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Frank C. Marini, Ph.D.Wake Forest School of Medicine

Frank C. Marini, Ph.D.


Contact Information

Academic: 336-713-1471


Education & Training

  • Ph.D., Univ Texas M D Anderson Hosp, 1998
Frank C. Marini, Ph.D.

Frank C. Marini, Ph.D.

Professor, Institute for Regenerative Medicine
Center on Diabetes, Obesity, and Metabolism
Cancer Biology

Research Interests

Ovarian Neoplasms; Mesenchymal Stem Cell Transplantation; Stromal Cells; Neoplasms; Cell Movement
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Contact Information

Academic: 336-713-1471


Recent Publications

A phase I trial of mesenchymal stem cells transfected with a plasmid secreting interferon beta in advanced ovarian cancer [abstract]. Olson A, Marini F, Westin S, Coleman R, Thall P, Al Jhadhami V, Qazilbash MH, Rezvani K, Timmons M, Heese L, Wang RY, Champlin RE, Shpall EJ, Andreeff M.. Biol Blood Marrow Transplant. 2018;24(3 Suppl 1):S421.

Sustained adrenergic signaling promotes intratumoral innervation through BDNF induction. Allen JK, Armaiz-Pena GN, Nagaraja AS, Sadaoui NC, Ortiz T, Dood R, Ozcan M, Herder DM, Haemerrle M, Gharpure KM, Rupaimoole R, Previs R, Wu SY, Pradeep S, Xu X, Dong Han H, Zand B, Dalton HJ, Taylor M, Hu W, Bottsford-Miller J,.. Cancer Res. 2018;():.

Practical guidelines for Cerenkov luminescence imaging with clinically relevant isotopes. Bhatt NB, Pandya DN, Dezarn WA, Marini FC, Zhao D, Gmeiner WH, Triozzi PL, Wadas TJ.. Methods Mol Biol. 2018;1790():197-208.

Novel peripherally derived neural-like stem cells as therapeutic carriers for treating glioblastomas. Birbrair A, Sattiraju A, Zhu D, Zulato G, Batista I, Nguyen VT, Messi ML, Solingapuram Sai KK, Marini FC, Delbono O, Mintz A.. Stem Cells Transl Med. 2017;6(2):471-481.

Characterization of a murine model of bioequivalent bladder wound healing and repair following subtotal cystectomy. Zarifpour M, Andersson KE, Kelkar SS, Mohs A, Mendelsohn C, Schneider K, Marini F, Christ GJ.. Biores Open Access. 2017;6(1):35-45.

Bioengineered submucosal organoids for in vitro modeling of colorectal cancer. Devarasetty M, Skardal A, Cowdrick K, Marini F, Soker S.. Tissue Eng Part A. 2017;23(19-20):1026-1041.

inCITE optical clearing affords unprecedented interrogation of macroscale architecture and cell/matrix content within bioengineered heart valves [abstract]. Marini FK [sic] [Marini FC], Stumpf K, Mutkus L, Williams JK.. Tissue Eng Part A. 2017;23(Suppl 1):S60-S61.

Non-invasive cell tracking with brighter and red-transferred luciferase for potential application in stem cell therapy [abstract]. Shu F, Dou L, Paxton J, Long T, song Q, Mutkus L, Marini F, Yoo J, Atala A, Jackson J, Zhang Y.. Tissue Eng Part A. 2017;23(Suppl 1):s133.

Soluble Tie2 overrides the heightened invasion induced by anti-angiogenesis therapies in gliomas. Cortes-Santiago N, Hossain MB, Gabrusiewicz K, Fan X, Gumin J, Marini FC, Alonso MM, Lang F, Yung WK, Fueyo J, Gomez-Manzano C.. Oncotarget. 2016;7(13):.

Near infrared fluorescent nanoparticles based on hyaluronic acid: self-assembly, optical properties, and cell interaction. Kelkar SS, Hill TK, Marini FC, Mohs AM.. Acta Biomater. 2016;36():112-121.

Tumor-associated stromal cells as key contributors to the tumor microenvironment. Bussard KM, Mutkus L, Stumpf K, Gomez-Manzano C, Marini FC.. Breast Cancer Res. 2016;18(1):84.

Near infrared fluorescent nanoparticles derived from hyaluronic acid improve tumor contrast for image-guided surgery. Hill TK, Kelkar SS, Wojtynek NE, Souchek JJ, Payne WM, Stumpf K, Marini FC, Mohs AM.. Theranostics. 2016;6(13):2314-2328.

Selection of a novel aptamer against vitronectin using capillary electrophoresis and next generation sequencing. Stuart CH, Riley KR, Boyacioglu O, Herpai DM, Debinski W, Qasem S, Marini FC, Colyer CL, Gmeiner WH.. Mol Ther Nucleic Acids. 2016;5(11):e386.

Indocyanine green-loaded nanoparticles for image-guided tumor surgery. Hill TK, Abdulahad A, Kelkar SS, Marini FC, Long TE, Provenzale JM, Mohs AM.. Bioconjug Chem. 2015;26(2):294-303.

Breast cancer cell quiescence in bone is orchestrated by osteoblasts transitioned into tumor-associated fibroblasts via exosomal miRs [abstract]. Bussard KM, Marini FC.. Clin Exp Metastasis. 2015;32(3):195-196.

Macrophage ablation reduces M2-like populations and jeopardizes tumor growth in a MAFIA-based glioma model. Gabrusiewicz K, Hossain MB, Cortes-Santiago N, Fan X, Kaminska B, Marini FC, Fueyo J, Gomez-Manzano C.. Neoplasia. 2015;17(4):374-384.

Mesenchymal stem cells isolated from human gliomas increase proliferation and maintain stemness of glioma stem cells through the IL-6/gp130/STAT3 pathway. Hossain A, Gumin J, Gao F, Figueroa J, Shinojima N, Takezaki T, Priebe W, Villarreal D, Kang SG, Joyce C, Sulman E, Wang Q, Marini FC, Andreeff M, Colman H, Lang FF.. Stem Cells. 2015;33(8):2400-2415.

Breast cancer cell quiescence in bone is modulated by Osteo-TAFs [abstract]. Bussard KM, Marini FC.. Cancer Res. 2015;75(15 Suppl):3205.

Characterization of functional bladder regeneration in mice [abstract]. Zarifpour M, Sandberg J, Abolbashari M, Vadhavkar M, Kelkar S, Mohs A, Marini F, Andersson KE, Christ G.. Neurourol Urodyn. 2014;33(2):186.

Lineage of origin in rhabdomyosarcoma informs pharmacological response. Abraham J, Nunez-Alvarez Y, Hettmer S, Carrio E, Chen HI, Nishijo K, Huang ET, Prajapati SI, Walker RL, Davis S, Rebeles J, Wiebush H, McCleish AT, Hampton ST, Bjornson CR, Brack AS, Wagers AJ, Rando TA, Capecchi MR, Marini FC, Ehler BR, Zarzabal LA,.. Genes Dev. 2014;28(14):1578-1591.

Anti-vascular endothelial growth factor therapy-induced glioma invasion is associated with accumulation of Tie2-expressing monocytes. Gabrusiewicz K, Liu D, Cortes-Santiago N, Hossain MB, Conrad CA, Aldape KD, Fuller GN, Marini FC, Alonso MM, Idoate MA, Gilbert MR, Fueyo J, Gomez-Manzano C.. Oncotarget. 2014;5(8):2208-2220.

Eliminating leukemia cells from human testicular cell cultures prior to spermatogonial stem cell autotransplantation to restore fertility [abstract]. Katsivalis K, Reid T, Marini FC, Atala A, Sadri-Ardekani H.. Tissue Eng Part A. 2014;20(Suppl 1):S136.

Fiber-based imaging on electrospun scaffold [abstract]. Sapoznik E, Niu G, Lu P, Zhou Y, Criswell T, Marini F, Xu Y, Soker S.. Tissue Eng Part A. 2014;20(Suppl 1):S61.

Metastatic breast cancer cells induce an osteoblast-TAF-like phenotype and communicate with osteoblasts via gap junctions and exosomal crosstalk to facilitate breast cancer cell quiescence in bone [abstract]. Bussard KM, Marini FC.. Cancer Res. 2014;74(19 Suppl):A4804.

Tumor stroma engraftment of gene-modified mesenchymal stem cells as anti-tumor therapy against ovarian cancer. Dembinski JL, Wilson SM, Spaeth EL, Studeny M, Zompetta C, Samudio I, Roby K, Andreeff M, Marini FC.. Cytotherapy. 2013;15(1):20-32.

Discarded human kidneys as a source of ECM scaffold for kidney regeneration technologies. Orlando G, Booth C, Wang Z, Totonelli G, Ross CL, Moran E, Salvatori M, Maghsoudlou P, Turmaine M, Delario G, Al-Shraideh Y, Farooq U, Farney AC, Rogers J, Iskandar SS, Burns A, Marini FC, De Coppi P, Stratta RJ, Soker S.. Biomaterials. 2013;34(24):5915-5925.

Mesenchymal CD44 expression contributes to the acquisition of an activated fibroblast phenotype via TWIST activation in the tumor microenvironment. Spaeth EL, Labaff AM, Toole BP, Klopp A, Andreeff M, Marini FC.. Cancer Res. 2013;73(17):5347-5359.

Modeling tumor microenvironment in vivo: impact of conditional macrophage ablation in glioma progression [abstract]. Gabrusiewicz K, Cortes-Santiago N, Fan XJ, Hossain MB, Kaminska B, Heimberger A, Rao G, Yung WKA, Marini F, Fueyo J, Gomez-Manzano C.. Neuro Oncol. 2013;15(Suppl 3):236.

Human omental-derived adipose stem cells increase ovarian cancer proliferation, migration, and chemoresistance. Nowicka A, Marini FC, Solley TN, Elizondo PB, Zhang Y, Sharp HJ, Broaddus R, Kolonin M, Mok SC, Thompson MS, Woodward WA, Lu K, Salimian B, Nagrath D, Klopp AH.. PLoS One. 2013;8(12):e81859.

Crosstalk between breast cancer and stromal cells occurs via exosomes and gap junctions in bone metastatic breast cancer [abstract]. Bussard KM, Marini FC.. Cancer Res. 2013;73(8 Suppl 1):A1625.

The developmental patterning gene HOXA9 promotes ovarian cancer growth via paracrine effects on mesenchymal stem cells and peritoneal fibroblasts [abstract]. Ko SY, Barengo N, Ladanyi A, Lee J-S, Marini F, Lengyel E, Naora H.. Cancer Res. 2013;73(8 Suppl 1):A2611.

Production and characterization of human renal and ileal ECM scaffols: the ideal platform for renal and intestinal bioengineering investigations [abstract]. Orlando G, Wang Z, Booth C, Ross C, Totonelli G, De Coppi P, Marini F, Atala A, Stratta RJ, Soker S.. J Tissue Eng Regen Med. 2012;6(Suppl 1):127-128.

HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts. Ko SY, Barengo N, Ladanyi A, Lee JS, Marini F, Lengyel E, Naora H.. J Clin Invest. 2012;122(10):3603-3617.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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