Jessica N. Cooke

Jessica Cook photo cropped

Postdoctoral Scholar
Case Western Reserve University
Cleveland/Akron, OH


E-mail:   jnc43@case.edu

Education:

Ph.D. 2012, Wake Forest School of Medicine

B.S. Biology, (minor in Chemistry) 2008, Winthrop University, Honors degree

Advisor: Donald W. Bowden, PhD; Biochemistry (Genomics Ctr) 

Current Research:

The World Health Organization (WHO) estimates that more than 180 million people worldwide have diabetes; this number is likely to more than double by 2030. Diabetes is a group of diseases marked by high levels of blood glucose, resulting from defects in insulin production and/or insulin action. Diabetes can lead to serious health complications and premature death. Type 2 diabetes (T2D) is associated with older age, obesity, family history of diabetes, impaired glucose metabolism, physical inactivity, and race/ethnicity. Complications resulting from diabetes can include: heart disease, stroke, blindness, kidney disease, nervous system disease, and amputation. One of the complications of diabetes is diabetic nephropathy – damage to the kidneys as a result of diabetes. Ten to twenty percent of diabetic patients die of kidney failure, and diabetes is the most common cause of kidney failure, accounting for nearly 44% of new cases. End-stage renal disease (ESRD) develops when nephropathy has progressed until either dialysis or a kidney transplant is necessary for life. ESRD and diabetes are complex diseases that are influenced by several factors, including environment, lifestyle, and genetics.  

My research focuses on identifying genetic variants contributing to the development of diabetes and diabetic nephropathy; thus far I have conducted association studies to evaluate the influence of polymorphisms in acetyl coenzyme A carboxylase beta (ACACB) and non-muscle myosin heavy chain 9 (MYH9) on T2D-ESRD in European Americans. I am currently researching copy number variation and how it may contribute to T2D and/or T2D-ESRD in African Americans. I am also evaluating European-identified T2D risk variants and their cumulative contribution to T2D risk in African Americans.

Honors and Awards:

Wake Forest University 2011 Lindau Nobel Laureate Meeting nominee

Molecular Medicine and Translational Science Alumni Travel Award: fall 2011

St. Jude NGSS Award, Invitation and funding to present at St. Jude National Graduate Student Symposium: March 20-24, 2012

Scholastic and Professional Experience:
Teaching Assistant, Human Molecular Genetics: 2010

Member of Health and Effectiveness Council of WFU Graduate School of Arts & Sciences: 2008-present

  • Newsletter coordinator: 2010-present

Student Representative to the Molecular Medicine and Translational Science Executive Committee: 2009-2011

Student Member of the Molecular Medicine and Translational Science Curriculum Committee: 2011-present

Professional Memberships:

Member of the American Society of Human Genetics

Publications:

Freedman BI, Langefeld CD, Lu L, Divers J, Comeau ME, Kopp JB, Winkler CA, Nelson GW, Johnson RC, Palmer ND, Hicks PJ, Bostrom MA, Cooke JN, McDonough CW, Bowden DW. Differential Effects of MYH9 and APOL1 Risk Variants on FRMD3 Association with Diabetic ESRD in African Americans. PLoS Genet. 2011 June; 7(6): e1002150.

McDonough CW, Palmer ND, Hicks PJ, Roh BH, An SS, Cooke JN, Hester JM, Wing MR, Bostrom MA, Rudock ME, Lewis JP, Talbert ME, Blevins RA, Lu L, Ng MC, Sale MM, Divers J, Langefeld CD, Freedman BI, Bowden DW.  A genome wide association study for diabetic nephropathy genes in African Americans. Kidney Int. 2011; 79(5):563-72. Epub 2010 Dec 8. PMID: 21150874 [PubMed - in process] PMCID: PMC3056271 [Available on 2012/3/1]

Maeda S, Kobayashi MA, Araki S, Babazono T, Freedman BI, Bostrom MA, Cooke JN, Toyoda M, Umezono T, Tarnow L, Hansen T, Gaede P, Jorsal A, Ng DP, Ikeda M, Yanagimoto T, Tsunoda T, Unoki H, Kawai K, Imanishi M, Suzuki D, Shin HD, Park KS, Kashiwagi A, Iwamoto Y, Kaku K, Kawamori R, Parving HH, Bowden DW, Pedersen O, Nakamura Y. A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes. PLoS Genet. 2010 Feb 12;6(2):e1000842.

Cooke JN, Westover KM. Serotype-specific differences in antigenic regions of foot-and-mouth disease virus (FMDV): A comprehensive statistical analysis. Infect Genet Evol. 2008 Dec;8(6):855-63. Epub 2008 Aug 23.

Poster Presentations:

JN Cooke. Genetic variants contributing to type 2 diabetes and type 2 diabetic end-stage renal disease. Molecular Medicine and Translational Science Departmental Seminar, February 4 2011, Winston Salem, NC.

JN Cooke. Genetic risk assessment of type 2 diabetes associated polymorphisms in African Americans. Molecular Medicine and Translational Science Departmental Seminar, November 4 2011, Winston Salem, NC.

JN Cooke. Genetic risk assessment of type 2 diabetes associated polymorphisms in African-Americans. St. Jude National Graduate Student Symposium, March 22 2012, Memphis, TN.

Cooke JN, Palmer ND, Lu L, Chou JW, McDonough CW, Freedman BI, Langefeld CD, Bowden DW. Evaluation of copy number variation in an African American type 2 diabetes and diabetic nephropathy Genome-Wide Association Study. Poster presented at the 11th Annual WFU Graduate School of Arts & Sciences Graduate Student and Postdoctoral Research Day, March 22 2011, Winston Salem, NC.

Cooke J, Ng M, Lu L, Li J, An S, Hester J, Xu J, Freedman B, Langefeld C, Bowden D, Palmer N. Genetic Risk Assessment of Type 2 Diabetes-Associated Polymorphisms in African Americans. Abstract 1325. Poster displayed at the 12th International Congress of Human Genetics / 61st Annual Meeting of the American Society of Human Genetics, October 12 2011, Montreal, Canada.

Cooke J, Ng M, Lu L, Li J, An S, Hester J, Xu J, Freedman B, Langefeld C, Bowden D, Palmer N. Genetic Risk Assessment of Type 2 Diabetes-Associated Polymorphisms in African-Americans. Poster presented at the 11th Annual St. Jude National Graduate Student Symposium, March 22 2012, Memphis, TN.

Cooke J, Ng M, Lu L, Li J, An S, Hester J, Xu J, Freedman B, Langefeld C, Bowden D, Palmer N. Genetic Risk Assessment of Type 2 Diabetes-Associated Polymorphisms in African-Americans. Poster presented at the 12th Annual WFU Graduate School of Arts & Sciences Graduate Student and Postdoctoral Research Day, March 29 2012, Winston Salem, NC.

Conference Abstracts:

Cooke JN, Ng M, Lu L, Li J, An S, Hester J, Xu J, Freedman B, Langefeld C, Bowden D, Palmer N. Genetic Risk Assessment of Type 2 Diabetes-Associated Polymorphisms in African Americans. Abstract 1325. Poster displayed at the 12th International Congress of Human Genetics / 61st Annual Meeting of the American Society of Human Genetics, October 12, 2011; Montreal, Canada.

Cooke JN, Hicks PJ, Palmar NC, Ng MCY, Hester JM, Ma L, Langefeld CD, Freedman BI, Bowden DW. Analysis of Coding Variants from Exome Sequencing in Diabetic Nephropathy (DN) Genes in African Americans. Accepted for oral presentation at the 72nd Scientific Sessions of the American Diabetes Association, June 9, 2012, Philadelphia, PA.


 

 

 

 

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