Multi-Center Trial to Evaluate Home-Based Assessment Methods for Alzheimer Disease Prevention Research in People Over 75 Years Old (HBA)

Short Study Name (acronym):HBA

Long Name:Multi-Center Trial to Evaluate Home-Based Assessment Methods for Alzheimer Disease Prevention Research in People Over 75 Years Old

Investigators (list PI first):
Kaycee Sink, MD

Jeff Williamson, MD
Franklin Watkins, MD

Funding Agency:
National Institute on Aging, through a grant to the Alzheimer’s Disease Cooperative Study

Funding Dates:
1/2008 – 6/2012

Research questions or aims:

  1. Establish the feasibility of the three in-house assessments methods—Mail in forms with live phone, automated telephone IVR technology and computer-based kiosk assessment and validate them by comparing them to traditional evaluation instruments.
  2. To evaluate the ability of the brief instruments proposed here to capture rate of change as an outcome for primary prevention trials.
  3. To examine medication adherence as a performance based assessment of functional ability in all 3 methods.

Target population:
Male and female age 75 years and older with a
Mini Mental State Exam score of >=26, willing to take multi-vitamins provided by the study,able to answer and dial a telephone, have access to secure mail, with minimal computers skills or willingness to learn.

Total enrolled:
30

Dates of enrollment:
July 2007 – August 2008

Types of assessments and questionnaires:
Medical History, Demographics, height, weight, Vital Signs, Concomitant Medications, MMSE, MCI ADCS-ADL, Logical Memory Test, Boston Naming, Category Fluency, Digit Span, Trail Making Test (A & B), Digit Symbol Substitution, Immediate and Delayed Word Recall, East Boston Memory, Abbreviated TICS, QOL, Brief Cognitive Function Screening, Behavioral Scale, CGIC, Resource Use Inventory

Other data collected:
Blood, MRI

Study Website (if applicable): www.adcs.org/Studies/HBA.aspx

Coordinator Contact Info:
Sheri Mayer

Email: smayer@wakehealth.edu
Phone: 336-713-8520

 

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