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Jason M. Grayson, Ph.D.Wake Forest School of Medicine

Jason M. Grayson, Ph.D.

Associate Professor,

Contact Information

Academic: 336-716-0268 | Department: 336-716-2011


Education & Training

  • B.S., University of Maryland-College Park, 1991
  • Ph.D., University of Texas Health Sci Center-Dallas, 1997
  • Fellowship, Immunology, Emory University, 2001
Jason M. Grayson, Ph.D.

Jason M. Grayson, Ph.D.

Associate Professor, Microbiology & Immunology

Research Interests

CD8-Positive T-Lymphocytes; Immunologic Memory; Lymphocytic choriomeningitis virus; Lymphocytic Choriomeningitis; Lymphocyte Activation
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Contact Information

Academic: 336-716-0268 | Department: 336-716-2011


Recent Publications

Human serum albumin-delivered [Au(PEt3)]+ is a potent inhibitor of T cell proliferation. Dean TC, Yang M, Liu M, Grayson JM, DeMartino AW, Day CS, Lee J, Furdui CM, Bierbach U.. ACS Med Chem Lett. 2017;8(5):572-576.

Unsupervised learning techniques reveal heterogeneity in memory CD8+ T cell differentiation following acute, chronic and latent viral infections. Liu M, Barton ES, Jennings RN, Oldenburg DG, Whirry JM, White DW, Grayson JM.. Virology. 2017;509():266-279.

Targeting T cell bioenergetics by modulating P-glycoprotein improves selectivity of phototherapy [abstract]. McIver ZA, Grayson J, Hill J, Schamerhorn GA, Ohulchanskyy TY, Linder MK, Davies KS, Weiner R, Detty MR.. Biol Blood Marrow Transplant. 2016;22(3 Suppl 1):S89-S90.

Selective photodepletion of malignant T cells in extracorporeal photopheresis with selenorhodamine photosensitizers. McIver ZA, Kryman MW, Choi Y, Coe BN, Schamerhorn GA, Linder MK, Davies KS, Hill JE, Sawada GA, Grayson JM, Detty MR.. Bioorg Med Chem. 2016;24(17):3918-3931.

Targeting T cell bioenergetics by modulating P-glycoprotein selectively depletes alloreactive T cells to prevent graft-versus-host disease. McIver ZA, Grayson JM, Coe BN, Hill JE, Schamerhorn GA, Ohulchanskyy TY, Linder MK, Davies KS, Weiner RS, Detty MR.. J Immunol. 2016;197(5):1631-1641.

Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease. Grieves JL, Fye JM, Harvey S, Grayson JM, Hollis T, Perrino FW.. Proc Natl Acad Sci U S A. 2015;112(16):5117-5122.

Au-ACRAMTU-PEt3 alters redox balance to inhibit T cell proliferation and function. Langston PK, Yang M, Bierbach U, Parsonage D, Poole LB, Price MJ, Grayson JM.. J Immunol. 2015;195(5):1984-1994.

P-glycoprotein modulation facilitates the selective inhibition of oxidative phosphorylation in alloreactive T cells to prevent graft-versus-host disease after hematopoietic stem cell transplant [abstract]. McIver ZA, Phipps JP, Grayson JM, Hill JE, Schamerhorn GA, Ohulchanskyy TY, Linder MK, Davies KS, Weiner RS, Detty MR.. Blood. 2015;126(23):1879.

Acute and chronic B cell depletion disrupts CD4+ and CD8+ T cell homeostasis and expansion during acute viral infection in mice. Lykken JM, DiLillo DJ, Weimer ET, Roser-Page S, Heise MT, Grayson JM, Weitzmann MN, Tedder TF.. J Immunol. 2014;193(2):746-756.

Gammaherpesvirus latency differentially impacts the generation of primary versus secondary memory CD8+T cells during subsequent infection. Barton ES, Rajkarnikar S, Langston PK, Price MJ, Grayson JM.. J Virol. 2014;88(21):12740-51.

Type I interferon signaling enhances CD8+ T cell effector function and differentiation during murine gammaherpesvirus 68 infection. Jennings RN, Grayson JM, Barton ES.. J Virol. 2014;88(24):14040-49.

Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis. Gorentla BK, Krishna S, Shin J, Inoue M, Shinohara ML, Grayson JM, Fukunaga R, Zhong XP.. J Immunol. 2013;190(3):1026-1037.

Antioxidant treatment regulates the humoral immune response during acute viral infection. Crump KE, Langston PK, Rajkarnikar S, Grayson JM.. J Virol. 2013;87(5):2577-2586.

Herpesvirus latency differentially impacts primary versus secondary memory T cell pools [abstract]. Grayson J, Jennings R, Rajkarnikar S, Barton E.. J Immunol. 2013;190():P6119.

Increased cell surface free thiols identify effector CD8+ T cells undergoing T cell receptor stimulation. Pellom ST, Michalek RD, Crump KE, Langston PK, Juneau DG, Grayson JM.. PLoS One. 2013;8(11):e81134.

Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases. Shin J, O'Brien TF, Grayson JM, Zhong X-P.. J Immunol. 2012;188(5):2111-2117.

Increased CD8+ T-cell function following castration and immunization is countered by parallel expansion of regulatory T cells. Tang S, Moore ML, Grayson JM, Dubey P.. Cancer Res. 2012;72(8):1975-1985.

Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infection. Amoah S, Yammani RD, Grayson JM, Alexander-Miller MA.. J Immunol. 2012;189(2):638-645.

The reversible formation of cysteine sulfenic acid promotes B-cell activation and proliferation. Crump KE, Juneau DG, Poole LB, Haas KM, Grayson JM.. Eur J Immunol. 2012;42(8):2152-2164.

Peroxiredoxin II regulates effector and secondary memory CD8+ T cell responses. Michalek RD, Crump KE, Weant AE, Hiltbold EM, Juneau DG, Moon EY, Yu DY, Poole LB, Grayson JM.. J Virol. 2012;86(24):13629-41.

Distinct responses of splenic dendritic cell subsets to infection with Listeria monocytogenes: maturation phenotype, level of infection, and T cell priming capacity ex vivo. Mitchell LM, Brzoza-Lewis KL, Henry CJ, Grayson JM, Westcott MM, Hiltbold EM.. Cell Immunol. 2011;268(2):79-86.

The role of reactive oxygen intermediates in B cell activiation and differentiation [abstract]. Crump K, Liu C, Konopitski A, Poole L, Haas K, Grayson J.. J Immunol. 2011;186(1 Meeting Abstracts):45.12.

Defects in apoptosis increase memory CD8+ T cells following infection of Bim-/-Faslpr/lpr mice. Weant AE, Michalek RD, Crump KE, Liu C, Konopitski AP, Grayson JM.. Cell Immunol. 2011;271(2):256-266.

The roles of IL-12 and IL-23 in CD8+ T cell-mediated immunity against Listeria monocytogenes: insights from a DC vaccination model. Henry CJ, Grayson JM, Brzoza-Lewis K, Mitchell LM, Westcott MM, Cook AS, Hiltbold EM.. Cell Immunol. 2010;264(1):23-31.

Apolipoprotein A-I modulates regulatory T cells in autoimmune LDLr-/-, ApoA-I-/- mice. Wilhelm AJ, Zabalawi M, Owen JS, Shah D, Grayson JM, Major AS, Bhat S, Gibbs DP Jr, Thomas MJ, Sorci-Thomas MG.. J Biol Chem. 2010;285(46):36158-69.

Apolipoprotein A-I improves the regulatory T-cell response in autoimmune LDLr-/-, ApoA-I-/- mice [abstract]. Wilhelm AJ, Zabalawi M, Grayson JM, Major AS, Owen JS, Bhat S, Gibbs DP, Thomas MJ, Sorci-Thomas MG.. Arterioscler Thromb Vasc Biol. 2010;30(11):e269.

The angiotensin II-AT1 receptor stimulates reactive oxygen species within the cell nucleus. Pendergrass KD, Gwathmey TM, Michalek RD, Grayson JM, Chappell MC.. Biochem Biophys Res Commun. 2009;384(2):149-154.

Apolipoprotein A-I and its role in lymphocyte cholesterol homeostasis and autoimmunity. Wilhelm AJ, Zabalawi M, Grayson JM, Weant AE, Major AS, Owen J, Bharadwaj M, Walzem R, Thomas MJ, Sorci-Thomas MG, et al.. Arterioscler Thromb Vasc Biol. 2009;29(6):843-849.

Apolipoprotein A-I: a common link between inflammation, atherosclerosis, and autoimmunity [abstract]. Wilhelm AJ, Zabalawi M, Grayson JM, Weant AE, Major AS, Owen JS, Thomas MJ, Sorci-Thomas MG.. Arterioscler Thromb Vasc Biol. 2009;29(7):e13.

Protein kinase C and PI3 kinase mediate Ang II-dependent generation of reactive oxygen species in renal nuclei [abstract]. Pendergrass KD, Gwathmey TYM, Grayson JM, Chappell MC.. FASEB J. 2009;23(1 Meeting Abstracts):803.7.

Apoptosis regulators Bim and Fas function concurrently to control autoimmunity and CD8+ T cell contraction. Weant AE, Michalek RD, Khan IU, Holbrook BC, Willingham MC, Grayson JM.. Immunity. 2008;28(2):218-230.

Absence of ApoA-I leads to dysregulation of lymph node immune cell cholesterol homeostasis and increased atherosclerosis in LDLr-/-, ApoA-I-/- mice [abstract]. Wilhelm AJ, Zabalawi M, Grayson J, Weant AE, Sorci-Thomas M.. Arterioscler Thromb Vasc Biol. 2008;28(6):e-65.

The requirement of reactive oxygen intermediates for lymphocytic choriomeningitis virus binding and growth. Michalek RD, Pellom ST, Holbrook BC, Grayson JM.. Virology. 2008;379(2):205-212.

Nuclear angiotensin II AT1 receptors mediate the formation of reactive oxygen species [abstract]. Pendergrass KD, Gwathmey TM, Michalek RD, Grayson JM, Chappell MC.. Hypertension. 2008;52(4):e48.

Normal establishment of virus-specific memory CD8 T cell pool following primary infection during pregnancy. Constantin CM, Masopust D, Gourley T, Grayson J, Strickland OL, Ahmed R, Bonney EA.. J Immunol. 2007;179(7):4383-4389.

The requirement of reversible cysteine sulfenic acid formation for T cell activation and function. Michalek RD, Nelson KJ, Holbrook BC, Yi JS, Stridiron D, Daniel LW, Fetrow JS, King SB, Poole LB, Grayson JM.. J Immunol. 2007;179(10):6456-6467.

Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-beta in primary pro-B cells. Gamero AM, Potla R, Wegrzyn J, Szelag M, Edling AE, Shimoda K, Link DC, Dulak J, Baker DP, Grayson JM, et al.. J Biol Chem. 2006;281(24):16238-44.

Electron transport complex I is required for CD8+ T cell function. Yi JS, Holbrook BC, Michalek RD, Laniewski NG, Grayson JM.. J Immunol. 2006;177(2):852-862.

Role of Bim in regulating CD8+ T-cell responses during chronic viral infection. Grayson JM, Weant AE, Holbrook BC, Hildeman D.. J Virol. 2006;80(17):8627-8638.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Microbiology & Immunology

Jason M. Grayson, Ph.D.

Jason M. Grayson, Ph.D.

Associate Professor, Microbiology & Immunology

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