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Raghunatha Yammani, Ph.D.Wake Forest School of Medicine

Raghunatha Yammani, Ph.D.

Associate Professor,

Contact Information

Academic: 336-716-1578 | Department: 336-713-4259

Education & Training

  • B.S., Osmania University-India, 1990
  • M.S., Free Standing Institute-India, 1993
  • Ph.D., Osmania University-India, 1999
  • Fellowship, Indian Institute Of Science-In, 1999
  • Fellowship, Medical College of Wisconsin, 2004
  • Fellowship, Rush Medical College, 2004
Raghunatha Yammani, Ph.D.

Raghunatha Yammani, Ph.D.

Associate Professor, Molecular Medicine
Center for Diabetes Research
Rheumatology and Immunology
Orthopaedic Surgery

Research Interests

Chondrocytes; S100 Proteins; Cartilage, Articular; Matrix Metalloproteinase 13; Osteoarthritis
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Contact Information

Academic: 336-716-1578 | Department: 336-713-4259

Recent Publications

Saturated fatty acid palmitate negatively regulates autophagy by promoting ATG5 protein degradation in meniscus cells. Mallik A, Yammani RR.. Biochem Biophys Res Commun. 2018;502(3):370-374.

Palmitate-induced ER stress negatively regulates autophagy in primary meniscus cells [abstract]. Yammani R, Mallik A.. Osteoarthritis Cartilage. 2018;26(Suppl 1):S114.

High fat-diet and saturated fatty acid palmitate inhibits IGF-1 function in chondrocytes. Nazli SA, Loeser RF, Chubinskaya S, Willey JS, Yammani RR.. Osteoarthritis Cartilage. 2017;25(9):1516-1521.

Association of endoplasmic reticulum (ER) stress and mitochondrial dysfunction in meniscus cells [abstract]. Nazli S, Yammani R.. Osteoarthritis Cartilage. 2017;25(Suppl 1):S284-S285.

Effects of post-delivery placenta disc (HPH) on porcine hyaline cartilage matrix breakdown [abstract]. Ma X, Tomblyn S, Willey J, Washburn S, Smith TL, Yammani R.. Tissue Eng Part A. 2017;23(Suppl 1):S70-S71.

Cysteine-mediated redox regulation of cell signaling in chondrocytes stimulated with fibronectin fragments. Wood ST, Long DL, Reisz JA, Yammani RR, Burke EA, Klomsiri C, Poole LB, Furdui CM, Loeser RF.. Arthritis Rheumatol. 2016;68(1):117-126.

Free fatty acid palmitate activates unfolded protein response pathway and promotes apoptosis in meniscus cells. Haywood J, Yammani RR.. Osteoarthritis Cartilage. 2016;24(5):942-945.

Endoplasmic reticulum (ER) stress inhibits IGF-1 function in articular cartilage [abstract]. Yammani RR, Haywood J, Loeser RF Jr.. Osteoarthritis Cartilage. 2016;24(Suppl):S180-S181.

Spaceflight-relevant challenges of radiation and/or reduced weight bearing cause arthritic responses in knee articular cartilage. Willey JS, Kwok AT, Moore JE, Payne V, Lindburg CA, Balk SA, Olson J, Black PJ, Walb MC, Yammani RR, Munley MT.. Radiat Res. 2016;186(4):333-344.

Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting. Files DC, Liu C, Pereyra A, Wang ZM, Aggarwal NR, D'Alessio FR, Garibaldi BT, Mock JR, Singer BD, Feng X, Yammani RR, Zhang T, Lee AL, Philpott S, Lussier S, Purcell L, Chou J, Seeds M, King LS, Morris PE, Delbono O.. Sci Transl Med. 2015;7(278):278ra32.

Cysteine-mediated redox regulation of cell signaling in chondrocytes stimulated with fibronectin fragments [abstract]. Wood ST, Long D, Reisz J, Yammani R, Burke E, Klomsiri C, Poole L, Furdui C, Loeser R.. Osteoarthritis Cartilage. 2015;23(Suppl 2):A65-A66.

Palmitate induces endoplasmic reticulum (ER) stress and activates unfolded protein response (UPR) signaling in meniscus cells [abstract]. Yammani R.. Osteoarthritis Cartilage. 2015;23(Suppl 2):A273.

Brief report: stress-inducible nuclear protein 1 regulates matrix metalloproteinase 13 expression in human articular chondrocytes. Yammani RR, Loeser RF.. Arthritis Rheum. 2014;66(5):1266-1271.

Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes. Yammani RR, Loeser RF.. Arthritis Res Ther. 2012;14(1):R23.

S100 proteins in cartilage: role in arthritis. Yammani RR.. Biochim Biophys Acta. 2012;1822(4):600-606.

Sumoylation and nuclear translocation of S100A4 regulate IL-1beta-mediated production of matrix metalloproteinase-13. Miranda KJ, Loeser RF, Yammani RR.. J Biol Chem. 2010;285(41):31517-24.

Response to Berge et al.: comment on the importance of S100A4 in regulation of MMP-13 [letter]. Miranda KJ, Loeser RF, Yammani RR.. J Biol Chem. 2010;285(53):Ie24.

Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis. Cravero JD, Carlson CS, Im H-J, Yammani RR, Long D, Loeser RF.. Arthritis Rheum. 2009;60(2):492-500.

Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes. Yammani RR, Long D, Loeser RF.. Arthritis Rheum. 2009;60(3):792-800.

Interactions of cubillin with megalin and the product of the amnionless gene (AMN): effect on its stability. Ahuja R, Yammani R, Bauer JA, Kaira S, Seetharam S, Seetharam B.. Biochem J. 2008;410(2):301-308.

Plasma membrane delivery, endocytosis and turnover of transcobalamin receptor in polarized human intestinal epithelial cells. Bose S, Kalra S, Yammani RR, Ahuja R, Seetharam B.. J Physiol. 2007;581(Pt 2):457-466.

Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: role of the receptor for advanced glycation end products. Yammani RR, Carlson CS, Bresnick AR, Loeser RF.. Arthritis Rheum. 2006;54(9):2901-2911.

Chondrocyte MMP-13 expression in response to alpha 5 beta 1 integrin stimulation requires protein sulfenic acids as signaling intermediates [abstract]. Loeser RF, Yammani R, Erickson E, King B, Poole L.. Arthritis Rheum. 2006;54(9 Suppl):S318.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Molecular Medicine

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