Skip Navigation


Hui-Wen Lo, Ph.D.Wake Forest School of Medicine

Hui-Wen Lo, Ph.D.


Contact Information

Academic: 336-716-0695 | Department: 336-716-0695


Education & Training

  • B.S., Chung Shan Med University, Taichung, Taiwan, 1986
  • M.A., University of Texas-Austin, 1990
  • M.S., Univ of Texas Health Science Center At Houston, 1994
  • Ph.D., Univ of Texas Health Science Center At Houston, 2002
Hui-Wen Lo, Ph.D.

Hui-Wen Lo, Ph.D.

Professor, Cancer Biology
Brain Tumor Center of Excellence

Research Interests

Receptor, Epidermal Growth Factor; Glioblastoma; Brain Neoplasms; Transcription Factors; Breast Neoplasms
More »

Contact Information

Academic: 336-716-0695 | Department: 336-716-0695


Recent Publications

Use of non-ionizing electromagnetic fields for the treatment of cancer. Jimenez H, Blackman C, Lesser G, Debinski W, Chan M, Sharma S, Watabe K, Lo HW, Thomas A, Godwin D, Blackstock W, Mudry A, Posey J, O'Connor R, Brezovich I, Bonin K, Kim-Shapiro D, Barbault A, Pasche B.. Front Biosci (Landmark Ed). 2018;23():284-297.

Interaction between STAT3 and GLI1/tGLI1 oncogenic transcription factors promotes the aggressiveness of triple-negative breast cancers and HER2-enriched breast cancer. Sirkisoon SR, Carpenter RL, Rimkus T, Anderson A, Harrison A, Lange AM, Jin G, Watabe K, Lo HW.. Oncogene. 2018;37(19):2502-2514.

Inhibiting TRK proteins in clinical cancer therapy. Lange AM, Lo HW.. Cancers (Basel). 2018;10(4):E105.

Truncated glioma-associated oncogene homolog 1 (tGLI1) mediates mesenchymal glioblastoma via transcriptional activation of CD44. Rimkus TK, Carpenter RL, Sirkisoon S, Zhu DQ, Pasche BC, Chan MD, Lesser GJ, Tatter SB, Debinski KW, Debinski W, Lo HW.. Cancer Res. 2018;78(10):2589-2600.

Repeat stereotactic radiosurgery as salvage therapy for locally recurrent brain metastases previously treated with radiosurgery. McKay WH, McTyre ER, Okoukoni C, Alphonse-Sullivan NK, Ruiz J, Munley MT, Qasem S, Lo HW, Xing F, Laxton AW, Tatter SB, Watabe K, Chan MD.. J Neurosurg. 2017;127(1):148-156.

Outcomes for anaplastic glioma treated with radiation therapy with or without concurrent temozolomide. McTyre E, Lucas JT, Helis C, Farris M, Soike M, Mott R, Laxton AW, Tatter SB, Lesser GJ, Strowd RE, Lo HW, Debinski W, Chan MD.. Am J Clin Oncol. 2017;():.

Leptomeningeal failure in patients with breast cancer receiving stereotactic radiosurgery for brain metastases. Wang EC, Huang AJ, Huang KE, McTyre ER, Lo HW, Watabe K, Metheny-Barlow L, Laxton AW, Tatter SB, Strowd RE, Chan MD, Page BR.. J Clin Neurosci. 2017;43():6-10.

Combined inhibition of AKT and HSF1 suppresses breast cancer stem cells and tumor growth. Carpenter RL, Sirkisoon S, Zhu D, Rimkus T, Harrison A, Anderson A, Paw I, Qasem S, Xing F, Liu Y, Chan M, Metheny-Barlow L, Pasche BC, Debinski W, Watabe K, Lo HW.. Oncotarget. 2017;8(43):73947-63.

Tumor suppressor candidate 2 (TUSC2, FUS-1) and human cancers. Rimkus T, Sirkisoon S, Harrison A, Lo HW.. Discov Med. 2017;23(128):325-330.

Stereotactic radiosurgery in the treatment of brain metastases from gynecologic primary cancer. Johnston H, McTyre ER, Cramer CK, Lesser GJ, Ruiz J, Bourland JD, Watabe K, Lo HW, Qasem S, Laxton AW, Tatter SB, Chan MD.. J Radiosurg SBRT. 2017;5(1):55-61.

Staged stereotactic radiosurgery for large brain metastases: local control and clinical outcomes of a one-two punch technique. Dohm A, McTyre ER, Okoukoni C, Henson A, Cramer CK, LeCompte MC, Ruiz J, Munley MT, Qasem S, Lo HW, Xing F, Watabe K, Laxton AW, Tatter SB, Chan MD.. Neurosurgery. 2017;():.

Determination of tumor gene expression in non-small cell lung cancer patients who develop brain metastasis diagnosis: analysis of a prospective trial [abstract]. Dohm AE, Su J, McTyre E, Soike M, Miller LD, Petty WJ, Xing F, Lo HW, Metheny-Barlow L, Watabe K, Chan MD, Ruiz J, Pasche B.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E453.

The number of prior lines of systemic therapy as a prognostic factor for patients with brain metastases treated with stereotactic radiosurgery: results of a large single institution retrospective analysis. Lanier CM, McTyre E, LeCompte M, Cramer CK, Hughes R, Watabe K, Lo HW, O'Neill S, Munley MT, Laxton AW, Tatter SB, Ruiz J, Chan MD.. Clin Neurol Neurosurg. 2017;165():24-28.

Survival and failure outcomes predicted by brain metastasis volumetric kinetics in melanoma patients following upfront treatment with stereotactic radiosurgery alone. LeCompte MC, McTyre E, Henson A, Farris M, Okoukoni C, Cramer CK, Triozzi P, Ruiz J, Watabe K, Lo HW, Munley MT, Laxton AW, Tatter SB, Zhou X, Chan M.. Cureus. 2017;9(12):e1934.

Biology and treatment of metastasis of sarcoma to the brain. Ahmad O, Chan M, Savage P, Watabe K, Lo HW, Qasem S.. Front Biosci (Elite Ed). 2016;8():233-244.

EGFR and HER2 signaling in breast cancer brain metastasis. Sirkisoon SR, Carpenter RL, Rimkus T, Miller L, Metheny-Barlow L, Lo HW.. Front Biosci (Elite Ed). 2016;8():245-263.

Targeting the sonic hedgehog signaling pathway: review of smoothened and GLI inhibitors. Rimkus TK, Carpenter RL, Qasem S, Chan M, Lo HW.. Cancers (Basel). 2016;8(2):E22.

Activation of the c-Met pathway mobilizes an inflammatory network in the brain microenvironment to promote brain metastasis of breast cancer. Xing F, Liu Y, Sharma S, Wu K, Chan MD, Lo HW, Carpenter RL, Metheny-Barlow LJ, Zhou X, Qasem SA, Pasche B, Watabe K.. Cancer Res. 2016;76(17):4970-4980.

Genomic predictors of imaging response and survival in glioblastoma [abstract]. Soike M, McTyre E, Holmes JA, Paulsson AK, Miller L, Lesser GJ, Strowd RE, Johnson A, Lo HW, Laxton AW, Tatter SB, Debinski W, Chan MD.. Int J Radiat Oncol Biol Phys. 2016;96(2 Suppl):E121-E122.

Impact of timing of radiotherapy in patients with newly diagnosed glioblastoma. Randolph DM II, McTyre ER, Paulsson AK, Holmes JA, Hinson WH, Lesser GJ, Strowd R, Lo HW, Laxton AW, Tatter SB, Debinski W, Chan MD.. Clin Neurol Neurosurg. 2016;151():73-78.

miR-509 suppresses brain metastasis of breast cancer cells by modulating RhoC and TNF-alpha. Xing F, Sharma S, Liu Y, Mo YY, Wu K, Zhang YY, Pochampally R, Martinez LA, Lo HW, Watabe K.. Oncogene. 2015;34(37):4890-4900.

Mechanisms regulating glioma invasion. Paw I, Carpenter RC [sic] [Carpenter RL], Watabe K, Debinski W, Lo HW.. Cancer Lett. 2015;362(1):1-7.

Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells. Carpenter RL, Paw I, Dewhirst MW, Lo HW.. Oncogene. 2015;34(5):546-557.

The gain-of-function truncated GLI1 (TGLI1) promotes glioblastoma angiogenesis by direct upregulation of VEGF-C and TEM7 expression [abstract]. Carpenter RL, Paw I, Sirkisoon S, Xing F, Gibo D, Watabe K, Debinski W, Lo HW.. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research (AACR); 2015 Apr 18-22; Philadelphia (PA). 2015;():A4165.

The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis. Carpenter RL, Paw I, Zhu H, Sirkisoon S, Xing F, Watabe K, Debinski W, Lo HW.. Oncotarget. 2015;6(26):22653-65.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Cancer Biology

Hui-Wen Lo, Ph.D.

Hui-Wen Lo, Ph.D.

Professor, Cancer Biology
Brain Tumor Center of Excellence

Quick Reference

Request an Appointment
New Patients


Existing patients may contact the clinic directly.
Find a Doctor Ways to Give
Wake Forest Baptist Ranked among Nation’s ‘Best Hospitals’  25 Years in a Row by U.S. News & World ReportComprehensive Cancer Centers National Designation is Renewed2017-2018 Best DoctorsNursing Magnet StatusJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.

© Wake Forest Baptist Medical Center, Medical Center Boulevard, Winston-Salem, NC 27157. All Rights Reserved.