Hayashida Lab Publications

Hayashida Lab Publications

  1. Gutierrez S, Hayashida KI, Eisenach JC. The puerperium alters spinal cord plasticity following peripheral nerve injury. Neuroscience 2013: 228:301-8.
  2. Gutierrez S, Lu B, Hayashida KI, Houle TT, Eisenach JC. Reversal of Peripheral Nerve Injury-induced Hypersensitivity in the Postpartum Period: Role of Spinal Oxytocin. Anesthesiology 2013: 188:152-9. K
  3. Kimura M, Hayashida KI, Eisenach JC, Saito S, Obata H. Relief of Hypersensitivity after Nerve Injury from Systemic Donepezil Involves Spinal Cholinergic and γ-Amino Butyric Acid Mechanisms. Anesthesiology 2013: 188:173-80.
  4. Hayashida KI, Kimura M, Yoshizumi M, Hobo S, Obata H, Eisenach JC. Ondansetron reverses anti-hypersensitivity from clonidine in rats following peripheral nerve injury: Role of γ-amino butyric acid (GABA) in α2-adrenoceptor and 5-HT3 serotonin receptor analgesia. Anesthesiology 2012: 117: 389-398.
  5. Yoshizumi M, Parker RA, Eisenach JC, Hayashida KI. Gabapentin inhibits γ-Amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats. Anesthesiology 2012: 116: 1347-53.
  6. Hayashida KI, Peters CM, Gutierrez S, Eisenach JC. Depletion of endogenous noradrenaline enhances spinal cord plasticity following peripheral nerve injury. J Pain 2012: 13:49-57.
  7. Yoshizumi M, Eisenach JC, Hayashida KI. Riluzole and gabapentinoids activate glutamate transporters to facilitate glutamate-induced glutamate release from cultured astrocytes. Eur J Pharmacol 2012: 677: 87-92.
  8. Hobo S, Hayashida KI, Eisenach JC. Oxytocin Inhibits the Membrane Depolarization-Induced Increase in Intracellular Calcium in Capsaicin Sensitive Sensory Neurons: A Peripheral Mechanism of Analgesic Action. Anesth Analg 2012: 114: 442-449.
  9. Hayashida KI, Peter CM: Nerve injury-induced chronic pain models. Pain Clinic 2011; 32: 1625-1632(Japanese).
  10. Hobo S, Eisenach JC, Hayashida KI. Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury. Neurosci Lett 2011: 502 (1): 52-55.
  11. Hayashida KI, Eisenach JC. A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats. with peripheral nerve injury. J pain 2011: 12: 94-100.
  12. Peters CM, Hayashida KI, Ewan EE, Nakajima K, Obata H, Xu Q, Yaksh TL, Eisenach JC. Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat. Brain Res 2010: 1352: 83-93.
  13. Hayashida KI, Eisenach JC. Spinal α2-adrenoceptor mediated analgesia in neuropathic pain reflects brain derived nerve growth factor and changes in spinal cholinergic neuronal function. Anesthesiology 2010: 113: 406-412.
  14. Hayashida KI, Eisenach JC. Activation of glutamate transporters in the locus coeruleus paradoxically activates descending inhibition in rats. Brain Res 2010: 1317: 80-86.
  15. Obata H, Hayashida KI, Nakajima K, Saito S: Alpha2-adrenoceptor as a target for the treatment of chronic pain (Vol.2). Pain Clinic 2009; 30: 233-242 (Japanese).
  16. Obata H, Hayashida KI: Drug treatments for CRPS: Gabapentin and anti-depressants. Pain Clinic 2008; 29: 1189-1197(Japanese).
  17. Obata H, Hayashida KI, Nakajima K, Saito S: Alpha2-adrenoceptor as a target for the treatment of chronic pain. Pain Clinic 2008; 29: 239-249 (Japanese).
  18. Hayashida KI, Obata H, Nakajima K, Eisenach JC: Gabapentin acts within the locus coeruleus to alleviate neuropathic pain Anesthesiology 2008:109: 1077-84.
  19. Hayashida KI, Eisenach JC. Multiplicative interactions to enhance gabapentin to treat neuropathic pain. Eur J Pharmacol 2008: 598: 21-26.
  20. Hayashida KI, Clayton BA, Johnson JE, Eisenach JC: Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in rats. Pain 2008;136:348-355.
  21. Obata H, Hayashida KI: Alpha2-adrenergic receptors in the dorsal horn of the spinal cord--their function and the descending inhibitory systems. Masui 2007; 56: S161-S171 (Japanese).
  22. Brett K, Parker R, Wittenauer S, Hayashida KI, Young T, Vincler M: Impact of chronic nicotine on sciatic nerve injury in the rat. J Neuroimmunol 2007; 186: 37-44.
  23. Hayashida K, Parker R, Eisenach JC: Oral Gabapentin Activates Spinal Cholinergic Circuits to Reduce Hypersensitivity after Peripheral Nerve Injury and Interacts Synergistically with Oral Donepezil. Anesthesiology 2007; 106: 1213-9.
  24. Hayashida K, DeGoes S, Curry R, Eisenach JC: Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery. Anesthesiology 2007; 106: 557-62.
  25. Clayton BA, Hayashida KI, Childers SR, Xiao R, Eisenach JC: Oral Donepezil Reduces Hypersensitivity after Nerve Injury by a Spinal Muscarinic Receptor Mechanism. Anesthesiology 2007; 106: 1019-1025.
  26. Tsuchiya T, Takeuchi T, Hayashida K, Shimizu H, Ando K, Harada E: Milk-derived lactoferrin may block tolerance to morphine analgesia. Brain Res 2006; 1068: 102-8.
  27. Hayashida KI, Bynum T, Vincler M, Eisenach JC: Inhibitory M2 muscarinic receptors are upregulated in both axotomized and intact small diameter dorsal root ganglion cells after peripheral nerve injury. Neuroscience 2006; 140: 259-68.
  28. Kamemori N, Takeuchi T, Hayashida K, Harada E: Suppressive effects of milk-derived lactoferrin on psychological stress in adult rats. Brain Res 2004; 1029: 34-40.
  29. Hayashida K, Kaneko T, Takeuchi T, Shimizu H, Ando K, Harada E: Oral administration of lactoferrin inhibits inflammation and nociception in rat adjuvant-induced arthritis. J Vet Med Sci 2004; 66: 149-54.
  30. Hayashida K, Takeuchi T, Harada E: Lactoferrin enhances peripheral opioid-mediated antinociception via nitric oxide in rats. Eur J Pharmacol 2004; 484: 175-81.
  31. Hayashida K, Takeuchi T, Ozaki T, Shimizu H, Ando K, Miyamoto A, Harada E: Bovine lactoferrin has a nitric oxide-dependent hypotensive effect in rats. Am J Physiol Regul Integr Comp Physiol 2004; 286: R359-65.
  32. Takeuchi T, Hayashida K, Inagaki H, Kuwahara M, Tsubone H, Harada E: Opioid mediated suppressive effect of milk-derived lactoferrin on distress induced by maternal separation in rat pups. Brain Res 2003; 979: 216-24.
  33. Hayashida K, Takeuchi T, Shimizu H, Ando K, Harada E: Lactoferrin enhances opioid-mediated analgesia via nitric oxide in the rat spinal cord. Am J Physiol Regul Integr Comp Physiol 2003; 285: R306-12.
  34. Hayashida K, Takeuchi T, Shimizu H, Ando K, Harada E: Novel function of bovine milk-derived lactoferrin on antinociception mediated by mu-opioid receptor in the rat spinal cord. Brain Res 2003; 965: 239-45.
  35. Hayashida K: Interaction between secretory responses to nicotine and muscarine from perfused adrenal gland of the guinea pig. Jap J Vet Res 1996; 44: 27.

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