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Leanne Groban, M.D.Wake Forest School of Medicine

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Leanne Groban, M.D.

Professor,

Clinical Interests

Cardiothoracic Anesthesia, Adult Cardiothoracic Anesthesia, Major Vascular Anesthesia, Myocardial Protection, Cardiac Aging, Diastolic Dysfunction

Contact Information

Email: lgroban@wakehealth.edu

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Education & Training

  • B.S., University of Wisconsin-Madison, 1982
  • M.S., University of Wisconsin-Milwaukee, 1988
  • M.D., Medical College of Wisconsin, 1992
  • Internship, Anesthesiology, St Luke's Hosp, 1993
  • Residency, Anesthesiology, NC Baptist Hospital, 1996
  • Fellowship, WFU School of Medicine, 1997

Board Certifications

  • American Board of Anesthesiology, Anesthesiology

Memberships

  • Alpha Omega Alpha

NPI Number

  • 1669457545
Leanne Groban, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

Leanne Groban, M.D.

Professor, Anesthesiology
Office of Women in Medicine and Science

Research Interests

Diastole; Myocardium; Receptors, G-Protein-Coupled; Estrogens; Ovariectomy
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Contact Information

Academic: 336-716-1187

Email: lgroban@wakehealth.edu

Recent Publications

Blunting of estrogen modulation of cardiac cellular chymase/RAS activity and function in SHR. Ahmad S, Sun X, Lin M, Varagic J, Zapata-Sudo G, Ferrario CM, Groban L, Wang H.. J Cell Physiol. 2018;233(4):3330-3342.

Self- vs proxy-reported mobility using the mobility assessment tool-short form in elderly preoperative patients. Kim S, Miller ME, Lin M, Rejeski WJ, Kritchevsky SB, Marsh AP, Groban L.. Eur Rev Aging Phys Act. 2018;15(5):.

G protein-coupled estrogen receptor (GPER) deficiency induces cardiac remodeling through oxidative stress. Wang H, Sun X, Lin MS, Ferrario CM, Van Remmen H, Groban L.. Transl Res. 2018;():.

Development of isolated diastolic dysfunction associated with early impairment in coronary blood flow in hypertensive diabetes [abstract]. Varagic J, Ahmad S, Ola M, VonCannon JL, Wright K, Ramirez SR, Wang H, Groban L, Cheng CP, Ferrario CM.. FASEB J. 2018;32(1 Suppl):903.5.

Cardioprotection induced by activation of GPER in ovariectomized rats with pulmonary hypertension. Alencar AKN, Montes GC, Costa DG, Mendes LVP, Silva AMS, Martinez ST, Trachez MM, Cunha VDMN, Montagnoli TL, Fraga AGM, Wang H, Groban L, Fraga CAM, Sudo RT, Zapata-Sudo G.. J Gerontol A Biol Sci Med Sci. 2018;():.

GPER agonist G1, but not other specific ERs improves diastolic function and attenuates cardiac RAS activation in estrogen-deficient SHR [abstract]. Groban L, da Silva J, Sun X, Ahmad S, Sudo R, Wang H, Ferrario C, Zapata-Sudo G.. FASEB J. 2018;32(1 Suppl):584.2.

The mitochondrial-targeted antioxidant MitoQ attenuates LV dysfunction and gene expression related to oxidative stress in cardiomyocyte-specific GPER KO female mice [abstract]. Groban L, Sun X, Ferrario CM, Wang H.. FASEB J. 2018;32(1 Suppl):618.20.

Knockdown of GPER in cardiomyocytes activates NLRP3 pathways [abstract]. Groban L, Wang H, Sun X, Ferrario CM.. FASEB J. 2018;32(1 Suppl):718.4.

. Groban L, Garner CR, eds.. In: Tee Pocket Manual. 2nd ed. Philadelphia (PA): Elsevier;2018: .

Self-reported mobility as a preoperative risk assessment tool in older surgical patients compared to the American College of Surgeons National Surgical Quality Improvement Program. Kim S, Neiberg R, Rejeski WJ, Marsh AP, Kritchevsky SB, Leng XI, Groban L.. Perioper Med (Lond). 2018;7():12.

Cardiovascular pharmacology. Royster RL, Butterworth JF IV, Groban L, Slaughter TF, Zvara DA. In: Kaplan JA, ed. Kaplan's essentials of cardiac anesthesia. 2nd ed. Philadelphia (PA): Elsevier;2018: 132-166.

Effect of age, estrogen status, and late-life GPER activation on cardiac structure and function in the Fischer344xBrown Norway female rat. Alencar AK, da Silva JS, Lin M, Silva AM, Sun X, Ferrario CM, Cheng C, Sudo RT, Zapata-Sudo G, Wang H, Groban L.. J Gerontol A Biol Sci Med Sci. 2017;72(2):152-162.

Cardiomyocyte-specific deletion of the G protein-coupled estrogen receptor (GPER) leads to left ventricular dysfunction and adverse remodeling: a sex-specific gene profiling analysis. Wang H, Sun X, Chou J, Lin M, Ferrario CM, Zapata-Sudo G, Groban L.. Biochim Biophys Acta. 2017;1863(8):1870-1882.

Novel cardiac intracrine mechanisms based on Ang-(1-12)/chymase axis require a revision of therapeutic approaches in human heart disease. Reyes S, Varagic J, Ahmad S, VonCannon J, Kon ND, Wang H, Groban L, Cheng CP, Dell'Italia LJ, Ferrario CM.. Curr Hypertens Rep. 2017;19(2):16.

Adenosine A2A receptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction. da Silva JS, Gabriel-Costa D, Sudo RT, Wang H, Groban L, Ferraz EB, Nascimento JH, Fraga CA, Barreiro EJ, Zapata-Sudo G.. Drug Des Devel Ther. 2017;11():553-562.

Cardiovascular pharmacology. Royster RL, Groban L, Locke AQ, Morris BN, Slaughter TF. In: Kaplan JA, Augoustides JGT, Manecke GR, Maus T Jr, Reich DL, eds. Kaplan's cardiac anesthesia: for cardiac and noncardiac surgery. 7th ed. Philadelphia (PA): Elsevier;2017: 292-354.

Long-term sertraline treatment and depression effects on carotid artery atherosclerosis in premenopausal female primates. Silverstein-Metzler MG, Justice JN, Appt SE, Groban L, Kitzman DW, Carr JJ, Register TC, Shively CA.. Menopause. 2017;24(10):1175-1184.

Pharmacological evaluation of the agonists of nuclear and G protein coupled estrogen receptors in arterial hypertension associated with estrogen depletion [abstract]. Zapata-Sudo G, Da Silva JS, Da Silva AM, Montagnoli TL, Wang H, Sun X, Groban L, Sudo RT.. Eur J Heart Fail. 2017;19(Suppl 1):340.

Activation of a new estrogen receptor (GPER) ameliorates cardiopulmonary dysfunction in female rats with pulmonary hypertension [abstract]. Zapata-Sudo G, De Alencar AKN, Da Silva AM, Montes GC, Montagnoli TL, Martinez S, Villarinho L, Cunha VN, Fraga A, Wang H, Groban L, Fraga CAM, Sudo RT.. Eur J Heart Fail. 2017;19(Suppl 1):519.

Blunting of cardioprotective actions of estrogen in female rodent heart linked to altered expression of cardiac tissue chymase and ACE2. da Silva JS, Gabriel-Costa D, Wang H, Ahmad S, Sun X, Varagic J, Sudo RT, Ferrario CM, Dell Italia LJ, Sudo GZ, Groban L.. J Renin Angiotensin Aldosterone Syst. 2017;18(3):.

Patient-reported outcome measures (PROM) as a preoperative assessment tool. Kim S, Duncan PW, Groban L, Segal H, Abbott RM, Williamson JD.. J Anesth Perioper Med. 2017;4(6):274-281.

Sex-related differences in age-associated alterations in expression and function of beta-adrenergic receptor subtypes in murine left ventricular myocytes [abstract]. Cheng HJ, Zhang Z, Chen Z, Zhou P, Kitzman D, Groban L, Cheng CP.. Circulation. 2017;136(Suppl 1):A15763.

Development and implementation of a tool to assess patient-reported outcome measures (PROM) in preoperative setting. Kim S, Duncan PW, Groban L, Segal H, Abbott RM, Williamson JD.. Glob J Perioper Med. 2017;1(1):17-21.

Cardiac angiotensin-(1-12) expression and systemic hypertension in rats expressing the human angiotensinogen gene. Ferrario CM, VonCannon JL, Jiao Y, Ahmad S, Bader M, Dell'Italia LJ, Groban L, Varagic J.. Am J Physiol Heart Circ Physiol. 2016;310(8):H995-H1002.

Mast cell inhibition attenuates cardiac remodeling and diastolic dysfunction in middle-aged, ovariectomized Fischer 344 x Brown Norway rats. Wang H, da Silva J, Alencar A, Zapata-Sudo G, Lin MS, Sun X, Ahmad S, Ferrario CM, Groban L.. J Cardiovasc Pharmacol. 2016;68(1):49-57.

Self-reported mobility in older patients predicts early postoperative outcomes after elective noncardiac surgery. Kim S, Marsh AP, Rustowicz L, Roach C, Leng XI, Kritchevsky SB, Rejeski WJ, Groban L.. Anesthesiology. 2016;124(4):815-825.

Activation of GPR30 improves exercise capacity and skeletal muscle strength in senescent female Fischer344 x Brown Norway rats. Wang H, Alencar A, Lin M, Sun X, Sudo RT, Zapata-Sudo G, Lowe DA, Groban L.. Biochem Biophys Res Commun. 2016;475(1):81-86.

Intracrine angiotensin II functions originate from noncanonical pathways in the human heart. Ferrario CM, Ahmad S, Varagic J, Cheng CP, Groban L, Wang H, Collawn JF, Dell'Italia LJ.. Am J Physiol Heart Circ Physiol. 2016;311(2):H404-H414.

Primacy of cardiac chymase over angiotensin converting enzyme as an angiotensin-(1-12) metabolizing enzyme. Ahmad S, Varagic J, VonCannon JL, Groban L, Collawn JF, Dell'Italia LJ, Ferrario CM.. Biochem Biophys Res Commun. 2016;478(2):559-564.

Activation of GPER ameliorates experimental pulmonary hypertension in male rats. Alencar AK, Montes GC, Montagnoli T, Silva AM, Martinez ST, Fraga AG, Wang H, Groban L, Sudo RT, Zapata-Sudo G.. Eur J Pharm Sci. 2016;97():208-217.

Inflammatory and mitochondrial gene expression data in GPER-deficient cardiomyocytes from male and female mice. Wang H, Sun X, Chou J, Lin M, Ferrario CM, Zapata-Sudo G, Groban L.. Data Brief. 2016;10():465-473.

Chronic GPER activation attenuates cardiac dysfunction in a male mouse model of progressive heart failure: insights into cellular mechanisms [abstract]. Zhang X, Li T, Wang H, Cheng H-J, Li W, Ferrario CM, Groban L, Cheng C-P.. Circulation. 2016;134(Suppl 1):A12559.

Altered cardiomyocyte inotropic response to chymase/Ang-(1-12) pathway activation in heart failure [abstract]. Li T, Zhang X, Ahmad S, Varagic J, Cheng H-J, Zhang Z, Groban L, Ferrario CM, Cheng C-P.. Circulation. 2016;134(Suppl 1):A12206.

Reversal of aging-induced upregulation of cardiac inducible nitric oxide synthase and beta-adrenergic desensitization in mice deficient in beta3-adrenoreceptor [abstract]. Cheng H-J, Zhou P, Li T, Zhang Z, Kitzman DW, Gorban L, Cheng C-P.. Circulation. 2016;134(Suppl 1):A14375.

Effects of ovarian estrogens on local RAS activity in cardiomyocytes and non-cardiomyocytes [abstract]. Sun X, Ahmad S, Lin M, Zapata-Sudo G, Cheng C-P, Varagic J, Ferrario C, Wang H, Groban L.. Hypertension. 2016;68(Suppl 1):AP283.

Diastolic dysfunction after estrogen loss is linked to cardiac chymase in WKY but not SHR rats [abstract]. Wang H, da Silva J, Gabriel-Costa D, Ahmad S, Sun X, Lin M, Sudo RT, Varagic J, Ferrario C, Zapata-Sudo G, Groban L.. Hypertension. 2016;68(Suppl 1):AP285.

Preoperative assessment of the older surgical patient: honing in on geriatric syndromes. Kim S, Brooks AK, Groban L.. Clin Interv Aging. 2015;10():13-27.

GPR30 decreases cardiac chymase/angiotensin II by inhibiting local mast cell number. Zhao Z, Wang H, Lin M, Groban L.. Biochem Biophys Res Commun. 2015;459(1):131-136.

Activation of GPR30 inhibits cardiac fibroblast proliferation. Wang H, Zhao Z, Lin M, Groban L.. Mol Cell Biochem. 2015;405(1-2):135-148.

Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue. Nagata S, Varagic J, Kon ND, Wang H, Groban L, Simington SW, Ahmad S, Dell'Italia LJ, VonCannon JL, Deal D, Ferrario CM.. Ther Adv Cardiovasc Dis. 2015;9(4):168-180.

Augmentation of autophagy by atorvastatin via Akt/mTOR pathway in spontaneously hypertensive rats. Wang W, Wang H, Geng QX, Wang HT, Miao W, Cheng B, Zhao D, Song GM, Leanne G, Zhao Z.. Hypertens Res. 2015;38(12):813-820.

Chronic activation of GPR30 attenuates diastolic dysfunction in oophorectomized senescent rats [abstract]. Groban L, Kardec A, Wang H, da Silva J, Lin MS, Sun X.. In: Abstracts of the 2015 Annual Meeting of the American Society of Anesthesiologists (ASA); 2015 Oct 24-28; San Diego (CA). 2015;():A1265.

Mast cell inhibition attenuates cardiac remodeling and diastolic dysfunction in ovariectomized BNF344 female rats [abstract]. Groban L, Wang H, da Silva J, Kardec A, Lin MS, Sun X.. In: Abstracts of the 2015 Annual Meeting of the American Society of Anesthesiologists (ASA); 2015 Oct 24-28; San Diego (CA). 2015;():A1273.

Anatomic and physiopathologic changes affecting the airway of the elderly patient: implications for geriatric-focused airway management. Johnson KN, Botros DB, Groban L, Bryan YF.. Clin Interv Aging. 2015;10():1925-1934.

Functional significance of the chymase/ang-(1-12) pathway on cardiomyocytes [abstract]. Zhang X, Li T, Ahmad S, Varagic J, Groban L, Dell'Italia LJ, Cheng C-P, Ferrario CM.. Hypertension. 2015;66(Suppl 1):A078.

Distinct profiles of brain medullary metabolites detected by 1H-magnetic resonance spectroscopy correlate with indices of autonomic function and visceral fat in healthy adults [abstract]. Diz DI, Olson J, Bourland JD, Kitzman D, Carr JJ, Kritchevsky SB, Groban L, Shaltout HA.. Hypertension. 2015;66(Suppl 1):AP149.

Late-life activation of GPR30 by G1 reverses diastolic dysfunction in senescent BNF344 female rats [abstract]. Kardec A, Wang H, da Silva J, Lin M, Sun X, Groban L.. Gerontologist. 2015;55(Suppl 2):68.

How well does the NSQIP surgical calculator predict early adverse outcomes in older non-cardiac surgical patients with self-reported limitations in mobility? [abstract]. Harris C, Kim S, Groban L.. Gerontologist. 2015;55(Suppl 2):192.

GPR30 activation improves exercise capacity and skeletal muscle function in senescent female F344BN rats [abstract]. Wang H, Kardec A, Lin M, Sun X, Groban L.. Gerontologist. 2015;55(Suppl 2):105.

Late-life activation of GPR30 by G1 reverses diastolic dysfunction in senescent Fischer344 x Brown Norway female rats [abstract]. Alencar A, Wang H, de Silva J, Lin M, Sun XM, Groban L.. Circ Res. 2015;117(Suppl 1):A351.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Anesthesiology

Clinical Interests

Cardiothoracic Anesthesia, Adult Cardiothoracic Anesthesia, Major Vascular Anesthesia, Myocardial Protection, Cardiac Aging, Diastolic Dysfunction

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