Intentional Weight Reduction and Physical and Cognitive Function (LOOKAHEAD Ancillary)

Short Study Name (acronym):Look AHEAD Ancillary

Long Name: Intentional Weight Reduction and Physical and Cognitive Function (LOOKAHEAD Ancillary)

Investigators (list PI first):
Stephen Kritchevsky, PhD

Funding Agency:
National Institute on Aging

Funding Dates:
2009- 2014

Research questions or aims: 
We propose to add validated and well-established measures of physical and cognitive performance to the year 8 or year 9 follow-up visit – during the trial’s weight maintenance phase –in 1002 participants  

The specific aims of this ancillary study are: 1) To determine the long-term effects of a lifestyle intervention designed to achieve and maintain weight loss on physical function; and 2) To determine the long-term effects of a lifestyle intervention designed to achieve and maintain weight loss on cognitive function. In addition, we hypothesize that in the intervention group, larger initial weight loss, better weight loss maintenance, and higher physical activity will be associated with better physical and cognitive function. We also hypothesize that in the control group weight loss will be associated with worse physical and cognitive function than in those who are weight stable or who have gained weight. The number of obese older adults is rising rapidly and there are few data to guide an evidence-based clinical response to their management.  

Target population:
People who participated in the LOOK Ahead trial at
4 of the 16 Look AHEAD field sites (Colorado, Memphis, Pennington and Pittsburgh).

Target # to enroll:
1002                 

Target Dates of enrollment:
2009-2013

Types of assessments and questionnaires:
Modified Mini-Mental Status Examination (3MSE), Rey Auditory Verbal Learning Test, Digit Symbol Substitution Test (DSST), Stroop Test, PAT-D, Trails A&B, SPPB, Grip Strength,  400 m walk, Knee extensor strength

Other data collected:
Telephone Interview for Cognition (TICS), Functional Assessment Questionnaire (FAQ)

Project Manager Contact Info:
Michelle Gordon

Email: migordon@wakehealth.edu

Phone: 336-713-8546

Quick Reference

Gerontology and Geriatric Medicine

Geriatric Administration
336-713-8570
Geriatric Clinic
336-713-8250
Geriatric Research
336-713-8539
Elder Law Clinic
336-713-8630

Find A Doctor Ways to Give
Last Updated: 03-19-2014
USNWR 2013-2014Magnet Hospital RecognitionConsumer Choice2014 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.