Substrate specificity and membrane topologies of the iron-containing omega3 and omega6 desaturases from Mortierella alpina. Wang M, Chen H, Ailati A, Chen W, Chilton FH, Todd Lowther W, Chen YQ.. Appl Microbiol Biotechnol. 2018;102(1):211-223.
Tissue-specific impact of FADS cluster variants on FADS1 and FADS2 gene expression. Reynolds LM, Howard TD, Ruczinski I, Kanchan K, Seeds MC, Mathias RA, Chilton FH.. PLoS One. 2018;13(3):e0194610.
Allele-specific methylation in the FADS genomic region in DNA from human saliva, CD4+ cells, and total leukocytes. Rahbar E, Waits CMK, Kirby EH Jr, Miller LR, Ainsworth HC, Cui T, Sergeant S, Howard TD, Langefeld CD, Chilton FH.. Clin Epigenetics. 2018;10():46.
Compositions and methods for epigenetic regulation of long chain polyunsaturated fatty acid production. Chilton FH, Howard TD, inventors; Wake Forest University Health Sciences, assignee.. United States patent US 9,663,824. 2017 May 30. 2017;():.
Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster. Rahbar E, Ainsworth HC, Howard TD, Hawkins GA, Ruczinski I, Mathias R, Seeds MC, Sergeant S, Hixson JE, Herrington DM, Langefeld CD, Chilton FH.. PLoS One. 2017;12(9):e0180903.
Precision nutrition and omega-3 polyunsaturated fatty acids: a case for personalized supplementation approaches for the prevention and management of human diseases. Chilton FH, Dutta R, Reynolds LM, Sergeant S, Mathias RA, Seeds MC.. Nutrients. 2017;9(11):1165.
Alterations in levels and ratios of n-3 and n-6 polyunsaturated fatty acids in the temporal cortex and liver of vervet monkeys from birth to early adulthood. Miller LR, Jorgensen MJ, Kaplan JR, Seeds MC, Rahbar E, Morgan TM, Welborn A, Chilton SM, Gillis J, Hester A, Rukstalis M, Sergeant S, Chilton FH.. Physiol Behav. 2016;156():71-78.
Impact of methods used to express levels of circulating fatty acids on the degree and direction of associations with blood lipids in humans. Sergeant S, Ruczinski I, Ivester P, Lee TC, Morgan TM, Nicklas BJ, Mathias RA, Chilton FH.. Br J Nutr. 2016;115(2):251-261.
Gamma-linolenic acid, dihommo-gamma linolenic, eicosanoids and inflammatory processes. Sergeant S, Rahbar E, Chilton FH.. Eur J Pharmacol. 2016;785():77-86.
Impact of genetic and epigenetic variations within the FADS cluster on the composition and metabolism of polyunsaturated fatty acids in prostate cancer. Cui T, Hester AG, Seeds MC, Rahbar E, Howard TD, Sergeant S, Chilton FH.. Prostate. 2016;76(13):1182-1191.
DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver. Howard TD, Mathias RA, Seeds MC, Herrington DM, Hixson JE, Shimmin LC, Hawkins GA, Sellers M, Ainsworth HC, Sergeant S, Miller LR, Chilton FH.. PLoS One. 2014;9(5):e97510.
Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases. Chilton FH, Murphy RC, Wilson BA, Sergeant S, Ainsworth H, Seeds MC, Mathias RA.. Nutrients. 2014;6(5):1993-2022.
Genetic variants in the FADS gene: implications for dietary recommendations for fatty acid intake. Mathias RA, Pani V, Chilton FH.. Curr Nutr Rep. 2014;3(2):139-148.
Relationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans. Hester AG, Murphy RC, Uhlson CJ, Ivester P, Lee TC, Sergeant S, Miller LR, Howard TD, Mathias RA, Chilton FH.. J Biol Chem. 2014;289(32):22482-89.
LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma. Kazani S, Arm JP, Boyce J, Chhay H, Dutile S, Wechsler ME, Govindarajulu U, Ivester P, Ainsworth HC, Sergeant S, Chilton FH, Israel E.. Springerplus. 2014;3():661.
The impact of polyunsaturated fatty acid-based dietary supplements on disease biomarkers in a metabolic syndrome/diabetes population. Lee TC, Ivester P, Hester AG, Sergeant S, Case LD, Morgan T, Kouba EO, Chilton FH.. Lipids Health Dis. 2014;13(1):196.
DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver [abstract]. Chilton F, Mathias R, Seeds M, Herrington D, Hixson J, Hawkins G, Sergeant S, Miller L, Howard T.. FASEB J. 2014;28(1 Suppl):373.8.
Compositions, methods, and kits for polyunsaturated fatty acids from microalgae. Chilton F, Lu F, inventors; Wake Forest University Health Sciences, assignee.. United States patent US 8,343,753. 2013 Jan 1. 2013;():.
Stearidonic and gamma-linolenic acids in echium oil improves glucose disposal in insulin resistant monkeys. Kavanagh K, Flynn DM, Jenkins KA, Wilson MD, Chilton FH.. Prostaglandins Leukot Essent Fatty Acids. 2013;89(1):39-45.
Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics. Arm JP, Boyce JA, Wang L, Chhay H, Zahid M, Patil V, Govindarajulu U, Ivester P, Weaver KL, Sergeant S, Israel E, Chilton FH.. Lipids Health Dis. 2013;12():141.
Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome. Sergeant S, Hugenschmidt CE, Rudock ME, Ziegler JT, Ivester P, Ainsworth HC, Vaidya D, Case LD, Langefeld CD, Freedman BI, Bowden DW, Mathias RA, Chilton FH.. Br J Nutr. 2012;107(4):547-555.
Adaptive evolution of the FADS gene cluster within Africa. Mathias RA, Fu W, Akey JM, Ainsworth HC, Torgerson DG, Ruczinski I, Sergeant S, Barnes KC, Chilton FH.. PLoS One. 2012;7(9):e44926.
Botanical oil supplementation alters insulin levels in diabetic/metabolic syndrome subjects in a genotypic-specific manner [abstract]. Sergeant S, Lee TC, Ivester P, Ainsworth HC, Case LD, Chilton FH.. FASEB J. 2012;26(Meeting Abstracts Suppl):647.11.
Racial differences in plasma omega-3 long chain fatty acid levels in a cohort of African Americans and European Americans with diabetes and metabolic syndrome [abstract]. Wilson BA, Sergeant S, Ainsworth H, Mathias R, Chilton FH III.. FASEB J. 2012;26(Meeting Abstracts Suppl):266.4.
Dietary fish oil modestly attenuates the effect of age on diastolic function but has no effect on memory or brain inflammation in aged rats. Sergeant S, McQuail JA, Riddle DR, Chilton FH, Ortmeier SB, Jessup JA, Groban L, Nicolle MM.. J Gerontol A Biol Sci Med Sci. 2011;66(5):521-533.
The impact of FADS genetic variants on omega-6 polyunsaturated fatty acid metabolism in African Americans. Mathias RA, Sergeant S, Hugenschmidt CE, Ziegler JT, Ivester P, Case D, Freedman BI, Rudock ME, Langefeld CD, Bowden DW, Chilton FH, et al.. BMC Genet. 2011;12():article 50.
Depression and altered serum lipids in cynomolgus monkeys consuming a Western diet. Chilton FH, Lee TC, Willard SL, Ivester P, Sergeant S, Register TC, Shively CA.. Physiol Behav. 2011;104(2):222-227.
FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population. Mathias RA, Vergara C, Gao L, Rafaels N, Hand T, Campbell M, Bickel C, Ivester P, Sergeant, Chilton FH, et al.. J Lipid Res. 2010;51(9):2766-2774.
Effect of a multifaceted, church-based wellness program on metabolic syndrome in 41 overweight or obese congregants. Ivester P, Sergeant S, Danhauer SC, Case LD, Lamb A, Chilton BG, Delar B, Hollingshead ML, Weaver KL, Chilton FH.. Prev Chronic Dis. 2010;7(4):A81.
Effect of dietary fatty acids on inflammatory gene expression in healthy humans. Weaver KL, Ivester P, Seeds M, Case LD, Arm JP, Chilton FH.. J Biol Chem. 2009;284(23):15400-7.
Regulation of arachidonate remodeling enzymes impacts eosinophil survival during allergic asthma. Seeds MC, Peachman KK, Bowton DL, Sivertson KL, Chilton FH.. Am J Respir Cell Mol Biol. 2009;41(3):358-366.
Nonpharmacologic treatment of dyslipidemia. Houston MC, Fazio S, Chilton FH, Wise DE, Jones KB, Barringer TA, Bramlet DA.. Prog Cardiovasc Dis. 2009;52(2):61-94.
. Chilton FH, Tucker L. In: The gene smart diet: the revolutionary eating plan that will rewrite your genetic destiny--and melt away the pounds. Emmaus (PA): Rodale;2009: .
Technologies and experimental approaches at the National Institutes of Health Botanical Research Centers. Barnes S, Birt DF, Cassileth BR, Cefalu WT, Chilton FH, Farnsworth NR, Raskin I, van Breemen RB, Weaver CM.. Am J Clin Nutr. 2008;87(2 Suppl):476S-480S.
Mechanisms by which botanical lipids affect inflammatory disorders. Chilton FH, Rudel LL, Parks JS, Arm JP, Seeds MC.. Am J Clin Nutr. 2008;87(2 Suppl):498S-503S.
The content of favorable and unfavorable polyunsaturated fatty acids found in commonly eaten fish. Weaver KL, Ivester P, Chilton JA, Wilson MD, Pandey P, Chilton FH.. J Am Diet Assoc. 2008;108(7):1178-1185.
Concerning PUFA in fish [reply to letter]. Chilton FH.. J Am Diet Assoc. 2008;108(11):1831-1832.
Regarding favorable and unfavorable PUFA in fish [letter]. Chilton FH.. J Am Diet Assoc. 2008;108(10):1614, 1616.
Altering in vivo levels of n-6 and n-3 fatty acids in humans modulates the expression of inflammatory genes [abstract]. Weaver KL, Ivester P, Chilton F.. FASEB J. 2007;21(5):A61.
Arachidonic acid-induced gene expression in colon cancer cells. Monjazeb AM, High KP, Connoy A, Hart LS, Koumenis C, Chilton FH.. Carcinogenesis. 2006;27(10):1950-1960.
Dietary control of arachidonic acid metabolism. Chilton F, inventor; Wake Forest University Health Sciences, assignee.. United States patent US 7,138,431. 2006 Nov 21. 2006;():.
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