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Walter T. Ambrosius, Ph.D.Wake Forest School of Medicine

Walter T. Ambrosius, Ph.D.


Office of Research

Contact Information

Academic: 336-716-6281 | Department: 336-716-2011


Education & Training

  • A.B., Washington University, 1991
  • A.M., Washington University, 1991
  • Ph.D., University of Chicago, 1995


  • Am Statistical Assoc
  • Assn of GCRC Statisticians
  • Biometric Society
  • Institute Of Mathematical Stat
Walter T. Ambrosius, Ph.D.

Walter T. Ambrosius, Ph.D.

Professor, Biostatistical Sciences
Professor, Biostatistical Sciences
Office of Women in Medicine and Science
Office of Research

Research Interests

Diabetic Retinopathy; Hypertension; Weight Loss; Antihypertensive Agents; Diabetes Mellitus, Type 2
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Contact Information

Academic: 336-716-6281 | Department: 336-716-2011


Recent Publications

A comparison of self-report indices of major mobility disability to failure on the 400-meter walk test: the LIFE study. Chen H, Rejeski WJ, Gill TM, Guralnik J, King AC, Newman A, Blair SN, Conroy D, Liu C, Manini T, Pahor M, Ambrosius WT, Miller ME.. J Gerontol A Biol Sci Med Sci. 2018;73(4):513-518.

Factors mediating outcome after stroke: gender, thrombolysis, and their interaction. Lee SJ, Heo SH, Ambrosius WT, Bushnell CD.. Transl Stroke Res. 2018;9(3):267-273.

Change in health-related quality of life and social cognitive outcomes in obese, older adults in a randomized controlled weight loss trial: does physical activity behavior matter?. Fanning J, Walkup MP, Ambrosius WT, Brawley LR, Ip EH, Marsh AP, Rejeski WJ.. J Behav Med. 2018;41(3):299-308.

Lack of longitudinal association between thiazolidinediones and incidence and progression of diabetic eye disease: the ACCORD Eye Study. Gower EW, Lovato JF, Ambrosius WT, Chew EY, Danis RP, Davis MD, Goff DC Jr, Greven CM.. Am J Ophthalmol. 2018;187():138-147.

Response by Soliman et al to letters regarding article, "Effect of intensive blood pressure lowering on left ventricular hypertrophy in patients with hypertension: SPRINT (Systolic Blood Pressure Intervention Trial)" [letter]. Soliman EZ, Ambrosius WT, Lewis CE.. Circulation. 2018;137(12):1300-1301.

Impact of intensive versus standard blood pressure management by tertiles of blood pressure in SPRINT (Systolic Blood Pressure Intervention Trial). Shapiro BP, Ambrosius WT, Blackshear JL, Cushman WC, Whelton PK, Oparil S, Beddhu S, Dwyer JP, Gren LH, Kostis WJ, Lioudis M, Pisoni R, Rosendorff C, Haley WE.. Hypertension. 2018;71(6):1064-1074.

A new modeling and inference approach for the Systolic Blood Pressure Intervention Trial outcomes. Yang S, Ambrosius WT, Fine LJ, Bress AP, Cushman WC, Raj DS, Rehman S, Tamariz L.. Clin Trials. 2018;15(3):305-312.

Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: a systematic review and meta-analysis. Custodero C, Mankowski RT, Lee SA, Chen Z, Wu S, Manini TM, Hincapie Echeverri J, Sabba C, Beavers DP, Cauley JA, Espeland MA, Fielding RA, Kritchevsky SB, Liu CK, McDermott MM, Miller ME, Tracy RP, Newman AB, Ambrosius WT, Pahor M, Anton SD.. Ageing Res Rev. 2018;46():42-59.

Acid-base status as a modifier of loss of lean mass during intentional weight loss in older adults [abstract]. Petrovic S, Leng I, Walkup MP, Ambrosius WT, Rejeski WJ, Nicklas BJ.. In: Abstracts of the 2018 Annual Meeting of the EPI/Lifestyle Scientific Sessions; 2018 Mar 20-23; New Orleans (LA). 2018;():A1781.

Community weight loss to combat obesity and disability in at-risk older adults. Rejeski WJ, Ambrosius WT, Burdette JH, Walkup MP, Marsh AP.. J Gerontol A Biol Sci Med Sci. 2017;72(11):1547-1553.

Effect of metabolic syndrome on the mobility benefit of a structured physical activity intervention-the Lifestyle Interventions and Independence for Elders randomized clinical trial. Botoseneanu A, Chen H, Ambrosius WT, Allore HG, Anton S, Folta SC, King AC, Nicklas BJ, Spring BJ, Strotmeyer ES, Gill TM.. J Am Geriatr Soc. 2017;65(6):1244-1250.

Social participation modifies the effect of a structured physical activity program on major mobility disability among older adults: results from the LIFE study. Corbett DB, Rejeski WJ, Tudor-Locke C, Glynn NW, Kritchevsky SB, McDermott MM, Church TS, Fielding RA, Gill TM, King AC, Miller ME, Chen H, Pahor M, Manini TM, Pahor M, Guralnik JM, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Lee J,.. J Gerontol B Psychol Sci Soc Sci. 2017;():.

Effect of intensive blood pressure lowering on left ventricular hypertrophy in patients with hypertension: SPRINT (Systolic Blood Pressure Intervention Trial. Soliman EZ, Ambrosius WT, Cushman WC, Zhang ZM, Bates JT, Neyra JA, Carson TY, Tamariz L, Ghazi L, Cho ME, Shapiro BP, He J, Fine LJ, Lewis CE.. Circulation. 2017;136(5):440-450.

The Comprehensive Post-Acute Stroke Services (COMPASS) study: design and methods for a cluster-randomized pragmatic trial. Duncan PW, Bushnell CD, Rosamond WD, Jones Berkeley SB, Gesell SB, D'Agostino RB Jr, Ambrosius WT, Barton-Percival B, Bettger JP, Coleman SW, Cummings DM, Freburger JK, Halladay J, Johnson AM, Kucharska-Newton AM, Lundy-Lamm G,.. BMC Neurol. 2017;17(1):133.

Association between structured physical activity and sedentary time in older adults [research letter]. Wanigatunga AA, Ambrosius WT, Rejeski WJ, Gill TM, Glynn NW, Tudor-Locke C, Manini TM.. JAMA. 2017;318(3):297-299.

ENabling reduction of low-grade inflammation in SEniors Pilot Study: concept, rationale, and design. Manini TM, Anton SD, Beavers DP, Cauley JA, Espeland MA, Fielding RA, Kritchevsky SB, Leeuwenburgh C, Lewis KH, Liu C, McDermott MM, Miller ME, Tracy RP, Walston JD, Radziszewska B, Lu J, Stowe C, Wu S, Newman AB, Ambrosius WT, Pahor M.. J Am Geriatr Soc. 2017;65(9):1961-1968.

Effect of intensive blood-pressure treatment on patient-reported outcomes. Berlowitz DR, Foy CG, Kazis LE, Bolin LP, Conroy MB, Fitzpatrick P, Gure TR, Kimmel PL, Kirchner K, Morisky DE, Newman J, Olney C, Oparil S, Pajewski NM, Powell J, Ramsey T, Simmons DL, Snyder J, Supiano MA, Weiner DE, Whittle J, Rocco M,.. N Engl J Med. 2017;377(8):733-744.

Imputation of gait speed for noncompleters in the 400-meter walk: application to the Lifestyle Interventions for Elders study. Chen H, Ambrosius WT, Murphy TE, Fielding R, Pahor M, Santanasto A, Tudor-Locke C, Jack Rejeski W, Miller ME.. J Am Geriatr Soc. 2017;65(12):2566-2571.

Effect of exercise type during intentional weight loss on body composition in older adults with obesity. Beavers KM, Ambrosius WT, Rejeski WJ, Burdette JH, Walkup MP, Sheedy JL, Nesbit BA, Gaukstern JE, Nicklas BJ, Marsh AP.. Obesity (Silver Spring). 2017;25(11):1823-1829.

Association of accelerometry-measured physical activity and cardiovascular events in mobility-limited older adults: the LIFE (Lifestyle Interventions and Independence for Elders) study. Cochrane SK, Chen SH, Fitzgerald JD, Dodson JA, Fielding RA, King AC, McDermott MM, Manini TM, Marsh AP, Newman AB, Pahor M, Tudor-Locke C, Ambrosius WT, Buford TW.. J Am Heart Assoc. 2017;6(12):e007215.

Effect of exercise modality during weight loss on hip and spine bone mineral density in older adults with obesity [abstract]. Beavers K, Walkup M, Ambrosius W, Kritchevsky S, Lenchik L, Shapses S, Nicklas B, Marsh A, Rejeski WJ.. J Bone Miner Res. 2017;32(Suppl 1):S101.

Cardiovascular events in a physical activity intervention compared with a successful aging intervention: the LIFE study randomized trial. Newman AB, Dodson JA, Church TS, Buford TW, Fielding RA, Kritchevsky S, Beavers D, Pahor M, Stafford RS, Szady AD, Ambrosius WT, McDermott MM.. JAMA Cardiol. 2016;1(5):568-574.

Persistent effects of intensive glycemic control on retinopathy in type 2 diabetes in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Follow-On Study. Chew EY, Lovato JF, Davis MD, Gerstein HC, Danis RP, Ismail-Beigi F, Genuth S, Greven CM, Perdue LH, Cushman WC, Elam MB, Bigger JT, Ginsberg HN, Goff DC, Ambrosius WT.. Diabetes Care. 2016;39(7):1089-1100.

Let's not SPRINT to judgment about new blood pressure goals [letter]. Lewis CE, Johnson KC, Rahman M, Sink KM, Ambrosius WT.. Ann Intern Med. 2016;165(12):889.

Inflammation and gait speed: a meta-analysis [abstract]. Beavers DP, Ambrosius W, Newman AB, Manini T, McDermott M, Rejeski W, Fielding R.. Gerontologist. 2016;56(Suppl 3):26.

ENRGISE (Enabling Reduction of Low-Grade Inflammation in Seniors) pilot study [abstract]. Pahor M, Ambrosius W, Newman AB, McDermott M, Manini T, Anton S, Fielding R, Kritchevsky S.. Gerontologist. 2016;56(Suppl 3):26.

Effects of a long-term physical activity program on sedentary patterns in older adults [abstract]. Wanigatunga AA, Ambrosius W, McDermott M, King A, Glynn NW, Guralnik J, Manini T.. Gerontologist. 2016;56(Suppl 3):601.

Impact of weight loss plus aerobic or resistance training on quality of life in older adults [abstract]. Fanning J, Marsh A, Rejeski W, Walkup M, Ambrosius W.. Gerontologist. 2016;56(Suppl 3):.

Effect of exercise modality during weight loss on body mass and composition in older obese adults [abstract]. Beavers K, Rejeski W, Marsh A, Ambrosius W, Walkup M.. Gerontologist. 2016;56(Suppl 3):.

Association of objectively measured physical activity with cardiovascular risk in mobility-limited older adults. Fitzgerald JD, Johnson L, Hire DG, Ambrosius WT, Anton SD, Dodson JA, Marsh AP, McDermott MM, Nocera JR, Tudor-Locke C, White DK, Yank V, Pahor M, Manini TM, Buford TW.. J Am Heart Assoc. 2015;4(2):e001288.

Systolic blood pressure control among individuals with type 2 diabetes: a comparative effectiveness analysis of three interventions. Espeland MA, Probstfield J, Hire D, Redmon JB, Evans GW, Coday M, Lewis CE, Johnson KC, Wilmoth S, Bahnson J, Dulin MF, Green JB, Knowler WC, Kitabchi A, Murillo AL, Osei K, Rehman SU, Cushman WC, Ambrosius WT, Greven CM, Lovato JF, Perdue LH, et al.. Am J Hypertens. 2015;28(8):995-1009.

Prevalence of metabolic syndrome and its association with physical capacity, disability, and self-rated health in Lifestyle Interventions and Independence for Elders Study participants. Botoseneanu A, Ambrosius WT, Beavers DP, de Rekeneire N, Anton S, Church T, Folta SC, Goodpaster BH, King AC, Nicklas BJ, Spring B, Wang X, Gill TM.. J Am Geriatr Soc. 2015;63(2):222-232.

Assessing walking activity in older adults: development and validation of a novel computer-animated assessment tool. Marsh AP, Janssen JA, Ip EH, Barnard RT, Ambrosius WT, Brubaker PR, Burdette JH, Sheedy JL, Rejeski WJ.. J Gerontol A Biol Sci Med Sci. 2015;70(12):1555-1561.

Effects of TZD use and discontinuation on fracture rates in ACCORD bone study. Schwartz AV, Chen H, Ambrosius WT, Sood A, Josse RG, Bonds DE, Schnall AM, Vittinghoff E, Bauer DC, Banerji MA, Cohen RM, Hamilton BP, Isakova T, Sellmeyer DE, Simmons DL, Shibli-Rahhal A, Williamson JD, Margolis KL.. J Clin Endocrinol Metab. 2015;100(11):4059-4066.

Insulin dose and cardiovascular mortality in the ACCORD trial. Siraj ES, Rubin DJ, Riddle MC, Miller ME, Hsu FC, Ismail-Beigi F, Chen SH, Ambrosius WT, Thomas A, Bestermann W, Buse JB, Genuth S, Joyce C, Kovacs CS, O'Connor PJ, Sigal RJ, Solomon S.. Diabetes Care. 2015;38(11):2000-2008.

A randomized trial of intensive versus standard blood-pressure control. Wright JT Jr, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, Reboussin DM, Rahman M, Oparil S, Lewis CE, Kimmel PL, Johnson KC, Goff DC Jr, Fine LJ, Cutler JA, Cushman WC, Cheung AK, Ambrosius WT, Kitzman DW, et al.. N Engl J Med. 2015;373(22):2103-2116.

Fish oil supplementation is associated with improved physical function and reduced mobility disability [abstract]. Gundermann DM, Hire DG, Ambrosius WT, Kritchevsky SB, Pahor M, Axtell RS, Newman AB, Manini TM.. Gerontologist. 2015;55(Suppl 2):698.

Effects of randomization to intensive glucose control on adverse events, cardiovascular disease, and mortality in older versus younger adults in the ACCORD trial. Miller ME, Williamson JD, Gerstein HC, Byington RP, Cushman WC, Ginsberg HN, Ambrosius WT, Lovato L, Applegate WB.. Diabetes Care. 2014;37(3):634-643.

Characteristics associated with informed consent for genetic studies in the ACCORD trial. Simons-Morton DG, Chan JC, Kimel AR, Linz PE, Stowe CL, Summerson J, Ambrosius WT.. Contemp Clin Trials. 2014;37(1):155-164.

The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: the Systolic Blood Pressure Intervention Trial (SPRINT). Ambrosius WT, Sink KM, Foy CG, Berlowitz DR, Cheung AK, Cushman WC, Fine LJ, Goff DC Jr, Johnson KC, Killeen AA, Lewis CE, Oparil S, Reboussin DM, Rocco MV, Williamson JD, Wright JT Jr, Whelton PK.. Clin Trials. 2014;11(5):532-546.

Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. Pahor M, Guralnik JM, Ambrosius WT, Blair S, Bonds DE, Church TS, Espeland MA, Fielding RA, Gill TM, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Rejeski WJ, Sink KM, Williamson JD.. JAMA. 2014;311(23):2387-2396.

Application of random forests methods to diabetic retinopathy classification analyses. Casanova R, Saldana S, Chew EY, Danis RP, Greven CM, Ambrosius WT.. PLoS One. 2014;9(6):e98587.

The cross-sectional and longitudinal associations of diabetic retinopathy with cognitive function and brain MRI findings: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Hugenschmidt CE, Lovato JF, Ambrosius WT, Bryan RN, Gerstein HC, Horowitz KR, Launer LJ, Lazar RM, Murray AM, Chew EY, Danis RP, Williamson JD, Miller ME, Ding J.. Diabetes Care. 2014;37(12):3244-3252.

The degree of retinopathy is equally predictive for renal and macrovascular outcomes in the ACCORD trial. Mottl AK, Pajewski N, Fonseca V, Ismail-Beigi F, Chew E, Ambrosius WT, Greven C, Schubart U, Buse J.. J Diabetes Complications. 2014;28(6):874-879.

Intensive glycemic control and thiazolidinedione use: effects on cortical and trabecular bone at the radius and tibia. Schwartz AV, Vittinghoff E, Margolis KL, Scibora LM, Palermo L, Ambrosius WT, Hue TF, Ensrud KE.. Calcif Tissue Int. 2013;92(5):477-486.

Independent and combined effects of physical activity and weight loss on inflammatory biomarkers in overweight and obese older adults. Beavers KM, Ambrosius WT, Nicklas BJ, Rejeski WJ.. J Am Geriatr Soc. 2013;61(7):1089-1094.

Diabetic retinopathy, its progression, and incident cardiovascular events in the ACCORD trial. Gerstein HC, Ambrosius WT, Danis R, Ismail-Beigi F, Cushman W, Calles J, Banerji M, Schubart U, Chew EY.. Diabetes Care. 2013;36(5):1266-1271.

Comparison of standardized clinical classification with fundus photograph grading for the assessment of diabetic retinopathy and diabetic macular edema severity. Gangaputra S, Lovato JF, Hubbard L, Davis MD, Esser BA, Ambrosius WT, Chew EY, Greven C, Perdue LH, Wong WT, Condren A, Wilkinson CP, Agron E, Adler S, Danis RP.. Retina. 2013;33(7):1393-1399.

The Cooperative Lifestyle Intervention Program-II (CLIP-II): design and methods. Marsh AP, Janssen JA, Ambrosius WT, Burdette JH, Gaukstern JE, Morgan AR, Nesbit BA, Paolini JB, Sheedy JL, Rejeski WJ.. Contemp Clin Trials. 2013;36(2):382-393.

The effect of intensive risk factor management in type 2 diabetes on inflammatory biomarkers. Samaropoulos XF, Light L, Ambrosius WT, Marcovina SM, Probstfield J, Goff DC Jr.. Diabetes Res Clin Pract. 2012;95(3):389-398.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Walter T. Ambrosius, Ph.D.

Walter T. Ambrosius, Ph.D.

Professor, Biostatistical Sciences
Professor, Biostatistical Sciences
Office of Women in Medicine and Science
Office of Research

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