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David M. Herrington, M.D.Wake Forest School of Medicine

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David M. Herrington, M.D.

Professor,


Clinical Interests

Heart Disease in Women, Cardiac Catheterization, Cardiology (clinical), Preventive and Rehabilitative Cardiology

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New Patient Appointments: 336-716-WAKE
Returning Patient Appointments: 336-716-6674
Department: 336-716-9124

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Education & Training

  • B.S., Davidson College, 1979
  • M.D., University of North Carolina School of Medicine, 1983
  • M.H.S., Johns Hopkins University, 1989
  • Internship, Internal Medicine, Johns Hopkins Affil Hosps, 1984
  • Residency, Internal Medicine, Johns Hopkins Affil Hosps, 1986
  • Fellowship, Johns Hopkins Affil Hosps, 1988
  • Fellowship, Johns Hopkins Affil Hosps, 1990

Board Certifications

  • American Board of Internal Medicine, Cardiovascular Disease
  • American Board of Internal Medicine, Internal Medicine

Memberships

  • American College of Cardiology
  • Am Coll Of Physicians
  • Am Gerontological Society
  • Aha - Council On Epidemiology

NPI Number

  • 1932184215
David M. Herrington, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

David M. Herrington, M.D.

Professor, Cardiology
Sticht Center on Aging
Epidemiology & Prevention

Research Interests

Atherosclerosis; Coronary Artery Disease; Cardiovascular Diseases; Estrogen Replacement Therapy; Coronary Disease
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Contact Information

Request An Appointment

Academic: 336-716-4950 | Department: 336-716-9124

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Recent Publications

Predictors and outcomes of heart failure with mid-range ejection fraction. Bhambhani V, Kizer JR, Lima JAC, van der Harst P, Bahrami H, Nayor M, de Filippi CR, Enserro D, Blaha MJ, Cushman M, Wang TJ, Gansevoort RT, Fox CS, Gaggin HK, Kop W, Liu K, Vasan RS, Psaty BM, Lee DS, Brouwers FP, Hillege HL, Bartz TM,.. Eur J Heart Fail. 2018;20(4):651-659.

Association of cardiovascular biomarkers with incident heart failure with preserved and reduced ejection fraction. de Boer RA, Nayor M, deFilippi CR, Enserro D, Bhambhani V, Kizer JR, Blaha MJ, Brouwers FP, Cushman M, Lima JAC, Bahrami H, van der Harst P, Wang TJ, Gansevoort RT, Fox CS, Gaggin HK, Kop WJ, Liu K, Vasan RS, Psaty BM, Lee DS,.. JAMA Cardiol. 2018;3(3):215-224.

Revised Framingham Stroke Risk Score, nontraditional risk markers, and incident stroke in a multiethnic cohort. Flueckiger P, Longstreth W, Herrington D, Yeboah J.. Stroke. 2018;49(2):363-369.

Importance of the lipid-related pathways in the association between statins, mortality, and cardiovascular disease risk: the Multi-Ethnic Study of Atherosclerosis. Talbot D, Delaney JAC, Sandfort V, Herrington DM, McClelland RL.. Pharmacoepidemiol Drug Saf. 2018;27(4):365-372.

Coronary artery calcium scores and atherosclerotic cardiovascular disease risk stratification in smokers: MESA. Leigh A, McEvoy JW, Garg P, Carr JJ, Sandfort V, Oelsner EC, Budoff M, Herrington D, Yeboah J.. JACC Cardiovasc Imaging. 2018;():.

Genetic risk scores in premature coronary artery disease still only one piece of the prevention puzzle [editorial]. Assimes TL, Herrington DM.. Circ Cardiovasc Genet. 2018;11(1):e002006.

Left ventricular hypertrophy by ECG versus cardiac MRI as a predictor for heart failure. Oseni AO, Qureshi WT, Almahmoud MF, Bertoni AG, Bluemke DA, Hundley WG, Lima JA, Herrington DM, Soliman EZ.. Heart. 2017;103(1):49-54.

Guideline-based statin/lipid-lowering therapy eligibility for primary prevention and accuracy of coronary artery calcium and clinical cardiovascular events: the Multi-Ethnic Study of Atherosclerosis (MESA). Flueckiger P, Qureshi W, Michos ED, Blaha M, Burke G, Sandfort V, Herrington D, Yeboah J.. Clin Cardiol. 2017;40(3):163-169.

Use of the HEART Pathway with high sensitivity cardiac troponins: a secondary analysis. Mahler SA, Stopyra JP, Apple FS, Riley RF, Russell GB, Hiestand BC, Hoekstra JW, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Herrington DM, Burke GL, Miller CD.. Clin Biochem. 2017;50(7-8):401-407.

Coronary artery calcium scores for atherosclerotic cardiovascular disease risk stratification in smokers: MESA [abstract]. Leigh J, McEvoy J, Sandfort V, Qureshi W, Carr J, Oelsner EC, Budoff M, Herrington D, Yeboah J.. J Am Coll Cardiol. 2017;69(11 Suppl):1557.

Association between cardiovascular health and endothelial function with future erectile dysfunction: the Multi-Ethnic Study of Atherosclerosis. Lane-Cordova AD, Kershaw K, Liu K, Herrington D, Lloyd-Jones DM.. Am J Hypertens. 2017;30(8):815-821.

Higher number of live births is associated with left ventricular diastolic dysfunction and adverse cardiac remodelling among US Hispanic/Latina women: results from the Echocardiographic Study of Latinos. Aggarwal SR, Herrington DM, Vladutiu CJ, Newman JC, Swett K, Gonzalez F, Kizer JR, Kominiarek MA, Tabb KM, Gallo LC, Talavera GA, Hurwitz BE, Rodriguez CJ.. Open Heart. 2017;4(1):e000530.

Whole exome sequencing to identify genetic variants associated with raised atherosclerotic lesions in young persons. Hixson JE, Jun G, Shimmin LC, Wang Y, Yu G, Mao C, Warren AS, Howard TD, Heide RSV, Van Eyk J, Wang Y, Herrington DM.. Sci Rep. 2017;7(1):4091.

Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis. Liu Y, Reynolds LM, Ding J, Hou L, Lohman K, Young T, Cui W, Huang Z, Grenier C, Wan M, Stunnenberg HG, Siscovick D, Hou L, Psaty BM, Rich SS, Rotter JI, Kaufman JD, Burke GL, Murphy S, Jacobs DR Jr, Post W, Hoeschele I, Bell DA, Herrington D,.. Nat Commun. 2017;8(1):393.

Transcriptome-wide analysis identifies novel associations with blood pressure. Zeller T, Schurmann C, Schramm K, Muller C, Kwon S, Wild PS, Teumer A, Herrington D, Schillert A, Iacoviello L, Kratzer A, Jagodzinski A, Karakas M, Ding J, Neumann JT, Kuulasmaa K, Gieger C, Kacprowski T, Schnabel RB, Roden M, Wahl S, Rotter JI,.. Hypertension. 2017;70(4):743-750.

Low high-density lipoprotein cholesterol and particle concentrations are associated with greater levels of endothelial activation markers in Multi-Ethnic Study of Atherosclerosis participants. Steffen BT, Bielinski SJ, Decker PA, Berardi C, Larson NB, Pankow JS, Michos ED, Hanson NQ, Herrington DM, Tsai MY.. J Clin Lipidol. 2017;11(4):955-963.e3.

Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster. Rahbar E, Ainsworth HC, Howard TD, Hawkins GA, Ruczinski I, Mathias R, Seeds MC, Sergeant S, Hixson JE, Herrington DM, Langefeld CD, Chilton FH.. PLoS One. 2017;12(9):e0180903.

Improving visualization and interpretation of metabolome-wide association studies: an application in a population-based cohort using untargeted 1H NMR metabolic profiling. Castagne R, Boulange CL, Karaman I, Campanella G, Santos Ferreir DL, Kaluarachchi MR, Lehne B, Moayyeri A, Lewis MR, Spagou K, Dona AC, Evangelos V, Tracy R, Greenland P, Lindon JC, Herrington D, Ebbels TMD, Elliott P, Tzoulaki I, Chadeau-Hyam M.. J Proteome Res. 2017;16(10):3623-3633.

Bioinformatic analysis of coronary disease associated SNPs and genes to identify proteins potentially involved in the pathogenesis of atherosclerosis. Mao C, Howard TD, Sullivan D, Fu Z, Yu G, Parker SJ, Will R, Vander Heide RS, Wang Y, Hixson J, Van Eyk J, Herrington DM.. J Proteom Genom Res. 2017;2(1):1-12.

Plasma alkylresorcinols, biomarkers of whole-grain intake, are not associated with progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease. McKeown NM, Hruby A, Landberg R, Herrington DM, Lichtenstein AH.. Public Health Nutr. 2016;19(2):326-331.

Less favorable body composition and adipokines in South Asians compared with other US ethnic groups: results from the MASALA and MESA studies. Shah AD, Kandula NR, Lin F, Allison MA, Carr J, Herrington D, Liu K, Kanaya AM.. Int J Obes (Lond). 2016;40(4):639-645.

Adherence to an accelerated diagnostic protocol for chest pain: secondary analysis of the HEART Pathway randomized trial. Mahler SA, Riley RF, Russell GB, Hiestand BC, Hoekstra JW, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Bringolf J, Elliott SB, Herrington DM, Burke GL, Miller CD.. Acad Emerg Med. 2016;23(1):70-77.

Mathematical modelling of transcriptional heterogeneity identifies novel markers and subpopulations in complex tissues. Wang N, Hoffman EP, Chen L, Chen L, Zhang Z, Liu C, Yu G, Herrington DM, Clarke R, Wang Y.. Sci Rep. 2016;6():18909.

Utility of nontraditional risk markers in atherosclerotic cardiovascular disease risk assessment. Yeboah J, Young R, McClelland RL, Delaney JC, Polonsky TS, Dawood FZ, Blaha MJ, Miedema MD, Sibley CT, Carr JJ, Burke GL, Goff DC Jr, Psaty BM, Greenland P, Herrington DM.. J Am Coll Cardiol. 2016;67(2):139-147.

HEART pathway accelerated diagnostic protocol implementation: prospective pre-post interrupted time series design and methods. Mahler SA, Burke GL, Duncan PW, Case LD, Herrington DM, Riley RF, Wells BJ, Hiestand BC, Miller CD.. JMIR Res Protoc. 2016;5(1):e10.

C-type natriuretic peptide improves left ventricular functional performance at rest and restores normal exercise responses after heart failure. Li T, Cheng HJ, Ohte N, Hasegawa H, Morimoto A, Herrington D, Little W [deceased], Li W, Cheng CP.. J Pharmacol Exp Ther. 2016;357(3):545-553.

Prognosis of low normal left ventricular ejection fraction in an asymptomatic population-based adult cohort: the Multiethnic Study of Atherosclerosis. Yeboah J, Rodriguez CJ, Qureshi W, Liu S, Carr JJ, Lima JA, Hundley WG, Herrington DM.. J Card Fail. 2016;22(10):763-768.

Chest pain risk stratification: a comparison of the 2-hour accelerated diagnostic protocol (ADAPT) and the HEART Pathway. Stopyra JP, Miller CD, Hiestand BC, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Riley RF, Russell GB, Burke GL, Herrington D, Hoekstra JW, Mahler SA.. Crit Pathw Cardiol. 2016;15(2):46-49.

Primary low level of high-density lipoprotein cholesterol and risks of coronary heart disease, cardiovascular disease, and death: results from the Multi-Ethnic Study of Atherosclerosis. Ahmed HM, Miller M, Nasir K, McEvoy JW, Herrington D, Blumenthal RS, Blaha MJ.. Am J Epidemiol. 2016;183(10):875-883.

Fibroblast growth factor-23 and cardiac MRI indices of myocardial fibrosis in the Multi-ethnic Study of Atherosclerosis [abstract]. Almahmoud MF, Herrington D, Hundley W, Jordan J, Kestenbaum B, Katz R, Michos E, Liu CY, Venkatesh BA, Lima J.. J Am Coll Cardiol. 2016;67(13 Suppl):1684.

Impact of replacing the Pooled Cohort Equation with other cardiovascular disease risk scores on atherosclerotic cardiovascular disease risk assessment (from the Multi-Ethnic Study of Atherosclerosis [MESA]). Qureshi WT, Michos ED, Flueckiger P, Blaha M, Sandfort V, Herrington DM, Burke G, Yeboah J.. Am J Cardiol. 2016;118(5):691-696.

Development and validation of risk prediction models for cardiovascular events in black adults: the Jackson Heart Study cohort. Fox ER, Samdarshi TE, Musani SK, Pencina MJ, Sung JH, Bertoni AG, Xanthakis V, Balfour PC Jr, Shreenivas SS, Covington C, Liebson PR, Sarpong DF, Butler KR, Mosley TH, Rosamond WD, Folsom AR, Herrington DM, Vasan RS, Taylor HA.. JAMA Cardiol. 2016;1(1):15-25.

The association of calcium supplementation and incident cardiovascular events in the Multi-Ethnic Study of Atherosclerosis (MESA). Raffield LM, Agarwal S, Hsu FC, de Boer IH, Ix JH, Siscovick D, Szklo M, Burke GL, Frazier-Wood AC, Herrington DM.. Nutr Metab Cardiovasc Dis. 2016;26(10):899-907.

Workflow for integrated processing of multicohort untargeted 1H NMR metabolomics data in large-scale metabolic epidemiology. Karaman I, Ferreira DL, Boulange CL, Kaluarachchi MR, Herrington D, Dona AC, Castagne R, Moayyeri A, Lehne B, Loh M, de Vries PS, Dehghan A, Franco OH, Hofman A, Evangelou E, Tzoulaki I, Elliott P, Lindon JC, Ebbels TM.. J Proteome Res. 2016;15(12):4188-4194.

High-sensitivity C-reactive protein and risk of stroke in atrial fibrillation (from the Reasons for Geographic and Racial Differences in Stroke Study). Dawood FZ, Judd S, Howard VJ, Limdi NA, Meschia JF, Cushman M, Howard G, Herrington DM, Soliman EZ.. Am J Cardiol. 2016;118(12):1826-1830.

Ectopic fat depots and coronary artery calcium in South Asians compared with other racial/ethnic groups. Garg SK, Lin F, Kandula N, Ding J, Carr J, Allison M, Liu K, Herrington D, Vaidya D, Vittinghoff E, Kanaya AM.. J Am Heart Assoc. 2016;5(11):e004257.

Associations between a genetic risk score for clinical CAD and early stage lesions in the coronary artery and the aorta. Salfati EL, Herrington DM, Assimes TL.. PLoS One. 2016;11(11):e0166994.

The function of cathepsins B, D, and X in atherosclerosis. Zhao CF, Herrington DM.. Am J Cardiovasc Dis. 2016;6(4):163-170.

Enhanced angiotensin-(1-7) positive modulation on left ventricular functional performance in conscious dog with pacing-induced heart failure: assessment by pressure-volume analysis [abstract]. Zhang X, Morimoto A, Cheng H-J, Li T, Ohte N, Herrington DM, Cheng C-P.. Circulation. 2016;134(Suppl 1):A14985.

Comparing arterial function parameters for the prediction of coronary heart disease events: the Multi-Ethnic Study of Atherosclerosis (MESA). Hom EK, Duprez DA, Jacobs DR Jr, Bluemke DA, Brumback LC, Polak JF, Peralta CA, Greenland P, Magzamen SL, Lima JA, Redheuil A, Herrington DM, Stein JH, Vaidya D, Ouyang P, Kaufman JD.. Am J Epidemiol. 2016;184(12):894-901.

Heart failure risk prediction in the Multi-Ethnic Study of Atherosclerosis. Chahal H, Bluemke DA, Wu CO, McClelland R, Liu K, Shea SJ, Burke G, Balfour P, Herrington D, Shi P, Post W, Olson J, Watson KE, Folsom AR, Lima JA.. Heart. 2015;101(1):58-64.

Chronic statin administration may attenuate early anthracycline-associated declines in left ventricular ejection function. Chotenimitkhun R, D'Agostino R Jr, Lawrence JA, Hamilton CA, Jordan JH, Vasu S, Lash TL, Yeboah J, Herrington DM, Hundley WG.. Can J Cardiol. 2015;31(3):302-307.

KDDN: an open-source Cytoscape app for constructing differential dependency networks with significant rewiring. Tian Y, Zhang B, Hoffman EP, Clarke R, Zhang Z, Shih IeM, Xuan J, Herrington DM, Wang Y.. Bioinformatics. 2015;31(2):287-289.

The HEART pathway randomized trial: identifying emergency department patients with acute chest pain for early discharge. Mahler SA, Riley RF, Hiestand BC, Russell GB, Hoekstra JW, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Elliott SB, Herrington DM, Burke GL, Miller CD.. Circ Cardiovasc Qual Outcomes. 2015;8(2):195-203.

Sustained pre-hypertensive blood pressure and incident atrial fibrillation: the Multi-Ethnic Study of Atherosclerosis. O'Neal WT, Soliman EZ, Qureshi W, Alonso A, Heckbert SR, Herrington D.. J Am Soc Hypertens. 2015;9(3):191-196.

Implications of the new American College of Cardiology/American Heart Association cholesterol guidelines for primary atherosclerotic cardiovascular disease event prevention in a multi ethnic cohort: Multi-Ethnic Study of Atherosclerosis (MESA). Yeboah J, Sillau S, Delaney JC, Blaha MJ, Michos ED, Young R, Qureshi WT, McClelland R, Burke GL, Psaty BM, Herrington DM.. Am Heart J. 2015;169(3):387-395.e3.

Transcriptomic profiles of aging in purified human immune cells. Reynolds LM, Ding J, Taylor JR, Lohman K, Soranzo N, de la Fuente A, Liu TF, Johnson C, Barr RG, Register TC, Donohue KM, Talor MV, Cihakova D, Gu C, Divers J, Siscovick D, Burke G, Post W, Shea S, Jacobs DR Jr, Hoeschele I, McCall CE,.. BMC Genomics. 2015;16(1):333.

Association of the lipoprotein receptor SCARB1 common missense variant rs4238001 with incident coronary heart disease. Manichaikul A, Wang XQ, Musani SK, Herrington DM, Post WS, Wilson JG, Rich SS, Rodriguez A.. PLoS One. 2015;10(5):e0125497.

Microvasculature and incident atrioventricular conduction abnormalities in the Multi-Ethnic Study of Atherosclerosis (MESA). Chacko BG, Edwards MS, Sharrett AR, Qureshi WT, Klein BE, Klein R, Herrington DM, Soliman EZ.. Vasc Med. 2015;20(5):417-423.

Alterations of a cellular cholesterol metabolism network are a molecular feature of obesity-related type 2 diabetes and cardiovascular disease. Ding J, Reynolds LM, Zeller T, Muller C, Mstat KL, Nicklas BJ, Kritchevsky SB, Huang Z, Fuente A, Soranzo N, Settlage RE, Chuang CC, Howard T, Xu N, Goodarzi MO, Ida Chen YD, Rotter JI, Siscovick DS, Parks JS, Murphy S, Jacobs DR Jr,.. Diabetes. 2015;64(10):3464-3474.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Cardiology

Clinical Interests

Heart Disease in Women, Cardiac Catheterization, Cardiology (clinical), Preventive and Rehabilitative Cardiology
David M. Herrington, M.D.

David M. Herrington, M.D.

Professor, Cardiology
Sticht Center on Aging
Epidemiology & Prevention

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