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Gregory L. Burke, M.D.Wake Forest School of Medicine

Gregory L. Burke, M.D.

Shared Resource Director,

Contact Information

Department: 336-716-2930


Media Medical Expert »

Education & Training

  • B.A., University of Northern Iowa, 1977
  • M.D., University of Iowa College of Medicine, 1981
  • M.S., University of Iowa, 1983
  • Fellowship, University of Iowa College of, 1983


  • Am Soc of Preventiv Cardiology
  • American Epidemiologic Society
  • Am Heart Association
Gregory L. Burke, M.D.

Gregory L. Burke, M.D.

Shared Resource Director, Translational Science Institute
Professor, Translational Science Institute
Public Health Sciences

Research Interests

Atherosclerosis; Ethnic Groups; Cardiovascular Diseases; Coronary Artery Disease; Calcinosis
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Contact Information

Department: 336-716-2930


Media Medical Expert »

Recent Publications

Prognostic significance of large airway dimensions on computed tomography in the general population: the Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study. Oelsner EC, Smith BM, Hoffman EA, Kalhan R, Donohue KM, Kaufman JD, Nguyen JN, Manichaikul AW, Rotter JI, Michos ED, Jacobs DR Jr, Burke GL, Folsom AR, Schwartz JE, Watson K, Barr RG.. Ann Am Thorac Soc. 2018;15(6):718-727.

Contribution of the in-vehicle microenvironment to individual ambient-source nitrogen dioxide exposure: the Multi-Ethnic Study of Atherosclerosis and Air Pollution. Hazlehurst MF, Spalt EW, Nicholas TP, Curl CL, Davey ME, Burke GL, Watson KE, Vedal S, Kaufman JD.. J Expo Sci Environ Epidemiol. 2018;():.

Ten-year association of coronary artery calcium with atherosclerotic cardiovascular disease (ASCVD) events: the Multi-Ethnic Study of Atherosclerosis (MESA). Budoff MJ, Young R, Burke G, Jeffrey Carr J, Detrano RC, Folsom AR, Kronmal R, Lima JAC, Liu KJ, McClelland RL, Michos E, Post WS, Shea S, Watson KE, Wong ND.. Eur Heart J. 2018;():.

Association of sickle cell trait with ischemic stroke among African Americans: a meta-analysis. Hyacinth HI, Carty CL, Seals SR, Irvin MR, Naik RP, Burke GL, Zakai NA, Wilson JG, Franceschini N, Winkler CA, David VA, Kopp JB, Judd SE, Adams RJ, Longstreth WT Jr, Egede L, Lackland DT, Taylor H, Manson JE, Howard V, Allison M, Gee BE,.. JAMA Neurol. 2018;():.

Metabolically healthy obesity, transition to metabolic syndrome, and cardiovascular risk. Mongraw-Chaffin M, Foster MC, Anderson CAM, Burke GL, Haq N, Kalyani RR, Ouyang P, Sibley CT, Tracy R, Woodward M, Vaidya D.. J Am Coll Cardiol. 2018;71(17):1857-1865.

Is self-rated health associated with ideal cardiovascular health? The Multi-Ethnic Study of Atherosclerosis. Osibogun O, Ogunmoroti O, Spatz ES, Burke GL, Michos ED.. Clin Cardiol. 2018;():.

Left ventricular shape predicts different types of cardiovascular events in the general population. Ambale-Venkatesh B, Yoneyama K, Sharma RK, Ohyama Y, Wu CO, Burke GL, Shea S, Gomes AS, Young AA, Bluemke DA, Lima JA.. Heart. 2017;103(7):499-507.

Associations of coffee, tea, and caffeine intake with coronary artery calcification and cardiovascular events. Miller PE, Zhao D, Frazier-Wood AC, Michos ED, Averill M, Sandfort V, Burke GL, Polak JF, Lima JA, Post WS, Blumenthal RS, Guallar E, Martin SS.. Am J Med. 2017;130(2):188-197.e5.

Smoking intensity (pack/day) is a better measure than pack-years or smoking status for modeling cardiovascular disease outcomes. Nance R, Delaney J, McEvoy JW, Blaha MJ, Burke G, Navas-Acien A, Kaufman JD, Oelsner EC, McClelland RL.. J Clin Epidemiol. 2017;81():111-119.

Guideline-based statin/lipid-lowering therapy eligibility for primary prevention and accuracy of coronary artery calcium and clinical cardiovascular events: the Multi-Ethnic Study of Atherosclerosis (MESA). Flueckiger P, Qureshi W, Michos ED, Blaha M, Burke G, Sandfort V, Herrington D, Yeboah J.. Clin Cardiol. 2017;40(3):163-169.

Progression of carotid arterial stiffness with treatment of hypertension over 10 years: the Multi-Ethnic Study of Atherosclerosis. Gepner AD, Tedla Y, Colangelo LA, Tattersall MC, Korcarz CE, Kaufman JD, Liu K, Burke GL, Shea S, Greenland P, Stein JH.. Hypertension. 2017;69(1):87-95.

Sickle cell trait is not associated with an increased risk of heart failure or abnormalities of cardiac structure and function. Bello NA, Hyacinth HI, Roetker NS, Seals SR, Naik RP, Derebail VK, Kshirsagar AV, Key NS, Wilson JG, Correa A, Adams RJ, Egede LD, Longstreth W, Choudhary G, Gee BE, Hughes AL, Shah AM, Manson JE, Allison M, Burke GL, Folsom AR, Carty CL,.. Blood. 2017;129(6):799-801.

Integrating data from multiple time-location measurement methods for use in exposure assessment: the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). Hazlehurst MF, Spalt EW, Curl CL, Davey ME, Vedal S, Burke GL, Kaufman JD.. J Expo Sci Environ Epidemiol. 2017;27(6):569-574.

Use of the HEART Pathway with high sensitivity cardiac troponins: a secondary analysis. Mahler SA, Stopyra JP, Apple FS, Riley RF, Russell GB, Hiestand BC, Hoekstra JW, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Herrington DM, Burke GL, Miller CD.. Clin Biochem. 2017;50(7-8):401-407.

Association of cardiovascular health with subclinical disease and incident events: the Multi-Ethnic Study of Atherosclerosis. Polonsky TS, Ning H, Daviglus ML, Liu K, Burke GL, Cushman M, Eng J, Folsom AR, Lutsey PL, Nettleton JA, Post WS, Sacco RL, Szklo M, Lloyd-Jones DM.. J Am Heart Assoc. 2017;6(3):e004894.

Frequency of left ventricular end-diastolic volume-mediated declines in ejection fraction in patients receiving potentially cardiotoxic cancer treatment. Melendez GC, Sukpraphrute B, D'Agostino RB Jr, Jordan JH, Klepin HD, Ellis L, Lamar Z, Vasu S, Lesser G, Burke GL, Weaver KE, Ntim WO, Hundley WG.. Am J Cardiol. 2017;119(10):1637-1642.

Changes in metabolic risk factors over 10 years and their associations with late-life cognitive performance: the Multi-Ethnic Study of Atherosclerosis. Hughes TM, Craft S, Baker LD, Espeland MA, Rapp SR, Sink KM, Bertoni AG, Burke GL, Gottesman RF, Michos ED, Luchsinger JA, Fitzpatrick AL, Hayden KM.. Alzheimers Dement (Amst). 2017;8():18-25.

Cumulative number of treatment interventions predicts health-related quality of life in patients with critical limb ischemia. Corriere MA, Goldman MP, Barnard R, Saldana S, Stafford JM, Easterling D, Ip EH, Burke GL.. Ann Vasc Surg. 2017;44():41-47.

Associations of vitamin D-binding globulin and bioavailable vitamin D concentrations with coronary heart disease events: the Multi-Ethnic Study of Atherosclerosis (MESA). Robinson-Cohen C, Zelnick LR, Hoofnagle AN, Lutsey PL, Burke G, Michos ED, Shea SJC, Tracy R, Siscovick DS, Psaty B, Kestenbaum B, de Boer IH.. J Clin Endocrinol Metab. 2017;102(8):3075-3084.

Focus group study of questions, concerns, and treatment factors important to people with symptomatic peripheral artery disease: a roadmap for patient-centered care and communication [abstract]. Corriere MA, Keith D, Ip E, Burke G, Boone D Sr, Easterling D.. J Vasc Surg. 2017;65(6 Suppl):116S-117S.

Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis. Liu Y, Reynolds LM, Ding J, Hou L, Lohman K, Young T, Cui W, Huang Z, Grenier C, Wan M, Stunnenberg HG, Siscovick D, Hou L, Psaty BM, Rich SS, Rotter JI, Kaufman JD, Burke GL, Murphy S, Jacobs DR Jr, Post W, Hoeschele I, Bell DA, Herrington D,.. Nat Commun. 2017;8(1):393.

CT derived body fat distribution and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Mongraw-Chaffin ML, Allison MA, Burke GL, Criqui MH, Matsushita K, Ouyang P, Shah RV, Shay CM, Anderson CAM.. J Clin Endocrinol Metab. 2017;102(11):4173-4183.

Concordance with prevention guidelines and subsequent cancer, cardiovascular disease, and mortality: a longitudinal study of older adults. Greenlee H, Strizich G, Lovasi GS, Kaplan RC, Biggs ML, Li CI, Richardson J, Burke GL, Fitzpatrick AL, Fretts AM, Psaty BM, Fried LP.. Am J Epidemiol. 2017;186(10):1168-1179.

Rare exome sequence variants in CLCN6 reduce blood pressure levels and hypertension risk. Yu B, Pulit SL, Hwang SJ, Brody JA, Amin N, Auer PL, Bis JC, Boerwinkle E, Burke GL, Chakravarti A, Correa A, Dreisbach AW, Franco OH, Ehret GB, Franceschini N, Hofman A, Lin DY, Metcalf GA, Musani SK, Muzny D, Palmas W, Raffel L, Reiner A,.. Circ Cardiovasc Genet. 2016;9(1):64-70.

Adherence to an accelerated diagnostic protocol for chest pain: secondary analysis of the HEART Pathway randomized trial. Mahler SA, Riley RF, Russell GB, Hiestand BC, Hoekstra JW, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Bringolf J, Elliott SB, Herrington DM, Burke GL, Miller CD.. Acad Emerg Med. 2016;23(1):70-77.

Utility of nontraditional risk markers in atherosclerotic cardiovascular disease risk assessment. Yeboah J, Young R, McClelland RL, Delaney JC, Polonsky TS, Dawood FZ, Blaha MJ, Miedema MD, Sibley CT, Carr JJ, Burke GL, Goff DC Jr, Psaty BM, Greenland P, Herrington DM.. J Am Coll Cardiol. 2016;67(2):139-147.

HEART pathway accelerated diagnostic protocol implementation: prospective pre-post interrupted time series design and methods. Mahler SA, Burke GL, Duncan PW, Case LD, Herrington DM, Riley RF, Wells BJ, Hiestand BC, Miller CD.. JMIR Res Protoc. 2016;5(1):e10.

Role of coronary artery calcium score of zero and other negative risk markers for cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis (MESA). Blaha MJ, Cainzos-Achirica M, Greenland P, McEvoy JW, Blankstein R, Budoff MJ, Dardari Z, Sibley CT, Burke GL, Kronmal RA, Szklo M, Blumenthal RS, Nasir K.. Circulation. 2016;133(9):849-858.

Long-term coarse particulate matter exposure and heart rate variability in the Multi-Ethnic Study of Atherosclerosis. Adhikari R, D'Souza J, Soliman EZ, Burke GL, Daviglus M, Jacobs DR Jr, Park SK, Sheppard L, Thorne PS, Kaufman JD, Larson TV, Adar SD.. Epidemiology. 2016;27(3):405-413.

Incidence of age-related macular degeneration in a multi-ethnic United States population: the Multi-Ethnic Study of Atherosclerosis. Fisher DE, Klein BE, Wong TY, Rotter JI, Li X, Shrager S, Burke GL, Klein R, Cotch MF.. Ophthalmology. 2016;123(6):1297-1308.

Chest pain risk stratification: a comparison of the 2-hour accelerated diagnostic protocol (ADAPT) and the HEART Pathway. Stopyra JP, Miller CD, Hiestand BC, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Riley RF, Russell GB, Burke GL, Herrington D, Hoekstra JW, Mahler SA.. Crit Pathw Cardiol. 2016;15(2):46-49.

Association between air pollution and coronary artery calcification within six metropolitan areas in the USA (the Multi-Ethnic Study of Atherosclerosis and Air Pollution): a longitudinal cohort study. Kaufman JD, Adar SD, Barr RG, Budoff M, Burke GL, Curl CL, Daviglus ML, Roux AV, Gassett AJ, Jacobs DR Jr, Kronmal R, Larson TV, Navas-Acien A, Olives C, Sampson PD, Sheppard L, Siscovick DS, Stein JH, Szpiro AA, Watson KE.. Lancet. 2016;388(10045):696-704.

Physical activity, sedentary behaviors and the incidence of type 2 diabetes mellitus: the Multi-Ethnic Study of Atherosclerosis (MESA). Joseph JJ, Echouffo-Tcheugui JB, Golden SH, Chen H, Jenny NS, Carnethon MR, Jacobs D Jr, Burke GL, Vaidya D, Ouyang P, Bertoni AG.. BMJ Open Diabetes Res Care. 2016;4(1):e000185.

Impact of replacing the Pooled Cohort Equation with other cardiovascular disease risk scores on atherosclerotic cardiovascular disease risk assessment (from the Multi-Ethnic Study of Atherosclerosis [MESA]). Qureshi WT, Michos ED, Flueckiger P, Blaha M, Sandfort V, Herrington DM, Burke G, Yeboah J.. Am J Cardiol. 2016;118(5):691-696.

Anthracycline-associated T1 mapping characteristics are elevated independent of the presence of cardiovascular comorbidities in cancer survivors. Jordan JH, Vasu S, Morgan TM, D'Agostino RB Jr, Melendez GC, Hamilton CA, Arai AE, Liu S, Liu CY, Lima JA, Bluemke DA, Burke GL, Hundley WG.. Circ Cardiovasc Imaging. 2016;9(8):e004325.

Obesity severity and duration are associated with incident metabolic syndrome: evidence against metabolically healthy obesity from the Multi-Ethnic Study of Atherosclerosis. Mongraw-Chaffin M, Foster MC, Kalyani RR, Vaidya D, Burke GL, Woodward M, Anderson CA.. J Clin Endocrinol Metab. 2016;101(11):4117-4124.

The association of calcium supplementation and incident cardiovascular events in the Multi-Ethnic Study of Atherosclerosis (MESA). Raffield LM, Agarwal S, Hsu FC, de Boer IH, Ix JH, Siscovick D, Szklo M, Burke GL, Frazier-Wood AC, Herrington DM.. Nutr Metab Cardiovasc Dis. 2016;26(10):899-907.

Calcium intake from diet and supplements and the risk of coronary artery calcification and its progression among older adults: 10-year follow-up of the Multi-Ethnic Study of Atherosclerosis (MESA). Anderson JJ, Kruszka B, Delaney JA, He K, Burke GL, Alonso A, Bild DE, Budoff M, Michos ED.. J Am Heart Assoc. 2016;5(10):e003815.

The Multiethnic Study of Atherosclerosis [editorial]. Burke G, Lima J, Wong ND, Narula J.. Glob Heart. 2016;11(3):267-268.

Legacy of MESA. Olson JL, Bild DE, Kronmal RA, Burke GL.. Glob Heart. 2016;11(3):269-274.

Secondhand smoke exposure and subclinical cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Jones MR, Magid HS, Al-Rifai M, McEvoy JW, Kaufman JD, Hinckley Stukovsky KD, Szklo M, Polak J, Burke GL, Post WS, Blaha MJ, Navas-Acien A.. J Am Heart Assoc. 2016;5(12):e002965.

Calcium intake and 10 year risk of incident coronary artery calcification in the Multi-Ethnic Study of Atherosclerosis [abstract]. Kruszka B, He K, Delaney JA, Burke GL, Alonso A, Bild D, Budoff MJ, Michos ED, Anderson JJB.. Pharmacoepidemiol Drug Saf. 2016;25(Suppl 3):256-257.

New statin use and left ventricular structure: estimating long-term associationsin the Multi-Ethnic Study of Atherosclerosis (MESA) [abstract]. Strand LN, Young RL, Delaney JA, Bertoni AG, Bluemke DA, Burke GL, Lima JA, Sotoodehnia N, Psaty BM, Heckbert SR, McClelland RL.. Pharmacoepidemiol Drug Saf. 2016;25(Suppl 3):568-569.

Heart failure risk prediction in the Multi-Ethnic Study of Atherosclerosis. Chahal H, Bluemke DA, Wu CO, McClelland R, Liu K, Shea SJ, Burke G, Balfour P, Herrington D, Shi P, Post W, Olson J, Watson KE, Folsom AR, Lima JA.. Heart. 2015;101(1):58-64.

American Heart Association Cardiovascular Genome-Phenome Study: foundational basis and program. Benjamin I, Brown N, Burke G, Correa A, Houser SR, Jones DW, Loscalzo J, Vasan RS, Whitman GR.. Circulation. 2015;131(1):100-112.

Determinants of discrepancies in detection and comparison of the prognostic significance of left ventricular hypertrophy by electrocardiogram and cardiac magnetic resonance imaging. Bacharova L, Chen H, Estes EH, Mateasik A, Bluemke DA, Lima JA, Burke GL, Soliman EZ.. Am J Cardiol. 2015;115(4):515-522.

Comparison of coronary artery calcium presence, carotid plaque presence, and carotid intima-media thickness for cardiovascular disease prediction in the Multi-Ethnic Study of Atherosclerosis. Gepner AD, Young R, Delaney JA, Tattersall MC, Blaha MJ, Post WS, Gottesman RF, Kronmal R, Budoff MJ, Burke GL, Folsom AR, Liu K, Kaufman J, Stein JH.. Circ Cardiovasc Imaging. 2015;8(1):e002262.

Postoperative blood urea nitrogen is associated with stroke in cardiac surgical patients. Arnan MK, Hsieh TC, Yeboah J, Bertoni AG, Burke GL, Bahrainwala Z, Grega MA, Baumgartner WA, Gottesman RF.. Ann Thorac Surg. 2015;99(4):1314-1320.

The HEART pathway randomized trial: identifying emergency department patients with acute chest pain for early discharge. Mahler SA, Riley RF, Hiestand BC, Russell GB, Hoekstra JW, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Elliott SB, Herrington DM, Burke GL, Miller CD.. Circ Cardiovasc Qual Outcomes. 2015;8(2):195-203.

Implications of the new American College of Cardiology/American Heart Association cholesterol guidelines for primary atherosclerotic cardiovascular disease event prevention in a multi ethnic cohort: Multi-Ethnic Study of Atherosclerosis (MESA). Yeboah J, Sillau S, Delaney JC, Blaha MJ, Michos ED, Young R, Qureshi WT, McClelland R, Burke GL, Psaty BM, Herrington DM.. Am Heart J. 2015;169(3):387-395.e3.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Gregory L. Burke, M.D.

Gregory L. Burke, M.D.

Shared Resource Director, Translational Science Institute
Professor, Translational Science Institute
Public Health Sciences

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