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Paul J. Laurienti, M.D., Ph.D.Wake Forest School of Medicine

Paul J. Laurienti, M.D., Ph.D.

Substance Addiction& Abuse Ctr

Contact Information

Academic: 336-716-3261 | Department: 336-760-3261


Education & Training

  • B.S., University of Houston, 1991
  • Ph.D., University of Texas Medical School-Galveston, 1995
  • M.D., University of Texas Medical School-Galveston, 1999
  • Fellowship, University of Texas Medical Sc, 1995
  • Residency, Radiology, NC Baptist Hospital, 1999
  • Fellowship, WFU School of Medicine, 2000


  • Sigma Xi Society
  • Soc Of Neuroscience
  • Western Nc Chpt Soc For Neuros
Paul J. Laurienti, M.D., Ph.D.

Paul J. Laurienti, M.D., Ph.D.

Professor, Radiology
Substance Addiction& Abuse Ctr

Research Interests

Brain; Nerve Net; Attention; Aging; Auditory Perception
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Contact Information

Academic: 336-716-3261 | Department: 336-760-3261


Recent Publications

Farmworker and nonfarmworker Latino immigrant men in North Carolina have high levels of specific pesticide urinary metabolites. Arcury TA, Chen H, Laurienti PJ, Howard TD, Barr DB, Mora DC, Quandt SA.. Arch Environ Occup Health. 2018;73(4):219-227.

Pesticide urinary metabolites among Latina farmworkers and non-farmworkers in North Carolina. Arcury TA, Laurienti PJ, Talton JW, Chen H, Howard TD, Barr DB, Mora DC, Quandt SA.. J Occup Environ Med. 2018;60(1):e63-e71.

Long term effect of intensive lifestyle intervention on cerebral blood flow. Espeland MA, Luchsinger JA, Neiberg RH, Carmichael O, Laurienti PJ, Pi-Sunyer X, Wing RR, Cook D, Horton E, Casanova R, Erickson K, Nick Bryan R.. J Am Geriatr Soc. 2018;66(1):120-126.

Exploring associations between postural balance and levels of urinary organophosphorus pesticide metabolites. Kim S, Nussbaum MA, Laurienti PJ, Chen H, Quandt SA, Barr DB, Arcury TA.. J Occup Environ Med. 2018;60(2):174-179.

Dynamic fMRI networks predict success in a behavioral weight loss program among older adults. Mokhtari F, Rejeski WJ, Zhu Y, Wu G, Simpson SL, Burdette JH, Laurienti PJ.. Neuroimage. 2018;173():421-433.

Differing patterns of stress and craving across the day in moderate-heavy alcohol consumers during their typical drinking routine and an imposed period of alcohol abstinence. Mayhugh RE, Rejeski WJ, Petrie MR, Laurienti PJ, Gauvin L.. PLoS One. 2018;13(4):e0195063.

Mental health among Latina farmworkers and other employed Latinas in North Carolina. Arcury TA, Sandberg JC, Talton JW, Laurienti PJ, Daniel SS, Quandt SA.. J Rural Ment Health. 2018;42(2):89-101.

Relationship between functional brain connectivity and cardiac vagal functioning in moderate to heavy alcohol consumers [abstract]. Mayhugh R, Rejeski WJ, Bahrami M, Simpson SL, Heilman K, Porges S, Gauvin L, Laurienti PJ.. Alcohol Clin Exp Res. 2018;42(Suppl 1):127A.

Hippocampal contributions to the large-scale episodic memory network predict vivid visual memories. Geib BR, Stanley ML, Wing EA, Laurienti PJ, Cabeza R.. Cereb Cortex. 2017;27(1):680-693.

Effects of supervised exercise and dietary nitrate in older adults with controlled hypertension and/or heart failure with preserved ejection fraction. Shaltout HA, Eggebeen J, Marsh AP, Brubaker PH, Laurienti PJ, Burdette JH, Basu S, Morgan A, Dos Santos PC, Norris JL, Morgan TM, Miller GD, Rejeski WJ, Hawfield AT, Diz DI, Becton JT, Kim-Shapiro DB, Kitzman DW.. Nitric Oxide. 2017;69():78-90.

The impacts of pesticide and nicotine exposures on functional brain networks in Latino immigrant workers. Bahrami M, Laurienti PJ, Quandt SA, Talton J, Pope CN, Summers P, Burdette JH, Chen H, Liu J, Howard TD, Arcury TA, Simpson SL.. Neurotoxicology. 2017;62():138-150.

In vivo imaging of venous side cerebral small-vessel disease in older adults: an MRI method at 7T. Shaaban CE, Aizenstein HJ, Jorgensen DR, MacCloud RL, Meckes NA, Erickson KI, Glynn NW, Mettenburg J, Guralnik J, Newman AB, Ibrahim TS, Laurienti PJ, Vallejo AN, Rosano C.. AJNR Am J Neuroradiol. 2017;38(10):1923-1928.

Beet root juice: an ergogenic aid for exercise and the aging brain. Petrie M, Rejeski WJ, Basu S, Laurienti PJ, Marsh AP, Norris JL, Kim-Shapiro DB, Burdette JH.. J Gerontol A Biol Sci Med Sci. 2017;72(9):1284-1289.

Personal samplers of bioavailable pesticides integrated with a hair follicle assay of DNA damage to assess environmental exposures and their associated risks in children. Vidi PA, Anderson KA, Chen H, Anderson R, Salvador-Moreno N, Mora DC, Poutasse C, Laurienti PJ, Daniel SS, Arcury TA.. Mutat Res. 2017;822():27-33.

Urinary cotinine levels among Latino tobacco farmworkers in North Carolina compared to Latinos not employed in agriculture. Arcury TA, Laurienti PJ, Talton JW, Chen H, Howard TD, Summers P, Quandt SA.. Nicotine Tob Res. 2016;18(6):1517-1525.

Disentangling brain graphs: a note on the conflation of network and connectivity analyses. Simpson SL, Laurienti PJ.. Brain Connect. 2016;6(2):95-98.

Alcohol consumption and risk for dependence among male Latino migrant farmworkers compared to Latino nonfarmworkers in North Carolina. Arcury TA, Talton JW, Summers P, Chen H, Laurienti PJ, Quandt SA.. Alcohol Clin Exp Res. 2016;40(2):377-384.

Effects of lifetime occupational pesticide exposure on postural control among farmworkers and non-farmworkers. Sunwook K, Nussbaum MA, Quandt SA, Laurienti PJ, Arcury TA.. J Occup Environ Med. 2016;58(2):133-139.

Brain and white matter hyperintensity volumes after 10 years of random assignment to lifestyle intervention. Espeland MA, Erickson K, Neiberg RH, Jakicic JM, Wadden TA, Wing RR, Desiderio L, Erus G, Hsieh MK, Davatzikos C, Maschak-Carey BJ, Laurienti PJ, Demos-McDermott K, Bryan RN.. Diabetes Care. 2016;39(5):764-771.

Brain anatomy in Latino farmworkers exposed to pesticides and nicotine. Laurienti PJ, Burdette JH, Talton J, Pope CN, Summers P, Walker FO, Quandt SA, Lyday RG, Chen H, Howard TD, Arcury TA.. J Occup Environ Med. 2016;58(5):436-443.

Military personnel with traumatic stress show changes in large-scale brain networks after use of a closed-loop neurotechnology [abstract]. Tegeler C, Tegeler C, Cook J, Lee S, Shaltout H, Laurienti P.. Neurology. 2016;86(16 Suppl):A17.009.

Graph-theoretical study of functional changes associated with the Iowa Gambling Task. Bolt T, Laurienti PJ, Lyday R, Morgan A, Dagenbach D.. Front Hum Neurosci. 2016;10():314.

Moderate-heavy alcohol consumption lifestyle in older adults is associated with altered central executive network community structure during cognitive task. Mayhugh RE, Moussa MN, Simpson SL, Lyday RG, Burdette JH, Porrino LJ, Laurienti PJ.. PLoS One. 2016;11(8):e0160214.

Moderate alcohol consumption lifestyle in older adults is associated with altered central executive network community structure [abstract]. Mayhugh RE, Moussa MN, Lyday RG, Burdette JH, Laurienti PJ.. Alcohol Clin Exp Res. 2016;40(Suppl 1):213A.

Relative differences in resting-state brain connectivity associated with long term intensive lifestyle intervention. Casanova R, Hayasaka S, Saldana S, Bryan NR, Demos KE, Desiderio L, Erickson KI, Espeland MA, Nasrallah IM, Wadden T, Laurienti PJ.. Psychoneuroendocrinology. 2016;74():231-239.

Baseline gray- and white-matter volume predict successful weight loss in the elderly. Mokhtari F, Paolini BM, Burdette JH, Marsh AP, Rejeski WJ, Laurienti PJ.. Obesity (Silver Spring). 2016;24(12):2475-2480.

Organophosphate pesticide urinary metabolites among Latino immigrants: North Carolina farmworkers and non-farmworkers compared. Arcury TA, Laurienti PJ, Chen H, Howard TD, Barr DB, Mora DC, Summers P, Quandt SA.. J Occup Environ Med. 2016;58(11):1079-1086.

Long-term moderate alcohol consumption does not exacerbate age-related cognitive decline in healthy, community-dwelling older adults. Moussa MN, Simpson SL, Mayhugh RE, Grata ME, Burdette JH, Porrino LJ, Laurienti PJ.. Front Aging Neurosci. 2015;6():341.

Mechanisms of human erythrocytic bioactivation of nitrite. Liu C, Wajih N, Liu X, Basu S, Janes J, Marvel M, Keggi C, Helms CC, Lee AN, Belanger AM, Diz DI, Laurienti PJ, Caudell DL, Wang J, Gladwin MT, Kim-Shapiro DB.. J Biol Chem. 2015;290(2):1281-1294.

A two-part mixed-effects modeling framework for analyzing whole-brain network data. Simpson SL, Laurienti PJ.. Neuroimage. 2015;113():310-319.

Changes in brain network efficiency and working memory performance in aging. Stanley ML, Simpson SL, Dagenbach D, Lyday RG, Burdette JH, Laurienti PJ.. PLoS One. 2015;10(4):e0123950.

The effects of chronic alcohol self-administration in nonhuman primate brain networks. Telesford QK, Laurienti PJ, Davenport AT, Friedman DP, Kraft RA, Daunais JB.. Alcohol Clin Exp Res. 2015;39(4):659-671.

Global integration of the hot-state brain network of appetite predicts short term weight loss in older adult. Paolini BM, Laurienti PJ, Simpson SL, Burdette JH, Lyday RG, Rejeski WJ.. Front Aging Neurosci. 2015;7():70.

Aging, the central nervous system, and mobility in older adults: neural mechanisms of mobility impairment. Sorond FA, Cruz-Almeida Y, Clark DJ, Viswanathan A, Scherzer CR, De Jager P, Csiszar A, Laurienti PJ, Hausdorff JM, Chen WG, Ferrucci L, Rosano C, Studenski SA, Black SE, Lipsitz LA.. J Gerontol A Biol Sci Med Sci. 2015;70(12):1526-1532.

The brain science interface. Simpson SL, Burdette JH, Laurienti PJ.. Signif (Oxf). 2015;12(4):34-39.

Military personnel with traumatic stress demonstrate changes in the default mode network after use of a closed-loop neurotechnology [abstract]. Tegeler CH, Laurienti PJ, Tegeler CL, Cook JF, Wistermayer PR, Lee SW, Shaltout HA.. Ann Neurol. 2015;78(Suppl 19):S22.

Age-related differences in advantageous decision making are associated with distinct differences in functional community structure. Moussa MN, Wesley MJ, Porrino LJ, Hayasaka S, Bechara A, Burdette JH, Laurienti PJ.. Brain Connect. 2014;4(3):193-202.

Meal replacement: calming the hot-state brain network of appetite. Paolini BM, Laurienti PJ, Norris J, Rejeski WJ.. Front Psychol. 2014;5():249.

The role of meal replacements in regulating the hedonic brain network of appetite [abstract]. Paolini B, Rejeski J, Laurienti P.. J Altern Complement Med. 2014;20(5):A31.

Graph theory analysis of functional brain networks and mobility disability in older adults. Hugenschmidt CE, Burdette JH, Morgan AR, Williamson JD, Kritchevsky SB, Laurienti PJ.. J Gerontol A Biol Sci Med Sci. 2014;69(11):1399-1406.

Neural murmurations: comment on "understanding brain networks and brain organization" by Luiz Pessoa [editorial]. Laurienti PJ.. Phys Life Rev. 2014;11(3):452-454.

Daily beet root juice supplement and exercise training in older hypertensive adults [abstract]. Marsh AP, Klebous CL, Laurienti PJ, Kim-Shapiro DB, Rejeski WJ, Robertson TP, Redman H.. Med Sci Sports Exerc. 2014;46(5 Suppl 1):665.

Network science and the effects of music preference on functional brain connectivity: from Beethoven to Eminem. Wilkins RW, Hodges DA, Laurienti PJ, Steen M, Burdette JH.. Sci Rep. 2014;4():6130.

Changes in global and regional modularity associated with increasing working memory load. Stanley ML, Dagenbach D, Lyday RG, Burdette JH, Laurienti PJ.. Front Hum Neurosci. 2014;8():954.

Effect of adding beet root juice to exercise on physical performance and cardiovascular measures in old hypertensive subjects [abstract]. Shaltout HA, Marsh AP, Laurienti P, Basu S, Klebous CC, Kus N, Morgan A, DosSantos PC, Norris JL, Miller G, Rejeski J, Hawfield AT, Diz DI, Kim-Shapiro DB.. Hypertension. 2014;64(Suppl 1):A462.

The human functional brain network demonstrates structural and dynamical resilience to targeted attack. Joyce KE, Hayasaka S, Laurienti PJ.. PLoS Comput Biol. 2013;9(1):e1002885.

An exploration of graph metric reproducibility in complex brain networks. Telesford QK, Burdette JH, Laurienti PJ.. Front Neurosci. 2013;7():67.

Stability of whole brain and regional network topology within and between resting and cognitive states. Rzucidlo JK, Roseman PL, Laurienti PJ, Dagenbach D.. PLoS One. 2013;8(8):e70275.

Analyzing complex functional brain networks: fusing statistics and network science to understand the brain. Simpson SL, Bowman FD, Laurienti PJ.. Stat Surv. 2013;7():1-36.

A permutation testing framework to compare groups of brain networks. Simpson SL, Lyday RG, Hayasaka S, Marsh AP, Laurienti PJ.. Front Comput Neurosci. 2013;7():171.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Radiology

Paul J. Laurienti, M.D., Ph.D.

Paul J. Laurienti, M.D., Ph.D.

Professor, Radiology
Substance Addiction& Abuse Ctr

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