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Herbert Lloyd Bonkovsky, M.D.Wake Forest Baptist Health

Doctor Rating

4.5 out of 5

69 Ratings

Herbert Lloyd Bonkovsky, M.D.


Clinical Interests

Hepatology, Porphyria, Drug-Induced Liver Injury

Contact Information

Returning Patient Appointments: 336-713-7777
Department: 336-713-7777

Insurance Accepted »

Education & Training

  • M.D., Case Western Reserve School of Medicine, 1967
  • Internship, Medicine, Duke University Medical Center, 1968
  • Residency, Medicine, Cleve Metro Gen-Lutheran, 1969
  • Fellowship, Medicine, Dartmouth Medical School, 1972
  • Fellowship, Hepatology, Yale University School of Medi, 1974

Board Certifications

  • American Board of Internal Medicine, Gastroenterology
  • American Board of Internal Medicine, Internal Medicine

NPI Number

  • 1821093592
Herbert Lloyd Bonkovsky, M.D.

Doctor Rating

4.5 out of 5

69 Ratings

Herbert Lloyd Bonkovsky, M.D.

Professor, Gastroenterology

Research Interests

Hepatitis C, Chronic; Liver; Iron; Antiviral Agents; Hepacivirus
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Contact Information

Department: 336-713-7777

Recent Publications

Drug-induced liver injury. Devarbhavi H, Bonkovsky HL, Russo M, Calasani N. In: Sanyal AJ, Boyer TD, Lindor KD, Terrault NA, eds. Zakim and Boyer's hepatology: a textbook of liver disease. 7th ed. Philadelphia (PA): Elsevier;2018: 844-90.e17.

Is liver transplantation for intractable attacks of porphyria a viable treatment in a developing country? [reply to letter]. Wang B, Balwani M, Bonkovsky HL, Anderson KE, Bloomer JR, Bissell DM, Phillips JD, Desnick RJ.. Hepatology. 2018;67(2):803-804.

Candidate biomarkers for the diagnosis and prognosis of drug-induced liver injury: an international collaborative effort. Church RJ, Kullak-Ublick GA, Aubrecht J, Bonkovsky HL, Chalasani N, Fontana RJ, Goepfert JC, Hackman F, King NMP, Kirby S, Kirby P, Marcinak J, Ormarsdottir S, Schomaker SJ, Schuppe-Koistinen I, Wolenski F, Arber N, Merz M, Sauer JM,.. Hepatology. 2018;():.

Peripheral neuropathy and the ceruloplasmin gene. Hines MC Jr, Bonkovsky HL, Rudnick SR, Mhoon JT.. Ann Intern Med. 2018;168(12):894-895.

Profiles of miRNAs in serum in severe acute drug induced liver injury and their prognostic significance. Russo MW, Steuerwald N, Norton HJ, Anderson WE, Foureau D, Chalasani N, Fontana RJ, Watkins PB, Serrano J, Bonkovsky HL.. Liver Int. 2017;37(5):757-764.

Clinical presentations and outcomes of bile duct loss caused by drugs and herbal and dietary supplements. Bonkovsky HL, Kleiner DE, Gu J, Odin JA, Russo MW, Navarro VM, Fontana RJ, Ghabril MS, Barnhart H, Hoofnagle JH.. Hepatology. 2017;65(4):1267-1277.

Development of a modified lymphocyte transformation test for diagnosing drug-induced liver injury associated with an adaptive immune response. Whritenour J, Ko M, Zong Q, Wang J, Tartaro K, Schneider P, Olson E, Van Volkenburg M, Serrano J, Hayashi P, Fontana R, Chalasani N, Bonkovsky HL.. J Immunotoxicol. 2017;14(1):31-38.

BMP4 promotes metastasis of hepatocellular carcinoma by an induction of epithelial-mesenchymal transition via upregulating ID2. Zeng S, Zhang Y, Ma J, Deng G, Qu Y, Guo C, Han Y, Yin L, Cai C, Li Y, Wang G, Bonkovsky HL, Shen H.. Cancer Lett. 2017;390():67-76.

Associations of gender and a proxy of female menopausal status with histological features of drug-induced liver injury. Suzuki A, Barnhart H, Gu J, Bonkovsky HL, Tillmann HL, Fontana RJ, Kleiner DE.. Liver Int. 2017;37(11):1723-1730.

Acute hepatic porphyrias: recommendations for evaluation and long term management. Balwani M, Wang B, Anderson KE, Bloomer JR, Bissell DM, Bonkovsky HL, Phillips JD, Desnick RJ.. Hepatology. 2017;66(4):1314-1322.

Clinical, biochemical, and genetic characterization of North American patients with erythropoietic protoporphyria and X-linked protoporphyria. Balwani M, Naik H, Anderson KE, Bissell DM, Bloomer J, Bonkovsky HL, Phillips JD, Overbey JR, Wang B, Singal AK, Liu LU, Desnick RJ.. JAMA Dermatol. 2017;153(8):789-796.

Porphyria. Bissell DM, Anderson KE, Bonkovsky HL.. N Engl J Med. 2017;377(9):862-872.

miR-122 inhibition in a human liver spheroid model leads to liver inflammation, necrosis, steatofibrosis and dysregulated insulin signaling [abstract]. Sendi H, Wan MM, Koch K, Atala A, Bonkovsky HL, Bishop CE.. Hepatology. 2017;66(Suppl 1):1044A.

Phase 1, randomized, placebo controlled study of givosiran, an investigational RNA interference (RNAi) therapeutic, in patients with acute intermittent porphyria: interim study results [abstract]. Sardh E, Harper P, Balwani M, Stein P, Rees D, Bloomer JR, Bissell DM, Desnick RJ, Parker C, Phillips J, Bonkovsky HL, Al-Tawil N, Penz C, Chan A, Soh CH, Querbes W, Simon A, Rock S, Anderson KE.. Hepatology. 2017;66(Suppl 1):427A.

Candidate liver safety biomarkers provide prognostic and mechanistic insights in patients with drug-induced liver injury [abstract]. Church RJ, Kullak-Ublick GA, Kleiner DE, Bonkovsky HL, Chalasani NP, Fontana RJ, Goepfert JC, Knorpp T, Schindler T, Schomaker S, Schuppe-Koisten I, Merz M, Watkins PB.. Hepatology. 2017;66(Suppl 1):24A-25A.

BMP4 promotes oxaliplatin resistance by an induction of epithelial-mesenchymal transition via MEK1/ERK/ELK1 signaling in hepatocellular carcinoma. Ma J, Zeng S, Zhang Y, Deng G, Qu Y, Guo C, Yin L, Han Y, Cai C, Li Y, Wang G, Bonkovsky HL, Shen H.. Cancer Lett. 2017;411():117-129.

EXPLORE: a prospective, multinational natural history study of patients with acute hepatic porphyria (AHP) with recurrent attacks [abstract]. Gouya L, Bloomer JR, Balwani M, Bissell DM, Rees D, Stolzel U, Phillips J, Kaupinnen R, Langendonk J, Desnick RJ, Deybach JC, Bonkovsky HL, Parker C, Naik H, Badminton M, Stein P, Minder E, Windyga J, Martasek P, Cappellini M, Ventura P,.. Hepatology. 2017;66(Suppl 1):443A.

Porphyria [reply to letter]. Bissell DM, Anderson KE, Bonkovsky HL.. N Engl J Med. 2017;377(21):2101.

Hepatotoxicity associated with the use of anti-TNF-alpha agents. French JB, Bonacini M, Ghabril M, Foureau D, Bonkovsky HL.. Drug Saf. 2016;39(3):199-208.

Amoxicillin-clavulanate-induced liver Injury. deLemos AS, Ghabril M, Rockey DC, Gu J, Barnhart HX, Fontana RJ, Kleiner DE, Bonkovsky HL.. Dig Dis Sci. 2016;61(8):2406-2416.

Genetic factors that affect nonalcoholic fatty liver disease: a systematic clinical review. Severson TJ, Besur S, Bonkovsky HL.. World J Gastroenterol. 2016;22(29):6742-6756.

EXPLORE: a prospective, multinational natural history study of acute hepatic porphyria patients with recurrent attacks [abstract]. Anderson KE, Balwani M, Ventura P, Ivanova A, Bloomer JR, Bissell DM, Stolzel U, Parker C, Rees D, Stein P, Windyga J, Kaupinnen R, Langendonk J, Badminton M, Minder E, Martasek P, Alegre F, Cappellini M, Bonkovsky HL, Sandberg S, Aarsand AK,.. Hepatology. 2016;64(1 Suppl):285A.

Advances in the management of erythropoietic protoporphyria - role of afamelanotide. Lane AM, McKay JT, Bonkovsky HL.. Appl Clin Genet. 2016;9():179-189.

Febuxostat-induced acute liver injury. Bohm M, Vuppalanchi R, Chalasani N, Bonkovsky HL, et al.. Hepatology. 2016;63(3):1047-1049.

On stress and the liver: a chicken and egg conundrum [editorial]. Bonkovsky HL.. Gastroenterology. 2015;148(5):894-897.

Comparative analysis of portal hepatic infiltrating leucocytes in acute drug-induced liver injury, idiopathic autoimmune and viral hepatitis. Foureau DM, Walling TL, Maddukuri V, Anderson W, Culbreath K, Kleiner DE, Ahrens WA, Jacobs C, Watkins PB, Fontana RJ, Chalasani N, Talwalkar J, Lee WM, Stolz A, Serrano J, Bonkovsky HL.. Clin Exp Immunol. 2015;180(1):40-51.

Herbal dietary supplement associated hepatotoxicity: an upcoming workshop and need for research [commentary]. Vuppalanchi R, Navarro V, Vega M, Bonkovsky HL, Seeff L, Serrano J.. Gastroenterology. 2015;148(3):480-482.

Acute porphyrias. Besur S, Schmeltzer P, Bonkovsky HL.. J Emerg Med. 2015;49(3):305-312.

Afamelanotide for erythropoietic protoporphyria. Langendonk JG, Balwani M, Anderson KE, Bonkovsky HL, Anstey AV, Bissell DM, Bloomer J, Edwards C, Neumann NJ, Parker C, Phillips JD, Lim HW, Hamzavi I, Deybach JC, Kauppinen R, Rhodes LE, Frank J, Murphy GM, Karstens FP,.. N Engl J Med. 2015;373(1):48-59.

Leukocyte expression of heme oxygenase-1 [hmox1] varies inversely with severity of tricuspid regurgitation in acute pulmonary embolism. Kline JA, Steuerwald NM, Watts JA, Courtney M, Bonkovsky HL.. Thromb Res. 2015;136(4):769-774.

Relation of pre-anthracycline serum bilirubin levels to left ventricular ejection fraction after chemotherapy. Vera T, D'Agostino RB Jr, Jordan JH, Whitlock MC, Melendez GC, Lamar ZS, Porosnicu M, Bonkovsky HL, Poole LB, Hundley WG.. Am J Cardiol. 2015;116(11):1752-1755.

Pitfalls in erythrocyte protoporphyrin measurement for diagnosis and monitoring of protoporphyrias. Gou EW, Balwani M, Bissell DM, Bloomer JR, Bonkovsky HL, Desnick RJ, Naik H, Phillips JD, Singal AK, Wang B, Keel S, Anderson KE.. Clin Chem. 2015;61(12):1453-1456.

Recent insights into the biological functions of liver fatty acid binding protein 1. Wang G, Bonkovsky HL, de Lemos A, Burczynski FJ.. J Lipid Res. 2015;56(12):2238-2247.

The clinical-pathological spectrum and outcomes of liver injury due to drugs and botanicals associated with loss of bile ducts [abstract]. Bonkovsky HL, Kleiner DE, Gu JZ, Odin JA, Russo MW, Navarro VJ, Vega M, Hoofnagle JH.. Hepatology. 2015;62(Suppl 1):505A.

Pitfalls in erythrocyte protoporphyrin measurement for diagnosis and monitoring of protoporphyrias [abstract]. Gou E, Balwani M, Bissell DM, Bloomer JR, Bonkovsky HL, Desnick RJ, Phillips JD, Singal A, Wang BM, Naik H, Anderson KE.. Hepatology. 2015;62(Suppl 1):.

Variation in erythrocyte and plasma protoporphyrin levels over time in protoporphyrias [abstract]. Gou E, Weng C, Phillips JD, Greene T, Balwani M, Bissell DM, Bloomer JR, Bonkovsky HL, Desnick RJ, Naik H, Sadagoparamanujam VM, Anderson KE.. Hepatology. 2015;62(Suppl 1):1237A.

Pre-treatment levels of miR-29b are associated with response to treatment and stage of fibrosis in patients with chronic hepatitis C [CHC] [abstract]. Sendi H, Mehrab-Mohseni M, Russo MW, Zamor PJ, Schmeltzer PA, Steuerwald N, Parsons J, Clemens MG, Kaplan K, Jacobs WC, Ahrens WA, Bonkovsky HL.. Hepatology. 2015;62(Suppl 1):709A.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Gastroenterology

Clinical Interests

Hepatology, Porphyria, Drug-Induced Liver Injury
Herbert Lloyd Bonkovsky, M.D.

Herbert Lloyd Bonkovsky, M.D.

Professor, Gastroenterology

Doctor Rating

4.5 out of 5

Herbert Lloyd Bonkovsky, M.D.69 Ratings


Doctor Ratings

The overall Patient Rating score is the average of responses to the nine questions listed below. The questions are from the Press Ganey Patient Satisfaction Survey. Responses are measured on a 1 to 5 scale, where 1 represents "very poor" and 5 represents "very good."
Press Ganey Patient Satisfaction Survey

CP concern for questions/worries
CP efforts to include in decisions
CP explanations of prob/condition
CP spoke using clear language
Friendliness/courtesy of CP
Likelihood of recommending CP
Patients' confidence in CP
Time CP spent with patient
Wait time at clinic

Patient Comments

Comments are taken from the Care Provider section of the Press Ganey Patient Satisfaction Survey. Comments are posted exactly as they are written. Comments are added weekly. To protect patient privacy and confidentiality, patient names are not included.


Doctor and his assistant were very thorough and asked a lot of questions and took time in examining me.


Great specialist! very friendly and easy to get along with. makes going to the doctor a lot easier


Was prescribed a Rx which I could not afford?




Very good doctor.





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