HS, Boackle SA, Criswell LA, Alarcon GS, Edberg JC, Stevens AM, Jacob CO, Gilkeson GS, Kamen DL, Tsao BP, Anaya JM, Guthridge JM, Nath SK, Richardson B,. Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries. Ann Rheum Dis. 2012;71(11):1809-1814.

Bostrom MA, Perlegas P, Lu L, Hicks PJ, Hawkins G, Ng MC, Langefeld CD, Freedman BI, Bowden DW. Relevance of the ACTN4 gene in African-Americans with non-diabetic end-stage renal disease. Am J Nephrol. 2012;36(3):252-260.

Freedman BI, Langefeld CD, Turner J, Nunez M, High KP, Spainhour M, Hicks PJ, Bowden DW, Reeves-Daniel AM, Murea M, Rocco MV, Divers J. Association of APOL1 variants with mild kidney disease in the first-degree relatives of African American patients with non-diabetic end-stage renal disease. Kidney Int. 2012;82(7):805-811.

Adrianto I, Wang S, Wiley GB, Lessard CJ, Kelly JA, Adler AJ, Glenn SB, Williams AH, Ziegler JT, Comeau ME, Marion MC, Wakeland BE, Liang C, Kaufman KM, Guthridge JM, Alarcon-Riquelme ME, Alarcon GS, Anaya JM, Bae SC, Kim JH,. Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus. Arthritis Rheum. 2012;64(11):3695-3705.

Murea M, Register TC, Divers J, Bowden DW, Carr JJ, Hightower CR, Xu J, Smith SC, Hruska KA, Langefeld CD, Freedman BI. Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study. BMC Nephrol. 2012;13(1):148.

Zaitlen N, Lindstrom S, Pasaniuc B, Cornelis M, Genovese G, Pollack S, Barton A, Bickeboller H, Bowden DW, Eyre S, Freedman BI, Friedman DJ, Field JK, Groop L, Haugen A, Heinrich J, Henderson BE, Hicks PJ, Hocking LJ,. Informed conditioning on clinical covariates increases power in case-control association studies. PLoS Genet. 2012;8(11):e1003032.

Deng Y, Zhao J, Sakurai D, Kaufman KM, Edberg JC, Kimberly RP, Kamen DL, Gilkeson GS, Jacob CO, Scofield RH, Langefeld CD, Kelly JA, Alarcun-Riquelme ME, Harley JB, Vyse TJ, Freedman BI, Gaffney PM, Sivils KM, James JA,. The SLE-associated TLR7 variant confers differential gene expression modulated by microRNA-3148 [abstract]. Arthritis Rheum. 2012;64(Suppl 10):S689.

Edberg JC, Duarte CW, Patki A, Brown EE, Kaufman KM, Kelly JA, Comeau ME, Alarcon-Riquelme ME, Bae S-C, Criswell LA, Freedman BI, Gaffney PM, Gilkeson GS, Jacob CO, James JA, Kamen DL, Sivils KM, Niewold TB, Scofield RH,. Genetic interactions between SNP variants in C3 receptor subunits in patients with SLE [abstract]. Arthritis Rheum. 2012;64(10 Suppl):S420.

Kimberly RP, Freedman BI, Langfeld CD [sic] [Langefeld CD], Absher D, Andringa KK, Birmingham D, Brown EE, Comeau ME, Costenbader KH, Criswell LA, Edberg JC, Harley JB, James JA, Kamen DL, Merrill JT, Niewold TB, Patel N,. Apolipoprotein L1 risk variants underlie racial disparities in lupus nephritis-induced end-stage renal disease [abstract]. Arthritis Rheum. 2012;64(Suppl 10):S313.

Woo JG, Martin LJ, Ding L, Brown WM, Howard TD, Langefeld CD, Moomaw CJ, Haverbusch M, Sun G, Indugula SR, Cheng H, Deka R, Woo D. Quantitative criteria for improving performance of buccal DNA for high-throughput genetic analysis. BMC Genet. 2012;13():75.

Giles BM, Zhao J, Lough KM, Gaffney PM, Alarcon-Riquelme ME, Brown EE, Criswell LA, Gilkeson GS, Jacob CO, James JA, Merrill JT, Moser KL, Niewold TB, Scofield RH, Vyse TJ, Harley JB, Kaufman KM, Kelly JA, Langefeld CD,. Preferential association of complement receptor 2 variants with anti-dsDNA autoantibodies in systemic lupus erythematosus [abstract]. Arthritis Rheum. 2012;64(10 Suppl):S965-S966.

Hinks A, Cobb J, Marion MC, Sudman M, Bowes J, Steel KJA, Keddache M, Bohnsack JF, Guthery S, Wedderburn LR, Haas JP, Glass DN, Prahalad S, Langefeld CD, Thomson W, Thompson SD. Analysis of the immunochip in a large cohort of juvenile idiopathic arthritis cases identifies 17 loci at genome-wide significance [abstract]. Arthritis Rheum. 2012;64(10 Suppl):S689-S690.

Hiraki LT, Williams AH, Manoharan A-P, Kraft P, Langefeld CD, Graham RR, Karlson EW. Genetic markers for circulating vitamin D and the associations with risk of systemic lupus erythematosus [abstract]. Arthritis Rheum. 2012;64(10 Suppl):S964.

Martini SR, Flaherty ML, Brown WM, Haverbusch M, Comeau ME, Sauerbeck LR, Kissela BM, Deka R, Kleindorfer DO, Moomaw CJ, Broderick JP, Langefeld CD, Woo D. Risk factors for intracerebral hemorrhage differ according to hemorrhage location. Neurology. 2012;79(23):2275-2282.

Ombrello MJ, Remmers E, Grom AA, Thomson W, Martini A, Gattorno M, Ozen S, PRahalad S, Bohnsack JF, Zeft A, Ilowite NT, Mellins ED, Russo RAG, Len C, Oliveira SK, Yeung RSM, Wedderburn LR, Lopez JA, Satorius C,. Genome-wide association meta-analysis of eight independent systemic juvenile idiopathic arthritis collections reveals regional association spanning the major histocompatibility complex class II and III gene cluster [abstract]. Arthritis Rheum. 2012;64(10 Suppl):S1126.

Ramos PS, Howard TD, Marion MC, Sajuthi S, Kelly JA, Moser KL, Langefeld CD. Epigenetic profiling in monozygotic twins discordant for systemic lupus erythematosus reveals prominent hypomethylation of interferon-inducible genes [abstract]. Arthritis Rheum. 2012;64(10 Suppl):S966.

Ramos PS, Howard TD, Marion MC, Sajuthi S, Clancy RM, Buyon JP, Langefeld CD. Epigenetic changes in fibrosis and myocyte repair genes may contribute to pathogenesis in monozygotic twins discordant for cardiac manifestations of neonatal lupus [abstract]. Arthritis Rheum. 2012;64(10 Suppl):S137.

Ramos PS, Sajuthi S, Huang Y, Kamen DL, Divers J, Kaufman KM, Harley JB, Kimberly RP, Langefeld CD, Sale MM, Garvey WT, Gilkeson GS. Genes associated with systemic lupus erythematosus show evidence of selection in the Gullah African American population [abstract]. Arthritis Rheum. 2012;64(10 Suppl):S962.

Sakurai D, Zhao J, Deng Y, Kelly JA, Sivils KM, Kaufman KM, Brown EE, Alarcon-Riquelme ME, Harley JB, Bae SC, Jacob CO, Vyse TJ, Niewold TB, Gaffney PM, James JA, Kimberly RP, Gilkeson GS, Kamen DL, Langefeld CD,. Preferential binding to Elk-1 by SLE-associated IL10 risk allele up-regulates IL10 expression [abstract]. Arthritis Rheum. 2012;64(10 Suppl):S369.

Sanchez E, Rasmussen A, Riba L, Acevedo-Vasquez E, Kelly JA, Langefeld CD, Williams AH, Ziegler JT, Comeau ME, Marion MC, Garcia-De La Torre I, Maradiaga-Cecena MA, Cardiel MH, Esquivel-Valerio JA, Rodriguez-Amado J,. Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations. Arthritis Rheum. 2012;64(11):3687-3694.

Steel KJA, Hinks A, Bowes J, Cobb J, Flynn E, Langefeld CD, Prahalad S, Haas JP, Bohnsack JF, Guthery S, Barton A, Thompson SD, Thomson W. Identification of susceptibility loci for inflammatory arthritis [abstract]. Arthritis Rheum. 2012;64(10 Suppl):S422.

Zoller E, Kottyan LC, Manjou B, Vaughn S, Marion MC, Langefeld CD, Alarcon-Riquelme ME, Anaya J-M, Brown EE, Bae S-C, Edberg JC, Gaffney PM, Kamen DL, Kimberly RP, Jacob CO, Merrill JT, Sivils KM, Petri MA,. Interferon regulatory factor 5 associates with systemic lupus erythematosus through two distinct and independent effects [abstract]. Arthritis Rheum. 2012;64(10 Suppl):S367-S368.

Falcone GJ, Biffi A, Devan WJ, Jagiella JM, Schmidt H, Kissela B, Hansen BM, Jimenez-Conde J, Giralt-Steinhauer E, Elosua R, Cuadrado-Godia E, Soriano C, Ayres AM, Schwab K, Pera J, Urbanik A, Rost NS, Goldstein JN,. Burden of risk alleles for hypertension increases risk of intracerebral hemorrhage. Stroke. 2012;43(11):2877-2283.

Foroud T, Koller DL, Lai D, Sauerbeck L, Anderson C, Ko N, Deka R, Mosley TH, Fornage M, Woo D, Moomaw CJ, Hornung R, Huston J, Meissner I, Bailey-Wilson JE, Langefeld C, Rouleau G, Connolly ES, Worrall BB, Kleindorfer D, et al. Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk. Stroke. 2012;43(11):2846-2852.

Morris DL, Taylor KE, Fernando MM, Nititham J, Alarcon-Riquelme ME, Barcellos LF, Behrens TW, Cotsapas C, Gaffney PM, Graham RR, Pons-Estel BA, Gregersen PK, Harley JB, Hauser SL, Hom G, Langefeld CD, Noble JA, Rioux JD, Seldin MF,. Unraveling multiple MHC gene associations with systemic lupus erythematosus: model choice indicates a role for HLA alleles and non-HLA genes in Europeans. Am J Hum Genet. 2012;91(5):778-793.

An SS, Hanley AJ, Ziegler JT, Brown WM, Haffner SM, Norris JM, Rotter JI, Guo X, Chen Y-DI, Wagenknecht LE, Langefeld CD, Bowden DW, Palmer ND. Association between ADIPOQ SNPs with plasma adiponectin and glucose homeostasis and adiposity phenotypes in the IRAS Family Study. Mol Genet Metab. 2012;107(4):721-728.

Freedman BI, Murea M, Rocco MV, Ma L, Bowden DW, Ornelles DA, Kleiboeker S, Langefeld CD, Turner J, Divers J. JC polyoma virus interacts with apolipoprotein L1 genetic risk in African Americans with non-diabetic nephropathy [abstract]. J Am Soc Nephrol. 2012;23():178A.

Freedman BI, Langefeld CD, Comeau ME, Hebert LA, Segal MS, Edberg J, Julian BA, Kimberly RP. Apolipoprotein L1 risk variants associate with lupus nephritis-induced end-stage renal disease in African Americans [abstract]. J Am Soc Nephrol. 2012;23():248A.

Deng Y, Zhao J, Sakurai D, Kaufman KM, Edberg JC, Kimberly RP, Kamen DL, Gilkeson GS, Jacob CO, Scofield RH, Langefeld CD, Kelly JA, Alarcon-Riquelme ME, Harley JB, Vyse TJ, Freedman BI, Gaffney PM, Sivils KM, James JA, Niewold TB,. MicroRNA-3148 modulates differential gene expression of the SLE-associated TLR7 variant [abstract]. Arthritis Res Ther. 2012;14(Suppl 3):A5.

Ramos PS, Marion MC, Langefeld CD, Buyon JP, Clancy RM. Enrichment of associations in genes with fibrosis, apoptosis, and innate immunity functions with cardiac manifestations of neonatal lupus. Arthritis Rheum. 2012;64(12):4060-4065.

Martins M, Williams AH, Alarcon-Riquelme M, Anaya JM, Bae SC, Boackle SA, Criswell LA, Gilkeson GS, Kamen DL, Jacob CO, James JA, Kelly JA, Moser KL, Scofield RH, Kimberly RP, Edberg JC, Vila LM, Petri M,. Genetic association of SLE with CD247 (CD3zeta) [abstract]. In: Abstracts of the American Society of Human Genetics 62nd Annual Meeting; 2012 Nov 6-10; San Francisco (CA). 2012;():454.

Young KA, Fingerlin TE, Langefeld CD, Lorenzo C, Haffner SM, Wagenknecht LE, Norris JM. Exploring differences in adiposity in two U.S. Hispanic populations of Mexican origin using social, behavioral, physiologic and genetic markers: the IRAS Family Study. Ethn Dis. 2012;22(1):65-71.

Wagenknecht LE, Divers J, Bertoni AG, Langefeld CD, Carr JJ, Bowden DW, Elbein SC [deceased], Shea S, Lewis CE, Freedman BI. Correlates of coronary artery calcified plaque in blacks and whites with type 2 diabetes. Ann Epidemiol. 2011;21(1):34-41.

Gopalakrishnan I, Iskandar SS, Daeihagh P, Divers J, Langefeld CD, Bowden DW, Hicks PJ, Rocco MV, Freedman BI. Coincident idiopathic focal segmental glomerulosclerosis collapsing variant and diabetic nephropathy in an African American homozygous for MYH9 risk variants. Hum Pathol. 2011;42(2):291-294.

McDonough CW, Palmer ND, Hicks PJ, Roh BH, An SS, Cooke JN, Hester JM, Wing MR, Bostrom MA, Rudock ME, Lewis JP, Talbert ME, Blevins RA, Lu L, Ng MCY, Divers J, Langefeld CD, Freedman BI, Bowden DW, et al. A genome-wide association study for diabetic nephropathy genes in African Americans. Kidney Int. 2011;79(5):563-572.

Palmer ND, Hester JM, An SS, Adeyemo A, Rotimi C, Langefeld CD, Freedman BI, Ng MCY, Bowden DW. Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant. Diabetes. 2011;60(2):662-668.

Wagenknecht LE, Palmer ND, Bowden DW, Rotter JI, Norris JM, Ziegler J, Chen YI, Haffner S, Scherzinger A, Langefeld CD. Association of PNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study. Liver Int. 2011;31(3):412-416.

Campeau L, Gorbachinsky I, Ziegler JT, Langefeld CD, Andersson KE, Rohozinski J, Badlani G. Comparison of MMP-1 enzymatic activity and TIMP-1 inhibition in women with pelvic organ prolapse [abstract]. Neurourol Urodyn. 2011;30(2):240-241.

Lehtinen AB, Cox AJ, Ziegler JT, Voruganti VS, Xu J, Freedman BI, Carr JJ, Comuzzie AG, Langefeld CD, Bowden DW. Genetic mapping of vascular calcified plaque loci on chromosome 16p in European Americans from the Diabetes Heart Study. Ann Hum Genet. 2011;75(2):222-235.

Lessard CJ, Adrianto I, Kelly JA, Kaufman KM, Grundahl KM, Adler A, Williams AH, Gallant CJ, Freedman BI, Langefeld CD, et al. Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study. Am J Hum Genet. 2011;88(1):83-91.

Chung SA, Taylor KE, Graham RR, Nititham J, Lee AT, Ortmann WA, Jacob CO, Alarcon-Riquelme ME, Tsao BP, Langefeld CD, et al. Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. PLoS Genet. 2011;7(3):e1001323.

Adrianto I, Wen F, Templeton A, Wiley G, King JB, Lessard CJ, Bates JS, Hu Y, Freedman BI, Langefeld CD, et al. Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet. 2011;43(3):253-258.

Taylor KE, Chung SA, Graham RR, Ortmann WA, Lee AT, Langefeld CD, Jacob CO, Kamboh MI, Alarcon-Riquelme ME, Tsao BP, et al. Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes. PLoS Genet. 2011;7(2):e1001311.

Reeves-Daniel AM, DePalma JA, Bleyer AJ, Rocco MV, Murea M, Adams PL, Langefeld CD, Bowden DW, Hicks PJ, Stratta RJ, Lin J-J, Kiger DF, Gautreaux MD, Divers J, Freedman BI. The APOL1 gene and allograft survival after kidney transplantation. Am J Transplant. 2011;11(5):1025-1030.

Freedman BI, Langefeld CD, Lu L, Divers J, Comeau ME, Palmer ND, Hicks PJ, Bostrom MA, Cooke JN, McDonough CW, Bowden DW, et al. Differential effects of MYH9 and APOL1 risk variants on FRMD3 association with diabetic ESRD in African Americans. PLoS Genet. 2011;7(6):e1002150.

Namjou B, Kothari PH, Kelly JA, Glenn SB, Ojwang JO, Adler A, Alarcon-Riquelme ME, Perrino FW, Freedman BI, Langefeld CD, et al. Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort. Genes Immun. 2011;12(4):270-279.

Murea M, Lu L, Ma L, Hicks PJ, Divers J, McDonough CW, Langefeld CD, Bowden DW, Freedman BI. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. Am J Nephrol. 2011;33(6):502-509.

Mathias RA, Sergeant S, Hugenschmidt CE, Ziegler JT, Ivester P, Case D, Freedman BI, Rudock ME, Langefeld CD, Bowden DW, Chilton FH, et al. The impact of FADS genetic variants on omega-6 polyunsaturated fatty acid metabolism in African Americans. BMC Genet. 2011;12():article 50.

Zhao J, Wu H, Khosravi M, Cui H, Langefeld CD, Williams AH, Comeau ME, Ziegler JT, Marion MC, Freedman BI, et al. Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. PLoS Genet. 2011;7(5):e1002079.

Brown WM, Biffi A, Jagiella J, Comeau M, Cortellini L, Woo JG, Martin L, Flaherty ML, Broderick JP, Langefeld CD, et al. Genome wide association study of intracerebral hemorrhage [abstract]. Stroke. 2011;42(3):e218-e219.

Igo RP Jr, Iyengar SK, Nicholas SB, Goddard KAB, Langefeld CD, Hanson RL, Duggirala R, Divers J, Bowden DW, Freedman BI, et al. Genomewide linkage scan for diabetic renal failure and albuminuria: the FIND study. Am J Nephrol. 2011;33(5):381-389.

Hixson JE, Shimmin LC, Montasser ME, Kim D-K, Zhong Y, Howard T, Langefeld C, Liu Y, Herrington D, et al. Common variants in the periostin gene influence development of atherosclerosis in young persons. Arterioscler Thromb Vasc Biol. 2011;31(7):1661-1667.

Divers J, Register TC, Langefeld CD, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Xu J, Hruska KA, Freedman BI. Relationships between calcified atherosclerotic plaque and bone mineral density in African Americans with type 2 diabetes. J Bone Miner Res. 2011;26(7):1554-1560.

Gray SB, Langefeld CD, Ziegler JT, Hawkins GA, Wagner JD, Howard TD. Single-nucleotide polymorphisms in the TNF gene are associated with obesity-related phenotypes in vervet monkeys. Obesity (Silver Spring). 2011;19(7):1427-1432.

Ramos PS, Williams AH, Ziegler JT, Comeau ME, Guy RT, Lessard CJ, Li H, Edberg JC, Zidovetzki R, Langefeld CD, et al. Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosus. Arthritis Rheum. 2011;63(7):2049-2057.

Hughes T, Kim-Howard X, Kelly JA, Kaufman KM, Langefeld CD, Ziegler J, Sanchez E, Kimberly RP, Edberg JC, Ramsey-Goldman R, et al. Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21. Arthritis Rheum. 2011;63(6):1689-1697.

Sibble SP, Talbert ME, Bowden DW, Haffner SM, Taylor KD, Chen Y-DI, Wagenknecht LE, Langefeld CD, Norris JM. RGS6 variants are associated with dietary fat intake in Hispanics: the IRAS Family Study. Obesity (Silver Spring). 2011;19(7):1433-1438.

Chen L, Yu G, Langefeld CD, Miller DJ, Guy RT, Raghuram J, Yuan X, Herrington DM, Wang Y. Comparative analysis of methods for detecting interacting loci. BMC Genomics. 2011;12():344.

Sanchez E, Nadig A, Richardson BC, Freedman BI, Kaufman KM, Kelly JA, Niewold TB, Kamen DL, Ziegler JT, Langefeld CD, et al. Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus. Ann Rheum Dis. 2011;70(10):1752-1757.

Wing MR, Ziegler JM, Langefeld CD, Roh BH, Palmer ND, Mayer-Davis EJ, Rewers MJ, Haffner SM, Wagenknecht LE, Bowden DW. Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort. Int J Obes (Lond). 2011;35(9):1173-1182.

Reeves-Daniel AM, Divers J, Langefeld CD, Freedman BI. Response to mechanism of action of APOL1 in renal allograft survival (and native CKD) remains unclear [letter]. Am J Transplant. 2011;11(10):2260.

Tan W, Sunahori K, Zhao J, Deng Y, Langefeld CD, Williams AH, Comeau ME, Ziegler JT, Marion MC, Freedman BI, et al. Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups. Arthritis Rheum. 2011;63(9):2755-2763.

Murea M, Register TC, Divers J, Bowden DW, Carr JJ, Hightower RC, Smith SC, Hruska KA, Langefeld CD, Freedman BI. Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study [abstract]. J Am Soc Nephrol. 2011;22(Abstract Suppl):715A.

Freedman BI, Langefeld CD, Murea M, Ma L, Otvos JD, Turner J, Antinozzi PA, Rocco MV, Parks JS. Apolipoprotein L1 (APOL1) nephropathy risk variants associate with HDL subfraction concentration in African Americans [abstract]. J Am Soc Nephrol. 2011;22(Abstract Suppl):178A.

Freedman BI, Hicks PJ, Langefeld CD, Lu L, Bleyer AJ, Divers J, Nachman PH, Derebail VK, Bowden DW. Sickle cell trait is not associated with ESRD susceptibility in African Americans [abstract]. J Am Soc Nephrol. 2011;22(Abstract Suppl):463A.

Winkler CA, Freedman BI, Kao WHL, Langefeld CD, Astor BC, Nelson GW, Comeau ME, Bowden DW, Kopp JB, Lipkowitz MS. APOL1 risk genotypes are enriched in African American Study of Kidney Disease and Hypertension (AASK) participants, particularly among those with kidney disease progression [abstract]. J Am Soc Nephrol. 2011;22(Abstract Suppl):458A-459A.

Kopp JB, Freedman BI, Winkler CA, Nelson GW, Bowden DW, Comeau ME, Langefeld CD. APOL1 and MYH9 genetic variants are independently associated with kidney disease risk in African Americans [abstract]. J Am Soc Nephrol. 2011;22(Abstract Suppl):460A-461A.

Cox AJ, Lehtinen AB, Xu J, Langefeld CD, Freedman BI, Carr JJ, Bowden DW. Polymorphisms in the selenoprotein S gene are associated with quantitative measures of subclinical cardiovascular disease in the Diabetes Heart Study [abstract]. Diabetes. 2011;60(Suppl 1):A5.

Hugenschmidt C, Hayasaka S, Langefeld C, Freedman B, Carr JJ, Williamson J, Bowden DW. Cognitive performance is related to vascular disease and diabetes in a family study of type 2 diabetes [abstract]. Diabetes. 2011;60(Suppl 1):A225-A226.

Ramos PS, Oates JC, Kamen DL, Gaffney PM, Langefeld CD, Kelly JA, Kaufman KM, Kimberly RP, Niewold TB, Freedman BI, et al. Association of reactive intermediate genes with systemic lupus erythematosus (SLE) varies across populations with differnet African ancestries [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S250.

Lessard CJ, Adrianto I, Ice JA, Kelly JA, Li H, Wiley GB, Rasmussen A, Alarcon-Riquelme ME, Anaya J-M, Langefeld CD, et al. A large-scale, multi-racial replication study identifies novel systemic lupus erythematosus susceptibility loci at IRF8, TMEM39A, and IKZF3/ZPBP2 [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S965.

Adrianto I, Wiley GB, Wang S, Kaufman KM, Anaya J-M, Alarcon-Riquelme ME, Bae S-C, Brown EE, Freedman BI, Langefeld CD, et al. A functional haplotype in the region of TNIP1 is associated with systemic lupus erythematosus in multiple populations [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S248.

Wang S, Adrianto I, Wiley GB, Kaufman KM, Anaya J-M, Alarcon-Riquelme ME, Bae S-C, Brown EE, Freedman BI, Langefeld CD, et al. A single risk haplotype in the region of UBE2L3 is associated with systemic lupus erythematosus in multiple ethnic populations [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S247-S248.

Kariuki S, Franek BS, Kumar AA, Kumabe M, Kaufman KM, Anaya J-M, Alarcon-Riquelme ME, Bae S-C, Freedman BI, Langefeld CD, et al. Genetic associations with serologic autoimmunity in a large multi-ancestral systemic lupus erythematosus cohort [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S246.

Sanchez E, Nadig A, Richardson BC, Freedman BI, Kaufman K, Niewold TB, Kamen DL, Gilkeson GS, Langefeld CD, Kimberly RP, et al. Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S245-S246.

Chung SA, Brown EE, Williams AH, Bhangale T, Ramos PS, Ziegler JT, Freedman BI, Kimberly RP, Vyse TJ, Langefeld CD, et al. Lupus nephritis susceptibility markers in PDGRFA-GSX2, SLC5A11, ID4, and HAS2-SNTB1 regions identified from a meta-analysis of genome wide association studies of women with systemic lupus erythematosus [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S967.

Hester J, Li J, Hicks P, Langefeld C, Freedman B, Bowden D, Ng M. Implication of European-derived adiposity loci in African Americans [abstract]. In: Abstracts of the 61st Annual Meeting of the American Society of Human Genetics; 2011 Oct 11-15; Montreal (Canada). 2011;():.

Price A, Zaitlen N, Lindstrom S, Pasaniuc B, Cornelis M, Genovese G, Bowden D, Freedman B, Hicks P, Langefeld C, et al. Liability threshold modeling of covariates increases power in case-control association studies [abstract]. In: Abstracts of the 61st Annual Meeting of the American Society of Human Genetics; 2011 Oct 11-15; Montreal (Canada). 2011;():.

Oates J, Kamen D, Gaffney P, Langefeld C, Kelly J, Kaufman K, Kimberly R, Niewold T, Freedman B, Ramos P, et al. Genetic risk factors associated with systemic lupus erythematosus (SLE) in reactive intermediate genes vary across African ancestries [abstract]. In: Abstracts of the 61st Annual Meeting of the American Society of Human Genetics; 2011 Oct 11-15; Montreal (Canada). 2011;():.

Cooke J, Ng M, Lu L, Li J, An S, Hester J, Xu J, Freedman B, Langefeld C, Bowden D, Palmer N. Genetic risk assessment of type 2 diabetes associated polymorphisms in African-Americans [abstract]. In: Abstracts of the 61st Annual Meeting of the American Society of Human Genetics; 2011 Oct 11-15; Montreal (Canada). 2011;():.

Ehret GB, Munroe PB, Rice KM, Liu Y, Palmer ND, Lohman KK, Rudock ME, Langefeld CD, Prokopenko I, Wagenknecht LE, et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011;478(7367):103-109.

Freedman BI, Langefeld CD, Murea M, Ma L, Otvos JD, Turner J, Antinozzi PA, Divers J, Hicks PJ, Bowden DW, Rocco MV, Parks JS. Apolipoprotein L1 nephropathy risk variants associate with HDL subfraction concentration in African Americans. Nephrol Dial Transplant. 2011;26(11):3805-3810.

Schauberger EM, Ewart SL, Arshad SH, Huebner M, Karmaus W, Holloway JW, Friderici KH, Ziegler JT, Zhang H, Langefeld CD, et al. Identification of ATPAF1 as a novel candidate gene for asthma in children. J Allergy Clin Immunol. 2011;128(4):753-760.

Cobb J, Hinks A, Bowes J, Sudman M, Marion MC, Keddache M, Wedderburn LR, Haas JP, Glass DN, Langefeld CD, Thomson W, Thompson SD. Analysis of the immunochip in a large cohort of oligo- and polyarthritis juvenile idiopathic arthritis cases confirms previous and identifies novel associations [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S660.

Deng Y, Zhao J, Tan W, Kaufman KM, Brown EE, Edberg JC, Kamen DL, Gilkeson GS, Jacob CO, Langefeld CD, et al. Association of a functional variant in TLR7 with systemic lupus erythematosus and rheumatoid arthritis in multiple ancestries [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S246-S247.

Hicks PJ, Langefeld CD, Lu L, Bleyer AJ, Divers J, Nachman PH, Derebail VK, Bowden DW, Freedman BI. Sickle cell trait is not independently associated with susceptibility to end-stage renal disease in African Americans. Kidney Int. 2011;80(12):1339-1343.

Hughes T, Adler A, Kelly JA, Kaufman K, Williams A, Langefeld CD, Brown E, Sanchez E, Martin J, Vila LM, Gilkeson GS, Gaffney PM, Moser KL, Merrill JT, James JA, Vyse TJ, Alarcon-Riquelme ME, Harley JB, Richardson BC, Sawalha AH. Evidence for epistatic gene-gene interactions in systemic lupus erythematosus [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S55.

Hughes T, Adler A, Merrill JT, Kelly JA, Kaufman K, Williams A, Langefeld CD, Gilkeson GS, Sanchez E, Martin J, Brown EE, Gaffney PM, Moser KL, Vyse TJ, Alarcon-Riquelme ME, James JA, Scofield RH, Harley JB, Richardson BC, Sawalha Ah. Sex-specific genetic architecture of systemic lupus erythematosus [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S57.

Kaufman KM, Kelly JA, Hughes T, Adler A, Sanchez E, Ojwang JO, Langefeld CD, Ziegler JT, James JA, Brown EE, Kimberly RP, Edberg JC, Criswell LA, Chang D-M, Gilkeson GS, Niewold TB, Bae S-C, Alarcon-Riquelme ME, Jacob CO, et al. Fine mapping of Xq28: both MECP2/IRAK1 and NAA10/RENBP contribute to risk for SLE in multiple ancestral groups [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S250-S251.

Kim K, Brown EE, Choi C-B, Alarcon-Riquelme ME, Kelly JA, Kaufman KM, Bang S-Y, Lee H-S, Kim T, Nath S, Tsao BP, Sawalha AH, Pons-Estel B, Vyse TJ, Gaffney PM, Langefeld DC, Harley JB, Kang C, Kimberly RP, Bae S-C. Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestry populations [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S657-S658.

Lin CP, Adrianto I, Hale JJ, Kelly JA, Glenn SB, Anderson J, Kaufman KM, Harley JB, Vyse TJ, Kimberly RP, Alarcon-Riquelme ME, Langefeld CD, Tsao BP, Criswell LA, Jacob CO, Gaffney PM, Moser KL, James JA, Montgomery CG. Genome-wide association scan of antigenic epitopes of lupus specific autoantibodies in European Americans [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S253.

Ombrello MJ, Remmers E, Grom AA, Thomson W, Martini A, Gattorno M, Ozen S, Gul A, Bohnsack JF, Langefeld CD, et al. Major histocompatibility complex class II gene cluster harbors systemic juvenile idiopathic arthritis susceptibility locus [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S659-S660.

Ramos PS, Marion MC, Langefeld CD, Buyon JP, Clancy RM. Pathway-based analysis identifies significant enrichment of apoptosis, immune and fibrosis genes associated with cardiac manifestations of neonatal lupus [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S114.

Sakurai D, Zhao J, Deng Y, Kaufman K, Kelly JA, Kimberly RP, Alarcon-Riquelme ME, Harley JB, Bae SC, Langefeld CD, et al. Risk alleles of SLE associated IL10 SNPs conferred differential binding to transcription factors [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S966.

Sanchez E, Comeau ME, Freedman BI, Kelly JA, Kaufman K, Langefeld CD, Brown EE, Merrill JT, Tsao BP, Kamen DL, et al. Identification of novel genetic susceptibility loci in African-American lupus patients using a candidate gene association study [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S965-S966.

Sanchez E, Comeau ME, Freedman BI, Kelly JA, Kaufman KM, Langefeld CD, Brown EE, Alarcon GS, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Vila LM, Merrill JT, Tsao BP, Kamen DL, Gilkeson GS, James JA, Vyse TJ, Gaffney PM,. Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study. Arthritis Rheum. 2011;63(11):3493-3501.

Saxena A, McDonnell E, Ramos PS, Sajuthi S, Marion MC, Langefeld CD, Buyon JP, Clancy RM. Preferential transmission of genetic risk variants of candidate loci at 6p21 from asymptomatic grandparents to anti-SSA/Ro positive mothers of children with neonatal lupus [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S302-S303.

Zhao J, Sakurai D, Deng Y, Sestak AL, Langefeld CD, Kaufman KM, Kelly JA, Gaffney PM, Moser KL, Alarcon-Riquelme ME, et al. SLE-risk alleles of SNPs in the NMNAT2/SMG7 region are associated with lower mRNA levels of SMG7 [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S249.

Rudock ME, Cox AJ, Ziegler JT, Lehtinen AB, Connelly JJ, Freedman BI, Carr JJ, Langefeld CD, Hauser ER, Horne BD, Bowden DW. Cigarette smoking status has a modifying effect on the association between polymorphisms in KALRN and measures of cardiovascular risk in the Diabetes Heart Study. Genes Genomics. 2011;33(5):483-490.

Ramos PS, Criswell LA, Moser KL, Comeau ME, Williams AH, Pajewski NM, Chung SA, Graham RR, Zidovetzki R, Kelly JA, Kaufman KM, Jacob CO, Vyse TJ, Tsao BP, Kimberly RP, Gaffney PM, Alarcon-Riquelme ME, Harley JB, Langefeld CD. A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap. PLoS Genet. 2011;7(12):e1002406.

Divers J, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Xu J, Langefeld CD, Freedman BI. Ethnic differences in the relationship between albuminuria and calcified atherosclerotic plaque: the African American-Diabetes Heart Study. Diabetes Care. 2010;33(1):131-138.

Leak TS, Langefeld CD, Keene KL, Gallagher CJ, Lu L, Mychaleckyj JC, Rich SS, Freedman BI, Bowden DW, Sale MM. Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy. BMC Med Genet. 2010;11(1):article 22.

Divers J, Sale MM, Lu L, Chen W-M, Lok KH, Spruill IJ, Fernandes JK, Langefeld CD, Garvey WT. The genetic architecture of lipoprotein subclasses in Gullah-speaking African American families enriched for type 2 diabetes: the Sea Islands Genetic African American Registry (Project SuGAR). J Lipid Res. 2010;51(3):586-597.

Miller MR, Zhang W, Sibbel SP, Langefeld CD, Bowden DW, Haffner SM, Bergman RN, Norris JM, Fingerlin TE. Variant in the 3' region of the IkappaBalpha gene associated with insulin resistance in Hispanic Americans: the IRAS Family Study. Obesity (Silver Spring). 2010;18(3):555-562.

Palmer ND, Langefeld CD, Ziegler JT, Hsu F, Haffner SM, Fingerlin T, Norris JM, Chen YI, Rich SS, Bowden DW, et al. Candidate loci for insulin sensitivity and disposition index from a genome-wide association analysis of Hispanic participants in the Insulin Resistance Atherosclerosis (IRAS) Family Study. Diabetologia. 2010;53(2):281-289.

Palmer ND, Mychaleckyj JC, Langefeld CD, Ziegler JT, Williams AH, Bryer-Ash M, Bowden DW. Evaluation of DLG2 as a positional candidate for disposition index in African-Americans from the IRAS Family Study. Diabetes Res Clin Pract. 2010;87(1):69-76.

Freedman BI, Wagenknecht LE, Hairston KG, Bowden DW, Carr JJ, Hightower RC, Gordon EJ, Xu J, Langefeld CD, Divers J. Vitamin D, adiposity, and calcified atherosclerotic plaque in African-Americans. J Clin Endocrinol Metab. 2010;95(3):1076-1083.

Ramos PS, Brown EE, Kimberly RP, Langefeld CD. Genetic factors predisposing to systemic lupus erythematosus and lupus nephritis. Semin Nephrol. 2010;30(2):164-176.

Nelson GW, Freedman BI, Bowden DW, Langefeld CD, An P, Hicks PJ, Bostrom MA, Johnson RC, Kopp JB, Winkler CA. Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15. Hum Mol Genet. 2010;19(9):1805-1815.

Burdon KP, Rudock ME, Lehtinen AB, Langefeld CD, Bowden DW, Register TC, Liu Y, Freedman BI, Carr JJ, Hedrick CC, et al. Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the Diabetes Heart Study. Mediators Inflamm. 2010;2010():170153.

Reeves-Daniel AM, Iskandar SS, Bowden DW, Bostrom MA, Hicks PJ, Comeau ME, Langefeld CD, Freedman BI. Is collapsing C1q nephropathy another MYH9-associated kidney disease? A case report. Am J Kidney Dis. 2010;55(5):e21-e24.

Freedman BI, Edberg JC, Comeau ME, Murea M, Bowden DW, Divers J, Alarcon GS, Brown EE, McGwin G Jr, Langefeld CD, et al. The non-muscle myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans. Am J Nephrol. 2010;32(1):66-72.

Deka R, Koller DL, Lai D, Indugula SR, Sun G, Woo D, Sauerbeck L, Moomaw CJ, Hornung R, Langefeld CD, et al. The relationship between smoking and replicated sequence variants on chromosomes 8 and 9 with familial intracranial aneurysm. Stroke. 2010;41(6):1132-1137.

Broderick J, Hornung R, Koller D, Woo D, Sauerbeck L, Deka R, Anderson C, Connolly ES, Rouleau G, Langfeld C [sic] [Langefeld C], et al. Relationship between gene variants and smoking in the Familial Intracranial Aneurysm (FIA) study [abstract]. Stroke. 2010;41(4):E243.

Gensic AP, Brown WM, Haverbusch M, Flaherty ML, Kissela BM, Kleindorfer D, Moomaw CJ, Broderick JP, Langefeld CD, Woo D. Routine use of pseudoephedrine is not associated with increased risk of intracerebral hemorrhage [abstract]. Stroke. 2010;41(4):E270.

Bostrom MA, Lu L, Chou J, Hicks PJ, Xu J, Langefeld CD, Bowden DW, Freedman BI. Candidate genes for non-diabetic ESRD in African Americans: a genome-wide association study using pooled DNA. Hum Genet. 2010;128(2):195-204.

Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, Freedman BI, Bowden DW, Langefeld CD, Oleksyk TK, Hicks PJ, et al. Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science. 2010;329(5993):841-845.

Hollenbach JA, Thompson SD, Bugawan TL, Ryan M, Sudman M, Marion M, Langefeld CD, Thomson G, Erlich HA, Glass DN. Juvenile idiopathic arthritis and HLA class I and class II interactions and age-at-onset effects. Arthritis Rheum. 2010;62(6):1781-1791.

Lewis JP, Palmer ND, Ellington JB, Divers J, Ng MCY, Lu L, Langefeld CD, Freedman BI, Bowden DW. Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans. Genomics. 2010;96(4):211-219.

Harley ITW, Niewold TB, Stormont RM, Kaufman KM, Glenn SB, Franek BS, Kelly JA, Kilpatrick JR, Divers J, Langefeld CD, et al. The role of genetic variation near interferon-kappa in systemic lupus erythematosus. J Biomed Biotechnol. 2010;2010():706825.

Bostrom MA, Hicks PJ, Lu L, Langefeld CD, Freedman BI, Bowden DW. Association of polymorphisms in the klotho gene with severity of non-diabetic ESRD in African Americans. Nephrol Dial Transplant. 2010;25(10):3348-3355.

Divers J, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Ding J, Xu J, Langefeld CD, Freedman BI. Regional adipose tissue associations with calcified atherosclerotic plaque: African American-Diabetes Heart Study. Obesity (Silver Spring). 2010;18(10):2004-2009.

Freedman BI, Kopp JB, Langefeld CD, Genovese G, Friedman DJ, Nelson GW, Winkler CA, Bowden DW, Pollak MR. The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans. J Am Soc Nephrol. 2010;21(9):1422-1426.

Tang SCW, Leung VTM, Chan LYY, Ma L, Elbein SC [deceased], Bowden DW, Hicks PJ, Comeau ME, Langefeld CD, Freedman BI, et al. The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes. Nephrol Dial Transplant. 2010;25(12):3931-3934.

Divers J, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Register TC, Xu J, Langefeld CD, Freedman BI. Ethnic differences in the relationship between pericardial adipose tissue and coronary artery calcified plaque: African-American-diabetes heart study. J Clin Endocrinol Metab. 2010;95(12):5382-5389.

Bowden DW, An SS, Palmer ND, Brown WM, Norris JM, Haffner SM, Hawkins GA, Guo X, Wagenknecth LE, Langefeld CD, et al. Molecular basis of a linkage peak: exome sequencing and family-based analysis identify a rare genetic variant in the ADIPOQ gene in the IRAS Family Study. Hum Mol Genet. 2010;19(20):4112-4120.

Engelman CD, Meyers KJ, Ziegler JT, Taylor KD, Palmer ND, Haffner SM, Fingerlin TE, Wagenknecht LE, Bowden DW, Langefeld CD, et al. Genome-wide association study of vitamin D concentrations in Hispanic Americans: the IRAS Family Study. J Steroid Biochem Mol Biol. 2010;122(4):186-192.

Clancy RM, Marion MC, Kaufman KM, Ramos PS, Adler A, Harley JB, Langefeld CD, Buyon JP. Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus. Arthritis Rheum. 2010;62(11):3415-3424.

Hollenbach JA, Meller J, Thompson S, Langefeld C, Bugawan T, Sudman M, Thomson G, Ryan M, Erlich H, Glass D. Fine-mapping of MHC region variants in juvenile idiopathic arthritis (JIA) reveals evidence of additional predisposing sites telomeric to class I [abstract]. Hum Immunol. 2010;71(Suppl 1):S141.

Bowden DW, Cox AJ, Freedman BI, Hugenschimdt CE [sic] [Hugenschmidt CE], Wagenknecht LE, Herrington D, Agarwal S, Register TC, Maldjian JA, Ng MC-Y, Hsu F-C, Langefeld CD, Williamson JD, Carr JJ. Review of the Diabetes Heart Study (DHS) family of studies: a comprehensively examined sample for genetic and epidemiological studies of type 2 diabetes and its complications. Rev Diabet Stud. 2010;7(3):188-201.

Mcdonough CW, Allred ND, Hicks PJ, Bostrom MA, Lu L, Ng M, Divers J, Langefeld CD, Freedman BI, Bowden DW. A genome wide association study for diabetic nephropathy genes in African Americans [abstract]. J Am Soc Nephrol. 2010;21(Suppl):729A.

Freedman BI, Langefeld CD, Lu L, Divers J, Comeau ME, Allred ND, Hicks PJ, Bostrom MA, Cooke JN, Mcdonough CW, Bowden DW, et al. Accounting for risk variants in MYH9 reveals FRMD3 association with diabetic ESRD in African Americans [abstract]. J Am Soc Nephrol. 2010;21(Suppl):728A.

Bostrom MA, Lu L, Chou JW, Hicks PJ, Xu J, Langefeld CD, Bowden DW, Freedman BI. Non-diabetic end-stage renal disease (ESRD) in African Americans: candidate genes from analysis of a pooled DNA-based genome wide association study (GWAS) [abstract]. J Am Soc Nephrol. 2010;21(Suppl):89A.

Bostrom MA, Hicks PJ, Lu L, Ng M, Langefeld CD, Freedman BI, Bowden DW. Sequencing of alpha-actinin-4 to identify variants associated with non-diabetic end-stage renal disease (ESRD) in African Americans [abstract]. J Am Soc Nephrol. 2010;21(Suppl):729A.

Murea M, Lu L, Hicks PJ, Bowden DW, Divers J, Langefeld CD, Freedman BI. Genetic variants identified by GWAS suggest intracellular calcium, vascular remodeling, and cardiac repolarization pathways impact dialytic survival in African Americans with diabetes [abstract]. J Am Soc Nephrol. 2010;21(Suppl):730A.

Cooke JN, Bostrom MA, Hicks PJ, Ng M, Comeau ME, Divers J, Langefeld CD, Freedman BI, Bowden DW. Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans [abstract]. J Am Soc Nephrol. 2010;21(Suppl):731A.

Thompson SD, Sudman M, Ramos PS, Marion MC, Ryan M, Tsoras M, Weiler T, Wagner M, Keddache M, Langefeld CD, et al. The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1. Arthritis Rheum. 2010;62(11):3265-3276.

Lehtinen AB, Daniel KR, Shah SA, Nelson MR, Ziegler JT, Freedman BI, Carr JJ, Herrington DM, Langefeld CD, Bowden DW. Relationship between genetic variants in myocardial sodium and potassium channel genes and QT interval duration in diabetics: the Diabetes Heart Study. Ann Noninvasive Electrocardiol. 2009;14(1):72-79.

Freedman BI, Kopp JB, Winkler CA, Nelson GW, Rao DC, Eckfeldt JH, Leppert MF, Hicks PJ, Divers J, Langefeld CD, Hunt SC. Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with albuminuria in hypertensive African Americans: the HyperGEN study. Am J Nephrol. 2009;29(6):626-632.

Talbert ME, Langefeld CD, Ziegler J, Mychaleckyj JC, Haffner SM, Norris JM, Bowden DW. Polymorphisms near SOCS3 are associated with obesity and glucose homeostasis traits in Hispanic Americans from the Insulin Resistance Atherosclerosis Family Study. Hum Genet. 2009;125(2):153-162.

Freedman BI, Hicks PJ, Bostrom MA, Cunningham ME, Liu Y, Divers J, Kopp JB, Winkler CA, Langefeld CD, Bowden DW, et al. Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans. Kidney Int. 2009;75(7):736-745.

Hinks A, Ke X, Barton A, Eyre S, Bowes J, Worthington J, Thompson SD, Langefeld CD, Glass DN, Thomson W, et al. Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis. Arthritis Rheum. 2009;60(1):251-257.

Leak TS, Perlegas PS, Smith SG, Keene KL, Hicks PJ, Langefeld CD, Mychaleckyj JC, Kirk JK, Freedman BI, Bowden DW, Sale MM, et al. Variants in intron 13 of the ELMO1 gene are associated with diabetic nephropathy in African Americans. Ann Hum Genet. 2009;73(2):152-159.

Sale MM, Lu L, Spruill IJ, Fernandes JK, Lok KH, Divers J, Langefeld CD, Garvey WT. Genome-wide linkage scan in Gullah-speaking African American families with type 2 diabetes: the Sea Islands Genetic African American Registry (Project SuGAR). Diabetes. 2009;58(1):260-267.

Bostrom MA, Freedman BI, Langefeld CD, Liu L, Hicks PJ, Bowden DW. Association of adiponectin gene polymorphisms with type 2 diabetes in an African American population enriched for nephropathy. Diabetes. 2009;58(2):499-504.

Foroud T, Sauerbeck L, Brown R, Anderson C, Woo D, Kleindorfer D, Flaherty ML, Deka R, Hornung R, Langefeld C, et al. Genome screen in familial intracranial aneurysm. BMC Med Genet. 2009;10():article 3.

Rudock ME, Liu Y, Ziegler JT, Allen SG, Lehtinen AB, Freedman BI, Carr JJ, Langefeld CD, Bowden DW. Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study. Atherosclerosis. 2009;203(2):459-465.

Gu YY, Harley ITW, Henderson LB, Aronow BJ, Vietor I, Huber LA, Harley JB, Kilpatrick JR, Langefeld CD, Williams AH, et al. Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease [research letter]. Nature. 2009;458(7241):1039-1042.

Harley ITW, Kaufman KM, Langefeld CD, Harley JB, Kelly JA. Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies. Nat Rev Genet. 2009;10(5):285-290.

Jacob CO, Zhu J, Armstrong DL, Yan M, Han J, Zhou XJ, Thomas JA, Reiff A, Ziegler J, Langefeld CD, et al. Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc Natl Acad Sci U S A. 2009;106(15):6256-6261.

Namjou B, Sestak AL, Armstrong DL, Zidovetzki R, Kelly JA, Jacob N, Ciobanu V, Kaufman KM, Ziegler J, Langefeld CD, et al. High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups. Arthritis Rheum. 2009;60(4):1085-1095.

Ramos PS, Langefeld CD, Bera LA, Gaffney PM, Noble JA, Moser KL. Variation in the ATP-binding cassette transporter 2 gene is a separate risk factor for systemic lupus erythematosus within the MHC. Genes Immun. 2009;10(4):350-355.

Wing MR, Ziegler J, Langefeld CD, Ng MCY, Haffner SM, Norris JM, Goodarzi MO, Bowden DW. Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study. Hum Genet. 2009;125(5-6):615-626.

Sutton BS, Palmer ND, Langefeld CD, Xue B, Proctor A, Ziegler JT, Haffner SM, Norris JM, Bowden DW. Association of SSTR2 polymorphisms and glucose homeostasis phenotypes: the Insulin Resistance Atherosclerosis Family Study. Diabetes. 2009;58(6):1457-1462.

Hollenbach JA, Bugawan T, Sudman M, Thomson G, Thompson S, Ryan M, Langefeld C, Erlich H, Glass D. Association of HLA class II in juvenile idiopathic arthritis (JIA): interaction and age of onset effects [abstract]. Tissue Antigens. 2009;73(5):405-406.

Rich SS, Goddarzi MO, Palmer ND, Langefeld CD, Ziegler J, Haffner SM, Bryer-Ash M, Norris JM, Wagenknecht LE, Bowden DW, et al. A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS). Diabetologia. 2009;52(7):1326-1333.

McDonough CW, Hicks PJ, Lu L, Langefeld CD, Freedman BI, Bowden DW. The influence of carnosinase gene polymorphisms on diabetic nephropathy risk in African-Americans. Hum Genet. 2009;126(2):265-275.

Talbert ME, Langefeld CD, Ziegler JT, Haffner SM, Norris JM, Bowden DW. INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study. Obesity (Silver Spring). 2009;17(8):1554-1562.

Armstrong DL, Reiff A, Myones BL, Quismorio FP Jr, Klein-Gitelman M, McCurdy D, Wagner-Weiner L, Silverman E, Ojwang JO, Langefeld CD, et al. Identification of new SLE-associated genes with a two-step Bayesian study design. Genes Immun. 2009;10(5):446-456.

Douglas KB, Windels DC, Zhao J, Gadeliya AV, Wu H, Kaufman KM, Harley JB, Merrill J, Ziegler JT, Langefeld CD, et al. Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicing. Genes Immun. 2009;10(5):457-469.

Guo L, Deshmukh H, Lu R, Vidal GS, Kelly JA, Kaufman KM, Langefeld CD, Marion MC, Williams AH, Divers J, et al. Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived population. Genes Immun. 2009;10(5):531-538.

Lu R, Vidal GS, Kelly JA, Delgado-Vega AM, Howard XK, Macwana SR, Dominguez N, Langefeld CD, Marion MC, Divers J, et al. Genetic associations of LYN with systemic lupus erythematosus. Genes Immun. 2009;10(5):397-403.

Namjou B, Gray-McGuire C, Sestak AL, Gilkeson GS, Jacob CO, Merrill JT, James JA, Langefeld CD, Divers J, Ziegler J, et al. Evaluation of C1q genomic region in minority racial groups of lupus. Genes Immun. 2009;10(5):517-524.

Schmitz KJ, Skinner HG, Bautista LE, Fingelin TE, Langefeld CD, Hicks PJ, Haffner SM, Bryer-Ash M, Wagenknecht LE, Bowden DW, et al. Association of 25-hydroxyvitamin D with blood pressure in predominantly 25-hydroxyvitamin D deficient Hispanic and African Americans. Am J Hypertens. 2009;22(8):867-870.

Bowden DW, Allred NP, Ng MC, Langefeld CD, Freedman BI. Genome wide analysis of African American type 2 diabetes [abstract]. Diabetologia. 2009;52(Suppl 1):S37.

Chung SA, Tian C, Taylor KE, Lee AT, Ortmann WA, Hom G, Graham RR, Nititham J, Kelly JA, Langefeld CD, et al. European population substructure is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosus. Arthritis Rheum. 2009;60(8):2448-2456.

Webb R, Merrill JT, Kelly JA, Sestak A, Kaufman KM, Langefeld CD, Ziegler J, Kimberly RP, Edberg JC, Ramsey-Goldman R, et al. A polymorphism within IL21R confers risk for systemic lupus erythematosus. Arthritis Rheum. 2009;60(8):2402-2407.

Young KA, Engelman CD, Langefeld CD, Hairston KG, Haffner SM, Bryer-Ash M, Norris JM. Association of plasma vitamin D levels with adiposity in Hispanic and African Americans. J Clin Endocrinol Metab. 2009;94(9):3306-3313.

Freedman BI, Bowden DW, Ziegler JT, Langefeld CD, Lehtinen AB, Rudock ME, Lenchik L, Hruska KA, Register TC, Carr JJ. Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study. J Bone Miner Res. 2009;24(10):1719-1727.

Miller DJ, Zhang Y, Yu G, Liu Y, Chen L, Langefeld CD, Herrington D, Wang Y. An algorithm for learning maximum entropy probability models of disease risk that efficiently searches and sparingly encodes multilocus genomic interactions. Bioinformatics. 2009;25(19):2478-2485.

Norris JM, Langefeld CD, Talbert ME, Wing MR, Haritunians T, Fingerlin TE, Hanley AJG, Ziegler JT, Bowden DW, Wagenknecht LE, et al. Genome-wide association study and follow-up analysis of adiposity traits in Hispanic Americans: the IRAS Family Study. Obesity (Silver Spring). 2009;17(10):1932-1941.

Freedman BI, Hicks PJ, Bostrom MA, Comeau ME, Divers J, Bleyer AJ, Kopp JB, Winkler CA, Langefeld CD, Bowden DW, et al. Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD. Nephrol Dial Transplant. 2009;24(11):3366-3371.

McDonough CW, Bostrom MA, Lu L, Hicks PJ, Langefeld CD, Divers J, Mychaleckyj JC, Freedman BI, Bowden DW. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. Hum Genet. 2009;126(6):805-817.

Gray SB, Howard TD, Langefeld CD, Hawkins GA, Diallo AF, Wagner JD. Comparative analyses of single-nucleotide polymorphisms in the TNF promoter region provide further validation for the vervet monkey model of obesity. Comp Med. 2009;59(6):580-588.

Hollenbach J, Bugawan T, Sudman M, Thomson G, Thompson S, Ryan M, Langefeld C, Erlich H, Glass D. Examination of HLA class II amino acid variation in juvenile idiopathic arthritis (JIA) implicates P4 with position 86 [abstract]. Hum Immunol. 2009;70(Suppl 1):S123.

Engelman CD, Lo J, O'Brien M, Langefeld CD, Fingerlin TE, Norris JM. Comparison of three machine learning approaches to examine the genetic and environmental predictors of vitamin D levels [abstract]. Genet Epidemiol. 2009;33(8):774.

Bostrom MA, Lu L, Chou J, Hicks PJ, Xu J, Langefeld CD, Freedman BI, Bowden DW. Genome wide association study of non-diabetic end stage renal disease in African Americans using pooled DNA [abstract]. Presented at the 59th Annual Meeting of The American Society of Human Genetics, October 21, 2009, Honolulu, Hawaii. 2009;():A676.

Divers J, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Xu J, Langefeld CD, Freedman BI. Ethnic differences in the relationship between albuminuria and calcified atherosclerotic plaque: African American-Diabetes Heart Study [abstract]. J Am Soc Nephrol. 2009;20(Renal Week 2009 Abstract Issue):395A.

McDonough CW, Palmer ND, Bostrom MA, Hicks PJ, Lu L, Divers J, Langefeld CD, Freedman BI, Bowden DW. A genome-wide association study (GWAS) of diabetic nephropathy (DN) in African Americans (AA) [abstract]. J Am Soc Nephrol. 2009;20(Renal Week 2009 Abstract Issue):433A.

Freedman BI, Bostrom MA, Cooke JN, Divers J, Langefeld CD, Nelson RG, Kretzler M, Maeda S, Bowden DW. ACACB gene associations with type 2 diabetes-associated ESRD [abstract]. J Am Soc Nephrol. 2009;20(Renal Week 2009 Abstract Issue):55A.

Bostrom MA, Hicks PJ, Lu L, Langefeld CD, Bowden DW, Freedman BI. Association of polymorphisms in the Klotho gene with age at onset of non-diabetic ESRD in African Americans [abstract]. J Am Soc Nephrol. 2009;20(Renal Week 2009 Abstract Issue):431A.

Freedman BI, Hicks PJ, Bostrom MA, Comeau ME, Divers J, Bleyer AJ, Kopp JB, Winkler CA, Langefeld CD, Bowden DW, et al. Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans (AA) with type 2 diabetes (T2DM)-associated ESRD [abstract]. J Am Soc Nephrol. 2009;20(Renal Week 2009 Abstract Issue):431A.

Lipkowitz MS, Iyengar SK, Molineros J, Langefeld CD, Comeau ME, Klotman PE, Bowden DW, Freedman RG, Khitrov G, Freedman BI, et al. Association analysis of the non-muscle myosin heavy chain 9 gene (MYH9) in hypertensive nephropathy: results from the African American Study of Kidney Disease and Hypertension (AASK) [abstract]. J Am Soc Nephrol. 2009;20(Renal Week 2009 Abstract Issue):56A.

Bostrom MA, Lu L, Chou J, Hicks PJ, Xu J, Langefeld CD, Bowden DW, Freedman BI. Candidate genes for non-diabetic end stage renal disease in African Americans identified by genome-wide association [abstract]. J Am Soc Nephrol. 2009;20(Renal Week 2009 Abstract Issue):431A.

Winkler C, Nelson GW, Freedman BI, Bowden DW, Langefeld CD, Kopp JB. MYH9 fine mapping refines region of association with chronic and end stage kidney diseases to introns 12 and 13 [abstract]. J Am Soc Nephrol. 2009;20(Renal Week 2009 Abstract Issue):431A.

Carr JJ, Register TC, Hsu F-C, Lohman K, Lenchik L, Bowden DW, Langefeld CD, Xu J, Wagenknecht LE, Freedman BI, et al. Calcified atherosclerotic plaque and bone mineral density in type 2 diabetes: the Diabetes Heart Study. Bone. 2008;42(1):43-52.

Palmer ND, Lehtinen AB, Langefeld CD, Campbell JK, Haffner SM, Norris JM, Bergman RN, Goodarzi MO, Rotter JI, Bowden DW. Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans. J Clin Endocrinol Metab. 2008;93(1):304-309.

Freedman BI, Bowden DW, Rich SS, Xu J, Wagenknecht LE, Ziegler J, Hicks PJ, Langefeld CD. Genome-wide linkage scans for renal function and albuminuria in type 2 diabetes mellitus: the Diabetes Heart Study. Diabet Med. 2008;25(3):268-276.

Harley JB, Alarcon-Riquelme ME, Criswell LA, Jacob CO, Kimberly RP, Moser KL, Tsao BP, Vyse TJ, Langefeld CD. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet. 2008;40(2):204-210.

Keene KL, Mychaleckyj JC, Smith SG, Leak TS, Perlegas PS, Langefeld CD, Freedman BI, Rich SS, Bowden DW, Sale MM. Association of the distal region of the ectonucleotide pyrophosphatase/phosphodiesterase 1 gene with type 2 diabetes in an African-American population enriched for nephropathy. Diabetes. 2008;57(4):1057-1062.

Edberg JC, Wu J, Langefeld CD, Brown EE, Marion MC, McGwin G Jr, Petri M, Ramsey-Goldman R, Reveille JD, Frank SG, et al. Genetic variation in the CRP promoter: association with systemic lupus erythematosus. Hum Mol Genet. 2008;17(8):1147-1155.

Lehtinen AB, Newton-Cheh C, Ziegler JT, Langefeld CD, Freedman BI, Daniel KR, Herrington DM, Bowden DW. Association of NOS1AP genetic variants with QT interval duration in families from the Diabetes Heart Study. Diabetes. 2008;57(4):1108-1114.

Palmer ND, Goodarzi MO, Langefeld CD, Ziegler J, Norris JM, Haffner SM, Bryer-Ash M, Bergman RN, Wagenknecht LE, Bowden DW, et al. Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study. Diabetes. 2008;57(4):1093-1100.

Hinks A, Barton A, Ke X, Eyre S, Bowes J, Worthington J, Thompson SD, Langefeld CD, Glass DN, Thomson W. Association of juvenile idiopathic arthritis (JIA) with the IL2RA gene [abstract]. Rheumatology. 2008;47(Suppl 2):II3-II4.

Keene KL, Mychaleckyj JC, Smith SG, Leak TS, Perlegas PS, Langefeld CD, Herrington DM, Freedman BI, Bowden DW, Sale MM, et al. Comprehensive evaluation of the estrogen receptor alpha gene reveals further evidence for association with type 2 diabetes enriched for nephropathy in an African American population. Hum Genet. 2008;123(4):333-341.

Kelly JA, Kelley JM, Kaufman KM, Kilpatrick J, Bruner GR, Merrill JT, James JA, Frank SG, Marion MC, Langefeld CD, et al. Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans. Genes Immun. 2008;9(3):187-194.

Burdon KP, Lehtinen AB, Langefeld CD, Carr JJ, Rich SS, Freedman BI, Herrington D, Bowden DW. Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study. Diab Vasc Dis Res. 2008;5(2):128-134.

Hicks PJ, Staten JL, Palmer ND, Langefeld CD, Ziegler JT, Keene KL, Sale MM, Bowden DW, Freedman BI. Association analysis of the ephrin-B2 gene in African-Americans with end-stage renal disease. Am J Nephrol. 2008;28(6):914-920.

Harley J, Alarcon-Riquelme M, Criswell L, Jacob C, Kimberly R, Moser K, Tsao B, Vyse T, Langefeld C. A genome-wide association scan in women with systemic lupus erythematosus identifies risk variants in ITGAM, PXK, KIAA1542 and other loci and confirms multiple loci contributing to disease susceptibility [abstract]. Clin Immunol. 2008;127(Suppl):S90.

Divers J, Moossavi S, Langefeld CD, Freedman BI. Genetic admixture: a tool to identify diabetic nephropathy genes in African Americans. Ethn Dis. 2008;18(3):384-388.

Liu Y, Freedman BI, Burdon KP, Langefeld CD, Howard T, Herrington D, Goff DC Jr, Bowden DW, Wagenknecht LE, Rich SS, et al. Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes. Am J Kidney Dis. 2008;52(2):242-250.

Keene KL, Mychaleckyj JC, Leak TS, Smith SG, Perlegas PS, Divers J, Langefeld CD, Freedman BI, Bowden DW, Sale MM. Exploration of the utility of ancestry informative markers for genetic association studies of African Americans with type 2 diabetes and end stage renal disease. Hum Genet. 2008;124(2):147-154.

Lewis JP, Palmer ND, Hicks PJ, Sale MM, Langefeld CD, Freedman BI, Divers J, Bowden DW. Association analysis in African Americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies. Diabetes. 2008;57(8):2220-2225.

Bowden DW, Lewis JP, Allred ND, Langefeld CD, Divers J, Freedman BI. Genetic analysis of 'European' type 2 diabetes SNPs from whole genome association studies in African Americans [abstract]. Diabetologia. 2008;51(Suppl 1):S129.

Bowden DW, Lehtinen AB, Ziegler JT, Rudock ME, Xu J, Wagenknecht LE, Herrington DM, Rich SS, Freedman BI, Carr JJ, Langefeld CD. Genetic epidemiology of subclinical cardiovascular disease in the Diabetes Heart Study. Ann Hum Genet. 2008;72(Pt 5):598-610.

Engelman CD, Fingerlin TE, Langefeld CD, Hicks PJ, Rich SS, Wagenknecht LE, Bowden DW, Norris JM. Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans. J Clin Endocrinol Metab. 2008;93(9):3381-3388.

Harley JB, Alarcon-Riquelme ME, Criswell LA, Jacob CO, Kimberly RP, Moser KL, Tsao BP, Vyse TJ, Langefeld CD. A genome-wide association scan with systemic lupus erythematosus identifies risk variants contributing to disease risk [abstract]. Arthritis Rheum. 2008;58(9 Suppl):S340.

Hinks A, Barton A, Eyre S, Ke X, Worthington J, Thompson S, Langefeld C, Glass D, Thomson W. Rheumatoid arthritis susceptibility loci, STAT4, TRAF1/C5 and the 6q23 region, are also associated with juvenile idiopathic arthritis [abstract]. Arthritis Rheum. 2008;58(9 Suppl):S409.

Bento JL, Palmer ND, Zhong M, Roh B, Lewis JP, Wing MR, Pandya H, Freedman BI, Langefeld CD, Bowden DW, et al. Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1. Genomics. 2008;92(4):226-234.

Freedman BI, Hicks PJ, Bostrom MA, Divers J, Winkler CA, Kopp JB, Nelson GW, Cunningham ME, Langefeld CD, Bowden DW. Non-muscle myosin heavy chain 9 (MYH9) gene associations in African Americans (AA) with non-diabetic ESRD [abstract]. J Am Soc Nephrol. 2008;19():132A.

Freedman BI, Edberg C, Kopp JB, Winkler CA, Nelson GW, Alarcon GS, Brown EE, Divers J, Cunningham ME, Langefeld CD, et al. Association analysis of the non-muscle myosin heavy chain 9 (MYH9) gene in African Americans with lupus nephritis (LN) [abstract]. J Am Soc Nephrol. 2008;19():134A.

Duran S, Apte M, Alarcon GS, Marion MC, Edberg JC, Kimberly RP, Zhang J, Langefeld CD, Vila LM, Reveille JD. Features associated with, and the impact of, hemolytic anemia in patients with systemic lupus erythematosus: LX, results from a multiethnic cohort. Arthritis Rheum. 2008;59(9):1332-1340.

Palmer ND, Langefeld CD, Bryer-Ash M, Rotter JI, Taylor KD, Bowden DW. Association of the Kir6.2 E23K variant with reduced acute insulin response in African-Americans. J Clin Endocrinol Metab. 2008;93(12):4979-4983.

Hollenbach J, Bugawan T, Sudman M, Thomson G, Thompson S, Ryan M, Langefeld C, Erlich H, Glass D. Association of HLA-DR-DQ haplotypes with juvenile idiopathic arthritis (JIA) [abstract]. Hum Immunol. 2008;69(Suppl 1):S94.

Howard TD, Liu Y, Langefeld CD, Konvicka K, Beilharz E, Johnson C, Hixson JE, Rotter JI, Chen Y-DI, Herrington DM, et al. Association of 9p21 SNPs with premature atherosclerosis in the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study [abstract]. In: Abstracts of the 58th Annual Meeting of the American Society of Human Genetics; 2008 Nov 11-15; Philadelphia (PA). 2008;():379.

Lehtinen AB, Burdon KP, Lewis JP, Langefeld CD, Ziegler JT, Rich SS, Register TC, Carr JJ, Freedman BI, Bowden DW. Association of alpha2-Heremans-Schmid glycoprotein polymorphisms with subclinical atherosclerosis. J Clin Endocrinol Metab. 2007;92(1):345-352.

Gallagher CJ, Keene KL, Mychaleckyj JC, Langefeld CD, Hirschhorn JN, Gordon CJ, Freedman BI, Rich SS, Bowden DW, Sale MM, et al. Investigation of the estrogen receptor-alpha gene with type 2 diabetes and/or nephropathy in African-American and European-American populations. Diabetes. 2007;56(3):675-684.

Freedman BI, Hicks PJ, Sale MM, Pierson ED, Langefeld CD, Rich SS, Xu J, McDonough C, Janssen B, Bowden DW, et al. A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans. Nephrol Dial Transplant. 2007;22(4):1131-1135.

Lakoski SG, Li L, Langefeld CD, Liu Y, Howard TD, Brosnihan KB, Xu J, Bowden DW, Herrington DM. The association between innate immunity gene (IRAK1) and C-reactive protein in the Diabetes Heart Study. Exp Mol Pathol. 2007;82(3):280-283.

Wu J, JI C, Xie F, Langefeld CD, Qian K, Gibson AW, Edberg JC, Kimberly RP. Fc alpha RI (CD89) alleles determine the proinflammatory potential of serum IgA. J Immunol. 2007;178(6):3973-3982.

Adamo KB, Dent R, Langefeld CD, Cox M, Williams K, Carrick KM, Stuart JS, Sundseth SS, Harper M-E, McPherson R, et al. Peroxisome proliferator-activated receptor gamma 2 and acyl-CoA synthetase 5 polymorphisms influence diet response. Obesity. 2007;15(5):1068-1075.

Matarin M, Brown WM, Scholz S, Simon-Sanchez J, Fung H-C, Hernandez D, Gibbs JR, Langefeld CD, Case LD, Rich SS, et al. A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release. Lancet Neurol. 2007;6(5):414-420.

Gallagher CJ, Langefeld CD, Gordon CJ, Campbell JK, Mychalecky JC, Bryer-Ash M, Rich SS, Bowden DW, Sale MM. Association of the estrogen receptor-alpha gene with the metabolic syndrome and its component traits in African-American families: the Insulin Resistance Atherosclerosis Family Study. Diabetes. 2007;56(8):2135-2141.

Leak TS, Keene KL, Langefeld CD, Gallagher CJ, Mychaleckyj JC, Freedman BI, Bowden DW, Rich SS, Sale MM. Association of the proprotein convertase subtilisin/kexin-type 2 (PCSK2) gene with type 2 diabetes in an African American population. Mol Genet Metab. 2007;92(1-2):145-150.

Wagenknecht LE, Langefeld CD, Freedman BI, Carr JJ, Bowden DW. A comparison of risk factors for calcified atherosclerotic plaque in the coronary, carotid, and abdominal aortic arteries: the Diabetes Heart Study. Am J Epidemiol. 2007;166(3):340-347.

Hanley AJG, Bowden D, Wagenknecht LE, Balasubramanyam A, Langfeld C [sic] [Langefeld C], Saad MF, Rotter JI, Guo X, Chen Y-DI, Bryer-Ash M, et al. Associations of adiponectin with body fat distribution and insulin sensitivity in non-diabetic Hispanic and African Americans. J Clin Endocrinol Metab. 2007;92(7):2665-2671.

Langefeld CD, Fingerlin TE. Association methods in human genetics. Methods Mol Biol. 2007;404():431-460.

Gawrieh S, Marion M, Smith K, Komorowski R, Wallace J, Nuttleman P, Andris D, Kissebah A, Langefeld C, Olivier M. Genetic variation in the peroxisome proliferator activated receptor-gamma gene is associated with NAFLD and its histological phenotypes [abstract]. Am J Gastroenterol. 2007;102(Suppl 2):S246-S247.

Graham RR, Ortmann W, Rodine P, Espe K, Langefeld C, Lange E, Williams A, Beck S, Kyogoku C, Moser K, et al. Specific combinations of HLA-DR2 and DR3 class II haplotypes contribute graded risk for disease susceptibility and autoantibodies in human SLE. Eur J Hum Genet. 2007;15(8):823-830.

Kelly JA, Edberg JC, Kaufman KM, Merrill J, James JA, Marion MC, Langefeld CD, Petri MA, Reveille JD, Ramsey-Goldman R, et al. IRF5 and lupus risk in multiple races [abstract]. Genet Epidemiol. 2007;31(6):633-634.

Sale MM, Smith SG, Mychaleckyj JC, Keene KL, Langefeld CD, Leak TS, Hicks PJ, Bowden DW, Rich SS, Freedman BI. Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy. Diabetes. 2007;56(10):2638-2642.

Leak TS, Perlegas PS, Smith SG, Hicks PJ, Li L, Langefeld CD, Keene KL, Sale MM, Freedman BI, Bowden DW. Variants in the ELMO1 gene are associated with diabetes and nephropathy in African Americans [abstract]. J Am Soc Nephrol. 2007;18(Abstracts Issue):14A.

Lehtinen AB, Newton-Cheh C, Ziegler JT, Langefeld CD, Freedman BI, Daniel KR, Herrington DM, Bowden DW. Association of NOS1AP genetic variants with QT interval duration in families from the Diabetes Heart Study [abstract]. Circulation. 2007;116(16 Suppl):652-653.

Sutton BS, Langefeld CD, Campbell JK, Haffner SM, Norris JM, Scherzinger AL, Wagenknecht LE, Bowden DW. Genetic mapping of a 17q chromosomal region linked to obesity phenotypes in the IRAS family study. Int J Obes. 2006;30(9):1433-1441.

Freedman BI, Bowden DW, Sale MM, Langefeld CD, Rich SS. Genetic susceptibility contributes to renal and cardiovascular complications of type 2 diabetes mellitus. Hypertension. 2006;48(1):8-13.

Bowden DW, Rudock M, Ziegler J, Lehtinen AB, Xu J, Wagenknecht LE, Herrington D, Rich SS, Freedman BI, Carr JJ, Langefeld CD. Coincident linkage of type 2 diabetes, metabolic syndrome, and measures of cardiovascular disease in a genome scan of the Diabetes Heart Study. Diabetes. 2006;55(7):1985-1994.

Bowden DW, Lohman K, Hsu F-C, Langefeld CD, Carr JJ, Lenchik L, Wagenknecht LE, Freedman BI, Herrington DM. Hormone replacement therapy is associated with increased C-reactive protein in women with type 2 diabetes in the Diabetes Heart Study. Diabet Med. 2006;23(7):763-767.

Liu Y, Herrington D, Burdon KP, Langefeld CD, Rich SS, Bowden DW, Freedman BI, Wagenknecht LE. A functional polymorphism in the lymphotoxin-alpha gene is associated with carotid artery wall thickness: the Diabetes Heart Study. Eur J Cardiovasc Prev Rehabil. 2006;13(4):655-657.

Ramos PS, Kelly JA, Gray-McGuire C, Bruner GR, Leiran AN, Meyer CM, Namjou B, Espe KJ, Ortmann WA, Langefeld CD, et al. Familial aggregation and linkage analysis of autoantibody traits in pedigrees multiplex for systemic lupus erythematosus. Genes Immun. 2006;7(5):417-432.

Sale MM, Gallagher CJ, Langefeld CD, Gordon CJ, Campbell JK, Mychaleckyj JC, Bryer-Ash M, Rich SS, Bowden DW. Association of the estrogen receptor alpha gene with glucose homeostasis, lipid, and obesity traits in African American families: the IRAS Family Study [abstract]. Diabetes. 2006;55(Suppl 1):A264.

Keene KL, Gallagher CJ, Mychaleckyj JC, Langefeld CD, Hirschhorn JN, Henderson BE, Freedman BI, Rich SS, Bowden DW, Sale MM, et al. Association of the estrogen receptor alpha gene with type 2 diabetes in African American and European American populations [abstract]. Diabetes. 2006;55(Suppl 1):A260.

Bowden DW, Lehtinen AB, Ziegler JT, Herrington D, Wagenknecht LE, Rich SS, Freedman BI, Carr JJ, Langefeld CD. A genome scan for subclinical cardiovascular disease in the Diabetes Heart Study [abstract]. Atheroscler Suppl. 2006;7(3):89.

Rich SS, Burdon KP, Langefeld CD, Liu Y, Freedman BI, Carr JJ, Hedrick CC, Bowden DW. Human lipoxygenase gene variation in subclinical atherosclerosis: the Diabetes Heart Study [abstract]. Atheroscler Suppl. 2006;7(3):335.

Freedman BI, Hsu FC, Lohman K, Bowden DW, Leonchik L [sic] [Lenchik L], Langefeld CD, Xu J, Register Tc, Rich SS, Wagenknecht LE. The relationship between calcified atherosclerotic plaque and bone mineral density: the Diabetes Heart Study [abstract]. Atheroscler Suppl. 2006;7(3):14.

Lange LA, Burdon K, Langefeld CD, Liu Y, Beck SR, Rich SS, Freedman BI, Brosnihan KB, Herrington DM, Wagenknecht LE, Bowden DW. Heritability and expression of C-reactive protein in type 2 diabetes in the Diabetes Heart Study. Ann Hum Genet. 2006;70(Pt 6):717-725.

Freedman BI, Bowden DW, Rich SS, Wagenknecht LE, Ziegler J, Sale MM, Langefeld CD. Genome scans for glomerular filtration rate (GFR) and albuminuria: the Diabetes Heart Study (DHS) [abstract]. J Am Soc Nephrol. 2006;17(Abstr Issue):84A.

Freedman BI, Hicks PJ, Sale MM, Pierson ED, Langefeld CD, Rich SS, Janssen B, Yard BA, van der Woude FJ. A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic nephropathy (DN) in European Americans (EA) [abstract]. J Am Soc Nephrol. 2006;17(Abstr Issue):391A.

Fung H-C, Scholz S, Matarin M, Simon-Sanchez J, Hernandez D, Britton A, Gibbs JR, Langefeld C, Stiegert ML, Schymick J, et al. Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data. Lancet Neurol. 2006;5(11):911-916.

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