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Daniel Clark Files, M.D.Wake Forest School of Medicine

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Daniel Clark Files, M.D.

Associate Professor,

Clinical Interests

Pulmonary Diseases, Critical Care

Contact Information

Department: 336-716-2011

Insurance Accepted »

Education & Training

  • B.S., University of the South, 1999
  • M.D., University of Mississippi School of Medicine, 2003
  • Internship, Internal Medicine, Vanderbilt Univ Medical Center, 2004
  • Residency, Internal Medicine, Vanderbilt Univ Medical Center, 2006
  • Residency, Internal Medicine, Vanderbilt Univ Medical Center, 2007
  • Fellowship, Internal Medicine, Johns Hopkins University Schoo, 2011

Board Certifications

  • American Board of Internal Medicine, Critical Care Medicine
  • American Board of Internal Medicine, Pulmonary Disease


  • American Thoracic Society

NPI Number

  • 1376690248
Daniel Clark Files, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

Daniel Clark Files, M.D.

Associate Professor, Pulmonary, Critical Care, Allergy, and Immunologic Medicine
Center on Diabetes, Obesity, and Metabolism
Gerontology and Geriatric Medicine

Research Interests

Acute Lung Injury; Endocarditis; Injections; Muscular Atrophy; Muscle Proteins
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Contact Information

Academic: 336-713-7516 | Department: 336-716-2011

Recent Publications

Influence of prehospital function and strength on outcomes of critically ill older adults. Files DC, Neiberg R, Rushing J, Morris PE, Young MP, Ayonayon H, Harris T, Newman A, Rubin S, Shiroma E, Houston D, Miller ME, Kritchevsky SB.. J Am Geriatr Soc. 2018;66(3):525-531.

Physical function impairment in survivors of critical illness in an ICU Recovery Clinic. Bakhru RN, Davidson JF, Bookstaver RE, Kenes MT, Welborn KG, Morris PE, Clark Files D.. J Crit Care. 2018;45():163-169.

Liberal versus restrictive intravenous fluid therapy for early septic shock: rationale for a randomized trial. Self WH, Semler MW, Bellomo R, Brown SM, deBoisblanc BP, Exline MC, Ginde AA, Grissom CK, Janz DR, Jones AE, Liu KD, Macdonald SPJ, Miller CD, Park PK, Reineck LA, Rice TW, Steingrub JS, Talmor D, Yealy DM, Douglas IS, Shapiro NI, Files DC, et al.. Ann Emerg Med. 2018;():.

BDA-410 treatment reduces body weight and fat content by enhancing lipolysis in sedentary senescent mice. Pereyra AS, Wang ZM, Messi ML, Zhang T, Wu H, Register TC, Forbes E, Devarie-Baez NO, Files DC, Abba MC, Furdui C, Delbono O.. J Gerontol A Biol Sci Med Sci. 2017;72(8):1045-1053.

Angioedema. LoVerde D, Files DC, Krishnaswamy G.. Crit Care Med. 2017;45(4):725-735.

Cardiac troponin T and fast skeletal muscle denervation in ageing. Xu Z, Feng X, Dong J, Wang ZM, Lee J, Furdui C, Files DC, Beavers KM, Kritchevsky S, Milligan C, Jin JP, Delbono O, Zhang T.. J Cachexia Sarcopenia Muscle. 2017;8(5):808-823.

Effect of ganciclovir on IL-6 levels among cytomegalovirus-seropositive adults with critical illness: a randomized clinical trial. Limaye AP, Stapleton RD, Peng L, Gunn SR, Kimball LE, Hyzy R, Exline MC, Files DC, Morris PE, Frankel SK, Mikkelsen ME, Hite D, Enfield KB, Steingrub J, O'Brien J, Parsons PE, Cuschieri J, Wunderink RG, Hotchkin DL, Chen YQ, Rubenfeld GD, Boeckh M.. JAMA. 2017;318(8):731-740.

Too weak to breathe: an odd case of Lambert Eaton myasthenic syndrome [abstract]. Brehm C, Barrios C, Caress J, Files D, LoVerde D.. Chest. 2017;152(4 Suppl):277A.

Monitoring activity levels in ICU survivors with accelerometers [abstract]. Gandotra S, Bakhru R, Shields K, Berry M, Files D.. Chest. 2017;152(4 Suppl):394A.

Intramyocellular lipid and impaired myofiber contraction in normal weight and obese older adults. Choi SJ, Files DC, Zhang T, Wang ZM, Messi ML, Gregory H, Stone J, Lyles MF, Dhar S, Marsh AP, Nicklas BJ, Delbono O.. J Gerontol A Biol Sci Med Sci. 2016;71(4):557-564.

Decision conflict and regret among surrogate decision makers in the medical intensive care unit. Miller JJ, Morris P, Files DC, Gower E, Young M.. J Crit Care. 2016;32():79-84.

Enhanced resolution of experimental ARDS through IL-4-mediated lung macrophage reprogramming. D'Alessio FR, Craig JM, Singer BD, Files DC, Mock JR, Garibaldi BT, Fallica J, Tripathi A, Mandke P, Gans JH, Limjunyawong N, Sidhaye VK, Heller NM, Mitzner W, King LS, Aggarwal NR.. Am J Physiol Lung Cell Mol Physiol. 2016;310(8):L733-L746.

Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice. Zhang T, Pereyra AS, Wang ZM, Birbrair A, Reisz JA, Files DC, Purcell L, Feng X, Messi ML, Feng H, Chalovich J, Jin JP, Furdui C, Delbono O.. Aging Cell. 2016;15(3):488-498.

Standardized rehabilitation and hospital length of stay among patients with acute respiratory failure: a randomized clinical trial. Morris PE, Berry MJ, Files DC, Thompson JC, Hauser J, Flores L, Dhar S, Chmelo E, Lovato J, Case LD, Bakhru RN, Sarwal A, Parry SM, Campbell P, Mote A, Winkelman C, Hite RD, Nicklas B, Chatterjee A, Young MP.. JAMA. 2016;315(24):2694-2702.

Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism. Files DC, Ilaiwy A, Parry TL, Gibbs KW, Liu C, Bain JR, Delbono O, Muehlbauer MJ, Willis, MS.. Metabolomics. 2016;12(8):134.

Opiate injection-associated infective endocarditis in the southeastern United States. Hartman L, Barnes E, Bachmann L, Schafer K, Lovato J, Files DC.. Am J Med Sci. 2016;352(6):603-608.

Medication reconciliation in an Icu recovery clinic [abstract]. Bookstaver R, Griffin K, Davidson JF, Morris P, Files DC, Guest C, Bakhru RN.. Am J Respir Crit Care Med. 2016;193():A1825.

Failed recovery of muscle function in aged mice with lung injury is linked to specific metabolic alterations by non-targeted metabolomics in vivo [abstract]. Files DC, Haiwy A, Liu C, Parry T, Bain J, Muehlbauer M, Willis MS.. Am J Respir Crit Care Med. 2016;193():A7929.

Application of a practice assessment tool for rehabilitation of critically ill patients [abstract]. Ellison JT, Schweickert WD, Kellner K, Mirafuente B, Morris P, Files DC, Bakhru RN.. Am J Respir Crit Care Med. 2016;193():A1160.

Implementation of formal multidisciplinary rounds in a medical intensive care unit [abstract]. Hwalek TE, Schweickert WD, Dixon L, Butcher W, Strickland JE, Bishop J, Young M, Files DC, Morris P, Bakhru RN.. Am J Respir Crit Care Med. 2016;193():A4701.

Safety, feasibility, and cellular recovery of serial bronchoscopic alveolar lavage in patients with ards in the modern era [abstract]. Koch A, Sanchez M, Flores L, Thompson C, Purcell L, Gibbs K, Bakhru RN, Morris P, Files DC.. Am J Respir Crit Care Med. 2016;193():A1796.

Inducing muscle heat shock protein 70 improves insulin sensitivity and muscular performance in aged mice. Silverstein MG, Ordanes D, Wylie AT, Files DC, Milligan C, Presley TD, Kavanagh K.. J Gerontol A Biol Sci Med Sci. 2015;70(7):800-808.

Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting. Files DC, Liu C, Pereyra A, Wang ZM, Aggarwal NR, D'Alessio FR, Garibaldi BT, Mock JR, Singer BD, Feng X, Yammani RR, Zhang T, Lee AL, Philpott S, Lussier S, Purcell L, Chou J, Seeds M, King LS, Morris PE, Delbono O.. Sci Transl Med. 2015;7(278):278ra32.

A conceptual framework: the early and late phases of skeletal muscle dysfunction in the acute respiratory distress syndrome. Files DC, Sanchez MA, Morris PE.. Crit Care. 2015;19():266.

Pre-hospital physical function and hospital outcomes in critically ill older adults [abstract]. Files DC, Rushing J, Harris TB, Morris P, Newman AB, Young M, Miller ME, Kritchevsky SB.. Gerontologist. 2015;55(Suppl 2):342.

The design and implementation of a MICU survivors' clinic: a fellow's journey starting from square one [abstract]. Davidson J, Files DC, Bakhru RN, Griffin K, Morris PE.. Am J Respir Crit Care Med. 2015;191():A4499.

Randomization to rosuvastatin is associated with neuromyopathy in patients with ards [abstract]. Hough CL, Ney JP, Miller RR, Rice TW, Caldwell ES, Rock P, Gundel SA, Robinson LR, Bunnell AE, Files DC, Morris PE, Needham DM.. Am J Respir Crit Care Med. 2015;191():A2281.

Use of hospice in place in medical intensive care unit patients [abstract]. Morris PE, Bakhru RN, Files DC, Young M, Dhar S, Lovato J, Flores L, Futrell W, Govert J, Cox CE.. Am J Respir Crit Care Med. 2015;191():A5222.

Feasibility of fall risk assessments within acute respiratory failure survivors with the falls efficacy scale-international [abstract]. Parry SM, Bakhru RN, Files DC, Dhar S, Young MT, Flores L, Lovato J, Hauser J, Chmelo FA, Mote P, Thompson C, Campbell P, Denehy L, Case L, Berry MJ, Morris PE.. Am J Respir Crit Care Med. 2015;191():A4495.

Cardiac and skeletal muscle dysfunction in an aging mouse model of acute lung injury [abstract]. Sanchez MA, Liu C, Varagic J, Morris PE, Files DC.. Am J Respir Crit Care Med. 2015;191():A2054.

The posterior cricoarytenoid muscle is spared from MuRF1-mediated muscle atrophy in mice with acute lung injury. Files DC, Xiao K, Zhang T, Liu C, Qian J, Zhao W, Morris PE, Delbono O, Feng X.. PLoS One. 2014;9(1):e87587.

Foxp3+ regulatory T cells promote lung epithelial proliferation. Mock JR, Garibaldi BT, Aggarwal NR, Jenkins J, Limjunyawong N, Singer BD, Chau E, Rabold R, Files DC, Sidhaye V, Mitzner W, Wagner EM, King LS, D'Alessio FR.. Mucosal Immunol. 2014;7(6):1440-1451.

Skeletal muscle ultrasound as a tool to assess muscle function [abstract]. Dhar S, Nicklas B, Lyles M, Morris P, Delbono O, Files DC.. Crit Care Med. 2014;42(12 Suppl 1):A1528.

RBC transfusion rates within mechanically ventilated, medical ICU shock patients requiring CRRT [abstract]. Young M, Bakhru R, Files DC, Dhar S, Flores L, Lovato J, Morris P.. Crit Care Med. 2014;42(12 Suppl 1):A1451.

Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner. Birbrair A, Zhang T, Files DC, Mannava S, Smith T, Wang ZM, Messi ML, Mintz A, Delbono O.. Stem Cell Res Ther. 2014;5(6):122.

Predicting acute lung injury resolution: a role for chest CT? [editorial]. Files DC, Hite RD.. Crit Care Med. 2013;41(2):668-669.

Macrophage A2A adenosinergic receptor modulates oxygen-induced augmentation of murine lung injury. Aggarwal NR, D'Alessio FR, Eto Y, Chau E, Avalos C, Waickman AT, Garibaldi BT, Mock JR, Files DC, Sidhaye V, Polotsky VY, Powell J, Horton M, King LS.. Am J Respir Crit Care Med. 2013;48(5):635-646.

Muscle ultrasound and short physical performance battery (SPPB) to predict ICU functional outcomes [abstract]. Dhar S, Sarwal A, Files DC, Berry M, Hauser J, Campbell P, Thompson C, Morris P.. Crit Care Med. 2013;41(12 Suppl 1):A89.

A critical role for muscle ring finger-1 in acute lung injury-associated skeletal muscle wasting. Files DC, D'Alessio FR, Johnston LF, Kesari P, Aggarwal NR, Garibaldi BT, Mock JR, Simmers JL, DeGorordo A, Murdoch J, Willis MS, Patterson C, Tankersley CG, Messi ML, Liu C, Delbono O, Furlow JD, Bodine SC, Cohn RD, King LS, Crow MT.. Am J Respir Crit Care Med. 2012;185(8):825-834.

A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension. Zaiman AL, Damico R, Thoms-Chesley A, Files DC, Kesari P, Johnston L, Swaim M, Mozammel S, Myers AC, Halushka M, El-Haddad H, Shimoda LA, Peng C-F, Hassoun PM, Champion HC, Kitsis RN, Crow MT.. Circulation. 2011;124(23):2533-2542.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Pulmonary, Critical Care, Allergy, and Immunologic Medicine

Clinical Interests

Pulmonary Diseases, Critical Care
Daniel Clark Files, M.D.
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