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Kimberly Johnson NelsonWake Forest School of Medicine

Kimberly Johnson Nelson

Instructor,

Contact Information

Academic: 336-716-6370 | Department: 336-716-2011

Email: kinelson@wakehealth.edu

Additional Languages

French

Education & Training

  • B.S., Furman University, 1997
  • Ph.D., Duke University, 2003

Memberships

  • Society Free Radical Biology
  • Phi Beta Kappa
  • Am Instit Of Chemists
Kimberly Johnson Nelson

Kimberly Johnson Nelson

Instructor, Biochemistry

Research Interests

Peroxiredoxins; Cysteine; Sulfenic Acids; Protein Processing, Post-Translational; Peroxides
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Contact Information

Academic: 336-716-6370 | Department: 336-716-2011

Email: kinelson@wakehealth.edu

Recent Publications

Experimentally dissecting the origins of peroxiredoxin catalysis. Nelson KJ, Perkins A, Van Swearingen AED, Hartman S, Brereton AE, Parsonage D, Salsbury FR Jr, Karplus PA, Poole LB.. Antioxid Redox Signal. 2018;28(7):521-536.

Oxidative stress-induced sulfenylation of SIRT6 is associated with enhanced NF-kappa B signaling in human chondrocytes [abstract]. Collins JA, Diekman BO, DeFoor MT, Wood ST, Bolduc JA, Nelson KJ, Chubinskaya S, Poole LB, Furdui CM, Loeser RF.. Osteoarthritis Cartilage. 2018;26(Suppl 1):S44.

Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins. Bolduc JA, Nelson KJ, Haynes AC, Lee J, Reisz JA, Graff AH, Clodfelter JE, Parsonage D, Poole LB, Furdui CM, Lowther WT.. J Biol Chem. 2018;():.

Endogenous, regulatory cysteine sulfenylation of ERK kinases in response to proliferative signals. Keyes JD, Parsonage D, Yammani RD, Rogers LC, Kesty C, Furdui CM, Nelson KJ, Poole LB.. Free Radic Biol Med. 2017;112():534-543.

Differential peroxiredoxin hyperoxidation regulates map kinase signaling in human articular chondrocytes [abstract]. Collins JA, Nelson KJ, Poole LB, Furdui CM, Loeser RF.. Osteoarthritis Cartilage. 2017;25(Suppl 1):S164-S165.

Structural changes upon peroxynitrite-mediated nitration of peroxiredoxin 2; nitrated Prx2 resembles its disulfide-oxidized form. Randall L, Manta B, Nelson KJ, Santos J, Poole LB, Denicola A.. Arch Biochem Biophys. 2016;590():101-108.

Distribution and features of the six classes of peroxiredoxins. Poole LB, Nelson KJ.. Mol Cells. 2016;39(1):53-59.

Peroxiredoxin catalysis at atomic resolution. Perkins A, Parsonage D, Nelson KJ, Ogba OM, Cheong PH, Poole LB, Karplus PA.. Structure. 2016;24(10):1668-1678.

Dissecting peroxiredoxin catalysis: separating binding, peroxidation, and resolution for a bacterial AhpC. Parsonage D, Nelson KJ, Ferrer-Sueta G, Alley S, Karplus PA, Furdui CM, Poole LB.. Biochemistry. 2015;54(7):1567-1575.

Disabling mitochondrial peroxide metabolism via combinatorial targeting of peroxiredoxin 3 as an effective therapeutic approach for malignant mesothelioma. Cunniff B, Newick K, Nelson KJ, Wozniak AN, Beuschel S, Leavitt B, Bhave A, Butnor K, Koenig A, Chouchani ET, James AM, Haynes AC, Lowther WT, Murphy MP, Shukla A, Heintz NH.. PLoS One. 2015;10(5):e0127310.

Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling. Perkins A, Nelson KJ, Parsonage D, Poole LB, Karplus PA.. Trends Biochem Sci. 2015;40(8):435-445.

Determining the molecular basis for differential hyperoxidation sensitivity in peroxiredoxin 1 & 2 [abstract]. Bolduc J, Reisz-Haines J, Nelson K, Furdui C, Lowther WT.. FASEB J. 2015;29(Suppl 1):895.10.

Endosomal H2O2 production leads to localized cysteine sulfenic acid formation on proteins during lysophosphatidic acid-mediated cell signaling. Klomsiri C, Rogers LC, Soito L, McCauley AK, King SB, Nelson KJ, Poole LB, Daniel LW.. Free Radic Biol Med. 2014;71():49-60.

Evaluating peroxiredoxin sensitivity toward inactivation by peroxide substrates. Nelson KJ, Parsonage D, Karplus PA, Poole LB.. Methods Enzymol. 2013;527():21-40.

Sulfenic acids and peroxiredoxins in oxidant defense. Poole LB, Nelson KJ, Karplus PA. In: Jakob U, Reichmann D, eds. Oxidative stress and redox regulation. Dordrecht: Springer;2013: 85-118.

Modulation of signaling proteins by reversible cysteine modification [abstract]. Keyes JD, Nelson K, Parsonage D, Daniel L, Furdui C, Poole L.. FASEB J. 2013;27():993.3.

D-alanine modification of a protease-susceptible outer membrane component by the Bordetella pertussis dra locus promotes resistance to antimicrobial peptides and polymorphonuclear leukocyte-mediated killing. Taneja NK, Ganguly T, Bakaletz LO, Nelson KJ, Dubey P, Poole LB, Deora R.. J Bacteriol. 2013;195(22):5102-5111.

The sensitive balance between the fully folded and locally unfolded conformations of a model peroxiredoxin. Perkins A, Nelson KJ, Williams JR, Parsonage D, Poole LB, Karplus PA.. Biochemistry. 2013;52(48):8708-8721.

Mapping the active site helix-to-strand conversion of CxxxxC peroxiredoxin Q enzymes. Perkins A, Gretes MC, Nelson KJ, Poole LB, Karplus PA.. Biochemistry. 2012;51(38):7638-7650.

Localized hydrogen peroxide-dependent cysteine oxidation is required for lysophosphatidic acid signaling in ovarian and prostate cancer cells [abstract]. Daniel LW, Klomsiri C, Rogers LC, Nelson KJ, Soito L, King SB, Poole LB.. Free Radic Biol Med. 2012;53(Suppl 2):S33.

Specific residues in peroxiredoxins promote peroxide reactivity through effects on cysteine pKa, transition state stabilization and oligomerization [abstract]. Nelson KJ, Parsonage D, Van Swearingen AED, Yuan Y, Salsbury FR, Hall A, Karplus PA, Poole LB.. Free Radic Biol Med. 2012;53(Suppl 2):S151.

Active site and interface communication regulating peroxiredoxin functions [abstract]. Poole L, Karplus PA, Nelson K, Parsonage D.. Free Radic Biol Med. 2012;53(Suppl 2):S8.

PREX: PeroxiRedoxin classification indEX, a database of subfamily assignments across the diverse peroxiredoxin family. Soito L, Williamson C, Knutson ST, Fetrow JS, Poole LB, Nelson KJ.. Nucleic Acids Res. 2011;39(Database issue):D332-7.

Analysis of the peroxiredoxin family: using active-site structure and sequence information for global classification and residue analysis. Nelson KJ, Knutson ST, Soito L, Klomsiri C, Poole LB, Fetrow JS.. Proteins. 2011;79(3):947-964.

Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins. Hall A, Nelson K, Poole LB, Karplus PA.. Antioxid Redox Signal. 2011;15(3):795-815.

Measurement of peroxiredoxin activity. Nelson KJ, Parsonage D. In: Costa LG, Davila JC, Lawrence DA, Reed DJ, Hodgson E, Coruzzi G, eds. Current protocols in toxicology, suppl 49. New York: John Wiley & Sons;2011: 7.10.1-28.

Overview of peroxiredoxins in oxidant defense and redox regulation. Poole LB, Hall, A, Nelson KJ. In: Costa LG, Davila JC, Lawrence DA, Reed DJ, Hodgson E, Coruzzi G, et al Current protocols in toxicology, suppl 49. New York: John Wiley & Sons;2011: 7.9.1-15.

Localized hydrogen peroxide-dependent cysteine oxidation is required for lysophosphatidic acid signaling in ovarian and prostate cancer cells [abstract]. Nelson KJ, Rogers LC, Klomsiri C, Soito L, Poole LB, Daniel LW.. Free Radic Biol Med. 2011;51(Suppl 1):S137.

Kinetic and thermodynamic features reveal that Escherichia coli BCP is an unusually versatile peroxiredoxin. Reeves SA, Parsonage D, Nelson KJ, Poole LB.. Biochemistry. 2011;50(41):8970-8981.

Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum. Parsonage D, Desrosiers DC, Hazlett KRO, Sun Y, Nelson KJ, Cox DL, Radolf JD, Poole LB.. Proc Natl Acad Sci U S A. 2010;107(14):6240-6245.

Use of dimedone-based chemical probes for sulfenic acid detection methods to visualize and identify labeled proteins. Nelson KJ, Klomsiri C, Codreanu SG, Soito L, Liebler DC, Rogers LC, Daniel LW, Poole LB.. Methods Enzymol. 2010;473():95-115.

Use of dimedone-based chemical probes for sulfenic acid detection evaluation of conditions affecting probe incorporation into redox-sensitive proteins. Klomsiri C, Nelson KJ, Bechtold E, Soito L, Johnson LC, Lowther WT, Ryu S-E, King SB, Furdui CM, Poole LB.. Methods Enzymol. 2010;473():77-94.

Detection and identification of oxidative cysteine modifications in proteins involved in signal transduction pathways [abstract]. Klomsiri C, Poole LB, Nelson KJ, Rogers L, Klorig EB, Daniel LW, King SB, Furdui CM.. Free Radic Biol Med. 2009;47(Suppl 1):S17-S18.

Discovering mechanisms of signaling-mediated cysteine oxidation. Poole LB, Nelson KJ.. Curr Opin Chem Biol. 2008;12(1):18-24.

Isotope-coded, iodoacetamide-based reagent to determine individual cysteine pKa values by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Nelson KJ, Day AE, Zeng B-B, King SB, Poole LB.. Anal Biochem. 2008;375(2):187-195.

Cysteine pKa values for the bacterial peroxiredoxin AhpC. Nelson KJ, Parsonage D, Hall A, Karplus A, Poole LB.. Biochemistry. 2008;47(48):12860-68.

Fluorescent and affinity-based tools to detect cysteine sulfenic acid formation in proteins. Poole LB, Klomsiri C, Knaggs SA, Furdui CM, Nelson KJ, Thomas MJ, Fetrow JS, Daniel LW, King SB.. Bioconjug Chem. 2007;18(6):2004-2017.

The requirement of reversible cysteine sulfenic acid formation for T cell activation and function. Michalek RD, Nelson KJ, Holbrook BC, Yi JS, Stridiron D, Daniel LW, Fetrow JS, King SB, Poole LB, Grayson JM.. J Immunol. 2007;179(10):6456-6467.

Cysteine sulfenic acid detection in signal transduction pathways [abstract]. Klomsiri C, Nelson KJ, Naggs SA, Fetrow JS, King SB, Furdui CM, Poole LB.. Free Radic Biol Med. 2007;43(Suppl 1):S157.

The role of cysteine sulfenic acid formation during NF-kappa B-mediated signaling [abstract]. Nelson KJ, Klomsiri C, Rogers RL, Daniel LW, Poole LB.. Free Radic Biol Med. 2007;43(Suppl 1):S156.

Substrate specificity and chemical characterization of a bacterial peroxiredoxin, AhpC [abstract]. Parsonage D, Nelson KJ, Day AE, Poole LB.. Free Radic Biol Med. 2007;43(Suppl 1):S113.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Instructor, Biochemistry

Kimberly Johnson Nelson

Kimberly Johnson Nelson

Instructor, Biochemistry

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