Profile

Lynne E. Wagenknecht, Dr.P.H.Wake Forest Baptist Health

Lynne E. Wagenknecht, Dr.P.H.

Associate Director,
Associate Dean, Dean's Office
Professor,



Clinical Specialties

Epidemiology

Contact Information

Academic: 336-716-7652 | Department: 336-716-7652

Email: lwgnkcht@wakehealth.edu

Education & Training

  • B.S., Lenoir Rhyne College , 1982
  • Dr.P.H., University of Alabama School of Public Health , 1989
  • M.P.H., University of Alabama School of Public Health , 1984

Memberships

  • Am Diabetes Assn
  • Am Heart Association
Lynne E. Wagenknecht, Dr.P.H.Wake Forest Baptist Health

Lynne E. Wagenknecht, Dr.P.H.

Associate Director, Public Health Sciences
Associate Dean, Dean's Office
Professor, Public Health Sciences
Center for Biomolecular Imaging
Sticht Center on Aging
Center for Diabetes Research

Research Interests

aging, atherosclerosis/thrombosis, cognition/learning, diabetes, epidemiology, health services, research/outc, metabolism, minority health issues, nutrition, obesity, radiology/imaging, vascular diseases

Contact Information

Academic: 336-716-7652 | Department: 336-716-7652

Email: lwgnkcht@wakehealth.edu

Recent Publications

Peter I, Papandonatos GD, Belalcazar LM, Yang Y, Erar B, Jakicic JM, Unick JL, Balasubramanyam A, Lipkin EW, Delahanty LM, Wagenknecht LE, Wing RR, McCaffery JM, Huggins GS, Espeland MA, Reboussin D, et al. Genetic modifiers of cardiorespiratory fitness response to lifestyle intervention. Med Sci Sports Exerc. 2014;46(2):302-311.

Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI. Sclerostin is positively associated with bone mineral density in men and women and negatively associated with carotid calcified atherosclerotic plaque in men from the African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2014;99(1):315-321.

Fitzpatrick SL, Jeffery R, Johnson KC, Roche CC, Van Dorsten B, Gee M, Dotson K, Walkup MP, Espeland MA, Bahnson JL, Wagenknecht LE, Reboussin D, Rejeski WJ, Bertoni AG, Lang W, Lawlor MS, Lefkowitz D, Miller GD, Reynolds PS, Ribisl PM,. Baseline predictors of missed visits in the Look AHEAD study. Obesity (Silver Spring). 2014;22(1):131-140.

Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI. Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetes. J Clin Endocrinol Metab. 2013;98(1):E60-E65.

An SS, Palmer ND, Hanley AJ, Ziegler JT, Brown WM, Haffner SM, Norris JM, Rotter JI, Guo X, Chen YD, Wagenknecht LE, Langefeld CD, Bowden DW. Estimating the contributions of rare and common genetic variations and clinical measures to a model trait: adiponectin. Genet Epidemiol. 2013;37(1):13-24.

Divers J, Palmer ND, Lu L, Register TC, Carr JJ, Hicks PJ, Hightower RC, Smith SC, Xu J, Cox AJ, Hruska KA, Bowden DW, Lewis CE, Heiss G, Province MA, Borecki IB, Kerr KF, Chen YD, Palmas W, Rotter JI, Wassel CL, Bertoni AG,. Admixture mapping of coronary artery calcified plaque in African Americans with type 2 diabetes mellitus. Circ Cardiovasc Genet. 2013;6(1):97-105.

Divers J, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Smith SC, Xu J, Langefeld CD, Freedman BI. Albuminuria associates with calcified atherosclerotic plaque in African Americans with diabetes [letter]. Diabetes Care. 2013;36(3):e34-e35.

Lee CC, Lorenzo C, Haffner SM, Wagenknecht LE, Festa A, Goodarzi MO, Stefanovski D, Olson NC, Norris JM, Rewers MJ, Hanley AJ. The association of inflammatory and fibrinolytic proteins with 5 year change in insulin clearance: the Insulin Resistance Atherosclerosis Study (IRAS). Diabetologia. 2013;56(1):112-120.

Lorenzo C, Hartnett S, Hanley AJ, Rewers MJ, Wagenknecht LE, Karter AJ, Haffner SM. Impaired fasting glucose and impaired glucose tolerance have distinct lipoprotein and apolipoprotein changes: the Insulin Resistance Atherosclerosis Study. J Clin Endocrinol Metab. 2013;98(4):1622-1630.

Lorenzo C, Hanley AJ, Wagenknecht LE, Rewers MJ, Stefanovski D, Goodarzi MO, Haffner SM. Relationship of insulin sensitivity, insulin secretion, and adiposity with insulin clearance in a multiethnic population: the Insulin Resistance Atherosclerosis Study. Diabetes Care. 2013;36(1):101-103.

Unick JL, Beavers D, Bond DS, Clark JM, Jakicic JM, Kitabchi AE, Knowler WC, Wadden TA, Wagenknecht LE, Wing RR. The long-term effectiveness of a lifestyle intervention in severely obese individuals. Am J Med. 2013;126(3):236-242.

Register TC, Divers J, Bowden DW, Carr JJ, Lenchik L, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Hruska KA, Langefeld CD, Freedman BI. Relationships between serum adiponectin and bone density, adiposity and calcified atherosclerotic plaque in the African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2013;98(5):1916-1922.

Lee CC, Haffner SM, Wagenknecht LE, Lorenzo C, Norris JM, Bergman RN, Stefanovski D, Anderson AM, Rotter JI, Goodarzi MO, Hanley AJ. Insulin clearance and the incidence of type 2 diabetes in Hispanics and African Americans: the IRAS Family Study. Diabetes Care. 2013;36(4):901-907.

Lee CC, Lorenzo C, Haffner SM, Wagenknecht LE, Goodarzi MO, Stefanovski D, Norris JM, Rewers MJ, Hanley AJ. Components of metabolic syndrome and 5-year change in insulin clearance--the Insulin Resistance Atherosclerosis Study. Diabetes Obes Metab. 2013;15(5):441-447.

Wing RR, Bolin P, Brancati FL, Bray GA, Clark JM, Coday M, Crow RS, Curtis JM, Egan CM, Espeland MA, Evans M, Foreyt JP, Ghazarian S, Gregg EW, Harrison B, Hazuda HP, Hill JO, Horton ES, Hubbard VS, Jakicic JM,. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med. 2013;369(2):145-154.

Huggins GS, Papandonatos GD, Erar B, Belalcazar LM, Brautbar A, Ballantyne C, Kitabchi AE, Wagenknecht LE, Knowler WC, Pownall HJ, Wing RR, Peter I, McCaffery JM. Do genetic modifiers of high-density lipoprotein cholesterol and triglyceride levels also modify their response to a lifestyle intervention in the setting of obesity and type-2 diabetes mellitus?: The Action for Health in Diabetes (Look AHEAD) study. Circ Cardiovasc Genet. 2013;6(4):391-399.

Festa A, Haffner SM, Wagenknecht LE, Lorenzo C, Hanley AJ. Longitudinal decline of beta-cell function: comparison of a direct method vs a fasting surrogate measure: the Insulin Resistance Atherosclerosis Study. J Clin Endocrinol Metab. 2013;98(10):4152-4159.

Lee C, Liese A, Wagenknecht L, Lorenzo C, Haffner S, Hanley A. Fish consumption, insulin sensitivity and beta-cell function in the Insulin Resistance Atherosclerosis Study (IRAS). Nutr Metab Cardiovasc Dis. 2013;23(9):829-835.

McCaffery JM, Papandonatos GD, Huggins GS, Peter I, Erar B, Kahn SE, Knowler WC, Lipkin EW, Kitabchi AE, Wagenknecht LE, Wing RR. Human cardiovascular disease IBC chip-wide association with weight loss and weight regain in the LOOK AHEAD trial. Hum Hered. 2013;75(2-4):160-174.

Samaropoulos XF, Hairston KG, Anderson A, Haffner SM, Lorenzo C, Montez M, Norris JM, Scherzinger AL, Chen YD, Wagenknecht LE. A metabolically healthy obese phenotype in Hispanic participants in the IRAS family study. Obesity (Silver Spring). 2013;21(11):2303-2309.

Sandy An S, Palmer ND, Hanley AJ, Ziegler JT, Mark Brown W, Freedman BI, Register TC, Rotter JI, Guo X, Ida Chen YD, Wagenknecht LE, Langefeld CD, Bowden DW. Genetic analysis of adiponectin variation and its association with type 2 diabetes in African Americans. Obesity (Silver Spring). 2013;21(12):E721-E729.

Johnson KC, Wagenknecht L, Bray GA, Walkup MP, Wing R. The effect of intentional weight loss on changes in body composition over eight years in the Look AHEAD clinical trial [abstract]. Gerontologist. 2013;53(Suppl 1):388-389.

Palmer ND, Musani SK, Yerges-Armstrong LM, Feitosa MF, Bielak LF, Hernaez R, Kahali B, Carr JJ, Harris TB, Jhun MA, Kardia SL, Langefeld CD, Mosley TH Jr, Norris JM, Smith AV, Taylor HA, Wagenknecht LE, Liu J, Borecki IB, Peyser PA, Speliotes EK. Characterization of European ancestry nonalcoholic fatty liver disease-associated variants in individuals of African and Hispanic descent. Hepatology. 2013;58(3):966-975.

McCaffery JM, Papandonatos GD, Huggins GS, Peter I, Kahn SE, Knowler WC, Hudnall GE, Lipkin EW, Kitabchi AE, Wagenknecht LE, Espeland MA, Bahnson JL, Reboussin D, Rejeski WJ, Bertoni A,. FTO predicts weight regain in the Look AHEAD clinical trial. Int J Obes (Lond). 2013;37(12):1545-1552.

Il'yasova D, Spasojevic I, Base K, Zhang H, Wang F, Young SP, Millington DS, D'Agostino RB Jr, Wagenknecht LE. Urinary F2-isoprostanes as a biomarker of reduced risk of type 2 diabetes. Diabetes Care. 2012;35(1):173-174.

Hairston KG, Vitolins MZ, Norris JM, Anderson AM, Hanley AJ, Wagenknecht LE. Lifestyle factors and 5-year abdominal fat accumulation in a minority dohort: the IRAS Family Study. Obesity (Silver Spring). 2012;20(2):421-427.

Mirabelli MC, London SJ, Charles LE, Pompeii LA, Wagenknecht LE. Occupation and the prevalence of respiratory health symptoms and conditions: the Atherosclerosis Risk in Communities Study. J Occup Environ Med. 2012;54(2):157-165.

Hester JM, Wing MR, Li J, Palmer ND, Xu J, Hicks PJ, Roh BH, Norris JM, Wagenknecht LE, Langefeld CD, Freedman BI, Bowden DW, Ng MCY. Implication of European-derived adiposity loci in African Americans. Int J Obes (Lond). 2012;36(3):465-473.

Mount DL, Davis C, Kennedy B, Raatz S, Dotson K, Gary-Webb TL, Thomas S, Johnson KC, Espeland MA, Bahnson J, Wagenknecht L, Reboussin D, Rejeski WJ, Lang W, Bertoni A, Vitolins M, Miller G, Ribisl P, Hodges A,. Factors influencing enrollment of African Americans in the Look AHEAD trial. Clin Trials. 2012;9(1):80-89.

Mirabelli MC, London SJ, Charles LE, Pompeii LA, Wagenknecht LE. Occupation and three-year incidence of respiratory symptoms and lung function decline: the ARIC Study. Respir Res. 2012;13(1):24.

Faulconbridge LF, Wadden TA, Rubin RR, Wing RR, Walkup MP, Fabricatore AN, Coday M, Van Dorsten B, Mount DL, Ewing LJ, Espeland MA, Bahnson JL, Wagenknecht L, Reboussin D, Rejeski WJ, Bertoni A, Lang W, Miller G, Lefkowitz D,. One-year changes in symptoms of depression and weight in overweight/obese individuals with type 2 diabetes in the Look AHEAD study. Obesity (Silver Spring). 2012;20(4):783-793.

Olson NC, Callas PW, Hanley AJG, Festa A, Haffner SM, Wagenknecht LE, Tracy RP. Circulating levels of TNF-alpha are associated with impaired glucose tolerance, increased insulin resistance, and ethnicity: the Insulin Resistance Atherosclerosis Study. J Clin Endocrinol Metab. 2012;97(3):1032-1040.

Schwartz AV, Johnson KC, Kahn SE, Shepherd JA, Nevitt MC, Peters AL, Walkup MP, Hodges A, Williams CC, Bray GA, Espeland MA, Bahnson JL, Wagenknecht L, Reboussin D, Rejeski WJ, Bertoni A, Lang W, Miller G, Lefkowitz D, Reynolds PS,. Effect of 1 year of an intentional weight loss intervention on bone mineral density in type 2 diabetes: results from the Look AHEAD randomized trial. J Bone Miner Res. 2012;27(3):619-627.

Rosamond WD, Chambless LE, Heiss G, Mosley TH, Coresh J, Whitsel E, Wagenknecht L, Ni H, Folsom AR. Twenty-two-year trends in incidence of myocardial infarction, coronary heart disease mortality, and case fatality in 4 US communities, 1987-2008. Circulation. 2012;125(15):1848-1857.

McCaffery JM, Papandonatos GD, Peter I, Huggins GS, Raynor HA, Delahanty LM, Cheskin LJ, Balasubramanyam A, Wagenknecht LE, Wing RR. Obesity susceptibility loci and dietary intake in the Look AHEAD Trial. Am J Clin Nutr. 2012;95(6):1477-1486.

Bertoni AG, Wagenknecht LE, Kitzman DW, Marcovina SM, Rushing JT, Espeland MA. Impact of the Look AHEAD intervention on NT-pro brain natriuretic peptide in overweight and obese adults with diabetes. Obesity (Silver Spring). 2012;20(7):1511-1518.

Peter I, McCaffery JM, Kelley-Hedgepeth A, Hakonarson H, Reis S, Wagenknecht LE, Kopin AS, Huggins GS. Association of type 2 diabetes susceptibility loci with one-year weight loss in the look AHEAD clinical trial. Obesity (Silver Spring). 2012;20(8):1675-1682.

Miller MR, Pereira RI, Langefeld CD, Lorenzo C, Rotter JI, Chen Y-DI, Bergman RN, Wagenknecht LE, Norris JM, Fingerlin TE. Levels of free fatty acids (FFA) are associated with insulin resistance but do not explain the relationship between adiposity and insulin resistance in Hispanic Americans: the IRAS Family Study. J Clin Endocrinol Metab. 2012;97(9):3285-3291.

Rowe MW, Bergman RN, Wagenknecht LE, Kolberg JA. Performance of a multi-marker diabetes risk score in the Insulin Resistance Atherosclerosis Study (IRAS), a multi-ethnic US cohort. Diabetes Metab Res Rev. 2012;28(6):519-526.

Il'yasova D, Wang F, Spasojevic I, Base K, D'Agostino RB Jr, Wagenknecht LE. Racial differences in urinary F2-isoprostane levels and the cross-sectional association with BMI. Obesity (Silver Spring). 2012;20(10):2147-2150.

Il'yasova D, Wang F, Spasojevic I, Base K, D'Agostino RB Jr, Wagenknecht LE. Urinary F2-isoprostanes, obesity, and weight gain in the IRAS cohort. Obesity (Silver Spring). 2012;20(9):1915-1921.

Watkins SM, Rowe MW, Kolberg JA, Wagenknecht LE, Bergman RN. Biomarker models as surrogates for the disposition index in the Insulin Resistance Atherosclerosis Study. Diabet Med. 2012;29(11):1399-1406.

Gregg EW, Chen H, Wagenknecht LE, Clark JM, Delahanty LM, Bantle J, Pownall HJ, Johnson KC, Safford MM, Kitabchi AE, Pi-Sunyer FX, Wing RR, Bertoni AG. Association of an intensive lifestyle intervention with remission of type 2 diabetes. JAMA. 2012;308(23):2489-2496.

An SS, Hanley AJ, Ziegler JT, Brown WM, Haffner SM, Norris JM, Rotter JI, Guo X, Chen Y-DI, Wagenknecht LE, Langefeld CD, Bowden DW, Palmer ND. Association between ADIPOQ SNPs with plasma adiponectin and glucose homeostasis and adiposity phenotypes in the IRAS Family Study. Mol Genet Metab. 2012;107(4):721-728.

Speliotes EK, Harnaez R, Feitosa MF, Palmer ND, Peyser PA, Harris TB, Wagenknecht LE, Liu J, Kahali B, Carr JJ, Smith AV, Musani SK, Borecki IB, Bielak LF, Yerges-Armstrong LM. Genetic variants predispose to nonalcoholic fatty live disease across ancestries [abstract]. Hepatology. 2012;56(Suppl 1):242A.

Young KA, Fingerlin TE, Langefeld CD, Lorenzo C, Haffner SM, Wagenknecht LE, Norris JM. Exploring differences in adiposity in two U.S. Hispanic populations of Mexican origin using social, behavioral, physiologic and genetic markers: the IRAS Family Study. Ethn Dis. 2012;22(1):65-71.

Wagenknecht LE, Divers J, Bertoni AG, Langefeld CD, Carr JJ, Bowden DW, Elbein SC [deceased], Shea S, Lewis CE, Freedman BI. Correlates of coronary artery calcified plaque in blacks and whites with type 2 diabetes. Ann Epidemiol. 2011;21(1):34-41.

Foy CG, Lewis CE, Hairston KG, Miller GD, Lang W, Jakicic JM, Rejeski WJ, Ribisl PM, Walkup MP, Wagenknecht LE. Intensive lifestyle intervention improves physical function among obese adults with knee pain: findings from the Look AHEAD trial. Obesity (Silver Spring). 2011;19(1):83-93.

Wagenknecht LE, Palmer ND, Bowden DW, Rotter JI, Norris JM, Ziegler J, Chen YI, Haffner S, Scherzinger A, Langefeld CD. Association of PNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study. Liver Int. 2011;31(3):412-416.

Loopstra-Masters RC, Liese AD, Haffner SM, Wagenknecht LE, Hanley AJ. Associations between the intake of caffeinated and decaffeinated coffee and measures of insulin sensitivity and beta cell function. Diabetologia. 2011;54(2):320-328.

Kucharska-Newton AM, Monda KL, Campbell S, Bradshaw PT, Wagenknecht LE, Boerwinkle E, Wasserman BA, Heiss G. Association of the platelet GPIIb/IIIa polymorphism with atherosclerotic plaque morphology: the Atherosclerosis Risk in Communities (ARIC) study. Atherosclerosis. 2011;216(1):151-156.

Fox ER, Young JH, Li Y, Dreisbach AW, Keating BJ, Musani SK, Liu K, Morrison AC, Ganesh S, Wagenknecht LE, et al. Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Hum Mol Genet. 2011;20(11):2273-2284.

Divers J, Register TC, Langefeld CD, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Xu J, Hruska KA, Freedman BI. Relationships between calcified atherosclerotic plaque and bone mineral density in African Americans with type 2 diabetes. J Bone Miner Res. 2011;26(7):1554-1560.

Wing RR, Lang W, Wadden TA, Safford M, Knowler WC, Bertoni AG, Hill JO, Brancati FL, Peters A, Wagenknecht L. Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes. Diabetes Care. 2011;34(7):1481-1486.

Belalcazar LM, Ballantyne CM, Lang W, Rushing J, Espeland MA, Bahnson JL, Wagenknecht L, Reboussin D, Rejeski WJ, Bertoni A, Miller G, Lefkowitz D, Reynolds PS, Ribisl P, Vitolins M, Booth M, Dotson KM, Hodges A, Williams CC,. Metabolic factors, adipose tissue, and plasminogen activator inhibitor-1 levels in type 2 diabetes: findings from the Look AHEAD study. Arterioscler Thromb Vasc Biol. 2011;31(7):1689-1695.

Sibble SP, Talbert ME, Bowden DW, Haffner SM, Taylor KD, Chen Y-DI, Wagenknecht LE, Langefeld CD, Norris JM. RGS6 variants are associated with dietary fat intake in Hispanics: the IRAS Family Study. Obesity (Silver Spring). 2011;19(7):1433-1438.

Wing MR, Ziegler JM, Langefeld CD, Roh BH, Palmer ND, Mayer-Davis EJ, Rewers MJ, Haffner SM, Wagenknecht LE, Bowden DW. Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort. Int J Obes (Lond). 2011;35(9):1173-1182.

Lorenzo C, Wagenknecht LE, Karter AJ, Hanley AJG, Rewers MJ, Haffner SM. Cross-sectional and longitudinal changes of glucose effectiveness in relation to glucose tolerance: the Insulin Resistance Atherosclerosis Study. Diabetes Care. 2011;34(9):1959-1964.

Cox AJ, Wing MR, Carr JJ, Hightower RC, Smith SC, Xu J, Wagenknecht LE, Bowden DW, Freedman BI. Association of PNPLA3 SNP rs738409 with liver density in African Americans with type 2 diabetes mellitus. Diabetes Metab. 2011;37(5):452-455.

Coker LH, Wagenknecht LE. Advanced glycation end products, diabetes, and the brain [editorial]. Neurology. 2011;77(14):1326-1327.

Ehret GB, Munroe PB, Rice KM, Liu Y, Palmer ND, Lohman KK, Rudock ME, Langefeld CD, Prokopenko I, Wagenknecht LE, et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011;478(7367):103-109.

Il'yasova D, Lin P-H, Svetkey L, Kraus W, Spasojevic I, Base K, Wang F, D'Agostino RB, Wagenknecht LE. Cross-sectional and prospective associations between urinary F2-isoprostanes and blood pressure in the IRAS cohort [abstract]. Free Radic Biol Med. 2011;51(Suppl 1):S44.

Il'yasova D, Spasojevic I, Base K, Wang F, D'Agostino RB Jr, Wagenknecht LE. Racial differences in urinary F2-isoprostanes may reflect weak metabolic adaptation in African Americans [abstract]. Free Radic Biol Med. 2011;51(Suppl 1):S62.

Loopstra-Masters RC, Haffner SM, Lorenzo C, Wagenknecht LE, Hanley AJ. Proinsulin-to-C-peptide ratio versus proinsulin-to-insulin ratio in the prediction of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS). Diabetologia. 2011;54(12):3047-3054.

Hanley AJG, Wagenknecht LE, Norris JM, Bergman R, Anderson A, Chen YI, Lorenzo C, Haffner SM. Adiponectin and the incidence of type 2 diabetes in Hispanics and African Americans: the IRAS Family Study. Diabetes Care. 2011;34(10):2231-2236.

Divers J, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Xu J, Langefeld CD, Freedman BI. Ethnic differences in the relationship between albuminuria and calcified atherosclerotic plaque: the African American-Diabetes Heart Study. Diabetes Care. 2010;33(1):131-138.

Lorenzo C, Wagenknecht LE, D'Agostino RB Jr, Rewers MJ, Karter AJ, Haffner SM. Insulin resistance, beta-cell dysfunction, and conversion to type 2 diabetes in a multiethnic population: the Insulin Resistance Atherosclerosis Study. Diabetes Care. 2010;33(1):67-72.

Freedman BI, Wagenknecht LE, Hairston KG, Bowden DW, Carr JJ, Hightower RC, Gordon EJ, Xu J, Langefeld CD, Divers J. Vitamin D, adiposity, and calcified atherosclerotic plaque in African-Americans. J Clin Endocrinol Metab. 2010;95(3):1076-1083.

Selvin E, Steffes MW, Zhu H, Matsushita K, Wagenknecht L, Pankow J, Coresh J, Brancati FL. Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults. N Engl J Med. 2010;362(9):800-811.

Il'yasova D, Wang F, D'Agostino RB Jr, Hanley A, Wagenknecht LE. Prospective association between fasting NEFA and type 2 diabetes: impact of post-load glucose. Diabetologia. 2010;53(5):866-874.

Avery CL, Mills KT, Chambless LE, Chang PP, Folsom AR, Mosley TH, Ni H, Rosamond WD, Wagenknecht L, Wood J, et al. Long-term association between self-reported signs and symptoms and heart failure hospitalizations: the Atherosclerosis Risk In Communities (ARIC) Study. Eur J Heart Fail. 2010;12(3):232-238.

Masters RC, Liese AD, Haffner SM, Wagenknecht LE, Hanley AJ. Whole and refined grain intakes are related to inflammatory protein concentrations in human plasma. J Nutr. 2010;140(3):587-594.

Volcik KA, Campbell S, Chambless LE, Coresh J, Folsom AR, Mosley TH, Ni H, Wagenknecht LE, Wasserman BA, Boerwinkle E. MMP2 genetic variation is associated with measures of fibrous cap thickness: the Atherosclerosis Risk in Communities Carotid MRI Study. Atherosclerosis. 2010;210(1):188-193.

Lorenzo C, Wagenknecht LE, Rewers MJ, Karter AJ, Bergman RN, Hanley AJG, Haffner SM. Disposition index, glucose effectiveness, and conversion to type 2 diabetes: the Insulin Resistance Atherosclerosis Study (IRAS). Diabetes Care. 2010;33(9):2098-2103.


Divers J, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Ding J, Xu J, Langefeld CD, Freedman BI. Regional adipose tissue associations with calcified atherosclerotic plaque: African American-Diabetes Heart Study. Obesity (Silver Spring). 2010;18(10):2004-2009.

Divers J, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Register TC, Xu J, Langefeld CD, Freedman BI. Ethnic differences in the relationship between pericardial adipose tissue and coronary artery calcified plaque: African-American-diabetes heart study. J Clin Endocrinol Metab. 2010;95(12):5382-5389.

Bowden DW, An SS, Palmer ND, Brown WM, Norris JM, Haffner SM, Hawkins GA, Guo X, Wagenknecth LE, Langefeld CD, et al. Molecular basis of a linkage peak: exome sequencing and family-based analysis identify a rare genetic variant in the ADIPOQ gene in the IRAS Family Study. Hum Mol Genet. 2010;19(20):4112-4120.

Lazo M, Solga SF, Horska A, Bonekamp S, Diehl A M, Brancati FL, Wagenknecht LE, Pi-Sunyer FX, Kahn SE, Clark JM. Effect of a 12-month intensive lifestyle intervention on hepatic steatosis in adults with type 2 diabetes. Diabetes Care. 2010;33(10):2156-2163.

Lorenzo C, Wagenknecht LE, Karter AJ, Hanley AJG, Norris JM, Haffner SM. Natural course of glucose effectiveness in nondiabetic and diabetic individuals: the Insulin Resistance Atherosclerosis Study [abstract]. Diabetologia. 2010;53(Suppl 1):S54-S55.

Watkins SM, Rowe MW, Kolberg JA, Bergman RN, Wagenknecht LE. A multi-marker risk score predicts insulin sensitivity and beta cell function-driven type 2 diabetes from a fasted sample [abstract]. Diabetologia. 2010;53(Suppl 1):A609.

Young KA, Fingerlin TE, Wagenknecht LE, Engelman CD, Haffner SM, Lorenzo C, Chen YD, Sibbel SP, Norris JM. Variants in vitamin D genes are associated with liver density and non-alcoholic fatty liver disease (NAFLD) in Hispanics and African Americans: the IRAS Family Study [abstract]. Diabetologia. 2010;53(Suppl 1):S139-S140.

Engelman CD, Meyers KJ, Ziegler JT, Taylor KD, Palmer ND, Haffner SM, Fingerlin TE, Wagenknecht LE, Bowden DW, Langefeld CD, et al. Genome-wide association study of vitamin D concentrations in Hispanic Americans: the IRAS Family Study. J Steroid Biochem Mol Biol. 2010;122(4):186-192.

Il'yasova D, Spasojevic I, Base K, Tolun A, Zhang HY, Wang F, Young S, Millington D, D'Agostino RB Jr, Wagenknecht LE. Systemic markers of oxidative status and the risk of type 2 diabetes [abstract]. Free Radic Biol Med. 2010;49(Suppl 1):S38.

Bowden DW, Cox AJ, Freedman BI, Hugenschimdt CE [sic] [Hugenschmidt CE], Wagenknecht LE, Herrington D, Agarwal S, Register TC, Maldjian JA, Ng MC-Y, Hsu F-C, Langefeld CD, Williamson JD, Carr JJ. Review of the Diabetes Heart Study (DHS) family of studies: a comprehensively examined sample for genetic and epidemiological studies of type 2 diabetes and its complications. Rev Diabet Stud. 2010;7(3):188-201.

Goodarzi MO, Palmer ND, Stefanovski D, Taylor KD, Jones MR, Cui J, Guo X, Chen YDI, Wagenknecht LE, Bowden DW, et al. Exostosin 2: a replicated quantitative trait locus for insulin clearance [abstract]. Endocr Rev. 2010;31(3 Suppl 1):S549.

Wing RR, Bahnson JL, Bray GA, Clark JM, Coday M, Egan C, Espeland MA, Reboussin D, Rejeski WJ, Wagenknecht L, et al. Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial. Arch Intern Med. 2010;170(17):1566-1575.

Masters RC, Liese AD, Haffner SM, Mayer-Davis EJ, Wagenknecht LE, Hanley AJ. Dietary intakes of whole and refined grains are independently associated with plasminogen activator inhibitor type 1: the Insulin Resistance Atherosclerosis Study (IRAS) [abstract]. Circulation. 2009;119(10):e306.

Mills KT, Anthony JA, Chambless LE, Coresh J, Folsom AR, Heiss G, Mosley TH Jr, Hanyu N, Rosamond WD, Wagenknecht L, et al. Prediction of heart failure hospitalization from self-reported signs and symptoms: the Atherosclerosis Risk in Communities (ARIC) Study [abstract]. Circulation. 2009;119(10):e359-e360.

MacKay MF, Haffner SM, Wagenknecht LE, D'Agostino RB Jr, Hanley AJG. Prediction of type 2 diabetes using alternate anthropometric measures in a multi-ethnic cohort: the Insulin Resistance Atherosclerosis Study. Diabetes Care. 2009;32(5):956-958.

Wagenknecht LE, Scherzinger AL, Stamm ER, Hanley AJG, Norris JM, Chen Y-DI, Bryer-Ash M, Haffner SM, Rotter JI. Correlates and heritability of nonalcoholic fatty liver disease in a minority cohort. Obesity (Silver Spring). 2009;17(6):1240-1246.

Hairston KG, Scherzinger A, Foy C, Hanley AJ, McCorkle O, Haffner S, Norris JM, Bryer-Ash M, Wagenknecht LE. Five-year change in visceral adipose tissue quantity in a minority cohort: the Insulin Resistance Atherosclerosis Study (IRAS) family study. Diabetes Care. 2009;32(8):1553-1555.

Rich SS, Goddarzi MO, Palmer ND, Langefeld CD, Ziegler J, Haffner SM, Bryer-Ash M, Norris JM, Wagenknecht LE, Bowden DW, et al. A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS). Diabetologia. 2009;52(7):1326-1333.

Schmitz KJ, Skinner HG, Bautista LE, Fingelin TE, Langefeld CD, Hicks PJ, Haffner SM, Bryer-Ash M, Wagenknecht LE, Bowden DW, et al. Association of 25-hydroxyvitamin D with blood pressure in predominantly 25-hydroxyvitamin D deficient Hispanic and African Americans. Am J Hypertens. 2009;22(8):867-870.

Wagenknecht L, Wasserman B, Chambless L, Coresh J, Folsom A, Mosley T, Ballantyne C, Sharrett R, Boerwinkle E. Correlates of carotid plaque presence and composition as measured by MRI: the Atherosclerosis Risk in Communities Study. Circ Cardiovasc Imaging. 2009;2(4):314-322.

Chang PP, Rosamond WD, Shahar E, Bertoni AG, Russell SD, Samdarshi T, Mosley TH, Ni HY, Wagenknecht LF, Chambless LE. Incidence of hospitalized acute decompensated heart failure in four US communities: the Atherosclerosis Risk in Communities (ARIC) Study [abstract]. J Card Fail. 2009;15(6 Suppl 1):S81.

Hanley AJG, Wagenknecht LE, Norris JM, Bryer-Ash M, Chen YI, Anderson AM, Bergman R, Haffner SM. Insulin resistance, beta cell dysfunction and visceral adiposity as predictors of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study. Diabetologia. 2009;52(10):2079-2086.

Norris JM, Langefeld CD, Talbert ME, Wing MR, Haritunians T, Fingerlin TE, Hanley AJG, Ziegler JT, Bowden DW, Wagenknecht LE, et al. Genome-wide association study and follow-up analysis of adiposity traits in Hispanic Americans: the IRAS Family Study. Obesity (Silver Spring). 2009;17(10):1932-1941.

Divers J, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Xu J, Langefeld CD, Freedman BI. Ethnic differences in the relationship between albuminuria and calcified atherosclerotic plaque: African American-Diabetes Heart Study [abstract]. J Am Soc Nephrol. 2009;20(Renal Week 2009 Abstract Issue):395A.

Carr JJ, Register TC, Hsu F-C, Lohman K, Lenchik L, Bowden DW, Langefeld CD, Xu J, Wagenknecht LE, Freedman BI, et al. Calcified atherosclerotic plaque and bone mineral density in type 2 diabetes: the Diabetes Heart Study. Bone. 2008;42(1):43-52.

Saran AM, Hsu F-C, Lohman KK, Carr JJ, Bowden DW, Wagenknecht LE, Freedman BI. Kidney volume associations with subclinical renal and cardiovascular disease: the Diabetes Heart Study. Am J Nephrol. 2008;28(3):366-371.

Freedman BI, Bowden DW, Rich SS, Xu J, Wagenknecht LE, Ziegler J, Hicks PJ, Langefeld CD. Genome-wide linkage scans for renal function and albuminuria in type 2 diabetes mellitus: the Diabetes Heart Study. Diabet Med. 2008;25(3):268-276.

Palmer ND, Goodarzi MO, Langefeld CD, Ziegler J, Norris JM, Haffner SM, Bryer-Ash M, Bergman RN, Wagenknecht LE, Bowden DW, et al. Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study. Diabetes. 2008;57(4):1093-1100.

Zhang Q, Lewis CE, Wagenknecht LE, Myers RH, Pankow JS, Hunt SC, North KE, Hixson JE, Carr JJ, Shimmin LC, et al. Genome-wide admixture mapping for coronary artery calcification in African Americans: the NHLBI Family Heart Study. Genet Epidemiol. 2008;32(3):264-272.


Liu Y, Freedman BI, Burdon KP, Langefeld CD, Howard T, Herrington D, Goff DC Jr, Bowden DW, Wagenknecht LE, Rich SS, et al. Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes. Am J Kidney Dis. 2008;52(2):242-250.

Espeland MA, Regensteiner JG, Jaramillo SA, Gregg E, Knowler WC, Wagenknecht LE, Bahnson J, Haffner S, Hill J, Hiatt WR. Measurement characteristics of the ankle-brachial index: results from the Action for Health in Diabetes study. Vasc Med. 2008;13(3):225-233.

Foy CG, Hsu F-C, Haffner SM, Norris JM, Rotter JI, Henkin LF, Bryer-Ash M, Chen Y-DI, Wagenknecht LE. Visceral fat and prevalence of hypertension among African Americans and Hispanic Americans: findings from the IRAS family study. Am J Hypertens. 2008;21(8):910-916.

Bowden DW, Lehtinen AB, Ziegler JT, Rudock ME, Xu J, Wagenknecht LE, Herrington DM, Rich SS, Freedman BI, Carr JJ, Langefeld CD. Genetic epidemiology of subclinical cardiovascular disease in the Diabetes Heart Study. Ann Hum Genet. 2008;72(Pt 5):598-610.

Engelman CD, Fingerlin TE, Langefeld CD, Hicks PJ, Rich SS, Wagenknecht LE, Bowden DW, Norris JM. Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans. J Clin Endocrinol Metab. 2008;93(9):3381-3388.

McKimmie RL, Daniel KR, Carr JJ, Bowden DW, Freedman BI, Register TC, Hsu F-C, Lohman KK, Weinberg RB, Wagenknecht LE. Hepatic steatosis and subclinical cardiovascular disease in a cohort enriched for type 2 diabetes: the Diabetes Heart Study. Am J Gastroenterol. 2008;103(12):3029-3035.

Williams K, Tchernof A, Hunt KJ, Wagenknecht LE, Haffner SM, Sniderman AD. Diabetes, abdominal adiposity, and atherogenic dyslipoproteinemia in women compared with men. Diabetes. 2008;57(12):3289-3296.

Goodarzi MO, Taylor KD, Guo X, Hokanson JE, Haffner SM, Cui J, Chen Y-DI, Wagenknecht LE, Bergman RN, Rotter JI. Haplotypes in the lipoprotein lipase gene influence fasting insulin and discovery of a new risk haplotype. J Clin Endocrinol Metab. 2007;92(1):293-296.

Pi-Sunyer X, Blackburn G, Brancati FL, Bray GA, Bright R, Clark JM, Curtis JM, Espeland MA, Foreyt JP, Wagenknecht L, et al. Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the Look AHEAD Trial. Diabetes Care. 2007;30(6):1374-1383.

Mellen PB, Liese AD, Tooze JA, Vitolins MZ, Wagenknecht LE, Herrington DM. Whole-grain intake and carotid artery atherosclerosis in a multiethnic cohort: the Insulin Resistance Atherosclerosis Study. Am J Clin Nutr. 2007;85(6):1495-1502.

Wagenknecht LE, Langefeld CD, Freedman BI, Carr JJ, Bowden DW. A comparison of risk factors for calcified atherosclerotic plaque in the coronary, carotid, and abdominal aortic arteries: the Diabetes Heart Study. Am J Epidemiol. 2007;166(3):340-347.

Hanley AJG, Bowden D, Wagenknecht LE, Balasubramanyam A, Langfeld C [sic] [Langefeld C], Saad MF, Rotter JI, Guo X, Chen Y-DI, Bryer-Ash M, et al. Associations of adiponectin with body fat distribution and insulin sensitivity in non-diabetic Hispanic and African Americans. J Clin Endocrinol Metab. 2007;92(7):2665-2671.

Hanley AJG, Wagenknecht LE, Festa A, D'Agostino RB Jr, Haffner SM. Alanine aminotransferase and directly measured insulin sensitivity in a multiethnic cohort: the Insulin Resistance Atherosclerosis Study. Diabetes Care. 2007;30(7):1819-1827.

Kraja AT, Province MA, Arnett D, Wagenknecht L, Tang W, Hopkins PN, Djousse L, Borecki IB. Do inflammation and procoagulation biomarkers contribute to the metabolic syndrome cluster?. Nutr Metab. 2007;4():article 28.

Sutton BS, Langefeld CD, Campbell JK, Haffner SM, Norris JM, Scherzinger AL, Wagenknecht LE, Bowden DW. Genetic mapping of a 17q chromosomal region linked to obesity phenotypes in the IRAS family study. Int J Obes. 2006;30(9):1433-1441.

Bowden DW, Rudock M, Ziegler J, Lehtinen AB, Xu J, Wagenknecht LE, Herrington D, Rich SS, Freedman BI, Carr JJ, Langefeld CD. Coincident linkage of type 2 diabetes, metabolic syndrome, and measures of cardiovascular disease in a genome scan of the Diabetes Heart Study. Diabetes. 2006;55(7):1985-1994.

Bowden DW, Lohman K, Hsu F-C, Langefeld CD, Carr JJ, Lenchik L, Wagenknecht LE, Freedman BI, Herrington DM. Hormone replacement therapy is associated with increased C-reactive protein in women with type 2 diabetes in the Diabetes Heart Study. Diabet Med. 2006;23(7):763-767.

Liu Y, Herrington D, Burdon KP, Langefeld CD, Rich SS, Bowden DW, Freedman BI, Wagenknecht LE. A functional polymorphism in the lymphotoxin-alpha gene is associated with carotid artery wall thickness: the Diabetes Heart Study. Eur J Cardiovasc Prev Rehabil. 2006;13(4):655-657.

Bowden DW, Lehtinen AB, Ziegler JT, Herrington D, Wagenknecht LE, Rich SS, Freedman BI, Carr JJ, Langefeld CD. A genome scan for subclinical cardiovascular disease in the Diabetes Heart Study [abstract]. Atheroscler Suppl. 2006;7(3):89.

Freedman BI, Hsu FC, Lohman K, Bowden DW, Leonchik L [sic] [Lenchik L], Langefeld CD, Xu J, Register Tc, Rich SS, Wagenknecht LE. The relationship between calcified atherosclerotic plaque and bone mineral density: the Diabetes Heart Study [abstract]. Atheroscler Suppl. 2006;7(3):14.

Espeland MA, Bahnson J, Wagenknecht, Reboussin D, Rejeski WJ, Lang W, Bertoni A, Vitolins M, Miller G, Ribisl P, Dotson K, Hodges A, Hogan P, et al. The Look AHEAD Study: a description of the lifestyle intervention and the evidence supporting it. Obesity. 2006;14(5):737-752.

Lange LA, Burdon K, Langefeld CD, Liu Y, Beck SR, Rich SS, Freedman BI, Brosnihan KB, Herrington DM, Wagenknecht LE, Bowden DW. Heritability and expression of C-reactive protein in type 2 diabetes in the Diabetes Heart Study. Ann Hum Genet. 2006;70(Pt 6):717-725.

McNeill AM, Katz R, Girman CJ, Rosamond WD, Wagenknecht LE, Barzilay JI, Tracy RP, Savage PJ, Jackson SA. Metabolic syndrome and cardiovascular disease in older people: the Cardiovascular Health Study. J Am Geriatr Soc. 2006;54(9):1317-1324.

Mellen PB, Bleyer AJ, Erlinger TP, Evans GW, Nieto FJ, Wagenknecht LE, Wofford MR, Herrington DM. Serum uric acid predicts incident hypertension in a biethnic cohort: the Atherosclerosis Risk in Communities Study. Hypertension. 2006;48(6):1037-1042.

Freedman BI, Bowden DW, Rich SS, Wagenknecht LE, Ziegler J, Sale MM, Langefeld CD. Genome scans for glomerular filtration rate (GFR) and albuminuria: the Diabetes Heart Study (DHS) [abstract]. J Am Soc Nephrol. 2006;17(Abstr Issue):84A.

Mellen PB, Liese AD, Tooze JA, Vitolins MZ, Wagenknecht LE, Herrington DM. Whole grain intake and carotid artery atherosclerosis in a multi-ethnic cohort: the Insulin Resistance Atherosclerosis Study [abstract]. Circulation. 2006;114(18 Suppl):889.

Foy CG, Hsu F-C, Haffner S, Norris JM, Rotter JI, Chen YI, Wagenknecht LE. Visceral fat deposition and prevalence of hypertension among United States adults: findings from the IRAS Family Study [abstract]. Hypertension. 2006;48(4):e76.

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