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Steven J. Kridel, Ph.D.Wake Forest School of Medicine

Steven J. Kridel, Ph.D.

Associate Professor,
Redox Biology & Medicine Ctr

Contact Information

Academic: 336-716-7299 | Department: 336-716-7299


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Education & Training

  • B.Sc., Cal State University-Los Angeles, 1992
  • Ph.D., University of California-Irvine, 1997
Steven J. Kridel, Ph.D.

Steven J. Kridel, Ph.D.

Associate Professor, Cancer Biology
Redox Biology & Medicine Ctr

Research Interests

Neoplasms; Fatty Acids; Lipogenesis; Enzyme Inhibitors; Antineoplastic Agents
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Contact Information

Academic: 336-716-7299 | Department: 336-716-7299


Related Links

Recent Publications

Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells. Jin G, Xu C, Zhang X, Long J, Rezaeian AH, Liu C, Furth ME, Kridel S, Pasche B, Bian XW, Lin HK.. Nat Immunol. 2018;19(1):29-40.

Combination treatment with orlistat-containing nanoparticles and taxanes is synergistic and enhances microtubule stability in taxane-resistant prostate cancer cells. Souchek JJ, Davis AL, Hill TK, Holmes MB, Qi B, Singh PK, Kridel SJ, Mohs AM.. Mol Cancer Ther. 2017;16(9):1819-1830.

Crystal structure and substrate specificity of human thioesterase 2: insights into the molecular basis for the modulation of fatty acid synthase. Ritchie MK, Johnson LC, Clodfelter JE, Pemble CW IV, Fulp BE, Furdui CM, Kridel SJ, Lowther WT.. J Biol Chem. 2016;291(7):3520-3530.

Yin Yang 1 promotes mTORC2-mediated AKT phosphorylation. Zhang Q, Wan M, Shi J, Horita DA, Miller LD, Kute TE, Kridel SJ, Kulik G, Sui G.. J Mol Cell Biol. 2016;8(3):232-243.

Palmitoylation regulates the intracellular trafficking and stability of c-Met. Coleman DT, Gray AL, Kridel SJ, Cardelli JA.. Oncotarget. 2016;7(22):32664-77.

Development of a self-assembled nanoparticle formulation of Orlistat, Nano-ORL, with increased cytotoxicity against human tumor cell lines. Hill TK, Davis AL, Wheeler FB, Kelkar SS, Freund EC, Lowther WT, Kridel SJ, Mohs AM.. Mol Pharm. 2016;13(3):720-728.

Fatty acid synthase is a primary target of MiR-15a and MiR-16-1 in breast cancer. Wang J, Zhang X, Shi J, Cao P, Wan M, Zhang Q, Wang Y, Kridel SJ, Liu W, Xu J, Zhang Q, Sui G.. Oncotarget. 2016;7(48):78566-76.

Trimming the fat in non-small cell lung cancer: a new small molecule inhibitor of acetyl-CoA carboxylase to target fatty acid synthesis [editorial]. Davis AL, Kridel SJ.. Transl Cancer Res. 2016;5(Suppl 7):S1449-1452.

Nicotinamide phosphoribosyltransferase (NAMPT) is required to maintain cellular metabolism in glioblastoma [abstract]. Wheeler F, Lesser GJ, Herpai D, Debinski W, Kridel S.. Neuro Oncol. 2016;18(Suppl 6):101.

A comprehensive analysis of common and rare variants to identify adiposity loci in Hispanic Americans: the IRAS Family Study (IRASFS). Gao C, Wang N, Guo X, Ziegler JT, Taylor KD, Xiang AH, Hai Y, Kridel SJ, Nadler JL, Kandeel F, Raffel LJ, Chen YD, Norris JM, Rotter JI, Watanabe RM, Wagenknecht LE, Bowden DW, Speliotes EK, Goodarzi MO, Langefeld CD, Palmer ND.. PLoS One. 2015;10(11):e0134649.

Fatty acid synthase is required for mammary gland development and milk production during lactation. Suburu J, Shi L, Wu J, Wang S, Samuel M, Thomas MJ, Kock ND, Yang G, Kridel S, Chen YQ.. Am J Physiol Endocrinol Metab. 2014;306(10):E1132-1143.

Inhibition of the thioesterase activity of human fatty acid synthase by 1,4- and 9,10-diones. Odens H, Lowther T, Kridel S, Watts L, Filipponi L, Schmitt J.. Chem Pharm Bull (Tokyo). 2014;62(9):933-936.

The potential of 11C-acetate PET for monitoring the fatty acid synthesis pathway in tumors. Deford-Watts LM, Mintz A, Kridel SJ.. Curr Pharm Biotechnol. 2013;14(3):300-312.

Metabolic regulation of invadopodia and invasion by acetyl-CoA carboxylase 1 and de novo lipogenesis. Scott KEN, Wheeler FB, Davis AL, Thomas MJ, Ntambi JM, Seals DF, Kridel SJ.. PLoS ONE. 2012;7(1):e29761.

An interleukin 13 receptor alpha 2-specific peptide homes to human glioblastoma multiforme xenografts. Pandya H, Gibo DM, Garg S, Kridel S, Debinski W.. Neuro Oncol. 2012;14(1):6-18.

Nicotinamide phosphoribosyl transferase (Nampt) is required for de novo lipogenesis in tumor cells. Bowlby SC, Thomas MJ, D'Agostino RB Jr, Kridel SJ.. PLoS ONE. 2012;7(6):e40195.

Polyunsaturated fatty acid metabolism in prostate cancer. Berquin IM, Edwards IJ, Kridel SJ, Chen YQ.. Cancer Metastasis Rev. 2011;30(3-4):295-309.

Altered lipid and mitochondrial metabolism are viable targets in acute leukemia [abstract]. Pardee T, DeFord-Watts LM, Peronto E, Levitan DA, Hurd DD, Kridel S.. Blood. 2011;118(21):1546.

Isolation and characterization of interleukin 13 receptor alpha2-specific heptapeptides [abstract]. Debinski W, Garg S, Gibo DM, Kridel S, Pandya H.. Neuro Oncol. 2009;11(6):898.

1-11C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer. Vavere AL, Kridel SJ, Wheeler FB, Lewis JS.. J Nucl Med. 2008;49(2):327-334.

Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways. Fels DR, Ye J, Segan AT, Kridel SJ, Spiotto M, Olson M, Koong AC, Koumenis C.. Cancer Res. 2008;68(22):9323-9330.

Disruption of crosstalk between the fatty acid synthesis and proteasome pathways enhances unfolded protein response signaling and cell death. Little JL, Wheeler FB, Koumenis C, Kridel SJ.. Mol Cancer Ther. 2008;7(12):3816-3824.

Fatty acid synthase activity in tumor cells. Little JL, Kridel SJ.. Subcell Biochem. 2008;49():169-194.

Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells. Little JL, Wheeler FB, Fels DR, Koumenis C, Kridel SJ.. Cancer Res. 2007;67(3):1262-1269.

Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat. Pemble CW IV, Johnson LC, Kridel SJ, Lowther WT.. Nat Struct Mol Biol. 2007;14(8):704-709.

Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library. Lally BE, Geiger GA, Kridel S, Arcury-Quandt AE, Robbins ME, Kock ND, Wheeler K, Peddi P, Georgakilas A, Koumenis C, et al.. Cancer Res. 2007;67(18):8791-8799.

Fatty acid synthase inhibitors: new directions for oncology. Kridel SJ, Lowther WT, Pemble CW IV.. Expert Opin Investig Drugs. 2007;16(11):1817-1829.

Dietary fat-gene interactions in cancer. Chen YQ, Edwards IJ, Kridel SJ, Thornburg T, Berquin IM.. Cancer Metastasis Rev. 2007;26(3-4):535-551.

Fatty acid synthase: a novel target for antiglioma therapy. Zhao W, Kridel S, Thorburn A, Kooshki M, Little J, Hebbar S, Robbins M.. Br J Cancer. 2006;95(7):869-878.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Cancer Biology

Steven J. Kridel, Ph.D.

Steven J. Kridel, Ph.D.

Associate Professor, Cancer Biology
Redox Biology & Medicine Ctr

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