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J. Mark Cline, D.V.M., Ph.D.Wake Forest School of Medicine

J. Mark Cline, D.V.M., Ph.D.


Ctr for Vaccines at Extremes
Office of Research

Contact Information

Academic: 336-716-1564 | Department: 336-716-2011


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Education & Training

  • B.S., North Carolina State University, 1982
  • D.V.M., North Carolina State University, 1986
  • Ph.D., North Carolina State University, 1992
  • Internship, Pathology - Anatomic, New York State College Veterna, 1987
  • Residency, Pathology - Anatomic, New York State College Veterna, 1988


  • Am Assn Of Cancer Research
  • Radiation Research Society
  • Soc for Toxicologic Pathology
  • Veterinary Cancer Society
  • Am Coll Of Veterinary Patholog
  • Am Veterinary Medical Assn
  • DVM Foun Adv of Vet & Com Path
J. Mark Cline, D.V.M., Ph.D.

J. Mark Cline, D.V.M., Ph.D.

Professor, Pathology-Comparative Medicine
Center for Genomics and Personalized Medicine Research
Office of Women in Medicine and Science
Ctr for Vaccines at Extremes
Office of Research
Radiation Oncology

Research Interests

Mammary Glands, Animal; Whole-Body Irradiation; Soybean Proteins; Macaca mulatta; Macaca fascicularis
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Contact Information

Academic: 336-716-1564 | Department: 336-716-2011


Media Medical Expert »

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Recent Publications

Whole thorax irradiation of non-human primates induces persistent nuclear damage and gene expression changes in peripheral blood cells. Ghandhi SA, Turner HC, Shuryak I, Dugan GO, Bourland JD, Olson JD, Tooze JA, Morton SR, Batinic-Haberle I, Cline JM, Amundson SA.. PLoS One. 2018;13(1):e0191402.

The Apathy in Dementia Methylphenidate Trial 2 (ADMET 2): study protocol for a randomized controlled trial. Scherer RW, Drye L, Mintzer J, Lanctot K, Rosenberg P, Herrmann N, Padala P, Brawman-Mintzer O, Burke W, Craft S, Lerner AJ, Levey A, Porsteinsson A, van Dyck CH, Baker LD, Williamson JD, Bell RA, Espeland M, Miller ME, Mott RT, Rapp S, Hayden K,.. Trials. 2018;19(1):46.

Post-irradiation treatment with a superoxide dismutase mimic, MnTnHex-2-PyP5+, mitigates radiation injury in the lungs of non-human primates after whole-thorax exposure to ionizing radiation. Cline JM, Dugan G, Bourland JD, Perry DL, Stitzel JD, Weaver AA, Jiang C, Tovmasyan A, Owzar K, Spasojevic I, Batinic-Haberle I, Vujaskovic Z.. Antioxidants (Basel). 2018;7(3):E40.

Labyrinthitis ossificans in a cynomolgus macaque (Macaca fascicularis). Balamayooran G, Atkins HM, Whitlow CT, Aycock ST, Nader MA, Cline JM, Caudell DL.. Comp Med. 2018;():.

IL-1 beta stimulates BDNF in human endometriosis stromal cells: model for neuroangiogenesis [abstract]. Yu J, Francisco AMC, Patel BG, Zou E, Cline JM, Berga SL, Taylor RN.. Reprod Sci. 2018;25(Suppl 1):93A.

Cortical thinning and structural bone changes in non-human primates after single-fraction whole-chest irradiation. Farris M, McTyre ER, Okoukoni C, Dugan G, Johnson BJ, Blackstock AW, Munley MT, Bourland JD, Cline JM, Willey JS.. Radiat Res. 2018;():.

Cerebrovascular remodeling and neuroinflammation is a late effect of radiation-induced brain injury in non-human primates. Andrews RN, Metheny-Barlow LJ, Peiffer AM, Hanbury DB, Tooze JA, Bourland JD, Hampson RE, Deadwyler SA, Cline JM.. Radiat Res. 2017;187(5):599-611.

Changes in microvascular density differentiate metabolic health outcomes in monkeys with prior radiation exposure and subsequent skeletal muscle ECM remodeling. Fanning KM, Pfisterer B, Davis AT, Presley TD, Williams IM, Wasserman DH, Cline JM, Kavanagh K.. Am J Physiol Regul Integr Comp Physiol. 2017;313(3):R290-R297.

Mammary gland cell culture of Macaca fascicularis as a reservoir for stem cells. Mariya S, Dewi FNA, Suparto IH, Wilkerson GK, Cline JM, Permanawati, Iskandriati D, Budiarsa IN, Sajuthi D.. Hayati J Biosci. 2017;24(3):136-141.

Effects of pubertal exposure to dietary soy on estrogen receptor activity in the breast of cynomolgus macaques. Dewi FN, Wood CE, Willson CJ, Register TC, Lees CJ, Howard TD, Huang Z, Murphy SK, Tooze JA, Chou JW, Miller LD, Cline JM.. Cancer Prev Res (Phila Pa). 2016;9(5):385-395.

Decidualization of endometriosis in macaques. Atkins HM, Lombardini ED, Caudell DL, Appt SE, Dubois A, Cline JM.. Vet Pathol. 2016;53(6):1252-1258.

Late effects of total-body gamma irradiation on cardiac structure and function in male rhesus macaques. DeBo RJ, Lees CJ, Dugan GO, Caudell DL, Michalson KT, Hanbury DB, Kavanagh K, Cline JM, Register TC.. Radiat Res. 2016;186(1):55-64.

The aging vervet as a model of Alzheimer's disease [abstract]. Latimer C, Kaplan J, Shively C, Cline J, Andrews R, Jorgensen M, Craft S, Montine T, Keene C.. J Neuropathol Exp Neurol. 2016;75(6):604.

Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys. Kiguchi N, Ding H, Peters CM, Kock ND, Kishioka S, Cline JM, Wagner JD, Ko MC.. Biochim Biophys Acta. 2016;1863(1):274-283.

Long-term cognitive functioning in single-dose total-body gamma-irradiated Rhesus monkeys ( Macaca mulatta ). Hanbury DB, Peiffer AM, Dugan G, Andrews RN, Cline JM.. Radiat Res. 2016;186(5):447-454.

Skeletal muscle perfusion protects against diabetes in nonhuman primate model of accelerated aging [abstract]. Fanning K, Pfisterer B, Davis AT, Cline M [sic] [Cline JM], Kavanagh K, Wasserman DS, Presley T.. Gerontologist. 2016;56(Suppl 3):.

Assessment of multiplate platelet aggregometry using citrate, heparin or hirudin in rhesus macaques. Dugan G, O'Donnell L, Hanbury DB, Cline JM, Caudell DL.. Platelets. 2015;26(8):730-735.

DMP1beta, a splice isoform of the tumour suppressor DMP1 locus, induces proliferation and progression of breast cancer. Maglic D, Stovall DB, Cline JM, Fry EA, Mallakin A, Taneja P, Caudell DL, Willingham MC, Sui G, Inoue K.. J Pathol. 2015;236(1):90-102.

The dose-effect safety profile of skeletal muscle precursor cell therapy in a dog model of intrinsic urinary sphincter deficiency. Williams JK, Eckman D, Dean A, Moradi M, Allickson J, Cline JM, Yoo JJ, Atala A.. Stem Cells Transl Med. 2015;4(3):286-294.

Novel in vivo model for combinatorial fluorescence labeling in mouse prostate. Fang X, Gyabaah K, Nickkholgh B, Cline JM, Balaji KC.. Prostate. 2015;75(9):988-1000.

Type 2 diabetes is a delayed late effect of whole-body irradiation in nonhuman primates. Kavanagh K, Dendinger MD, Davis AT, Register TC, DeBo R, Dugan G, Cline JM.. Radiat Res. 2015;183(4):398-406.

Pathology of fractionated whole-brain irradiation in rhesus monkeys (Macaca mulatta). Hanbury DB, Robbins ME [deceased], Bourland JD, Wheeler KT, Peiffer AM, Mitchell EL, Daunais JB, Deadwyler SA, Cline JM.. Radiat Res. 2015;183(3):367-374.

Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques. DeBo RJ, Register TC, Caudell DL, Sempowski GD, Dugan G, Gray S, Owzar K, Jiang C, Bourland JD, Chao NJ, Cline JM.. Int J Radiat Biol. 2015;91(6):510-518.

Hormone receptor expression in spontaneous uterine adenocarcinoma in Fischer 344 rats. Willson CJ, Herbert RA, Cline JM.. Toxicol Pathol. 2015;43(6):865-871.

The placenta in toxicology. Part III: pathologic assessment of the placenta. Cline JM, Dixon D, Ernerudh J, Faas MM, Gohner C, Hager JD, Markert UR, Pfarrer C, Svensson-Arvelund J, Buse E.. Toxicol Pathol. 2014;42(2):339-344.

Tamoxifen-DNA adduct formation in monkey and human reproductive organs. Hernandez-Ramon EE, Sandoval NA, John K, Cline JM, Wood CE, Woodward RA, Poirier MC.. Carcinogenesis. 2014;35(5):1172-1176.

Targeted deletion of RasGRP1 impairs skin tumorigenesis. Sharma A, Fonseca LL, Rajani C, Yanagida JK, Endo Y, Cline JM, Stone JC, Ji J, Ramos JW, Lorenzo PS.. Carcinogenesis. 2014;35(5):1084-1091.

The placenta in toxicology. Part I: animal models in toxicology: placental morphology and tolerance molecules in the cynomolgus monkey (Macaca fascicularis). Buse E, Haeger JD, Svensson-Arvelund J, Markert UR, Faas MM, Ernerudh J, Dixon D, Cline JM, Pfarrer C.. Toxicol Pathol. 2014;42(2):314-326.

The placenta in toxicology. Part IV: battery of toxicological test systems based on human placenta. Gohner C, Svensson-Arvelund J, Pfarrer C, Hager JD, Faas M, Ernerudh J, Cline JM, Dixon D, Buse E, Markert UR.. Toxicol Pathol. 2014;42(2):345-351.

The placenta in toxicology. Part II: systemic and local immune adaptations in pregnancy. Svensson-Arvelund J, Ernerudh J, Buse E, Cline JM, Haeger JD, Dixon D, Markert UR, Pfarrer C, De Vos P, Faas MM.. Toxicol Pathol. 2014;42(2):327-338.

Angiogenesis gene expression across different life stages in non-human primates (Macaca fascicularis) in normal and cancerous mammary gland - an exploratory study [abstract]. Noser L, Cline JM, Chou J, Stute P.. Menopause. 2014;21(12):1339.

Xenotransplantation model of human Spermatogonial Stem Cells (SSCs) to cynomolgus monkeys' testes-a feasibility study [abstract]. Sadri-Ardekani H, Sohutskay D, Cline JM, Atala A.. Tissue Eng Part A. 2014;20(Suppl 1):S78.

Safety of skeletal muscle precursor cell therapy in a dog model of urethral sphincter deficiency [abstract]. Williams J, Eckman D, Dean A, Allikson J, Cline J, Yoo J, Atala A.. Tissue Eng Part A. 2014;20(Suppl 1):S18-S19.

Tumor targeting and pharmacodynamics of the novel targeted immunocytokine FAP-IL2v in a tumor-bearing Rhesus monkey [abstract]. Evers S, Garg PK, Cline JM, Garg S, Dugan G, Freimoser-Grundschober A, Keirstead ND, Klein C, Nayak T.. Cancer Res. 2014;74(19 Suppl):A2592.

Monkey see, monkey do: contagious itch in nonhuman primates. Feneran AN, O'Donnell R, Press A, Yosipovitch G, Cline M, Dugan G, Papoiu AD, Nattkemper LA, Chan YH, Shively CA.. Acta Derm Venereol. 2013;93(1):27-29.

17-beta estradiol reduces atherosclerosis without exacerbating lupus in ovariectomized systemic lupus erythematosus-susceptible LDLr(-/-) mice. Shelton KA, Cline JM, Cann JA.. Atherosclerosis. 2013;227(2):228-235.

Behavioral stress accelerates prostate cancer development in mice. Hassan S, Karpova Y, Baiz D, Yancey D, Pullikuth A, Flores A, Register T, Cline JM, D'Agostino R Jr, Danial N, Datta SR, Kulik G.. J Clin Invest. 2013;123(2):874-886.

Parity and expression of epithelial histopathologic markers in breast tissue. Morimoto Y, Killeen J, Hernandez BY, Cline JM, Maskarinec G.. Eur J Cancer Prev. 2013;22(5):404-408.

Endometrial profile of bazedoxifene acetate alone and in combination with conjugated equine estrogens in a primate model. Ethun KF, Wood CE, Cline JM, Register TC, Appt SE, Clarkson TB.. Menopause. 2013;20(7):777-784.

Dietary soy effects on mammary gland development during the pubertal transition in nonhuman primates. Dewi FN, Wood CE, Lees CJ, Willson CJ, Register TC, Tooze JA, Franke AA, Cline JM.. Cancer Prev Res (Phila Pa). 2013;6(8):832-842.

The effects of adenocaine (adenosine and lidocaine) on early post-resuscitation cardiac and neurological dysfunction in a porcine model of cardiac arrest. Granfeldt A, Shi W, Schmarkey SL, Jiang R, Bone CC, Cline JM, Wogensen L, Dobson GP, Tonnesen E, Vinten-Johansen J.. Resuscitation. 2013;84(11):1611-1618.

Do variations in mast cell hyperplasia account for differences in radiation-induced lung injury among different mouse strains, rats and nonhuman primates? [commentary]. Down JD, Medhora M, Jackson IL, Cline JM, Vujaskovic Z.. Radiat Res. 2013;180(2):216-221.

Glyceollin-elicited soy protein consumption induces distinct transcriptional effects as compared to standard soy protein. Wood CE, Boue SM, Collins-Burow BM, Rhodes LV, Register TC, Cline JM, Dewi FN, Burow ME.. J Agric Food Chem. 2012;60(1):81-86.

Monkey see, monkey do: contagious itch in nonhuman primates [abstract]. Feneran AN, O'Donnell R, Press A, Yosipovitch G, Cline M, Dugan G, Papoiu A, Nattkemper L, Chan Y, Shively CA.. J Invest Dermatol. 2012;132(Suppl 1):S39.

Effects of long-term tibolone treatment on nuclear sex steroid hormone receptors and G-protein-coupled estrogen receptor-1 expression in the macaque uterus. Hulchiy M, Zhang H, Cline JM, Hirschberg AL, Sahlin L.. Menopause. 2012;19(3):332-338.

Suppression of Tak1 promotes prostate tumorigenesis. Wu M, Shi L, Cimic A, Romero L, Sui G, Lees CJ, Cline JM, Seals DF, Sirintrapun JS, McCoy TP, Liu W, Kim JW, Hawkins GA, Peehl DM, Xu J, Cramer SD.. Cancer Res. 2012;72(11):2833-2843.

Urogenital system. Cline JM, Brignolo L, Ford EW. In: Abee CR, Mansfield K, Tardif S, Morris T, eds. Nonhuman primates in biomedical research: diseases, vol 2. 2nd ed. Boston: Elsevier/Academic Press;2012: 483-562.

Morinda citrifolia (noni) juice augments mammary gland differentiation and reduces mammary tumor growth in mice expressing the unactivated c-erbB2 transgene. Clafshenkel WP, King TL, Kotlarczyk MP, Cline JM, Foster WG, Davis VL, Witt-Enderby PA.. Evid Based Complement Alternat Med. 2012;2012():487423.

Life stage differences in mammary gland gene expression profile in non-human primates. Stute P, Sielker S, Wood CE, Register TC, Lees CJ, Dewi FN, Williams JK, Wagner JD, Stefenelli U, Cline JM.. Breast Cancer Res Treat. 2012;133(2):617-634.

Coronary artery vitamin D receptor expression and plasma concentrations of 25-hydroxyvitamin D: their association with atherosclerosis. Schnatz PF, Nudy M, O'Sullivan DM, Jiang X, Cline JM, Kaplan JR, Clarkson TB, Appt SE.. Menopause. 2012;19(9):967-973.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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