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Denise Kathryn Houston, Ph.D.Wake Forest School of Medicine

Denise Kathryn Houston, Ph.D.

Associate Professor,

Contact Information

Academic: 336-713-8558 | Department: 336-713-8570


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Education & Training

  • B.S., University of Georgia, 1993
  • M.S., University of Georgia, 1998
  • Ph.D., University of North Carolina-Chapel Hill, 2004


  • Obesity Society
  • Am Dietetic Assn
  • Am Soc for Nutrition
  • Gerontological Society Of Amer
Denise Kathryn Houston, Ph.D.

Denise Kathryn Houston, Ph.D.

Associate Professor, Gerontology and Geriatric Medicine
Center on Diabetes, Obesity, and Metabolism
Office of Women in Medicine and Science
Epidemiology & Prevention

Research Interests

Vitamin D; Vitamin D Deficiency; Obesity; Mobility Limitation; Aging
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Contact Information

Academic: 336-713-8558 | Department: 336-713-8570


Media Medical Expert »

Recent Publications

Influence of prehospital function and strength on outcomes of critically ill older adults. Files DC, Neiberg R, Rushing J, Morris PE, Young MP, Ayonayon H, Harris T, Newman A, Rubin S, Shiroma E, Houston D, Miller ME, Kritchevsky SB.. J Am Geriatr Soc. 2018;66(3):525-531.

Transethnic evaluation identifies low-frequency loci associated with 25-hydroxyvitamin D concentrations. Hong J, Hatchell KE, Bradfield JP, Andrew B, Alessandra C, Chao-Qiang L, Langefeld CD, Lu L, Lu Y, Lutsey PL, Musani SK, Nalls MA, Robinson-Cohen C, Roizen JD, Saxena R, Tucker KL, Ziegler JT, Arking DE, Bis JC, Boerwinkle E, Bottinger EP,.. J Clin Endocrinol Metab. 2018;103(4):1380-1392.

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. Jiang X, O'Reilly PF, Aschard H, Hsu YH, Richards JB, Dupuis J, Ingelsson E, Karasik D, Pilz S, Berry D, Kestenbaum B, Zheng J, Luan J, Sofianopoulou E, Streeten EA, Albanes D, Lutsey PL, Yao L, Tang W, Econs MJ, Wallaschofski H, Volzke H, Zhou A,.. Nat Commun. 2018;9(1):260.

Genome-wide interactions with dairy intake for body mass index in adults of European descent. Smith CE, Follis JL, Dashti HS, Tanaka T, Graff M, Fretts AM, Kilpelainen TO, Wojczynski MK, Richardson K, Nalls MA, Schulz CA, Liu YM, Frazier-Wood AC, van Eekelen E, Wang C, de Vries PS, Mikkila V, Rohde R, Psaty BM, Hansen T, Feitosa MF,.. Mol Nutr Food Res. 2018;62(3):1700347.

Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI. Gong J, Nishimura KK, Fernandez-Rhodes L, Haessler J, Bien S, Graff M, Lim U, Lu Y, Gross M, Fornage M, Yoneyama S, Isasi CR, Buzkova P, Daviglus M, Lin DY, Tao R, Goodloe R, Bush WS, Farber-Eger E, Boston J, Dilks HH, Ehret G, Gu CC, Lewis CE,.. Int J Obes (Lond). 2018;42(3):384-390.

Low 25-hydroxyvitamin D concentrations and risk of incident cognitive impairment in black and white older adults: the Health ABC study. Kilpatrick L, Houston DK, Wilson VK, Lovato J, Ayonayon HN, Cauley JA, Harris T, Simonsick EM, Yaffe K, Kritchevsky SB, Sink KM.. J Nutr Gerontol Geriatr. 2018;37(1):1-13.

Promoting active aging: innovation in primary care [abstract]. Callahan KE, Miller ME, Kritchevsky S, Houston D, Williamson J, Neiberg R, Rejeski WJ.. J Am Geriatr Soc. 2018;66(Suppl 2):S36.

Characterizing the functional decline of older women with incident urinary incontinence [reply to letter]. Parker-Autry CY, Houston D, Kritchevsky S, Richter HE.. Obstet Gynecol. 2018;131(6):1160-1161.

Effects of longitudinal glucose exposure on cognitive and physical function: results from the Action for Health in Diabetes Movement and Memory study. Beavers KM, Leng I, Rapp SR, Miller ME, Houston DK, Marsh AP, Hire DG, Baker LD, Bray GA, Blackburn GL, Hergenroeder AL, Jakicic JM, Johnson KC, Korytkowski MT, Dorsten BV, Kritchevsky SB.. J Am Geriatr Soc. 2017;65(1):137-145.

Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations. Yoneyama S, Yao J, Guo X, Fernandez-Rhodes L, Lim U, Boston J, Buzkova P, Carlson CS, Cheng I, Cochran B, Cooper R, Ehret G, Fornage M, Gong J, Gross M, Gu CC, Haessler J, Haiman CA, Henderson B, Hindorff LA, Houston D, Irvin MR,.. Int J Obes (Lond). 2017;41(2):324-331.

Protein intake and mobility limitation in community-dwelling older adults: the Health ABC study. Houston DK, Tooze JA, Garcia K, Visser M, Rubin S, Harris TB, Newman AB, Kritchevsky SB.. J Am Geriatr Soc. 2017;65(8):1705-1711.

Trans-ethnic fine-mapping of genetic loci for body mass index in the diverse ancestral populations of the Population Architecture using Genomics and Epidemiology (PAGE) Study reveals evidence for multiple signals at established loci. Fernandez-Rhodes L, Gong J, Haessler J, Franceschini N, Graff M, Nishimura KK, Wang Y, Highland HM, Yoneyama S, Bush WS, Goodloe R, Ritchie MD, Crawford D, Gross M, Fornage M, Buzkova P, Tao R, Isasi C, Aviles-Santa L, Daviglus M,.. Hum Genet. 2017;136(6):771-800.

Promoting active aging in primary care [abstract]. Callahan KE, Miller ME, Kritchevsky S, Houston DK, Williamson J, Rejeski WJ.. J Am Geriatr Soc. 2017;65(Suppl 1):S36.

Poor appetite and dietary intake in community-dwelling older adults. van der Meij BS, Wijnhoven HAH, Lee JS, Houston DK, Hue T, Harris TB, Kritchevsky SB, Newman AB, Visser M.. J Am Geriatr Soc. 2017;65(10):2190-2197.

Is there a synergistic role for vitamin K and vitamin D in lower extremity function related to knee osteoarthritis? The Osteoarthritis Initiative and Health, Aging and Body Composition studies [abstract]. Shea M, Loeser RF, Kritchevsky SB, Houston DK, McAlindon TE, Booth SL.. Osteoarthritis Cartilage. 2017;25(Suppl 1):S185-S186.

Vitamin K, vitamin D, and lower extremity function: results from the Osteoarthritis Initiative and Health, Aging and Body Composition Studies [abstract]. Shea K, Loeser RF, Kritchevsky SB, Houston DK, McAlindon TE, Booth SL.. FASEB J. 2017;31(Suppl 1):967.4.

Characterizing the functional decline of older women with incident urinary incontinence. Parker-Autry C, Houston DK, Rushing J, Richter HE, Subak L, Kanaya AM, Kritchevsky SB.. Obstet Gynecol. 2017;130(5):1025-1032.

Sufficient vitamin K status combined with sufficient vitamin D status is associated with better lower extremity function: a prospective analysis of two knee osteoarthritis cohorts. Shea MK, Loeser RF, McAlindon TE, Houston DK, Kritchevsky SB, Booth SL.. Arthritis Care Res (Hoboken). 2017;():.

Physical function following a long-term lifestyle intervention among middle aged and older adults with type 2 diabetes: the Look AHEAD study. Houston DK, Neiberg RH, Miller ME, Hill JO, Jakicic JM, Johnson KC, Gregg EW, Hubbard VS, Pi-Sunyer X, Rejeski WJ, Wing RR, Bantle JP, Beale E, Berkowitz RI, Cassidy-Begay M, Clark JM, Coday M, Delahanty LM, Dutton G, Egan C, Foreyt JP,.. J Gerontol A Biol Sci Med Sci. 2017;():.

Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts. Mozaffarian D, Dashti HS, Wojczynski MK, Chu AY, Nettleton JA, Mannisto S, Kristiansson K, Reedik M, Lahti J, Houston DK, Cornelis MC, van Rooij FJA, Dimitriou M, Kanoni S, Mikkila V, Steffen LM, de Oliveira Otto MC, Qi L, Psaty B, Djousse L,.. PLoS One. 2017;12(12):e0186456.

Protein intake and incident sarcopenia in older adults: the Health ABC Study [abstract]. Houston DK, Tooze JA, Visser M, Tylavsky FA, Rubin S, Newman A, Harris TB, Kritchevsky SB.. Innov Aging. 2017;1(Suppl 1):8-9.

Apolipoprotein E allele and hearing thresholds in older adults. Mener DJ, Betz J, Yaffe K, Harris TB, Helzner EP, Satterfield S, Houston DK, Strotmeyer ES, Pratt SR, Simonsick EM, Lin FR.. Am J Alzheimers Dis Other Demen. 2016;31(1):34-39.

Caloric restriction during aerobic training enhances cardiorespiratory fitness in obese, older adults: a randomized controlled trial: 1529 Board #182 June 2, 9: 00 AM - 10: 30 AM [abstract]. Nicklas BJ, Crotts C, Chmelo EA, Yow D, Gordon M, Lyles MF, Beavers KM, Houston DK, Hugenschmidt C, Leng I, Brinkley TE.. Med Sci Sports Exerc. 2016;48(5 Suppl 1):416-417.

The decline in physical performance and onset of sarcopenia is associated with the development of urinary incontinence in older community dwelling women [abstract]. Parker-Autry C, Houston D, Rushing J, Richter H, Subak L, Kanaya A, Kritchevsky S.. Neurourol Urodyn. 2016;35(Suppl 4):S251-S252.

Association between the Mediterranean diet and cognitive decline in a biracial population. Koyama A, Houston DK, Simonsick EM, Lee JS, Ayonayon HN, Shahar DR, Rosano C, Satterfield S, Yaffe K.. J Gerontol A Biol Sci Med Sci. 2015;70(3):352-357.

Vitamin D insufficiency and abnormal hemoglobin A1c in black and white older persons. Kositsawat J, Kuchel GA, Tooze JA, Houston DK, Cauley JA, Kritchevsky SB, Strotmeyer ES, Kanaya AM, Harris TB, Johnson KC, Barry LC.. J Gerontol A Biol Sci Med Sci. 2015;70(4):525-531.

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Cornelis MC, Byrne EM, Esko T, Nalls MA, Ganna A, Paynter N, Monda KL, Amin N, Fischer K, Renstrom F, Ngwa JS, Huikari V, Cavadino A, Nolte IM, Teumer A, Yu K, Marques-Vidal P, Rawal R, Manichaikul A, Wojczynski MK, Vink JM, Zhao JH, Burlutsky G,.. Mol Psychiatry. 2015;20(5):647-656.

A long-term intensive lifestyle intervention and physical function: The Look AHEAD Movement and Memory Study. Houston DK, Leng X, Bray GA, Hergenroeder AL, Hill JO, Jakicic JM, Johnson KC, Neiberg RH, Marsh AP, Rejeski WJ, Kritchevsky SB.. Obesity (Silver Spring). 2015;23(1):77-84.

Genetic and environmental factors are associated with serum 25-hydroxyvitamin D concentrations in older African Americans. Hansen JG, Tang W, Hootman KC, Brannon PM, Houston DK, Kritchevsky SB, Harris TB, Garcia M, Lohman K, Liu Y, de Boer IH, Kestenbaum BR, Robinson-Cohen C, Siscovick DS, Cassano PA.. J Nutr. 2015;145(4):799-805.

Intentional weight loss and all-cause mortality: a meta-analysis of randomized clinical trials. Kritchevsky SB, Beavers KM, Miller ME, Shea MK, Houston DK, Kitzman DW, Nicklas BJ.. PLoS One. 2015;10(3):e0121993.

The long-term effects of intentional weight loss on body composition and physical function in older adults: a pilot study [abstract]. Houston DK, Miller ME, Kitzman DW, Rejeski WJ, Messier SP, Lyles MF, Kritchevsky S, Nicklas BJ.. J Am Geriatr Soc. 2015;63(Suppl 1):S14-S15.

Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults. Zimmermann E, Angquist LH, Mirza SS, Zhao JH, Chasman DI, Fischer K, Qi Q, Smith AV, Thinggaard M, Jarczok MN, Nalls MA, Trompet S, Timpson NJ, Schmidt B, Jackson AU, Lyytikainen LP, Verweij N, Mueller-Nurasyid M, Vikstrom M, Marques-Vidal P,.. Obes Rev. 2015;16(4):327-340.

Vitamin D and age-related health outcomes: movement, mood, and memory. Houston DK.. Curr Nutr Rep. 2015;4(2):185-200.

Low 25-hydroxyvitamin D concentrations predict incident depression in well-functioning older adults: the Health, Aging, and Body Composition Study. Williams JA, Sink KM, Tooze JA, Atkinson HH, Cauley JA, Yaffe K, Tylavsky FA, Rubin SM, Simonsick EM, Kritchevsky SB, Houston DK.. J Gerontol A Biol Sci Med Sci. 2015;70(6):757-763.

Gene x dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry. Nettleton JA, Follis JL, Ngwa JS, Smith CE, Ahmad S, Tanaka T, Wojczynski MK, Voortman T, Lemaitre RN, Kristiansson K, Nuotio ML, Houston DK, Perala MM, Qi Q, Sonestedt E, Manichaikul A, Kanoni S, Ganna A, Mikkila V, North KE, Siscovick DS,.. Hum Mol Genet. 2015;24(16):4728-4738.

Protein intake and incident mobility limitations in older adults: the Health ABC Study [abstract]. Houston DK, Tooze JA, Garcia KR, Visser M, Tylavsky FA, Hue TF, Lee JS, Murphy RA, Simonsick EM, Harris TB, Newman AB, Kritchevsky SB.. J Frailty Aging. 2015;4(Suppl 1):30.

Caloric restriction for treatment of geriatric obesity: do the benefits outweigh the risks?. Normandin E, Houstin DK, Nicklas BJ.. Curr Nutr Rep. 2015;4(2):143-155.

Delivery of a vitamin D intervention in homebound older adults using a Meals-on-Wheels program: a pilot study. Houston DK, Tooze JA, Demons JL, Davis BL, Shertzer-Skinner R, Kearsley LB, Kritchevsky SB, Williamson JD.. J Am Geriatr Soc. 2015;63(9):1861-1867.

Body mass index trajectories in relation to change in lean mass and physical function: the Health, Aging and Body Composition Study. Reinders I, Murphy RA, Martin KR, Brouwer IA, Visser M, White DK, Newman AB, Houston DK, Kanaya AM, Nagin DS, Harris TB.. J Am Geriatr Soc. 2015;63(8):1615-1621.

Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians. Fretts AM, Follis JL, Nettleton JA, Lemaitre RN, Ngwa JS, Wojczynski MK, Kalafati IP, Varga TV, Frazier-Wood AC, Houston DK, Lahti J, Ericson U, van den Hooven EH, Mikkila V, Kiefte-de Jong JC, Mozaffarian D, Rice K, Renstrom F, North KE, McKeown NM,.. Am J Clin Nutr. 2015;102(5):1266-1278.

Body weight dynamics following intentional weight loss and physical performance: the Look AHEAD Movement and Memory Study. Beavers KM, Neiberg RH, Houston DK, Bray GA, Hill JO, Jakicic JM, Johnson KC, Kritchevsky SB.. Obes Sci Pract. 2015;1(1):12-22.

Long-term impact of a behavioral weight loss intervention on mobility: the Look AHEAD Study [abstract]. Houston DK, Neiberg R, Hill JO, Johnson KC, Pi-Sunyer X, Jakicic JM, Wing R, Kritchevsky SB.. Gerontologist. 2015;55(Suppl 2):338.

Dietary interventions for the treatment of geriatric obesity: do the benefits outweigh the risks? [abstract]. Nicklas B, Houston DK.. Gerontologist. 2015;55(Suppl 2):517.

Relationship between 25-hydroxyvitamin d and cognitive function in older adults: the health, aging and body composition study. Wilson VK, Houston DK, Kilpatrick L, Lovato J, Yaffe K, Cauley JA, Harris TB, Simonsick EM, Ayonayon HN, Kritchevsky SB, Sink KM.. J Am Geriatr Soc. 2014;62(4):636-641.

Vitamin D status is associated with grip strength in centenarians. Haslam A, Johnson MA, Hausman DB, Cress ME, Houston DK, Davey A, Poon LW.. J Nutr Gerontol Geriatr. 2014;33(1):35-46.

Long-term impact of behavioral weight loss intervention on cognitive function. Espeland MA, Rapp SR, Bray GA, Houston DK, Johnson KC, Kitabchi AE, Hergenroeder AL, Williamson J, Jakicic JM, van Dorsten B, Kritchevsky SB.. J Gerontol A Biol Sci Med Sci. 2014;69(9):1101-1108.

Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. Vimaleswaran KS, Cavadino A, Berry DJ, Jorde R, Dieffenbach AK, Lu C, Alves AC, Heerspink HJ, Tikkanen E, Eriksson J, Wong A, Mangino M, Jablonski KA, Nolte IM, Houston DK, Ahluwalia TS, van der Most PJ, Pasko D, Zgaga L, Thiering E, Vitart V,.. Lancet Diabetes Endocrinol. 2014;2(9):719-729.

FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals. Qi Q, Kilpelainen TO, Downer MK, Tanaka T, Smith CE, Sluijs I, Sonestedt E, Chu AY, Renstrom F, Lin X, Angquist LH, Huang J, Liu Z, Li Y, Asif Ali M, Xu M, Ahluwalia TS, Boer JM, Chen P, Daimon M, Eriksson J, Perola M, Friedlander Y, Gao YT, Heppe DH,.. Hum Mol Genet. 2014;23(25):6961-6972.

Weight change, body composition, and risk of mobility disability and mortality in older adults: a population-based cohort study. Murphy RA, Patel KV, Kritchevsky SB, Houston DK, Newman AB, Koster A, Simonsick EM, Tylvasky FA, Cawthon PM, Harris TB.. J Am Geriatr Soc. 2014;62(8):1476-1483.

Protein intake and lower extremity physical performance in older adults: the Health ABC Study [abstract]. Houston DK, Tooze JA, Garcia KR, Visser M, Tylavsky FA, Newman AB, Harris TB, Kritchevsky SB.. J Nutr Health Aging. 2014;18(6):632.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Gerontology and Geriatric Medicine

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