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Sean L. Simpson, Ph.D.Wake Forest School of Medicine

Sean L. Simpson, Ph.D.

Associate Professor,

Contact Information

Academic: 336-716-8369 | Department: 336-716-2011


Additional Languages


Education & Training

  • B.A., Harvard University, 2002
  • Ph.D., University of North Carolina-Chapel Hill, 2008


  • Am Statistical Assoc
  • Biometric Society
Sean L. Simpson, Ph.D.

Sean L. Simpson, Ph.D.

Associate Professor, Biostatistical Sciences

Research Interests

Brain; Nerve Net; Models, Theoretical; Blood Pressure Monitoring, Ambulatory; Pesticides
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Contact Information

Academic: 336-716-8369 | Department: 336-716-2011


Recent Publications

Dynamic fMRI networks predict success in a behavioral weight loss program among older adults. Mokhtari F, Rejeski WJ, Zhu Y, Wu G, Simpson SL, Burdette JH, Laurienti PJ.. Neuroimage. 2018;173():421-433.

Improvements in heart rate variability, baroreflex sensitivity, and sleep after use of closed-loop allostatic neurotechnology by a heterogeneous cohort. Shaltout HA, Lee SW, Tegeler CL, Hirsch JR, Simpson SL, Gerdes L, Tegeler CH.. Front Public Health. 2018;6():116.

Clinical, hemispheric, and autonomic changes associated with use of closed-loop, allostatic neurotechnology by a case series of individuals with self-reported symptoms of post-traumatic stress. Tegeler CH, Cook JF, Tegeler CL, Hirsch JR, Shaltout HA, Simpson SL, Fidali BC, Gerdes L, Lee SW.. BMC Psychiatry. 2017;17(1):141.

The impacts of pesticide and nicotine exposures on functional brain networks in Latino immigrant workers. Bahrami M, Laurienti PJ, Quandt SA, Talton J, Pope CN, Summers P, Burdette JH, Chen H, Liu J, Howard TD, Arcury TA, Simpson SL.. Neurotoxicology. 2017;62():138-150.

Time of admission to the PICU and mortality. McCrory MC, Spaeder MC, Gower EW, Nakagawa TA, Simpson SL, Coleman MA, Morris PE.. Pediatr Crit Care Med. 2017;18(10):915-923.

Successful use of closed-loop allostatic neurotechnology for post-traumatic stress symptoms in military personnel: self-reported and autonomic improvements. Tegeler CL, Gerdes L, Shaltout HA, Cook JF, Simpson SL, Lee SW, Tegeler CH.. Mil Med Res. 2017;4():UNSP 38.

Disentangling brain graphs: a note on the conflation of network and connectivity analyses. Simpson SL, Laurienti PJ.. Brain Connect. 2016;6(2):95-98.

Moderate-heavy alcohol consumption lifestyle in older adults is associated with altered central executive network community structure during cognitive task. Mayhugh RE, Moussa MN, Simpson SL, Lyday RG, Burdette JH, Porrino LJ, Laurienti PJ.. PLoS One. 2016;11(8):e0160214.

Prediction of incident diabetes in the Jackson Heart Study using high-dimensional machine learning. Casanova R, Saldana S, Simpson SL, Lacy ME, Subauste AR, Blackshear C, Wagenknecht L, Bertoni AG.. PLoS One. 2016;11(10):e0163942.

A preliminary study of the effectiveness of an allostatic, closed-loop, acoustic stimulation neurotechnology in the treatment of athletes with persisting post-concussion symptoms. Tegeler CH, Tegeler CL, Cook JF, Lee SW, Gerdes L, Shaltout HA, Miles CM, Simpson SL.. Sports Med Open. 2016;2(1):39.

Multifractal analysis of information processing in hippocampal neural ensembles during working memory under Delta(9)-tetrahydrocannabinol administration. Fetterhoff D, Opris I, Simpson SL, Deadwyler SA, Hampson RE, Kraft RA.. J Neurosci Methods. 2015;244():136-153.

Long-term moderate alcohol consumption does not exacerbate age-related cognitive decline in healthy, community-dwelling older adults. Moussa MN, Simpson SL, Mayhugh RE, Grata ME, Burdette JH, Porrino LJ, Laurienti PJ.. Front Aging Neurosci. 2015;6():341.

A two-part mixed-effects modeling framework for analyzing whole-brain network data. Simpson SL, Laurienti PJ.. Neuroimage. 2015;113():310-319.

Changes in brain network efficiency and working memory performance in aging. Stanley ML, Simpson SL, Dagenbach D, Lyday RG, Burdette JH, Laurienti PJ.. PLoS One. 2015;10(4):e0123950.

Global integration of the hot-state brain network of appetite predicts short term weight loss in older adult. Paolini BM, Laurienti PJ, Simpson SL, Burdette JH, Lyday RG, Rejeski WJ.. Front Aging Neurosci. 2015;7():70.

Editorial: complexity and emergence in brain network analyses. Telesford QK, Simpson SL, Kolaczyk ED.. Front Comput Neurosci. 2015;9():65.

Analysis of feedback mechanisms with unknown delay using sparse multivariate autoregressive method. Ip EH, Zhang Q, Sowinski T, Simpson SL.. PLoS One. 2015;10(8):e0131371.

The brain science interface. Simpson SL, Burdette JH, Laurienti PJ.. Signif (Oxf). 2015;12(4):34-39.

Kronecker product linear exponent AR(1) correlation structures for multivariate repeated measures. Simpson SL, Edwards LJ, Styner MA, Muller KE.. PLoS One. 2014;9(2):e88864.

An analysis of 24-h ambulatory blood pressure monitoring data using orthonormal polynomials in the linear mixed model. Edwards LJ, Simpson SL.. Blood Press Monit. 2014;19(3):153-163.

Off-hours admission to pediatric intensive care and mortality. McCrory MC, Gower EW, Simpson SL, Nakagawa TA, Mou SS, Morris PE.. Pediatrics. 2014;134(5):e1345-1353.

A circular LEAR correlation structure for cyclical longitudinal data. Simpson SL, Edwards LJ.. Stat Methods Med Res. 2013;22(3):296-306.

Sex, weight status, and chronic kidney disease among African Americans: the Jackson Heart Study. Bruce MA, Beech BM, Crook ED, Sims M, Griffith DM, Simpson SL, Ard J, Norris KC.. J Investig Med. 2013;61(4):701-707.

Analyzing complex functional brain networks: fusing statistics and network science to understand the brain. Simpson SL, Bowman FD, Laurienti PJ.. Stat Surv. 2013;7():1-36.

A permutation testing framework to compare groups of brain networks. Simpson SL, Lyday RG, Hayasaka S, Marsh AP, Laurienti PJ.. Front Comput Neurosci. 2013;7():171.

Intraindividual variability in domain-specific cognition and risk of mild cognitive impairment and dementia. Vaughan L, Leng I, Dagenbach D, Resnick SM, Rapp SR, Jennings JM, Brunner RL, Simpson SL, Beavers DP, Coker LH, Gaussoin SA, Sink KM, Espeland MA.. Curr Gerontol Geriatr Res. 2013;():495793.

Off-hours admission and mortality in pediatric intensive care [abstract]. McCrory M, Gower E, Morris P, Simpson S.. Crit Care Med. 2013;41(12 Suppl 1):A135.

An exponential random graph modeling approach to creating group-based representative whole-brain connectivity networks. Simpson SL, Moussa MN, Laurienti PJ.. Neuroimage. 2012;60(2):1117-1126.

From politics to parity: using a health disparities index to guide legislative efforts for health equity. Webb BC, Simpson SL, Hairston KG.. Am J Public Health. 2011;101(3):554-560.

Exponential random graph modeling for complex brain networks. Simpson SL, Hayasaka S, Laurienti PJ.. PLoS ONE. 2011;6(5):e20039.

The brain as a complex system: using network science as a tool for understanding the brain. Telesford QK, Simpson SL, Burdette JH, Hayasaka S, Laurienti PJ.. Brain Connect. 2011;1(4):295-308.

Is social support from family associated with PSA testing? An exploratory analysis using the Health Information National Trends Survey (HINTS) 2005. Thomas KB, Simpson SL, Tarver WL, Gwede CK.. Am J Mens Health. 2010;4(1):50-59.

A linear exponent AR1 family of correlation structures. Simpson SL, Edwards LJ, Muller KE, Sen PK, Styner MA.. Stat Med. 2010;29(17):1825-1838.

Rhinitis associated with pesticide use among private pesticide applicators in the Agricultural Health Study. Slager RE, Simpson SL, LeVan TD, Poole JA, Sandler DP, Hopping JA.. J Toxicol Environ Health A. 2010;73(20):1382-1393.

Reproducibility of graph metrics in fMRI networks. Telesford QK, Morgan AR, Hayasaka S, Simpson SL, Barret W, Kraft RA, Mozolic JL, Laurienti PJ.. Front Neuroinform. 2010;4():117.

An adjusted likelihood ration test for separability in unbalanced multivariate repeated measures data. Simpson SL.. Stat Methodol. 2010;7():511-519.

POWERLIB: SAS/IML software for computing power in multivariate linear models. Johnson JL, Muller KE, Slaughter JC, Gurka MJ, Gribbin MJ, Simpson SL.. J Stat Softw. 2009;30(5):1-27.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Biostatistical Sciences

Sean L. Simpson, Ph.D.

Sean L. Simpson, Ph.D.

Associate Professor, Biostatistical Sciences

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