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Mei-Chuan Ko, Ph.D.Wake Forest School of Medicine

Mei-Chuan Ko, Ph.D.


Substance Addiction& Abuse Ctr

Contact Information

Academic: 336-713-5466 | Department: 336-716-2011


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Education & Training

  • B.S., Nat'l Cheng-Chi Univ, 1993
  • M.A., University of Michigan/Ann Arbor, 1996
  • Ph.D., University of Michigan/Ann Arbor, 1998


  • Int'L Union For Scientific Stu
  • Am Soc for Pharm & Exper Ther
  • Coll on Probs of Drug Dependen
  • Intl Forum for Study of Itch
Mei-Chuan Ko, Ph.D.

Mei-Chuan Ko, Ph.D.

Professor, Physiology & Pharmacology
Comprehensive Cancer Center
Office of Women in Medicine and Science
Center on Diabetes, Obesity, and Metabolism
Substance Addiction& Abuse Ctr

Research Interests

Receptors, Opioid; Analgesics, Opioid; Pruritus; Receptors, Opioid, mu; Opioid Peptides
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Contact Information

Academic: 336-713-5466 | Department: 336-716-2011


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Recent Publications

Differential mRNA expression of neuroinflammatory modulators in the spinal cord and thalamus of type 2 diabetic monkeys. Ding H, Kiguchi N, Kishioka S, Ma T, Peters CM, Ko MC.. J Diabetes. 2018;():.

Effects of BU08028, a mixed mu opioid receptor and nociceptin/orphanin FQ peptide (NOP) receptor agonist, on alcohol drinking in rhesus monkeys [abstract]. Czoty P, Epperly P, Davenport A, Ko MC, Husbands S, Flynn S.. Neuropsychopharmacology. 2017;43(Suppl 1):S630.

Spinal functions of B-type natriuretic peptide, gastrin-releasing peptide, and their cognate receptors for regulating itch in mice. Kiguchi N, Sukhtankar DD, Ding H, Tanaka KI, Kishioka S, Peters CM, Ko MC.. J Pharmacol Exp Ther. 2016;356(3):596-603.

Central N/OFQ-NOP receptor system in pain modulation. Kiguchi N, Ding H, Ko MC.. Adv Pharmacol. 2016;75():217-243.

A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates. Ding H, Czoty PW, Kiguchi N, Cami-Kobeci G, Sukhtankar DD, Nader MA, Husbands SM, Ko MC.. Proc Natl Acad Sci U S A. 2016;113(37):E5511-5518.

Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys. Kiguchi N, Ding H, Peters CM, Kock ND, Kishioka S, Cline JM, Wagner JD, Ko MC.. Biochim Biophys Acta. 2016;1863(1):274-283.

Pharmacological studies on the NOP and opioid receptor agonist PWT2-[Dmt1]N/OFQ(1-13). Cerlesi MC, Ding H, Bird MF, Kiguchi N, Ferrari F, Malfacini D, Rizzi A, Ruzza C, Lambert DG, Ko MC, Calo G, Guerrini R.. Eur J Pharmacol. 2016;794():115-126.

Supraspinal actions of nociceptin/orphanin FQ, morphine and substance P in regulating pain and itch in non-human primates. Ding H, Hayashida K, Suto T, Sukhtankar DD, Kimura M, Mendenhall V, Ko MC.. Br J Pharmacol. 2015;172(13):3302-3312.

Neuraxial opioid-induced itch and its pharmacological antagonism. Ko MC.. Handb Exp Pharmacol. 2015;226():315-335.

Bifunctional MOP/NOP receptor agonist, BU10038, as a strong and safe analgesic in monkeys [abstract]. Ding H, Cami-Kobeci G, Husbands S, Ko M.. J Pain. 2015;16(4 Suppl 1):S59.

TC-2559, an alpha4beta2 nicotinic acetylcholine receptor agonist, suppresses the expression of CCL3 and IL-1beta through STAT3 inhibition in cultured murine macrophages. Kiguchi N, Saika F, Kobayashi Y, Ko MC, Kishioka S.. J Pharmacol Sci. 2015;128(2):83-86.

Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates. Lee H, Ko MC.. Sci Rep. 2015;5():11676.

Spinal antinociceptive effects of the novel NOP receptor agonist PWT2-nociceptin/orphanin FQ in mice and monkeys. Rizzi A, Sukhtankar DD, Ding H, Hayashida K, Ruzza C, Guerrini R, Calo G, Ko MC.. Br J Pharmacol. 2015;172(14):3661-3670.

Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain. Sukhtankar DD, Lee H, Rice KC, Ko MC.. Psychopharmacology (Berl). 2014;231(7):1377-1387.

Functional plasticity of the N/OFQ-NOP receptor system determines analgesic properties of NOP receptor agonists. Schroder W, Lambert DG, Ko MC, Koch T.. Br J Pharmacol. 2014;171(16):3777-3800.

Effects of the NOP agonist SCH221510 on producing and attenuating reinforcing effects as measured by drug self-administration in rats. Sukhtankar DD, Lagorio CH, Ko MC.. Eur J Pharmacol. 2014;745():182-189.

Effects of spinally administered bifunctional nociceptin/orphanin FQ peptide receptor/mu-opioid receptor ligands in mouse models of neuropathic and inflammatory pain. Sukhtankar DD, Zaveri NT, Husbands SM, Ko MC.. J Pharmacol Exp Ther. 2013;346(1):11-22.

Physiological function of gastrin-releasing peptide and neuromedin B receptors in regulating itch scratching behavior in the spinal cord of mice. Sukhtankar DD, Ko MC.. PLoS One. 2013;8(6):e67422.

Inhibitory effects of dynorphin-A on spinally administered beta-endorphin-and GRP-induced scratching in nonhuman primates [abstract]. Lee H, Ko MC.. Acta Derm Venereol. 2013;93(5):609.

Selective role of spinal gastrin-releasing peptide receptor in regulation of itch neurotransmission in mice [abstract]. Sukhtankar DD, Ko MC.. Acta Derm Venereol. 2013;93(5):625.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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