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Xiaoyan Iris Leng, M.D., Ph.D.Wake Forest School of Medicine

Xiaoyan Iris Leng, M.D., Ph.D.

Associate Professor,

Clinical Interests

Clinical Trials

Contact Information

Academic: 336-716-4564 | Department: 336-716-2011


Additional Languages


Education & Training

  • M.D., Beijing Medical University-China, 1995
  • M.S., Beijing Medical University-China, 1998
  • M.S., University of California-Davis, 2001
  • Ph.D., University of California-Davis, 2004


  • Am Statistical Assoc
  • Institute Of Mathematical Stat
Xiaoyan Iris Leng, M.D., Ph.D.

Xiaoyan Iris Leng, M.D., Ph.D.

Associate Professor, Biostatistical Sciences

Research Interests

Geriatric Assessment; Gene Expression; Lung; Aging; Oligonucleotide Array Sequence Analysis
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Contact Information

Academic: 336-716-4564 | Department: 336-716-2011


Recent Publications

Cognitive function and changes in cognitive function as predictors of incident cardiovascular disease: the Women's Health Initiative Memory Study. Leng X, Espeland MA, Manson JE, Stefanick ML, Gower EW, Hayden KM, Limacher MC, Vaughan L, Robinson J, Wallace R, Wassertheil-Smoller S, Yaffe K, Shumaker SA.. J Gerontol A Biol Sci Med Sci. 2018;73(6):779-785.

Relationship of physical function to single muscle fiber contractility in older adults: effects of resistance training with and without caloric restriction. Wang ZM, Leng X, Messi ML, Choi SJ, Marsh AP, Nicklas B, Delbono O.. J Gerontol A Biol Sci Med Sci. 2018;():.

Risk factor burden, heart failure, and survival in women of different ethnic groups: insights from the Women's Health Initiative. Breathett K, Leng I, Foraker RE, Abraham WT, Coker L, Whitfield KE, Shumaker S, Manson JE, Eaton CB, Howard BV, Ijioma N, Cene CW, Martin LW, Johnson KC, Klein L.. Circ Heart Fail. 2018;11(5):e004642.

Self-reported mobility as a preoperative risk assessment tool in older surgical patients compared to the American College of Surgeons National Surgical Quality Improvement Program. Kim S, Neiberg R, Rejeski WJ, Marsh AP, Kritchevsky SB, Leng XI, Groban L.. Perioper Med (Lond). 2018;7():12.

Gait speed response to aerobic versus resistance exercise training in older adults. Henderson RM, Leng XI, Chmelo EA, Brinkley TE, Lyles MF, Marsh AP, Nicklas BJ.. Aging Clin Exp Res. 2017;29(5):969-976.

ACCORDION MIND: results of the observational extension of the ACCORD MIND randomised trial. Murray AM, Hsu FC, Williamson JD, Bryan RN, Gerstein HC, Sullivan MD, Miller ME, Leng I, Lovato LL, Launer LJ.. Diabetologia. 2017;60(1):69-80.

Racial differences in circulating levels of the soluble receptor for advanced glycation endproducts in middle-aged and older adults. Brinkley TE, Leng X, Nicklas BJ, Kritchevsky SB, Ding J, Kitzman DW, Hundley WG.. Metabolism. 2017;70():98-106.

Pain and function in older black and white adults: a secondary analysis of the Health ABC Study [abstract]. Brooks A, Leng X, Kritchevsky S.. J Pain. 2017;18(4 Suppl 1):S83-S84.

Patient portal utilization among ethnically diverse low income older adults: observational study. Arcury TA, Quandt SA, Sandberg JC, Miller DP Jr, Latulipe C, Leng X, Talton JW, Melius KP, Smith A, Bertoni AG.. JMIR Med Inform. 2017;5(4):e47.

Sleep duration, cognitive decline, and dementia risk in older women. Chen JC, Espeland MA, Brunner RL, Lovato LC, Wallace RB, Leng X, Phillips LS, Robinson JG, Kotchen JM, Johnson KC, Manson JE, Stefanick ML, Sarto GE, Mysiw WJ.. Alzheimers Dement. 2016;12(1):21-33.

The relationship of cardiovascular disease to physical functioning in women surviving to age 80 and above in the Women's Health Initiative. Stefanick ML, Brunner RL, Leng X, Limacher MC, Bird CE, Garcia DO, Hogan PE, LaMonte MJ, Mackey RH, Johnson KC, LaCroix A, Robinson JG, Seguin RA, Tindle HA, Wassertheil-Smoller S.. J Gerontol A Biol Sci Med Sci. 2016;71(Suppl 1):S42-S53.

Functional independence in late-life: maintaining physical functioning in older adulthood predicts daily life function after age 80. Vaughan L, Leng X, La Monte MJ, Tindle HA, Cochrane BB, Shumaker SA.. J Gerontol A Biol Sci Med Sci. 2016;71(Suppl 1):S79-S86.

Physical functioning among women 80 years of age and older with and without a cancer history. Weaver KE, Leach CR, Leng X, Danhauer SC, Klepin HD, Vaughan L, Naughton M, Chlebowski RT, Vitolins MZ, Paskett E.. J Gerontol A Biol Sci Med Sci. 2016;71(Suppl 1):S23-S30.

Risk profiles of lipids, blood pressure, and anthropometric measures in childhood and adolescence: project heartBeat!. Ip EH, Leng X, Zhang Q, Schwartz R, Chen SH, Dai S, Labarthe D.. BMC Obes. 2016;3():9.

Self-reported mobility in older patients predicts early postoperative outcomes after elective noncardiac surgery. Kim S, Marsh AP, Rustowicz L, Roach C, Leng XI, Kritchevsky SB, Rejeski WJ, Groban L.. Anesthesiology. 2016;124(4):815-825.

The evolution of the WHI 80+ cohort. Beavers DP, Pettinger M, Espeland MA, Snively BM, Leng X, Hunt JR, Tindle HA, Shumaker SA.. J Gerontol A Biol Sci Med Sci. 2016;71(Suppl 1):S13-S22.

A long-term intensive lifestyle intervention and physical function: The Look AHEAD Movement and Memory Study. Houston DK, Leng X, Bray GA, Hergenroeder AL, Hill JO, Jakicic JM, Johnson KC, Neiberg RH, Marsh AP, Rejeski WJ, Kritchevsky SB.. Obesity (Silver Spring). 2015;23(1):77-84.

Heterogeneity of physical function responses to exercise training in older adults. Chmelo EA, Crotts CI, Newman JC, Brinkley TE, Lyles MF, Leng X, Marsh AP, Nicklas BJ.. J Am Geriatr Soc. 2015;63(3):462-469.

Computed tomography pulmonary findings in healthy older adult aspirators versus nonaspirators. Butler SG, Clark H, Baginski SG, Todd JT, Lintzenich C, Leng X.. Laryngoscope. 2014;124(2):494-497.

A comparison of acetate and digital templating for hip resurfacing. Bracey DN, Seyler TM, Shields JS, Leng X, Jinnah RH, Lang JE.. Am J Orthop (Belle Mead NJ). 2014;43(1):E19-E24.

Self-monitoring of spontaneous physical activity and sedentary behavior to prevent weight regain in older adults. Nicklas BJ, Gaukstern JE, Beavers KM, Newman JC, Leng X, Rejeski WJ.. Obesity (Silver Spring). 2014;22(6):1406-1412.

Periaortic fat and cardiovascular risk: a comparison of high-risk older adults and age-matched healthy controls. Brinkley TE, Leng X, Chughtai HL, Nicklas BJ, Kritchevsky SB, Ding J, Kitzman DW, Hundley WG.. Int J Obes (Lond). 2014;38(11):1397-1402.

The impact of sarcopenia on a physical activity intervention: the Lifestyle Interventions and Independence for Elders Pilot Study (LIFE-P). Liu CK, Leng X, Hsu FC, Kritchevsky SB, Ding J, Earnest CP, Ferrucci L, Goodpaster BH, Guralnik JM, Lenchik L, Pahor M, Fielding RA.. J Nutr Health Aging. 2014;18(1):59-64.

Differential patterns of cortical reorganization following constraint-induced movement therapy during early and late period after stroke: a preliminary study. Sawaki L, Butler AJ, Leng X, Wassenaar PA, Mohammad YM, Blanton S, Sathian K, Nichols-Larsen DS, Wolf SL, Good DC, Wittenberg GF.. NeuroRehabilitation. 2014;35(3):415-426.

Self-renewal and differentiation capacity of urine-derived stem cells after urine preservation for 24 hours. Lang R, Liu G, Shi Y, Bharadwaj S, Leng X, Zhou X, Liu H, Atala A, Zhang Y.. PLoS One. 2013;8(1):e53980.

Ethnic variation in oral health and social integration among older rural adults. Arcury TA, Chen H, Savoca MR, Anderson AM, Leng X, Bell RA, Quandt SA.. J Appl Gerontol. 2013;32(3):302-323.

Translating the Dietary Approaches to Stop Hypertension (DASH) diet for use in underresourced, urban African American communities, 2010. Whitt-Glover MC, Hunter JC, Foy CG, Quandt SA, Vitolins MZ, Leng I, Hornbuckle LM, Sanya KA, Bertoni AG.. Prev Chronic Dis. 2013;10():120088.

Long-term effects on cognitive function of postmenopausal hormone therapy prescribed to women aged 50 to 55 years. Espeland MA, Shumaker SA, Leng I, Manson JE, Brown CM, LeBlanc ES, Vaughan L, Robinson J, Rapp SR, Goveas JS, Wactawski-Wende J, Stefanick ML, Li W, Resnick SM.. JAMA Intern Med. 2013;173(15):1429-1436.

Intraindividual variability in domain-specific cognition and risk of mild cognitive impairment and dementia. Vaughan L, Leng I, Dagenbach D, Resnick SM, Rapp SR, Jennings JM, Brunner RL, Simpson SL, Beavers DP, Coker LH, Gaussoin SA, Sink KM, Espeland MA.. Curr Gerontol Geriatr Res. 2013;():495793.

Impact of a long-term intensive lifestyle intervention on physical function: the action for health and memory study in diabetes movement [abstract]. Houston DK, Bray GA, Hill JO, Jakicic JM Johnson KC, Leng X, Rejeski W, Kritchevsky SB.. Gerontologist. 2013;53(Suppl 1):389.

Multi-profile hidden Markov model for mood, dietary intake, and physical activity in an intervention study of childhood obesity. Ip EH, Zhang Q, Schwartz R, Tooze J, Leng X, Han H, Williamson DA.. Stat Med. 2013;32(19):3314-3331.

Cardiovascular disease and cognitive decline in postmenopausal women: results from the Women's Health Initiative Memory Study. Haring B, Leng X, Robinson J, Johnson KC, Jackson RD, Beyth R, Wactawski-Wende J, von Ballmoos MW, Goveas JS, Kuller LH, Wassertheil-Smoller S.. J Am Heart Assoc. 2013;2(6):e000369.

Coronary heart disease is associated with cognitive decline in postmenopausal women: results from the Women's Health Initiative Memory Study [abstract]. Haring B, Leng I, Robinson J, Johnson KC, Jacksons R, Beyth R, Wactawski-Wende J, von Ballmoos MW, Goveas J, Kuller LH, Wassertheil-Smoller S.. Circulation. 2013;127(12 Suppl):AMP25.

Intervening on spontaneous physical activity to prevent weight regain in older adults: design of a randomized, clinical trial. Nicklas BJ, Gaukstern JE, Legault C, Leng I, Rejeski WJ.. Contemp Clin Trials. 2012;33(2):450-455.

Effects of effortful swallow on esophageal function in healthy adults. Nekl CG, Lintzenich CR, Leng X, Lever T, Butler SG.. Neurogastroenterol Motil. 2012;24(3):252-e108.

Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice. Loeser RF, Olex AL, McNulty MA, Carlson CS, Callahan MF, Ferguson CM, Chou J, Leng X, Fetrow JS.. Arthritis Rheum. 2012;64(3):705-717.

Parathyroid hormone early percent change: an individualized approach to predict postthyroidectomy hypocalcemia. Chapman DB, French CC, Leng X, Browne JD, Waltonen JD, Sullivan CA.. Am J Otolaryngol. 2012;33(2):216-220.

Tongue adiposity and strength in healthy older adults. Butler SG, Lintzenich CR, Leng X, Stuart A, Feng X, Carr JJ, Kritchevsky SB.. Laryngoscope. 2012;122(7):1600-1604.

Dental care utilization among North Carolina rural older adults. Arcury TA, Savoca MR, Anderson AM, Chen H, Gilbert GH, Bell RA, Leng X, Reynolds T, Quandt SA.. J Public Health Dent. 2012;72(3):190-197.

Lipopolysaccharide-binding protein, a surrogate marker of microbial translocation, is associated with physical function in healthy older adults. Stehle JR Jr, Leng X, Kitzman DW, Nicklas BJ, Kritchevsky SB, High KP.. J Gerontol A Biol Sci Med Sci. 2012;67(11):1212-1218.

Effects of aging and levodopa on the laryngeal adductor reflex in rats. Feng X, Xu Z, Butler SG, Leng I, Zhang T, Kritchevsky SB.. Exp Gerontol. 2012;47(12):900-907.

Impact of denture usage patterns on dietary quality and food avoidance among older adults. Savoca MR, Arcury TA, Leng X, Chen H, Bell RA, Anderson AM, Kohrman T, Gilbert GH, Quandt SA.. J Nutr Gerontol Geriatr. 2011;30(1):86-102.

Dry mouth and dietary quality in older adults in North Carolina. Quandt SA, Savoca MR, Leng X, Chen H, Bell RA, Gilbert GH, Anderson AM, Kohrman T, Arcury TA.. J Am Geriatr Soc. 2011;59(3):439-445.

Maternal depressive symptomatology: 16-month follow-up of infant and maternal health-related quality of life. Darcy JM, Grzywacz JG, Stephens RL, Leng I, Clinch CR, Arcury TA.. J Am Board Fam Med. 2011;24(3):249-257.

The impact of sarcopenia on the response to a physical activity intervention in older adults [abstract]. Liu C, Leng I, Kritchevsky S, Ding J, Earnest C, Ferrucci L, Goodpaster B, Guralnik J, Hsu F, Lenchik L, et al.. J Am Geriatr Soc. 2011;59(Suppl 1):S63.

Maximum phonation time in healthy older adults. Maslan J, Leng X, Rees C, Blalock D, Butler SG.. J Voice. 2011;25(6):709-713.

Factors influencing bolus dwell times in healthy older adults assessed endoscopically. Butler SG, Maslan J, Stuart A, Leng X, Wilhelm E, Lintzenich CR, Williamson J, Kritchevsky SB.. Laryngoscope. 2011;121(12):2526-2534.

Association between microbial translocation and adiposity in healthy elderly adults [abstract]. Stehle JR, Nicklas B, Kritchevsky SB, Kitzman DW, Leng X, High K.. Gerontologist. 2011;51(Suppl 2):490.

Food avoidance and food modification practices of older rural adults: association with oral health status and implications for service provision. Quandt SA, Chen H, Bell RA, Savoca MR, Anderson AM, Leng X, Kohrman T, Gilbert GH, Arcury TA.. Gerontologist. 2010;50(1):100-111.

Severe tooth loss in older adults as a key indicator of compromised dietary quality. Savoca MR, Arcury TA, Leng X, Chen H, Bell RA, Anderson AM, Kohrman T, Frazier RJ, Gilbert GH, Quandt SA.. Public Health Nutr. 2010;13(4):466-474.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Biostatistical Sciences

Clinical Interests

Clinical Trials
Xiaoyan Iris Leng, M.D., Ph.D.

Xiaoyan Iris Leng, M.D., Ph.D.

Associate Professor, Biostatistical Sciences

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