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Vidula Tushar Vachharajani, M.D.Wake Forest School of Medicine

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Vidula Tushar Vachharajani, M.D.


Associate Professor,

Clinical Interests

Sepsis, Critical Care

Contact Information


Insurance Accepted »

Education & Training

  • M.B.,B.S., Bombay Univ Grant Medical College-India, 1986
  • Residency, Lsu-Shreveport Affil Hsps, 2000
  • Fellowship, LSU School of Medicine-Shrevep, 2004

Board Certifications

  • American Board of Internal Medicine, Critical Care Medicine


  • Shock Society
  • Soc Of Critical Care Medicine
  • Amer Coll Of Chest Physicians

NPI Number

  • 1952323040
Vidula Tushar Vachharajani, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

Vidula Tushar Vachharajani, M.D.

Professor, Anesthesiology
Center on Diabetes, Obesity, and Metabolism
Associate Professor, Molecular Medicine

Research Interests

Sepsis; Inflammation; Sirtuin 1; Obesity; Leukocytes
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Contact Information

Academic: 336-716-4498


Recent Publications

Catheter directed thrombolysis combined with ECMO for massive pulmonary emboli. Lauren Lindsey J, Jain R, Vachharajani V.. Respir Med Case Rep. 2018;25():6-8.

Sirtuin 2 regulates microvascular inflammation during sepsis. Buechler N, Wang X, Yoza BK, McCall CE, Vachharajani V.. J Immunol Res. 2017;2017():2648946.

Potential therapeutic action of nitrite in sickle cell disease. Wajih N, Basu S, Jailwala A, Kim HW, Ostrowski D, Perlegas A, Bolden CA, Buechler NL, Gladwin MT, Caudell DL, Rahbar E, Alexander-Miller MA, Vachharajani V, Kim-Shapiro DB.. Redox Biol. 2017;12():1026-1039.

Safety of phenylephrine infusion through peripheral intravenous catheter in the neurological intensive care unit. Datar S, Gutierrez E, Schertz A, Vachharajani V.. J Intensive Care Med. 2017;():.

The oxidative state of cysteine thiol 144 regulates the SIRT6 glucose homeostat. Long D, Wu H, Tsang AW, Poole LB, Yoza BK, Wang X, Vachharajani V, Furdui CM, McCall CE.. Sci Rep. 2017;7(1):11005.

GAPDH binding to TNF-alpha mRNA contributes to posttranscriptional repression in monocytes: a novel mechanism of communication between inflammation and metabolism. Millet P, Vachharajani V, McPhail L, Yoza B, McCall CE.. J Immunol. 2016;196(6):2541-2551.

Sirtuins link inflammation and metabolism. Vachharajani VT, Liu T, Wang X, Hoth JJ, Yoza BK, McCall CE.. J Immunol Res. 2016;2016():8167273.

Rescuing immunosuppressed septic mice from death by reducing the mitochondrial block in glucose oxidation [abstract]. Liu T, Vachharajani V, Martin A, McCall C.. Shock. 2016;45(6 Suppl 1):130.

Sirtuin-2 regulates sepsis inflammation in ob/ob mice. Wang X, Buechler NL, Martin A, Wells J, Yoza B, McCall CE, Vachharajani V.. PLoS One. 2016;11(8):e0160431.

Precision immunometabolic checkpoint treatment of lethal murine sepsis: targeting the NAD plus and sirtuin 1-dependent homeostasis network [abstract]. Liu T, Vachharajani V, Zhang X, Xu J, McCall C.. Eur J Immunol. 2016;46(Suppl 1):1046.

Adiponectin treatment attenuates inflammatory response during early sepsis in obese mice. Wang X, Buechler NL, Yoza BK, McCall CE, Vachharajani V.. J Inflamm Res. 2016;9():167-174.

Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis. Liu TF, Vachharajani V, Millet P, Bharadwaj MS, Molina AJ, McCall CE.. J Biol Chem. 2015;290(1):396-408.

Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-induced modulation of adhesion molecules in ob/ob mice. Wang X, Buechler NL, Yoza BK, McCall CE, Vachharajani VT.. Obesity (Silver Spring). 2015;23(6):1209-1217.

SIRT1 mediates a primed response to immune challenge after traumatic lung injury. Smith LM, Wells JD, Vachharajani VT, Yoza BK, McCall CE, Hoth JJ.. J Trauma Acute Care Surg. 2015;78(5):1034-1038.

SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome. Vachharajani VT, Liu T, Brown CM, Wang X, Buechler NL, Wells JD, Yoza BK, McCall CE.. J Leukoc Biol. 2014;96(5):785-796.

Epigenetic coordination of acute systemic inflammation: potential therapeutic targets. Vachharajani V, Liu T, McCall CE.. Expert Rev Clin Immunol. 2014;10(9):1141-1150.

Adiponectin-deficiency exaggerates sepsis-induced microvascular dysfunction in the mouse brain. Vachharajani V, Cunningham C, Yoza B, Carson J Jr, Vachharajani TJ, McCall C.. Obesity (Silver Spring). 2012;20(3):498-504.

NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response. Liu TF, Vachharajani VT, Yoza BK, McCall CE.. J Biol Chem. 2012;287(31):25758-69.

Fueling the flame: bioenergy couples metabolism and inflammation. Liu TF, Brown CM, El Gazzar M, McPhail L, Millet P, Rao A, Vachharajani VT, Yoza BK, McCall CE.. J Leukoc Biol. 2012;92(3):499-507.

NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance. Liu TF, Yoza BK, El Gazzar M, Vachharajani VT, McCall CE.. J Biol Chem. 2011;286(11):9856-9864.

A circuitous detour. Vachharajani TJ, Vachharajani V.. Kidney Int. 2011;79(12):1383.

Re-evaluating the Fistula First Initiative in octogenarians on hemodialysis. Vachharajani TJ, Moossavi S, Jordan JR, Vachharajani V, Freedman BI, Burkart JM.. Clin J Am Soc Nephrol. 2011;6(7):1663-1667.

Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation. McCall CE, El Gazzar M, Liu T, Vachharajani V, Yoza B.. J Leukoc Biol. 2011;90(3):439-446.

Modulation of circulating cell-endothelial cell interaction by erythropoietin in lean and obese mice with cecal ligation and puncture. Vachharajani V, Vital S, Russell J.. Pathophysiology. 2010;17(1):9-18.

Obstacles for clinical monitoring in hemodialysis patients because of multiple vascular accesses. Vachharajani TJ, Vachharajani V.. Semin Dial. 2010;23(1):114-116.

Curcumin modulates leukocyte and platelet adhesion in murine sepsis. Vachharajani V, Wang SW, Mishra N, El Gazzar M, Yoza B, McCall C.. Microcirculation. 2010;17(6):407-416.

Adipose tissue: a motor for the inflammation associated with obesity. Vachharajani V, Granger DN.. IUBMB Life. 2009;61(4):424-430.

Diet-induced obesity exacerbates cell adhesion in sepsis [abstract]. Vachharajani V.. Shock. 2009;31(Suppl 1):72.

Influence of obesity on sepsis. Vachharajani V.. Pathophysiology. 2008;15(2):123-134.

Hypertonic saline and the cerebral microcirculation in obese septic mice. Vachharajani V, Vital S, Russell J, Granger DN.. Microcirculation. 2007;14(3):223-231.

Vasopressin-receptor antagonist therapy in patients with hyponatraemia. Vachharajani T, Vachharajani V.. Br J Hosp Med. 2007;68(7):367-372.

Obesity and sepsis. Vachharajani V, Vital S.. J Intensive Care Med. 2006;21(5):287-295.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Anesthesiology

Clinical Interests

Sepsis, Critical Care

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