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Thaddeus J. Wadas, Ph.D.Wake Forest School of Medicine

Thaddeus J. Wadas, Ph.D.

Assistant Professor,

Contact Information

Academic: 336-716-5696 | Department: 336-716-5696


Education & Training

  • B.S., Kings College, 1996
  • M.S., University of Rochester, 2000
  • Ph.D., University of Rochester, 2004
  • Fellowship, Radiological Science, Washington University School o, 2009
Thaddeus J. Wadas, Ph.D.

Thaddeus J. Wadas, Ph.D.

Assistant Professor, Cancer Biology
Biomedical Engineering

Research Interests

Radiopharmaceuticals; Chelating Agents; Positron-Emission Tomography; Zirconium; Copper Radioisotopes
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Contact Information

Academic: 336-716-5696 | Department: 336-716-5696


Recent Publications

Recent advances in zirconium-89 chelator development. Bhatt NB, Pandya DN, Wadas TJ.. Molecules. 2018;23(3):E638.

Practical guidelines for Cerenkov luminescence imaging with clinically relevant isotopes. Bhatt NB, Pandya DN, Dezarn WA, Marini FC, Zhao D, Gmeiner WH, Triozzi PL, Wadas TJ.. Methods Mol Biol. 2018;1790():197-208.

Zirconium tetraazamacrocycle complexes display extraordinary stability and provide a new strategy for zirconium-89-based radiopharmaceutical development. Pandya DN, Bhatt N, Yuan H, Day CS, Ehrmann BM, Wright M, Bierbach U, Wadas TJ.. Chem Sci. 2017;8(3):2309-2314.

Enhancing tissue permeability with MRI guided preclinical focused ultrasound system in rabbit muscle: from normal tissue to VX2 tumor. Sun Y, Xiong X, Pandya D, Jung Y, Mintz A, Hayasaka S, Wadas TJ, Li KCP.. J Control Release. 2017;256():1-8.

Evaluation of macrocyclic hydroxyisophthalamide ligands as chelators for zirconium-89. Bhatt NB, Pandya DN, Xu J, Tatum D, Magda D, Wadas TJ.. PLoS One. 2017;12(6):e0178767.

IL13RA2 targeted alpha particle therapy against glioblastomas. Sattiraju A, Solingapuram Sai KK, Xuan A, Pandya DN, Almaguel FG, Wadas TJ, Herpai DM, Debinski W, Mintz A.. Oncotarget. 2017;8(26):.

Alpha particle enhanced Blood Brain/Tumor Barrier permeabilization in glioblastomas using integrin alpha-v beta-3 targeted liposomes. Sattiraju A, Xiong X, Pandya DN, Wadas TJ, Xuan A, Sun Y, Jung Y, Solingapuram Sai KK, Dorsey JF, Li KC, Mintz A.. Mol Cancer Ther. 2017;16(10):2191-2200.

Dosimetry of a novel targeted alpha particle therapy for metastatic uveal melanoma [abstract]. Tichacek CJ, Tafreshi NK, Doligalski ML, Budzevich MM, Ruiz E, Delva NC, Wadas TJ, McLaughlin ML, Morse DL, Moros EG.. Med Phys. 2017;44(6):2986.

Evaluation of a 3-hydroxypyridin-2-one (2,3-HOPO) based macrocyclic chelator for (89)Zr(4+) and its use for immunoPET imaging of HER2 positive model of ovarian carcinoma in mice. N Tinianow J, Pandya DN, Pailloux SL, Ogasawara A, Vanderbilt AN, Gill HS, Williams SP, Wadas TJ, Magda D, Marik J.. Theranostics. 2016;6(4):511-521.

Preliminary therapy evaluation of (225)Ac-DOTA-c(RGDyK) demonstrates that cerenkov radiation derived from (225)Ac daughter decay can be detected by optical imaging for in vivo tumor visualization. Pandya DN, Hantgan R, Budzevich MM, Kock ND, Morse DL, Batista I, Mintz A, Li KC, Wadas TJ.. Theranostics. 2016;6(5):698-709.

Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89. Pandya DN, Pailloux S, Tatum D, Magda D, Wadas TJ.. Chem Commun (Camb). 2015;51(12):2301-2303.

Permeabilizing the blood-brain-barrier with alpha-particle therapy [abstract]. Sattiraju A, Xiong XB, Pandya D, Sun Y, Jung Y, Wadas T, Li K, Mintz A.. J Nucl Med. 2015;56(3 Suppl 3):1230.

Molecular targeted alpha-particle therapy for oncologic applications. Wadas TJ, Pandya DN, Solingapuram Sai KK, Mintz A.. AJR Am J Roentgenol. 2014;203(2):253-260.

The development of copper radiopharmaceuticals for imaging and therapy. Shokeen M, Wadas TJ.. Med Chem. 2011;7(5):413-429.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Cancer Biology

Thaddeus J. Wadas, Ph.D.

Thaddeus J. Wadas, Ph.D.

Assistant Professor, Cancer Biology
Biomedical Engineering

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