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Chia-Chi Chuang KeyWake Forest School of Medicine

Chia-Chi Chuang Key


Contact Information

Academic: 336-716-2821 | Department: 336-713-4259


Additional Languages


Education & Training

  • B.S., Taipei Medical College-Taiwan, 2003
  • Master's Degree, Natl Taiwan Univ College of Medicine-Taiwan, 2005
  • Ph.D., University of North Carolina-Greensboro, 2012
Chia-Chi Chuang Key

Chia-Chi Chuang Key

Instructor, Molecular Medicine
Center on Diabetes, Obesity, and Metabolism

Contact Information

Academic: 336-716-2821 | Department: 336-713-4259


Recent Publications

Targeted deletion of adipocyte Abca1 (ATP-binding cassette transporter A1) impairs diet-induced obesity. Cuffe H, Liu M, Key CC, Boudyguina E, Sawyer JK, Weckerle A, Bashore A, Fried SK, Chung S, Parks JS.. Arterioscler Thromb Vasc Biol. 2018;38(4):733-743.

Feeding of tobacco blend or nicotine induced weight loss associated with decreased adipocyte size and increased physical activity in male mice. Liu M, Chuang Key CC, Weckerle A, Boudyguina E, Sawyer JK, Gebre AK, Spoo W, Makwana O, Parks JS.. Food Chem Toxicol. 2018;113():287-295.

Hepatocyte ABCA1 deletion impairs liver insulin signaling and lipogenesis. Key CC, Liu M, Kurtz CL, Chung S, Boudyguina E, Dinh TA, Bashore A, Phelan PE, Freedman BI, Osborne TF, Zhu X, Ma L, Sethupathy P, Biddinger SB, Parks JS.. Cell Rep. 2017;19(10):2116-2129.

Dietary PUFAs attenuate NLRP3 inflammasome activation via enhancing macrophage autophagy. Shen L, Yang Y, Ou T, Key CC, Tong SH, Sequeira RC, Nelson JM, Nie Y, Wang Z, Boudyguina E, Shewale SV, Zhu X.. J Lipid Res. 2017;58(9):1808-1821.

Table grape consumption reduces adiposity and markers of hepatic lipogenesis and alters gut microbiota in butter fat-fed mice. Baldwin J, Collins B, Wolf PG, Martinez K, Shen W, Chuang CC, Zhong W, Cooney P, Cockrell C, Chang E, Gaskins HR, McIntosh MK.. J Nutr Biochem. 2016;27():123-135.

Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles. Liu M, Allegood J, Zhu X, Seo J, Gebre AK, Boudyguina E, Cheng D, Chuang CC, Shelness GS, Spiegel S, Parks JS.. J Biol Chem. 2015;290(12):7861-7870.

Low level of trans-10, cis-12 conjugated linoleic acid decreases adiposity and increases browning independent of inflammatory signaling in overweight Sv129 mice. Shen W, Baldwin J, Collins B, Hixson L, Lee KT, Herberg T, Starnes J, Cooney P, Chuang CC, Hopkins R, Reid T, Gupta S, McIntosh M.. J Nutr Biochem. 2015;26(6):616-625.

Alterations of a cellular cholesterol metabolism network are a molecular feature of obesity-related type 2 diabetes and cardiovascular disease. Ding J, Reynolds LM, Zeller T, Muller C, Mstat KL, Nicklas BJ, Kritchevsky SB, Huang Z, Fuente A, Soranzo N, Settlage RE, Chuang CC, Howard T, Xu N, Goodarzi MO, Ida Chen YD, Rotter JI, Siscovick DS, Parks JS, Murphy S, Jacobs DR Jr,.. Diabetes. 2015;64(10):3464-3474.

California table grape consumption reduces adiposity, hepatic triglycerides, lipogenic gene expression, and abundance of sulfidogenic bacteria in mice fed butter fat [abstract]. Baldwin J, Collins B, Wolfe P, Shen W, Chuang CC, Zhong W, Cooney P, Gaskins HR, McIntosh M.. FASEB J. 2015;29(Suppl 1):608.4.

An abundant dysfunctional apolipoprotein A1 in human atheroma. Huang Y, Didonato JA, Levison BS, Schmitt D, Li L, Wu Y, Buffa J, Kim T, Gerstenecker GS, Gu X, Kadiyala CS, Wang Z, Culley MK, Hazen JE, Didonato AJ, Fu X, Berisha SZ, Peng D, Nguyen TT, Liang S, Chuang CC, Cho L, Plow EF,.. Nat Med. 2014;20(2):193-203.

Myeloid cell-specific ABCA1 deletion does not worsen insulin resistance in HF diet-induced or genetically obese mouse models. Zhu X, Chung S, Bi X, Chuang CC, Brown AL, Liu M, Seo J, Cuffe H, Gebre AK, Boudyguina E, Parks JS.. J Lipid Res. 2013;54(10):2708-2717.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Instructor, Molecular Medicine

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