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Carl D. Langefeld, Ph.D.Wake Forest School of Medicine

Carl D. Langefeld, Ph.D.

Section Head,
Professor,

Contact Information

Academic: 336-713-0013 | Department: 336-716-2011

Email: clangefe@wakehealth.edu

Education & Training

  • Ph.D., University of Michigan/Ann Arbor, 1999

Memberships

  • Am Diabetes Assn
  • Am Soc of Human Genetics
  • Biometric Society
  • Int'L Genetic Epidemiology Soc
Carl D. Langefeld, Ph.D.

Carl D. Langefeld, Ph.D.

Section Head, Biostatistical Sciences
Professor, Biostatistical Sciences
Center for Genomics and Personalized Medicine Research

Research Interests

Genetic Predisposition to Disease; Polymorphism, Single Nucleotide; Lupus Erythematosus, Systemic; African Americans; Diabetes Mellitus, Type 2
More »

Contact Information

Academic: 336-713-0013 | Department: 336-716-2011

Email: clangefe@wakehealth.edu

Recent Publications

A null variant in the apolipoprotein L3 gene is associated with non-diabetic nephropathy. Skorecki KL, Lee JH, Langefeld CD, Rosset S, Tzur S, Wasser WG, Shemer R, Hawkins GA, Divers J, Parekh RS, Li M, Sampson MG, Kretzler M, Pollak MR, Shah S, Blackler D, Nichols B, Wilmot M, Alper SL, Freedman BI, Friedman DJ.. Nephrol Dial Transplant. 2018;33(2):323-330.

Effects of weight-based ultrafiltration rate limits on intradialytic hypotension in hemodialysis. Pirkle JL Jr, Comeau ME, Langefeld CD, Russell GB, Balderston SS, Freedman BI, Burkart JM.. Hemodial Int. 2018;22(2):270-278.

Early-life environmental exposures interact with genetic susceptibility variants in pediatric patients with eosinophilic esophagitis. Jensen ET, Kuhl JT, Martin LJ, Langefeld CD, Dellon ES, Rothenberg ME.. J Allergy Clin Immunol. 2018;141(2):632-637.e5.

FGF23 concentration and APOL1 genotype are novel predictors of mortality in African Americans with type 2 diabetes. Chan GC, Divers J, Russell GB, Langefeld CD, Wagenknecht LE, Hsu FC, Xu J, Smith SC, Palmer ND, Hicks PJ, Bowden DW, Register TC, Ma L, Carr JJ, Freedman BI.. Diabetes Care. 2018;41(1):178-186.

Genome-wide study of subcutaneous and visceral adipose tissue reveals novel sex-specific adiposity loci in Mexican Americans. Gao C, Langefeld CD, Ziegler JT, Taylor KD, Norris JM, Chen YI, Hellwege JN, Guo X, Allison MA, Speliotes EK, Rotter JI, Bowden DW, Wagenknecht LE, Palmer ND.. Obesity (Silver Spring). 2018;26(1):202-212.

The African Descent and Glaucoma Evaluation Study (ADAGES) III: contribution of genotype to glaucoma phenotype in African Americans: study design and baseline data. Zangwill LM, Ayyagari R, Liebmann JM, Girkin CA, Feldman R, Dubiner H, Dirkes KA, Holmann M, Williams-Steppe E, Hammel N, Saunders LJ, Vega S, Sandow K, Roll K, Slight R, Auerbach D, Samuels BC, Panarelli JF, Mitchell JP, Al-Aswad LA,.. Ophthalmology. 2018;():.

Transethnic evaluation identifies low-frequency loci associated with 25-hydroxyvitamin D concentrations. Hong J, Hatchell KE, Bradfield JP, Andrew B, Alessandra C, Chao-Qiang L, Langefeld CD, Lu L, Lu Y, Lutsey PL, Musani SK, Nalls MA, Robinson-Cohen C, Roizen JD, Saxena R, Tucker KL, Ziegler JT, Arking DE, Bis JC, Boerwinkle E, Bottinger EP,.. J Clin Endocrinol Metab. 2018;103(4):1380-1392.

Brief report: the genetic profile of rheumatoid factor-positive polyarticular juvenile idiopathic arthritis resembles that of adult rheumatoid arthritis. Hinks A, Marion MC, Cobb J, Comeau ME, Sudman M, Ainsworth HC, Bowes J, Becker ML, Bohnsack JF, Haas JP, Lovell DJ, Mellins ED, Nelson JL, Nordal E, Punaro M, Reed AM, Rose CD, Rosenberg AM, Rygg M, Smith SL, Stevens AM, Videm V,.. Arthritis Rheumatol. 2018;70(6):957-962.

Transcriptional regulatory mechanisms in adipose and muscle tissue associated with composite glucometabolic phenotypes. Langefeld CD, Comeau ME, Sharma NK, Bowden DW, Freedman BI, Das SK.. Obesity (Silver Spring). 2018;26(3):559-569.

JC polyoma viruria associates with protection from chronic kidney disease independently from apolipoprotein L1 genotype in African Americans. Freedman BI, Kistler AL, Skewes-Cox P, Ganem D, Spainhour M, Turner J, Divers J, Langefeld CD, Murea M, Hicks PJ, Hemal AK, Snipes JA, Zhao L, Abend JR, Lyles DS, Ma L, Skorecki KL.. Nephrol Dial Transplant. 2018;():.

Adipose tissue depot volume relationships with spinal trabecular bone mineral density in African Americans with diabetes. Chan GC, Divers J, Russell GB, Langefeld CD, Wagenknecht LE, Xu J, Smith SC, Bowden DW, Register TC, Carr JJ, Lenchik L, Freedman BI.. PLoS One. 2018;13(1):e0191674.

A large-scale multi-ancestry genome-wide study accounting for smoking behavior identifies multiple significant loci for blood pressure. Sung YJ, Winkler TW, de Las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I, Guo X, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Li C, Feitosa MF, Kilpelainen TO, Richard MA, Noordam R, Aslibekyan S,.. Am J Hum Genet. 2018;102(3):375-400.

Metabolomics identifies distinctive metabolite signatures for measures of glucose homeostasis: the Insulin Resistance Atherosclerosis Family Study (IRAS-FS). Palmer ND, Okut H, Hsu FC, Ng MCY, Ida Chen YD, Goodarzi MO, Taylor KD, Norris JM, Lorenzo C, Rotter JI, Bergman RN, Langefeld CD, Wagenknecht LE, Bowden DW.. J Clin Endocrinol Metab. 2018;103(5):1877-1888.

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S,.. Nat Genet. 2018;50(4):524-537.

Exome sequencing identifies genetic variants associated with circulating lipid levels in Mexican Americans: the Insulin Resistance Atherosclerosis Family Study (IRASFS). Gao C, Tabb KL, Dimitrov LM, Taylor KD, Wang N, Guo X, Long J, Rotter JI, Watanabe RM, Curran JE, Blangero J, Langefeld CD, Bowden DW, Palmer ND.. Sci Rep. 2018;8(1):5603.

Allele-specific methylation in the FADS genomic region in DNA from human saliva, CD4+ cells, and total leukocytes. Rahbar E, Waits CMK, Kirby EH Jr, Miller LR, Ainsworth HC, Cui T, Sergeant S, Howard TD, Langefeld CD, Chilton FH.. Clin Epigenetics. 2018;10():46.

Exposure of the bone marrow microenvironment to simulated solar and galactic cosmic radiation induces biological bystander effects on human hematopoiesis. Almeida-Porada G, Rodman C, Kuhlman B, Brudvik E, Moon J, George S, Guida P, Sajuthi SP, Langefeld CD, Walker SJ, Wilson PF, Porada CD.. Stem Cells Dev. 2018;():.

TMTC2 variant associated with sensorineural hearing loss and auditory neuropathy spectrum disorder in a family dyad. Guillen-Ahlers H, Erbe CB, Chevalier FD, Montoya MJ, Zimmerman KD, Langefeld CD, Olivier M, Runge CL.. Mol Genet Genomic Med. 2018;6(4):653-659.

Hypertension and intracerebral hemorrhage recurrence among white, black, and Hispanic individuals. Rodriguez-Torres A, Murphy M, Kourkoulis C, Schwab K, Ayres AM, Moomaw CJ, Young Kwon S, Berthaud JV, Gurol ME, Greenberg SM, Viswanathan A, Anderson CD, Flaherty M, James ML, Birnbaum L, Yong Sung G, Parikh G, Boehme AK, Mayson D,.. Neurology. 2018;91(1):e37-e44.

Genome-wide association studies suggest that APOL1-environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1-second gene interactions. Langefeld CD, Comeau ME, Ng MCY, Guan M, Dimitrov L, Mudgal P, Spainhour MH, Julian BA, Edberg JC, Croker JA, Divers J, Hicks PJ, Bowden DW, Chan GC, Ma L, Palmer ND, Kimberly RP, Freedman BI.. Kidney Int. 2018;():.

Minority patients are less likely to undergo withdrawal of care after spontaneous intracerebral hemorrhage. Ormseth CH, Falcone GJ, Jasak SD, Mampre DM, Leasure AC, Miyares LC, Hwang DY, James ML, Testai FD, Becker KJ, Tirschwell DL, Langefeld CD, Woo D, Sheth KN.. Neurocrit Care. 2018;():.

A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus. Patel Z, Lu X, Miller D, Forney CR, Lee J, Lynch A, Schroeder C, Parks L, Magnusen AF, Chen X, Pujato M, Maddox A, Zoller EE, Namjou B, Brunner HI, Henrickson M, Huggins JL, Williams AH, Ziegler JT, Comeau ME, Marion MC, Glenn SB, Adler A,.. Hum Mol Genet. 2018;27(13):2392-2404.

Association between inflammatory biomarker C-reactive protein and radiotherapy-induced early adverse skin reactions in a multiracial/ethnic breast cancer population. Hu JJ, Urbanic JJ, Case LD, Takita C, Wright JL, Brown DR, Langefeld CD, Lively MO, Mitchell SE, Thakrar A, Bryant D, Baglan K, Strasser J, Baez-Diaz L, Lesser GJ, Shaw EG.. J Clin Oncol. 2018;():.

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. Feitosa MF, Kraja AT, Chasman DI, Sung YJ, Winkler TW, Ntalla I, Guo X, Franceschini N, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Li C, Bentley AR, Brown MR, Schwander K, Richard MA, Noordam R, Aschard H, Bartz TM, Bielak LF, Dorajoo R,.. PLoS One. 2018;13(6):e0198166.

Racial/ethnic variation of APOE alleles for lobar intracerebral hemorrhage. Sawyer RP, Sekar P, Osborne J, Kittner SJ, Moomaw CJ, Flaherty ML, Langefeld CD, Anderson CD, Rosand J, Woo D.. Neurology. 2018;91(5):e410-e420.

Genome-wide linkage and association analysis of cardiometabolic phenotypes in Hispanic Americans. Hellwege JN, Palmer ND, Dimitrov L, Keaton JM, Tabb KL, Sajuthi S, Taylor KD, Ng MC, Speliotes EK, Hawkins GA, Long J, Ida Chen YD, Lorenzo C, Norris JM, Rotter JI, Langefeld CD, Wagenknecht LE, Bowden DW.. J Hum Genet. 2017;62(2):175-184.

Genome-wide association of CKD progression: the chronic renal insufficiency cohort study. Parsa A, Kanetsky PA, Xiao R, Gupta J, Mitra N, Limou S, Xie D, Xu H, Anderson AH, Ojo A, Kusek JW, Lora CM, Hamm LL, He J, Sandholm N, Jeff J, Raj DE, Boger CA, Bottinger E, Salimi S, Parekh RS, Adler SG, Langefeld CD, Bowden DW, Groop PH,.. J Am Soc Nephrol. 2017;28(3):923-934.

APOL1 renal-risk variants induce mitochondrial dysfunction. Ma L, Chou JW, Snipes JA, Bharadwaj MS, Craddock AL, Cheng D, Weckerle A, Petrovic S, Hicks PJ, Hemal AK, Hawkins GA, Miller LD, Molina AJ, Langefeld CD, Murea M, Parks JS, Freedman BI.. J Am Soc Nephrol. 2017;28(4):1093-1105.

In vitro and in vivo assessment of direct effects of simulated solar and galactic cosmic radiation on human hematopoietic stem/progenitor cells. Rodman C, Almeida-Porada G, George SK, Moon J, Soker S, Pardee T, Beaty M, Guida P, Sajuthi SP, Langefeld CD, Walker SJ, Wilson PF, Porada CD.. Leukemia. 2017;31(6):1398-1407.

Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications. Ombrello MJ, Arthur VL, Remmers EF, Hinks A, Tachmazidou I, Grom AA, Foell D, Martini A, Gattorno M, Ozen S, Prahalad S, Zeft AS, Bohnsack JF, Ilowite NT, Mellins ED, Russo R, Len C, Hilario MO, Oliveira S, Yeung RS, Rosenberg AM, Wedderburn LR,.. Ann Rheum Dis. 2017;76(5):906-913.

Genetic variation at 16q24.2 is associated with small vessel stroke. Traylor M, Malik R, Nalls MA, Cotlarciuc I, Radmanesh F, Thorleifsson G, Hanscombe KB, Langefeld C, Saleheen D, Rost NS, Yet I, Spector TD, Bell JT, Hannon E, Mill J, Chauhan G, Debette S, Bis JC, Longstreth WT Jr, Ikram MA, Launer LJ, Seshadri S,.. Ann Neurol. 2017;81(3):383-394.

Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation. Chu AY, Deng X, Fisher VA, Drong A, Zhang Y, Feitosa MF, Liu CT, Weeks O, Choh AC, Duan Q, Dyer TD, Eicher JD, Guo X, Heard-Costa NL, Kacprowski T, Kent JW Jr, Lange LA, Liu X, Lohman K, Lu L, Mahajan A, O'Connell JR, Parihar A, Peralta JM,.. Nat Genet. 2017;49(1):125-130.

Ischemic lesions, blood pressure dysregulation, and poor outcomes in intracerebral hemorrhage. Kidwell CS, Rosand J, Norato G, Dixon S, Worrall BB, James ML, Elkind MS, Flaherty ML, Osborne J, Vashkevich A, Langefeld CD, Moomaw CJ, Woo D.. Neurology. 2017;88(8):782-788.

Analysis of whole exome sequencing with cardiometabolic traits using family-based linkage and association in the IRAS Family Study. Tabb KL, Hellwege JN, Palmer ND, Dimitrov L, Sajuthi S, Taylor KD, Ng MC, Hawkins GA, Chen YI, Brown WM, McWilliams D, Williams A, Lorenzo C, Norris JM, Long J, Rotter JI, Curran JE, Blangero J, Wagenknecht LE, Langefeld CD, Bowden DW.. Ann Hum Genet. 2017;81(2):49-58.

Bladder capacity is a biomarker for a bladder-centric versus systemic manifestation in interstitial cystitis/bladder pain syndrome. Walker SJ, Zambon J, Andersson KE, Langefeld C, Matthews CA, Badlani G, Bowman H, Evans RJ.. J Urol. 2017;198(2):369-374.

Rare and low-frequency coding variants alter human adult height. Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y, Schurmann C, Highland HM, Rueger S, Thorleifsson G, Justice AE, Lamparter D, Stirrups KE, Turcot V, Young KL, Winkler TW, Esko T, Karaderi T, Locke AE, Masca NG,.. Nature. 2017;542(7640):186-190.

Association between telomere length and risk of cancer and non-neoplastic diseases: a Mendelian randomization study. Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM,.. JAMA Oncol. 2017;3(5):636-651.

A genome-wide linkage and association analysis of imputed insertions and deletions with cardiometabolic phenotypes in Mexican Americans: the Insulin Resistance Atherosclerosis Family Study. Gao C, Hsu FC, Dimitrov LM, Okut H, Chen YI, Taylor KD, Rotter JI, Langefeld CD, Bowden DW, Palmer ND.. Genet Epidemiol. 2017;41(4):353-362.

Alcohol use and risk of intracerebral hemorrhage. Chen CJ, Brown WM, Moomaw CJ, Langefeld CD, Osborne J, Worrall BB, Woo D, Koch S.. Neurology. 2017;88(21):2043-2051.

The SLCO1B1*14 allele is associated with poor response to subcutaneous methotrexate in patients with juvenile idiopathic arthritis [abstract]. Moncrieffe H, Ramsey LB, Sudman M, Gottlieb B, Langefeld CD, Lovell D, Thompson SD.. Arthritis Rheumatol. 2017;69(Suppl 4):48-50.

The TMAO-producing enzyme flavin-containing monooxygenase 3 regulates obesity and the beiging of white adipose tissue. Schugar RC, Shih DM, Warrier M, Helsley RN, Burrows A, Ferguson D, Brown AL, Gromovsky AD, Heine M, Chatterjee A, Li L, Li XS, Wang Z, Willard B, Meng Y, Kim H, Che N, Pan C, Lee RG, Crooke RM, Graham MJ, Morton RE, Langefeld CD,.. Cell Rep. 2017;19(12):2451-2461.

Genetic epidemiology in kidney disease. Ainsworth HC, Langefeld CD, Freedman BI.. Nephrol Dial Transplant. 2017;32(Suppl 2):159-169.

CETP genetic variants that increase HDL raise Intracerebral hemorrhage risk [abstract]. Anderson C, Falcone G, Peloso G, Langefeld C, Abecasis G, Kathiresan S, Woo D, Rosand J.. J Cereb Blood Flow Metab. 2017;37(Suppl 1):112-113.

Race/ethnic variation of Apolipoprotein E alleles for lobar intracerebral hemorrhage [abstract]. Woo D, Sekar P Rosand J, Osborne J, Kittner S, Langefeld C, Moomaw C, Flaherty M, Anderson C.. J Cereb Blood Flow Metab. 2017;37(Suppl 1):117.

Dense genotyping of immune-related regions identifies loci for rheumatoid arthritis risk and damage in African Americans. Danila MI, Laufer VA, Reynolds RJ, Yan Q, Liu N, Gregersen PK, Lee A, Kern M, Langefeld CD, Arnett DK, Bridges SL Jr.. Mol Med. 2017;23():177-187.

Variability in the use of platelet transfusion in patients with intracerebral hemorrhage: observations from the Ethnic/Racial Variations of Intracerebral Hemorrhage study. Guerrero WR, Gonzales NR, Sekar P, Kawano-Castillo J, Moomaw CJ, Worrall BB, Langefeld CD, Martini SR, Flaherty ML, Sheth KN, Osborne J, Woo D.. J Stroke Cerebrovasc Dis. 2017;26(9):1974-1980.

Aggressiveness of care following intracerebral hemorrhage in women and men. Guha R, Boehme A, Demel SL, Li JJ, Cai X, James ML, Koch S, Langefeld CD, Moomaw CJ, Osborne J, Sekar P, Sheth KN, Woodrich E, Worrall BB, Woo D, Chaturvedi S.. Neurology. 2017;89(4):349-354.

Use of statins and outcomes in intracerebral hemorrhage patients. Siddiqui FM, Langefeld CD, Moomaw CJ, Comeau ME, Sekar P, Rosand J, Kidwell CS, Martini S, Osborne JL, Stutzman S, Hall C, Woo D.. Stroke. 2017;48(8):2098-2104.

Type 2 diabetes variants disrupt function of SLC16A11 through two distinct mechanisms. Rusu V, Hoch E, Mercader JM, Tenen DE, Gymrek M, Hartigan CR, DeRan M, von Grotthuss M, Fontanillas P, Spooner A, Guzman G, Deik AA, Pierce KA, Dennis C, Clish CB, Carr SA, Wagner BK, Schenone M, Ng MCY, Chen BH, Centeno-Cruz F, Zerrweck C,.. Cell. 2017;170(1):.

Genomics in rheumatic diseases: hope for the future [editorial]. Bridges SL Jr, Langefeld CD.. Rheum Dis Clin North Am. 2017;43(3):15-16.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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