Suzanne Craft, PhD
Professor, Section on Gerontology and Geriatric Medicine, and Neurology, and Research Director of the J. Paul Sticht Center on Aging; Co-Director of the Roena B. Kulynych Center for Memory and Cognition Research
Dr. Craft is an internationally known researcher for her innovative work researching the role of insulin in Alzheimer’s disease and her clinical trials investigating intranasal insulin as a therapy to prevent cognitive impairment. Dr. Craft became the director of the Kulynych Center in 2012 and established the Wake Forest Alzheimer's Disease Prevention Program in 2013.
Alzheimer's disease, insulin metabolism, neuroendocrinology
Laura D. Baker, PhD
Associate Professor of Internal Medicine, Section on Gerontology and Geriatric Medicine, Neurology, and Public Health Sciences.
Dr. Baker is a cognitive neuroscientist who is a nationally recognized leader in clinical trials of aerobic exercise and hormone supplementation as treatments for memory decline associated with pre-clinical and early stage Alzheimer’s disease.
Alzheimer's disease, cognition, exercise, hormones, insulin resistance
Jeff D. Williamson, MD
Professor of Gerontology and Geriatric Medicine, Interim Chair of Internal Medicine and Program Director of the Sticht Center on Aging
Dr. Williamson is a board-certified Internist and geriatrician with established expertise in the design and implementation of large scale epidemiological studies and clinical trials involving older adults (WHAS, ALLHAT, ACCORD, GEMS, SPRINT, LIFE, ASPREE) which include cognitive and/or physical function assessment as a primary or secondary outcome.
Aging, Alzheimer's, cognitive impairment, drugs/therapeutic agents, pharmacology, physical fitness, cardiac function, epidemiology
Ronny A. Bell, PhD
Professor, Epidemiology & Prevention and Director, Maya Angelou Center for Health Equity
Dr. Bell’s primary research interests focus on racial and ethnic disparities in chronic disease management and control and includes the role of insulin resistance on cognitive impairment and in older adults.
Atherosclerosis, diabetes, pharmacology, education/training, epidemiology, health services, minority health issues, obesity, aging
Mark Espeland, PhD
Professor, Department of Biostatistics
Dr. Espeland is founding Chair of the Department of Biostatistical Sciences at the Wake Forest School of Medicine. His research focus is identifying approaches to preserving brain health during later life and the interfaces among aging, diabetes, obesity, and cognitive function.
Aging, Alzheimer's disease, cognition/learning, diabetes, environmental sciences, epidemiology, physical fitness, nutrition, obesity, prevention, statistics/mathematics, women's health issues, neurosciences, behavior
Michael E. Miller, PhD
Professor, Department of Biostatistics; Data and Biostatistics Core Co-Leader
Dr. Miller is a biostatistician active in Type 2 diabetes research since 1999, when the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial was originally funded. He served as Deputy Director and lead statistician for ACCORD from 1999 until the final results were published in 2011. He also has experience with cognitive and brain MRI-related research.
Aging, translational medicine, diabetes, physical fitness, statistics/mathematics
Ryan T. Mott, MD
Assistant Professor, Pathology; Neuropathology Core Co Leader
Dr. Mott has worked as a diagnostic neuropathologist and surgical pathologist in the Department of Pathology at Wake Forest School of Medicine (WFSM) since 2006. He has considerable experience in the pathological diagnosis of AD and other neurodegenerative disorders, and is familiar with all current best neuropathological practices. His past research projects have addressed neuronal regulation of microglial activation (Roskamp Institute for Neurodegenerative Disease Research, University of South Florida) and vascular pathology in mesial temporal sclerosis and neurodegenerative diseases (Brain Microvascular Pathology Laboratory, WFSM)
Alzheimer’s disease, aging, neuropathology, diagnosis, neurogenerative disease
Stephen Rapp, PhD
Professor, Psychiatry and Behavioral Medicine, Sticht Center on Aging
Dr. Rapp is a professor and clinical geropsychologist with specific training and expertise in the epidemiology of aging, cognitive aging, and cognitive disorders of later life including Alzheimer's dementia. A major focus of his research over the past 30 years has been to identify predictors of the pre-dementia syndromes and dementia including Alzheimer's dementia. He is the Principal Investigator of the Women’s Health Initiative Memory Study (WHIMS) and has been an investigator on several large clinical trials and observational studies in which cognitive functioning is an outcome including Cognition in the Study of Tamoxifen And Raloxifene (Co-STAR), Gingko Evaluation of Memory Study (GEMS), Multi-Ethnic Study of Atherosclerosis II (MESA-II), Lifestyle Interventions and Independence for Elders (LIFE), Look Action for Health in Diabetes (Look AHEAD), and Systolic Blood Pressure Intervention Trial (SPRINT). He also pioneered the development and validation of telephone administered and computer/tablet based assessment of everyday cognitive functioning.
Cognitive-Behavioral Therapy, Depression, Geriatrics, Stress
Kathleen Hayden, PhD
Associate Professor, Social Sciences & Health Policy, Sticht Center on Aging
Dr. Hayden is a psychiatric epidemiologist focused on modifiable risk factors for Alzheimer’s disease. Specific areas of interest include the cardiovascular determinants of Alzheimer’s disease in addition to environmental and genetic risk factors. She is also a Senior Associate Editor for Alzheimer’s & Dementia: the Journal of the Alzheimer’s Association.
Aging, Alzheimer's disease, Cognition/Learning, Genetics/Genome, Radiology Imaging/Nuclear Medicine
Edward Shaw, MD, MA
Director, Memory Assessment Clinic Counseling Center; PI, Pilot Study and Outreach, Recruitment and Education Core Investigator
Dr. Shaw is a full-time Professor in Gerontology/Geriatric Medicine and spends part of his time in the memory clinic diagnosing individuals with memory/cognitive decline. He also directs and counsels half-time in the Memory Counseling Program for families caring for Alzheimer’s patients.
Aging, Alzheimer’s disease, Dementia diagnosis, dementia counseling, cognition & cancer, Dementia caregiver stress and burden
Tao Ma, MD, PhD
Assistant Professor, Department of Internal Medicine, Gerontology and Geriatric Medicine; J. Paul Sticht Center on Aging; Roena B. Kulynych Center for Memory and Cognition Research; Assistant Professor, Department of Physiology & Pharmacololgy; Assistant Professor, Department of Neurobiology & Anatomy
Dr. Ma is a neuroscientist and his research focuses on identification of novel molecular mechanisms and potential therapeutic targets for Alzheimer’s disease and other aging-related cognitive impairments. Primary techniques applied in his laboratory include electrophysiology, confocal microscopy, behavioral tests, and molecular approaches in transgenic mouse models.
Alzheimer’s disease, memory, signaling transduction, synaptic plasticity
Timothy M. Hughes, PhD, MPH
Scholar, Department of Internal Medicine, Gerontology and Geriatric Medicine;
J. Paul Sticht Center on Aging; Roena B. Kulynych Center for Memory and
Cognition Research; Hypertension and Vascular Research Center
Dr. Hughes is
a neuroepidemiolgist and his research focuses on identification of cardiometabolic
risk factors for vascular cognitive impairment and Alzheimer’s
disease. The goal of his research is to develop strategies aimed at preventing dementia
and general brain aging. Dr. Hughes is nationally recognized for his work on
the vascular contributions to Alzheimer’s pathology.
Alzheimer’s disease, memory, brain imaging, vascular stiffness, brain
Anthony J. Molina, PhD
Assistant Professor, Gerontology and
Geriatric Medicine; PI, Pilot Study
Dr. Molina is a mitochondrial biologist and translational researcher interested in bioenergetics, metabolism, and aging. His laboratory provides expertise in the analysis of mitochondrial function by respirometry and fluorescence imaging.
Aging, biotechnology, cancer, pharmacology, medical technology/devices, neurosciences, behavior, nuclear medicine, radiology imaging/nuclear medicine
Cheryl D. Bushnell, MD
Professor, Neurology; Clinical
Dr. Bushnell is a vascular neurologist interested in stroke prevention, and the role of metabolic and vascular factors in AD pathogenesis and cognition after stroke.
Stroke, cognition, maternal & child health, neurosciences, behavior
J. Mark Cline, DVM, PhD
Section Head and Professor, Pathology-Comparative
Medicine; Neuropathology Core Investigator
Dr. Cline is an experienced, NIH-supported investigator and board-certified veterinary pathologist with many years’ experience in the conduct of primate trials for a variety of chronic disease conditions, including hormone dependent and virally-induced neoplasms, atherosclerosis, osteoporosis, and radiation injury. Recent work in his laboratory has identified delayed neurovascular injury as a critical element of cognitive decline in nonhuman primates after irradiation at doses relevant to human cancer therapy exposures
Aging, biotechnology, cancer, cardiac function, diabetes, therapeutic agents, model development, radiation exposure
Christopher T. Whitlow, MD, PhD
Associate Professor, Radiology; Clinical
Core Neuroimaging Service Investigator
Dr. Whitlow is Director of the Radiology Image Processing Laboratory (RIPL) and Associate Leader for MRI in the Translational Imaging Program of the CTSI. He has specific training in neurophysiology and neuropharmacology, as well as the use of advanced multi-modal functional and structural neuroimaging methods applied to basic science/translational research paradigms and clinical practice. He has leveraged his training and expertise to investigate changes in the brain associated with normal and abnormal brain aging and various neurodegenerative diseases, including dementia and Alzheimer’s disease.
Atherosclerosis, cognition, computer science, translational medicine, diabetes, epidemiology, neurosciences, behavior, radiology imaging/nuclear medicine, vascular diseases
Ramon Casanova Luis, PhD
Assistant Professor, Biostatistical
Sciences; Data and Biostatistics
Dr. Casanova’s research interests focus on the development and/or application of mathematical methodologies to the analysis and integration of high-dimensional biomedical data. Much of his research is dedicated to the application of machine learning and high-dimensional regularization techniques to analyze clinical databases.
Aging, cognition, computer science, diabetes, environmental sciences, physical fitness, immunology/allergy/inflammation, brain imaging
Donald W. Bowden, PhD
Associate Director, Center for Genomics
and Personalized Medicine Research; Director, Center for Diabetes Research; Professor, Biochemistry; Neuropathology
Core Genetics Service Leader
Dr. Bowden has been involved in human genetics research for almost 30 years with a focus on the genetics and epidemiology of type 2 diabetes, the complications of diabetes such as cardiovascular, renal, and cerebrovascular disease, and contributors to diabetes such as adiposity and control of glucose homeostasis. More recently, he has extended these studies into analysis of structure and function by MRI and cognitive testing to investigate the impact of diabetes on cognitive decline.
Atherosclerosis, diabetes, genetics, metabolism, minority health issues, molecular biology, vascular diseases
Ihtsham ul Haq, MD
Assistant Professor, Neurology; Clinical Core Investigator
Dr. Haq is a neurologist with a subspecialization in Movement Disorders with extensive experience in both pharmacological and medical management. He treats and studies both motor and non-motor manifestations of basal ganglia disease.
Neurosciences, behavior, movement disorders, Parkinson’s disease
Thomas C. Register, PhD
Professor, Pathology-Comparative Medicine; Neuropathology
Dr. Register is an expert in atherosclerosis and cardiovascular disease, with experience employing molecular, cellular, and imaging approaches in basic, translational, epidemiologic, and genetic studies. He has expertise in nuclear hormone receptors and was the first to demonstrate that estrogen receptor beta was expressed in nonhuman primate artery, arterial smooth muscle cells, hippocampus, and hypothalamus. He has experience in evaluation of biochemical markers in human and non-human primates in cross-translational studies, and in the assessment of gene expression to explore inflammation and tissue specific effects and mechanisms underlying pathologic processes and their treatment.
Atherosclerosis, biotechnology, cardiac function, comparative and translational medicine, therapeutic development, genomics and proteomics, hormones/cytokines/signaling, medical technology/devices, metabolism, molecular biology, osteoporosis, women's health issues
Jay R. Kaplan, PhD
Section Head, Pathology-Comparative
Medicine; Neuropathology Core Non-human Primate
Dr. Kaplan is Vice Chair for Research of Department of Pathology, Director of the Center for Comparative Medicine Research (CCMR), and Director of the Primate Signature Program of the Wake Forest Translational Science Institute (TSI). He has been conducting biomedical research with nonhuman primates for more than 30 years; among his studies are many relating to biobehavioral influences on the development and expression of chronic disease, including cardiometabolic disorders and behavioral abnormalities.
Cardiac function, comparative and translational medicine, genetics, health services, immunology/allergy/inflammation, infectious diseases, model development, molecular biology, neurosciences, behavior, nutrition, radiology imaging/nuclear medicine, vaccines, women's health issues
Carol A. Shively, PhD
Professor, Pathology-Comparative Medicine; Neuropathology Core Non-human Primate
Dr. Shively has served as a research administrator for close to 20 years, promoting, facilitating, and coordinating the use of nonhuman primates (NHPs) in vascular, brain and sex differences research. Her laboratory has published a wide array of systemic and neuropathologies in older NHPs with specific interest given to how aging NHPs respond to the Western-like diet. Her lab has developed adult NHP models of depression as well as aging and physical mobility. Her comparative research is translatable to older neurocognitive function in older adults through the development of batteries for physical and cognitive function assessments for NHPs. They have demonstrated concomitant increases in neural amyloid with age in these NHPs. These studies evidence animal modeling skills that will be utilized to promote the development of NHP studies of Alzheimer’s disease risk.
Atherosclerosis, depression, neurosciences, behavior, obesity, diet, women's health issues
Matthew J. Jorgensen, PhD
Assistant Professor, Pathology-Comparative
Medicine; Neuropathology Core Non-human Primate
Dr. Jorgensen has over 20 years of experience working with nonhuman primates and currently serve as the scientific manager of the Vervet Research Colony (VRC), an NIH-supported biomedical research resource (PI: Jay Kaplan).
Comparative and translational medicine, therapeutic development, genetics, immunology/allergy/inflammation, infectious diseases, neurosciences/behavior
Youngkyoo Jung, PhD
Assistant Professor, Radiology; Clinical Core Neuroimaging Service Investigator
Dr. Jung is an MR physicist at Wake Forest School of Medicine. His primary research interest is focused on technical developments of neurological applications, particularly arterial spin labeling (ASL) perfusion imaging, and translation technologies into clinical platforms. His research interests also extend to parallel imaging, where he developed a novel method to accelerate data acquisition speed.
Aging, engineering/bioengineering, radiology imaging / nuclear medicine, vascular diseases
Kimberly Stogner-Underwood, MD
Assistant Professor, Pathology; Neuropathology Core Investigator
Dr. Stogner-Underwood has experience diagnosing a variety of neurodegenerative diseases, including the use of special techniques (immunohistochemical and other special stains). She gained experience with brain tissue banking for Parkinson’s disease research during her neuropathology fellowship.
Aging, Alzheimer’s disease, neuropathology, diabetes, metabolism, vascular diseases
Julie A. Williams, MD
Assistant Professor, Gerontology and
Geriatric Medicine; Clinical
Dr. Williams completed a Clinical Fellowship at Wake Forest School of Medicine where she later joined the Geriatrics faculty in 2011. Her professional goal is to investigate methods of understanding and preventing loss of cognitive and physical function in later life. The care of individuals in later life represents for her the embodiment of compassion and complexity.
Aging, Alzheimer’s disease, caregiver stress
Colleen Sachs, Ph.D.
Professor, Department of Neurology, & Section on Gerontology and Geriatric
Sachs is a clinical neuropsychologist with expertise in aging, mild cognitive
impairment, and Alzheimer’s disease and other dementias. Clinically, she evaluates patients with a wide variety of cognitive concerns, and is
also involved in multiple research studies and clinical trials with patients
who have mild cognitive impairment or dementia.
Aging, Dementia, Mild Cognitive Impairment, Movement Disorders