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James Hill Holmes IV, M.D.Wake Forest School of Medicine

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James Hill Holmes IV, M.D.

Professor, General Surgery

Clinical Interests

Burns, Trauma and Surgical Critical Care, Emergency General Surgery

Contact Information

Returning Patient Appointments: 336-716-3813
Department: 336-716-7021


Insurance Accepted »

Education & Training

  • B.A., Southern Methodist University, 1990
  • M.D., U Texas Sthwstn Med Sch-Dallas, 1996
  • Internship, Virginia Mason Medical Center, 1997
  • Residency, Virginia Mason Medical Center, 1998
  • Fellowship, Virginia Mason Rsrch Ctr, 1999
  • Residency, Virginia Mason Medical Center, 2002
  • Fellowship, University of Washington Schoo, 2003
  • Fellowship, Univ of Pa School of Medicine, 2004

Board Certifications

  • American Board of Surgery, Surgery
  • American Board of Surgery, Surgical Critical Care


  • Int'l Soc of Burn Injuries
  • North Carolina Medical Society
  • Southern Medical Association
  • Texas Medical Assn
  • Am Burn Assn
  • Am Coll Of Surgeons
  • Assn Of Academic Surgery
  • Eastern Assn For The Surgery O
  • Golden Key National Honor Soc

NPI Number

  • 1831177138
James Hill Holmes IV, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

James Hill Holmes IV, M.D.

Professor, General Surgery
Institute for Regenerative Medicine

Research Interests

Burns; Burn Units; Hospitalization; Referral and Consultation; Regional Medical Programs
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Contact Information

Academic: 336-716-7021 | Department: 336-716-7021


Recent Publications

SJS/TEN 2017: building multidisciplinary networks to drive science and translation. White KD, Abe R, Ardern-Jones M, Beachkofsky T, Bouchard C, Carleton B, Chodosh J, Cibotti R, Davis R, Denny JC, Dodiuk-Gad RP, Ergen EN, Goldman JL, Holmes JH IV, Hung SI, Lacouture ME, Lehloenya RJ, Mallal S, Manolio TA, Micheletti RG,.. J Allergy Clin Immunol Pract. 2018;6(1):38-69.

A comparative study of the ReCell device and autologous spit-thickness meshed skin graft in the treatment of acute burn injuries. Holmes JH IV, Molnar JA, Carter JE, Hwang J, Cairns BA, King BT, Smith DJ, Cruse CW, Foster KN, Peck MD, Sood R, Feldman MJ, Jordan MH, Mozingo DW.. J Burn Care Res. 2018;():.

Return on investment of advanced practice medical degrees: NPs vs. PAs. Craig CK, Holmes JH IV, Carter JE.. JAAPA. 2017;30(6):35-38.

Inhalation injury: State of the Science 2016. Foster KN, Holmes JH IV.. J Burn Care Res. 2017;38(3):137-141.

Guidelines for burn care under austere conditions: surgical and nonsurgical wound management. Cancio LC, Barillo DJ, Kearns RD, Holmes JH IV, Conlon KM, Matherly AF, Cairns BA, Hickerson WL, Palmieri T.. J Burn Care Res. 2017;38(4):203-214.

Transfusion requirement in burn care evaluation (TRIBE): a multicenter randomized prospective trial of blood transfusion in major burn injury. Palmieri TL, Holmes JH IV, Arnoldo B, Peck M, Potenza B, Cochran A, King BT, Dominic W, Cartotto R, Bhavsar D, Kemalyan N, Tredget E, Stapelberg F, Mozingo D, Friedman B, Greenhalgh DG, Taylor SL, Pollock BH.. Ann Surg. 2017;266(4):595-602.

Development of a burn escharotomy assessment tool: a pilot study. Ur R, Holmes JH IV, Johnson JE, Molnar JA, Carter JE.. J Burn Care Res. 2016;37(2):e140-e144.

'It Happened in Seconds' Firefighter Burn Prevention Program: evaluation of a 'Train the Trainer' course. Kahn SA, Held JM, Hollowed KA, Woods J, Holmes JH IV.. J Burn Care Res. 2016;37(1):e33-e36.

Risk factors for in-hospital mortality in smoke inhalation-associated acute lung injury: data from 68 United States hospitals. Kadri SS, Miller AC, Hohmann S, Bonne S, Nielsen C, Wells C, Gruver C, Quraishi SA, Sun J, Cai R, Morris PE, Freeman BD, Holmes JH, Cairns BA, Suffredini AF.. Chest. 2016;150(6):1260-1268.

Disaster planning: financing a burn disaster, where do you turn and what are your options when your hospital has been impacted by a burn disaster in the United States?. Kearns RD, Hubble MW, Lord GC, Holmes JH IV, Cairns BA, Helminiak C.. J Burn Care Res. 2016;37(4):197-206.

Advanced burn life support for day-to-day burn injury management and disaster preparedness: stakeholder experiences and student perceptions following 56 advanced burn life support courses. Kearns RD, Ortiz-Pujols SM, Craig CK, Gusler JR, Skarote MB, Carter J, Rezak-Alger A, Cairns CB, Lofald D, Holmes JH IV, Cairns BA, Gamelli R.. J Burn Care Res. 2015;36(4):455-464.

Results of a pilot multicenter genotype-based randomized placebo-controlled trial of propranolol to reduce pain after major thermal burn injury. Orrey DC, Halawa OI, Bortsov AV, Shupp JW, Jones SW, Haith LR, Hoskins JM, Jordan MH, Bangdiwala SI, Roane BR, Platts-Mills TF, Holmes JH, Hwang J, Cairns BA, McLean SA.. Clin J Pain. 2015;31(1):21-29.

Disaster planning: the basics of creating a burn mass casualty disaster plan for a burn center. Kearns RD, Conlon KM, Valenta AL, Lord GC, Cairns CB, Holmes JH IV, Johnson DD, Matherly AF, Sawyer D, Skarote MB, Siler SM, Helminiak RC, Cairns BA.. J Burn Care Res. 2014;35(1):E1-E13.

ABA Southern Region Burn disaster plan: the process of creating and experience with the ABA Southern Region Burn Disaster Plan. Kearns RD, Cairns BA, Hickerson WL, Holmes JH IV.. J Burn Care Res. 2014;35(1):E43-E48.

Disaster planning: the past, present, and future concepts and principles of managing a surge of burn injured patients for those involved in hospital facility planning and preparedness. Kearns RD, Holmes JH IV, Alson RL, Cairns BA.. J Burn Care Res. 2014;35(1):E33-E42.

Disaster planning: transportation resources and considerations for managing a burn disaster. Kearns RD, Hubble MW, Holmes JH IV, Cairns BA.. J Burn Care Res. 2014;35(1):E21-E32.

Prospective trial of angiography and embolization for all grade III to V blunt splenic injuries: nonoperative management success rate is significantly improved. Miller PR, Chang MC, Hoth JJ, Mowery NT, Hildreth AN, Martin RS, Holmes JH, Meredith JW, Requarth JA.. J Am Coll Surg. 2014;218(4):644-648.

Disasters; the 2010 Haitian earthquake and the evacuation of burn victims to US burn centers. Kearns RD, Holmes JH IV, Skarote MB, Cairns CB, Strickland SC, Smith HG, Cairns BA.. Burns. 2014;40(6):1121-1132.

An update on the regional organizations of the American Burn Association. Harrington D, Holmes J, Conlon K, Jeng J.. J Burn Care Res. 2014;35(3):228-232.

Hospital bioterrorism planning and burn surge. Kearns RD, Myers B, Cairns CB, Rich PB, Hultman CS, Charles AG, Jones SW, Schmits GL, Skarote MB, Holmes JH IV, Cairns BA.. Biosecur Bioterror. 2014;12(1):20-28.

Chemical burn care: a review of best practices [magazine article]. Kearns RD, Cairns CB, Holmes JH IV, Rich PB, Cairns BA.. EMS World. 2014;43(5):40-45.

Referral patterns in pediatric burn patients. Doud AN, Swanson JM, Ladd MR, Neff LP, Carter JE, Holmes JH.. Am Surg. 2014;80(9):836-840.

Predictors of locoregional and intravesical recurrence among patients treated with nephroureterectomy for urothelial tract carcinoma [abstract]. Hughes RT, Lucas JT, Divers J, Holmes J, Krane S, Hemal AK, Frizzell BA.. Int J Radiat Oncol Biol Phys. 2014;90(Suppl 1):S466.

Deployable, portable, and temporary hospitals; one state's experiences through the years. Kearns RD, Skarote MB, Peterson J, Stringer L, Alson RL, Cairns BA, Hubble MW, Rich PB, Cairns CB, Holmes JH, Runge J, Siler SM, Winslow J.. Am J Disaster Med. 2014;9(3):195-210.

Burn disaster preparedness and the southern region of the United States. Kearns R, Holmes J IV, Cairns B.. South Med J. 2013;106(1):69-73.

Thermal burn care: a review of best practices. What should prehospital providers do for these patients?. Kearns RD, Cairns CB, Holmes JH IV, Rich PB, Cairns BA.. EMS World. 2013;42(1):43-51.

Burns/inhalation injury. Holmes JH IV. In: Peitzman AB, Schwab CW, Yealy DM, Rhodes M, Fabian TC, eds. The trauma manual: trauma and acute care surgery. 4th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins;2013: 443-455.

Surgical management of the burn wound and use of skin substitutes: an expert panel white paper. Kagan RJ, Peck MD, Ahrenholz DH, Hickerson WL, Holmes J IV, Korentager R, Kraatz J, Pollock K, Kotoski G.. J Burn Care Res. 2013;34(2):E60-E79.

Nutrition outcomes. Dylewski M, Wibbenmeyer L, Bessey PQ, Carter J, Gamelli R, Goodwin C, Graves T, Hollowed K, Holmes JH, Noordenbas J, Nordlund M, Savetamal A, Simpson P, Traber D, Traber L.. J Burn Care Res. 2013;34(4):371-375.

Burn injury: what's in a name? Labels used for burn injury classification: a review of the data from 2000-2012. Kearns RD, Holmes JH IV, Cairns BA.. Ann Burns Fire Disasters. 2013;26(3):115-120.

American Burn Association Southern Burn Region--recently revised [letter]. Holmes JH IV, Dimick AR.. J Burn Care Res. 2012;33(2):e94.

Regenerative medicine as applied to general surgery. Orlando G, Wood KJ, De Coppi P, Baptista PM, Binder KW, Bitar KN, Breuer C, Burnett L, Christ G, Farney A, Figliuzzi M, Holmes JH IV, Koch K, Macchiarini P, Mirmalek Sani S-H, Opara E, Remuzzi A, Rogers J, Saul JM, Seliktar D,.. Ann Surg. 2012;255(5):867-880.

Failure of propranolol to decrease anxiety and PTSD symptoms in a genotype-based RCT of patients with major thermal burn injury [abstract]. Orrey D, Bortsov A, Liberzon I, Shupp JW, Jones S, Hwang J, Jordan M, Holmes J, Haith L, Cairns B, McLean SA.. Biol Psychiatry. 2012;71(8 Suppl):56S.

Individuals with elevated PTSD symptoms experience increased itch symptom morbidity after major burn injury [abstract]. Orrey D, Bortsov A, Shupp J, Jones S, Hwang J, Jordan M, Holmes J, Haith L, Cairns B, Liberzon I, McLean S.. Biol Psychiatry. 2012;71(8 Suppl):242S-243S.

Catechol-O-methyltransferase genotype predicts pain severity in hospitalized burn patients. Orrey DC, Bortsov AV, Hoskins JM, Shupp JW, Jones SW, Cicuto BJ, Hwang J, Jordan MH, Holmes JH, Haith LR, Roane BM, Diatchenko L, Cairns BA, McLean SA.. J Burn Care Res. 2012;33(4):518-523.

The effectiveness of regionalized burn care: an analysis of 6,873 burn admissions in North Carolina from 2000 to 2007. Holmes JH IV, Carter JE, Neff LP, Cairns BA, d'Agostino RB Jr, Griffin LP, Meredith JW.. J Am Coll Surg. 2011;212(4):487-495.

Emergency department length of stay is an independent predictor of hospital mortality in trauma activation patients. Mowery NT, Dougherty SD, Hildreth AN, Holmes JH IV, Chang MC, Martin RS, Hoth JJ, Meredith JW, Miller PR.. J Trauma. 2011;70(6):1317-1325.

Adherence to burn center referral criteria: are patients appropriately being referred?. Carter JE, Neff LP, Holmes JH IV.. J Burn Care Res. 2010;31(1):26-30.

Systemic absorption of amphotericin B with topical 5% mafenide acetate/amphotericin B solution for grafted burn wounds: is it clinically relevant?. Pendleton RA, Holmes JH IV.. Burns. 2010;36(1):38-41.

The use of theraputic plasma exchange (TPE) in the setting of refractory burn shock. Neff LP, Allman JM, Holmes JH.. Burns. 2010;36(3):372-378.

Reimbursement for out-of-state burn patients is not always lower than that for in-state patients at regional burn centers. Peck MD, Pressman MA, Caruso DM, Edelman LS, Holmes JH IV, Hughes WB, Korentager RA, Saffle JR, Voigt DW.. J Burn Care Res. 2010;31(4):603-609.

Nutrition and venous access. Holmes JH IV. In: Gracias VH, McKenney MG, Reilly PM, Velmahos GC, eds. Acute care surgery: a guide for general surgeons. New York: McGraw-Hill Medical;2009: 257-262.

Critical issues in burn care. Holmes JH IV.. J Burn Care Res. 2008;29(6 Suppl 2):S180-S187.

Critical issues in burn care. Holmes JH IV.. South Med J. 2008;101(12 Suppl):S6-S12.

Systemic absorption of amphotericin B with topical 5% mafenide acetate/amphotericin B solution for grafted burn wounds: is it clinically relevant? [abstract]. Pendleton RA, Holmes JH IV.. South Med J. 2008;101(12 Suppl):S37.

Pediatric pancreatic trauma: predictors of nonoperative management failure and associated outcomes. Mattix KD, Tataria M, Holmes J, Kristoffersen K, Brown R, Groner J, Sciafe E, Mooney D, Nance M, Scherer L.. J Pediatr Surg. 2007;42(2):340-344.

Pediatric blunt abdominal injury: age is irrelevant and delayed operation is not detrimental. Tataria M, Nance ML, Holmes JH IV, Miller CC III, Mattix KD, Brown RL, Mooney DP, Scherer LRT III, Groner JI, Scaife ER, et al.. J Trauma. 2007;63(3):608-614.

American Burn Association Consensus Conference to define sepsis and infection in burns. Greenhalgh DG, Saffle JR, Holmes JH IV, Gamelli RL, Palmieri TL, Horton JW, Tompkins RG, Traber DL, Mozingo DW, Deitch EA, et al.. J Burn Care Res. 2007;28(6):776-790.

White phosphorus and its ability to cause serious burns [abstract]. Loveall CF, Manuel AL, Stansberry RD, Williams JH, Molnar JA, Holmes JH IV.. South Med J. 2007;100(12 Suppl):S16.

Timeline to operative intervention for solid organ injuries in children. Nance ML, Holmes JH IV, Wiebe DJ.. J Trauma. 2006;61(6):1389-1392.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, General Surgery

Clinical Interests

Burns, Trauma and Surgical Critical Care, Emergency General Surgery
James Hill Holmes IV, M.D.

James Hill Holmes IV, M.D.

Professor, General Surgery
Institute for Regenerative Medicine

CP concern for questions/worries
CP efforts to include in decisions
CP explanations of prob/condition
CP spoke using clear language
Friendliness/courtesy of CP
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Time CP spent with patient
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