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Hui-Kuan Lin, Ph.D.Wake Forest School of Medicine

Hui-Kuan Lin, Ph.D.


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Academic: 336-713-1483 | Department: 336-716-2011


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Education & Training

  • B.S., Natl Taiwan Univ College of Medicine-Taiwan, 1993
  • M.S., Natl Taiwan Univ College of Medicine-Taiwan, 1995
  • Ph.D., University of Rochester, 2002
Hui-Kuan Lin, Ph.D.

Hui-Kuan Lin, Ph.D.

Professor, Cancer Biology
Office of Women in Medicine and Science

Research Interests

TNF Receptor-Associated Factor 6; S-Phase Kinase-Associated Proteins; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Histones
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Contact Information

Academic: 336-713-1483 | Department: 336-716-2011


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Recent Publications

Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells. Jin G, Xu C, Zhang X, Long J, Rezaeian AH, Liu C, Furth ME, Kridel S, Pasche B, Bian XW, Lin HK.. Nat Immunol. 2018;19(1):29-40.

Functionalized spiroindolines with anticancer activity through a metal-free post-Ugi diastereoselective one-pot cascade reaction. Xu ZG, Li SQ, Meng JP, Tang DY, He LJ, Lei J, Lin HK, Li HY, Chen ZZ.. Chemistry. 2018;24(26):6732-6736.

A new mechanism for LKB1 activation. Lee SW, Lin HK.. Mol Cell Oncol. 2018;5(3):e1035691.

SENP1 regulates PTEN stability to dictate prostate cancer development. Bawa-Khalfe T, Yang FM, Ritho J, Lin HK, Cheng J, Yeh ET.. Oncotarget. 2017;8(11):17651-64.

A hypoxia-responsive TRAF6-ATM-H2AX signalling axis promotes HIF1alpha activation, tumorigenesis and metastasis. Rezaeian AH, Li CF, Wu CY, Zhang X, Delacerda J, You MJ, Han F, Cai Z, Jeong YS, Jin G, Phan L, Chou PC, Lee MH, Hung MC, Sarbassov D, Lin HK.. Nat Cell Biol. 2017;19(1):38-51.

NBR2-GLUT1 axis regulates cancer cell sensitivity to biguanides. Zhang X, Lin HK.. Cell Cycle. 2017;16(3):249-250.

Characterization of the GNMT-HectH9-PREX2 tripartite relationship in the pathogenesis of hepatocellular carcinoma. Li CH, Yen CH, Chen YF, Lee KJ, Fang CC, Zhang X, Lai CC, Huang SF, Lin HK, Arthur Chen YM.. Int J Cancer. 2017;140(10):2284-2297.

DNA damage players are linked to HIF-1alpha/hypoxia signaling [editorial]. Rezaeian AH, Wang YH, Lin HK.. Cell Cycle. 2017;16(8):725-726.

H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis. Zhang X, Li B, Rezaeian AH, Xu X, Chou PC, Jin G, Han F, Pan BS, Wang CY, Long J, Zhang A, Huang CY, Tsai FJ, Tsai CH, Logothetis C, Lin HK.. Nat Commun. 2017;8():14799.

Skp2 deficiency restricts the progression and stem cell features of castration-resistant prostate cancer by destabilizing Twist. Ruan D, He J, Li CF, Lee HJ, Liu J, Lin HK, Chan CH.. Oncogene. 2017;36(30):4299-4310.

Danshen improves survival of patients with advanced lung cancer and targeting the relationship between macrophages and lung cancer cells. Wu CY, Cherng JY, Yang YH, Lin CL, Kuan FC, Lin YY, Lin YS, Shu LH, Cheng YC, Liu HT, Lu MC, Lung J, Chen PC, Lin HK, Lee KD, Tsai YH.. Oncotarget. 2017;8(53):90925-47.

LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Liu X, Xiao ZD, Han L, Zhang J, Lee SW, Wang W, Lee H, Zhuang L, Chen J, Lin HK, Wang J, Liang H, Gan B.. Nat Cell Biol. 2016;18(4):431-442.

Secreted protein acidic and rich in cysteine (SPARC) mediates metastatic dormancy of prostate cancer in bone. Sharma S, Xing F, Liu Y, Wu K, Said N, Pochampally R, Shiozawa Y, Lin HK, Balaji KC, Watabe K.. J Biol Chem. 2016;291(37):19351-63.

TRAF6 restricts p53 mitochondrial translocation, apoptosis, and tumor suppression. Zhang X, Li CF, Zhang L, Wu CY, Han L, Jin G, Rezaeian AH, Han F, Liu C, Xu C, Xu X, Huang CY, Tsai FJ, Tsai CH, Watabe K, Lin HK.. Mol Cell. 2016;64(4):803-814.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Cancer Biology

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