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Katherine Loree Cook, Ph.D.Wake Forest School of Medicine

Katherine Loree Cook, Ph.D.

Assistant Professor,

Contact Information

Department: 336-716-2234


Education & Training

  • B.S., SUNY-Oswego, 2006
  • Ph.D., WFU School of Medicine, 2010
  • Fellowship, Georgetown University, 2014


  • Am Assn Of Cancer Research
Katherine Loree Cook, Ph.D.

Katherine Loree Cook, Ph.D.

Assistant Professor, Hypertension

Research Interests

Autophagy; Breast Neoplasms; Heat-Shock Proteins; Drug Resistance, Neoplasm; Estrogen Receptor Modulators
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Contact Information

Department: 336-716-2234


Recent Publications

Mitochondrial autophagosomes as a mechanism of drug resistance in breast carcinoma. Abunimer AN, Mohammed H, Cook KL, Soto-Pantoja DR, Campos MM, Abu-Asab MS.. Ultrastruct Pathol. 2018;42(2):170-180.

Effects of in utero exposure to ethinyl estradiol on tamoxifen resistance and breast cancer recurrence in a preclinical model. Hilakivi-Clarke L, Warri A, Bouker KB, Zhang X, Cook KL, Jin L, Zwart A, Nguyen N, Hu R, Cruz MI, de Assis S, Wang X, Xuan J, Wang Y, Wehrenberg B, Clarke R.. J Natl Cancer Inst. 2017;109(1):.

Lifetime genistein intake increases the response of mammary tumors to tamoxifen in rats. Zhang X, Cook KL, Warri A, Cruz IM, Rosim M, Riskin J, Helferich W, Doerge D, Clarke R, Hilakivi-Clarke L.. Clin Cancer Res. 2017;23(3):814-824.

Targeting of the unfolded protein response signaling arms differentially regulates macrophage proliferation, plasticity, and breast cancer cell clearance [abstract]. Cook KL, Wilson A, Westwood B, Soto-Pantoja DR.. Cancer Res. 2017;77(Suppl 4):P2-04-06.

Silver nanoparticles exhibit subtype specific cytotoxic and therapeutic effects in claudin low breast cancer in vitro and in vivo [abstract]. Swanner JL, Tenvooren I, Bernish BW, Fahrenholtz CD, Vidi PA, Cook KL, Singh RN.. Cancer Res. 2017;77(Suppl 2):B47.

"UPRegulation" of CD47 by the endoplasmic reticulum stress pathway controls anti-tumor immune responses. Cook KL, Soto-Pantoja DR.. Biomark Res. 2017;5():26.

Unfolded protein response signaling impacts macrophage polarity to modulate breast cancer cell clearance and melanoma immune checkpoint therapy responsiveness. Soto-Pantoja DR, Wilson AS, Clear KY, Westwood B, Triozzi PL, Cook KL.. Oncotarget. 2017;8(46):80545-59.

Leptin signaling disrupts tight junctions in the mammary gland [abstract]. Tenvooren I, Jenks M, Cook KL, Wang K, Bonin K, Seewaldt V, Lelievre SA, Vidi P.. Mol Biol Cell. 2017;28():P2318.

UPR signaling promotes T-cell dysfunction to prevent immune-mediated cancer cell killing and immune checkpoint therapy resistance [abstract]. Feliz-Mosquea YR, Soto-Pantoja DR, Wilson A, Triozzi PL, Cook KL.. Cancer Res. 2017;77(13 Suppl):1704.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S,.. Autophagy. 2016;12(1):1-222.

Social isolation induces autophagy in the mouse mammary gland: link to increased mammary cancer risk. Sumis A, Cook KL, Andrade FO, Hu R, Kidney E, Zhang X, Kim D, Carney E, Nguyen N, Yu W, Bouker KB, Cruz I, Clarke R, Hilakivi-Clarke L.. Endocr Relat Cancer. 2016;23(10):839-856.

Endoplasmic reticulum stress protein GRP78 modulates lipid metabolism to control drug sensitivity and antitumor immunity in breast cancer. Cook KL, Soto-Pantoja DR, Clarke PA, Cruz MI, Zwart A, Warri A, Hilakivi-Clarke L, Roberts DD, Clarke R.. Cancer Res. 2016;76(19):5657-5670.

Autophagy as a mediator of increased mammary cancer risk in socially isolated mice [abstract]. Hilakivi-Clarke LA, Andrade FO, Sumis A, Bouker KB, Hu R, Clarke R, Cook KL.. Cancer Res. 2016;76(14 Suppl):1027.

Heterozygous ATG7 inhibition enhances endocrine therapy responsiveness through regulation of damage associated molecular patterns and priming the immune system in ER+ breast tumors [abstract]. Clarke R, Clarke PAG, Warri A, Cook KL.. Cancer Res. 2016;76(14 Suppl):904.

Overcoming cancer resistance [foreword]. Cook KL, Clarke R.. Future Med Chem. 2015;7(12):1471.

Role of GRP78 in promoting therapeutic-resistant breast cancer. Cook KL, Clarke R.. Future Med Chem. 2015;7(12):1529-1534.

Unfolding the role of stress response signaling in endocrine resistant breast cancers. Clarke R, Cook KL.. Front Oncol. 2015;5():140.

Linking autophagy with inflammation through IRF1 signaling in ER+ breast cancer. Cook KL, Schwartz-Roberts JL, Baumann WT, Clarke R.. Mol Cell Oncol. 2015;3(1):e1023928.

Angiotensin peptides and lung cancer. Gallagher PE, Cook K, Soto-Pantoja D, Menon J, Tallant EA.. Curr Cancer Drug Targets. 2011;11(4):394-404.

Angiotensin-(1-7) reduces fibrosis in orthotopic breast tumors. Cook KL, Metheny-Barlow LJ, Tallant EA, Gallagher PE.. Cancer Res. 2010;70(21):8319-8328.

Angiotensin-(1-7) inhibition of human breast tumors with distinct hormone receptor expression results in a differential regulation of AKT [abstract]. Cook KL, Soto PD, Gallagher P, Tallant EA.. Cancer Res. 2009;69(2 Suppl):240S.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Hypertension

Katherine Loree Cook, Ph.D.

Katherine Loree Cook, Ph.D.

Assistant Professor, Hypertension

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