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Yuanyuan Zhang, M.D., Ph.D.Wake Forest School of Medicine

Yuanyuan Zhang, M.D., Ph.D.

Associate Professor,
Assistant Professor,
Redox Biology & Medicine Ctr

Contact Information

Academic: 336-713-1189

Email: yzhang@wakehealth.edu

Education & Training

  • M.D., China-Jiangxi Medical College, 1982
  • M.S., China-Jiangxi Medical College, 1989
  • Ph.D., Univ Lausanne Faculty of Medicine-Switzerland, 2001
  • Fellowship, Urology, Hospital-New Zealand, 1995
  • Fellowship, Pediatrics, Univ Lausanne Faculty of Medic, 1997
Yuanyuan Zhang, M.D., Ph.D.

Yuanyuan Zhang, M.D., Ph.D.

Associate Professor, Institute for Regenerative Medicine
Assistant Professor, Institute for Regenerative Medicine
Redox Biology & Medicine Ctr

Research Interests

Accident Prevention; Automobile Driving; Attention; Synaptophysin; GAP-43 Protein
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Contact Information

Academic: 336-713-1189

Email: yzhang@wakehealth.edu

Recent Publications

Controlled release of insulin-like growth factor 1 enhances urethral sphincter function and histological structure in the treatment of female stress urinary incontinence in a rat model. Yan H, Zhong L, Jiang Y, Yang J, Deng J, Wei S, Opara E, Atala A, Mao X, Damaser M, Zhang Y.. BJU Int. 2018;121(2):301-312.

Human umbilical cord mesenchymal stem cell conditioned medium attenuates renal fibrosis by reducing inflammation and epithelial-to-mesenchymal transition via the TLR4/NF-kB signaling pathway in vivo and in vitro. Liu B, Ding F, Hu D, Zhou Y, Long C, Shen L, Zhang Y, Zhang D, Wei G.. Stem Cell Res Ther. 2018;9(1):7.

Time-responsive osteogenic niche of stem cells: a sequentially triggered, dual-peptide loaded, alginate hybrid system for promoting cell activity and osteo-differentiation. Luo Z, Zhang S, Pan J, Shi R, Liu H, Lyu Y, Han X, Li Y, Yang Y, Xu Z, Sui Y, Luo E, Zhang Y, Wei S.. Biomaterials. 2018;163():25-42.

Genetically-modified bone mesenchymal stem cells with TGF-beta3 improve wound healing and reduce scar tissue formation in a rabbit model. Li M, Qiu L, Hu W, Deng X, Xu H, Cao Y, Xiao Z, Peng L, Johnson S, Alexey L, Kingston PA, Li Q, Zhang Y.. Exp Cell Res. 2018;367(1):24-29.

3D cone beam computed tomography reconstruction images in diagnosis of ameloblastomas of lower jaw: a case report and mini review. Li D, Yang Z, Chen T, Guan C, Wang F, Matz EL, Zhang Y, Ji P.. J Xray Sci Technol. 2018;26(1):133-140.

A case report of Rosai-Dorfman disease with kidney involvement. Wang F, Xu J, Chen J, Fu H, Wang Z, Cai D, Kang X, Zhang BB, Matz EL, Zhang Y, Wang W.. J Xray Sci Technol. 2018;26(1):141-146.

3D computed tomography angiography as a novel post-processing approach in diagnosis of pediatric malignant bone tumors. Wu J, Wang C, Li M, Luo C, Liu X, Xie L, He L, Gong M, Hu Z, Bleyer AJ, Zhang Y.. J Xray Sci Technol. 2018;26(1):147-154.

Diagnosis of lymphoepithelial carcinoma in parotid gland with three dimensional computed tomography angiography reconstruction: a case report. Yao L, Zhang Y, Chen Q, Wang S, Wang Q, Yi J, Zhang L, Matz EL, Hu X, Huang G.. J Xray Sci Technol. 2018;26(1):155-164.

3D reconstruction images of cone beam computed tomography applied to maxillofacial fractures: a case study and mini review. Bai L, Li L, Su K, Bleyer A, Zhang Y, Ji P.. J Xray Sci Technol. 2018;26(1):115-123.

Stem cell therapy for erectile dysfunction. Matz EL, Terlecki R, Zhang Y, Jackson J, Atala A.. Sex Med Rev. 2018;():.

Clinical significance of imaging findings for atlantoaxial rotatory subluxation in children. Zhang XB, Luo C, Li M, Zhang X, Hui H, Zeng Q, Li TY, Zhang DW, Zhang YY, Wang C, Liu CK, Liu X, Qu XY, Cao YJ, Zhou H, Weng LQ.. Turk J Med Sci. 2018;48(2):332-338.

Transparent PEG-fibrin gel as a flexible tool for cell encapsulation. Shpichka AI, Revkova VA, Aksenova NA, Yusubalieva GM, Kalsin VA, Semenova EF, Zhang Y, Baklaushev VP, Timashev PS.. Sovrem Tehnol Med. 2018;10(1):64-69.

Tissue-specific extracellular matrix with or without tissue protein components for cell culture. Zhang Y, Soker S, Atala A, Skardal A, inventors; Wake Forest University Health Sciences, assignee.. United States patent US 9938502. 2018 Apr 10. 2018;():.

Skeletal myogenic differentiation of human urine-derived cells as a potential source for skeletal muscle regeneration. Chen W, Xie M, Yang B, Bharadwaj S, Song L, Liu G, Yi S, Ye G, Atala A, Zhang Y.. J Tissue Eng Regen Med. 2017;11(2):334-341.

Co-expression of Piwil2/Piwil4 in nucleus indicates poor prognosis of hepatocellular carcinoma. Zeng G, Zhang D, Liu X, Kang Q, Fu Y, Tang B, Guo W, Zhang Y, Wei G, He D.. Oncotarget. 2017;8(3):4607-4617.

Characterization of sodium dodecyl sulfate decellularized cow diaphragmatic tendon extracellular matrix as sling biomaterial in stress urinary incontinence treatment. Xue L, Zhang X, Niu GG, Yang B, Zhang YY.. J Biomater Tissue Eng. 2017;7(1):83-89.

Human neural progenitors derived from integration-free iPSCs for SCI therapy. Liu Y, Zheng Y, Li S, Xue H, Schmitt K, Hergenroeder GW, Wu J, Zhang Y, Kim DH, Cao Q.. Stem Cell Res. 2017;19():55-64.

Piwil2-transfected human fibroblasts are cancer stem cell-like and genetically unstable. Zhang D, Wu X, Liu X, Cai C, Zeng G, Rohozinski J, Zhang Y, Wei G, He D.. Oncotarget. 2017;8(7):12259-71.

Bilateral duplex urinary collecting systems accompanied with horseshoe kidneys deformity and right renal ureteral calculi and hydronephrosis: diagnosis in magnetic resonance urography. Yu Y, Li J, Guo L, Gu T, Xiao R, Ye Y, Pan Q, Zhang Y, Huang H.. J Xray Sci Technol. 2017;25(4):667-672.

Urethral reconstruction with autologous urine-derived stem cells seeded in three-dimensional porous small intestinal submucosa in a rabbit model. Liu Y, Ma W, Liu B, Wang Y, Chu J, Xiong G, Shen L, Long C, Lin T, He D, Butnaru D, Alexey L, Zhang Y, Zhang D, Wei G.. Stem Cell Res Ther. 2017;8(1):63.

Therapeutic effect of urine-derived stem cells for protamine/lipopolysaccharide-induced interstitial cystitis in a rat model. Li J, Luo H, Dong X, Liu Q, Wu C, Zhang T, Hu X, Zhang Y, Song B, Li L.. Stem Cell Res Ther. 2017;8(1):107.

Subinguinal microsurgical varicocelectomy with intraoperative microvascular Doppler ultrasound leads to the pain-free outcome after surgery. Lv KL, Zhang YD, Zhuang JT, Gao Y, Zhao L, Wan Z, Zhou MK, Yu JW, Sun XZ, Zhang YY, Tu XA.. J Xray Sci Technol. 2017;25(5):839-846.

Benign mixed epithelial and stromal tumor of the kidney with inferior vena cava tumor thrombus: a rare case report and review of literature. Zhang C, Li X, Mo C, Peng Z, Yang R, Tang Y, Zhang Y, Wu R.. J Xray Sci Technol. 2017;25(5):831-837.

Tissue-specific extracellular matrix enhances skeletal muscle precursor cell expansion and differentiation for potential application in cell therapy. Zhang D, Zhang Y, Zhang Y, Yi H, Wang Z, Wu R, He D, Wei G, Wei S, Hu Y, Deng J, Criswell T, Yoo JJ, Zhou Y, Atala A.. Tissue Eng Part A. 2017;23(15-16):784-794.

Human umbilical cord-derived mesenchymal stem cells conditioned medium attenuate interstitial fibrosis and stimulate the repair of tubular epithelial cells in an irreversible model of unilateral ureteral obstruction. Liu B, Ding FX, Liu Y, Xiong G, Lin T, He DW, Zhang YY, Zhang DY, Wei GH.. Nephrology (Carlton). 2017;():.

Circular RNAs: a novel type of biomarker and genetic tools in cancer. Han YN, Xia SQ, Zhang YY, Zheng JH, Li W.. Oncotarget. 2017;8(38):64551-563.

Tissue-specific extracellular matrix promotes myogenic differentiation of human muscle progenitor cells on gelatin and heparin conjugated alginate hydrogels. Yi H, Forsythe S, He Y, Liu Q, Xiong G, Wei S, Li G, Atala A, Skardal A, Zhang Y.. Acta Biomater. 2017;62():222-233.

Early passage autologous mesenchymal stromal cells accelerate diabetic wound re-epithelialization: a clinical case study. Maksimova N, Krasheninnikov M, Zhang Y, Ponomarev E, Pomytkin I, Melnichenko G, Lyundup A.. Cytotherapy. 2017;19(12):1548-1550.

PIWI proteins and PIWI-interacting RNA: emerging roles in cancer. Han YN, Li Y, Xia SQ, Zhang YY, Zheng JH, Li W.. Cell Physiol Biochem. 2017;44(1):1-20.

Urine-derived stem cells: a potential bio-marker for renal insufficiency [abstract]. Dou L, Xiong G, Zhang D, Tang W, Yi H, Li G, Bleyer M, Bleyer A, Atala A, Takahashi Y, Ma J, Zhang Y.. Tissue Eng Part A. 2017;23(Suppl 1):S81.

Therapeutic outcomes of insulin-like growth factor-1 released from alginate-gelatin microbeads on stress urinary incontinence in rats with simulated childbirth injury [abstract]. Gu X, Yan H, Zhong L, Jiang Y, Yang J, Lin D, Yuan X, Kuang M, Rietsch A, Atala A, Opara E, Damaser M, Zhang Y.. Tissue Eng Part A. 2017;23(Suppl 1):S107-S108.

Human urine-derived stem cells lessen inflammation and fibrosis within kidney tissue in a rodent model of aging-related renal insufficiency [abstract]. Gu X, Jiang Y, Shi H, Zhong L, Zhang D, Li W, Zhang Y, Chen D, Jiao Y, Atala A, Diz D, Zhang Y.. Tissue Eng Part A. 2017;23(Suppl 1):S80.

Transplantation of human urine-derived stem cells transfected with pigment epithelium-derived factor to protect erectile function in a rat model of cavernous nerve injury [abstract]. Long T, Yang Q, Chen X, Zheng T, Han D, Zhang H, Shi Y, Bian J, Sun X, Xia K, Liang X, Liu G, Zhang Y, Deng C.. Tissue Eng Part A. 2017;23(Suppl1):S80-S81.

A novel in vitro model of human urothelium with barrier function differentiated from urine-derived stem cells [abstract]. Vasiutin I, Wan Q, Zhang D, Liu G, Zhang X, Liang D, Guodong L, Atala A, Zhang Y.. Tissue Eng Part A. 2017;23(Suppl 1):S132-S133.

Biofabrication of tissue-specific extracellular matrix proteins to enhance skeletal myocyte expansion and differentiation of muscle progenitor cells [abstract]. Vasiutin I, Zhang D, Zhang Y, Yi H, Wang Z, Zhou Y, Yoo J, Atala A, Zhang Y.. Tissue Eng Part A. 2017;23(Suppl 1):S71.

Non-invasive cell tracking with brighter and red-transferred luciferase for potential application in stem cell therapy [abstract]. Shu F, Dou L, Paxton J, Long T, song Q, Mutkus L, Marini F, Yoo J, Atala A, Jackson J, Zhang Y.. Tissue Eng Part A. 2017;23(Suppl 1):s133.

Urine stem cells for skeletal muscle generation and uses thereof. Zhang Y, Opara E, inventors; Wake Forest University Health Sciences, assignee.. United States patent US 9700581. 2017 July 11. 2017;():.

Minimally invasive surgery combined with regenerative biomaterials in treating intra-bony defects: a meta-analysis. Liu S, Hu B, Zhang Y, Li W, Song J.. PLoS One. 2016;11(1):e0147001.

Beneficial effects of urine-derived stem cells on fibrosis and apoptosis of myocardial, glomerular and bladder cells. Dong X, Zhang T, Liu Q, Zhu J, Zhao J, Li J, Sun B, Ding G, Hu X, Yang Z, Zhang Y, Li L.. Mol Cell Endocrinol. 2016;427():21-32.

Strategies to optimize adult stem cell therapy for tissue regeneration. Liu S, Zhou J, Zhang X, Liu Y, Chen J, Hu B, Song J, Zhang Y.. Int J Mol Sci. 2016;17(6):E982.

Diagnosis value of multi-slice spiral CT in renal trauma. Wang X, Zhang Z, Fu S, Fan J, Zhang Y.. J Xray Sci Technol. 2016;24(5):649-655.

Evaluation of a large adrenal carcinoma with 3D reconstruction of computed tomography images: a case report and literature review. Chen L, Zeng X, Li S, Gong C, Peng E, Wu B, Zhang W, Zhang Y.. J Xray Sci Technol. 2016;24(5):665-671.

3D reconstruction images of cone beam computed tomography in dental medicine application: a case study and mini-review. Li Y, Sun J, Zhang Y, Li W, Hu B, Song J.. J Xray Sci Technol. 2016;24(5):673-680.

Incidence and risk of hypertension associated with vascular endothelial growth factor receptor tyrosine kinase inhibitors in cancer patients: a comprehensive network meta-analysis of 72 randomized controlled trials involving 30013 patients. Liu B, Ding F, Liu Y, Xiong G, Lin T, He D, Zhang Y, Zhang D, Wei G.. Oncotarget. 2016;7(41):67661-73.

Urine-derived stem cells: a novel source for tissue engineering and regenerative medicine. Liu B, Ding FX, Liu Y, Xiong G, Lin T, He DW, Zhang YY, Zhang DY, Wei GH.. J Biomater Tissue Eng. 2016;6(8):589-601.

3D reconstruction computed tomography scan in diagnosis of bilateral wilm's tumor with its embolus in right atrium. Zhang D, Zeng G, Zhang Y, Liu X, Wu S, Hua Y, Liu F, Lu P, Feng C, Qin B, Cai J, Zhang Y, He D, Lin T, Wei G.. J Xray Sci Technol. 2016;24(5):657-660.

Intraglomerular crosstalk elaborately regulates podocyte injury and repair in diabetic patients: insights from a 3D multiscale modeling study. Tan H, Yi H, Zhao W, Ma JX, Zhang Y, Zhou X.. Oncotarget. 2016;7(45):73130-46.

Transplantation of human urine-derived stem cells transfected with pigment epithelium-derived factor to protect erectile function in a rat model of cavernous nerve injury. Yang Q, Chen X, Zheng T, Han D, Zhang H, Shi Y, Bian J, Sun X, Xia K, Liang X, Liu G, Zhang Y, Deng C.. Cell Transplant. 2016;25(11):1987-2001.

Hypoxia preconditioning enhances reparative function of urine derived stem cells from patients with diabetic nephropathy [abstract]. Xiong G, Zhang Y.. Tissue Eng Part A. 2016;22(Suppl 1):S107-S108.

Improvement of penile histomorphological structure and function with stem cell in a rat model of neurovascular erectile dysfunction [abstract]. Zhong L, Zhang Y, Jackson J, Atala A.. Tissue Eng Part A. 2016;22(Suppl 1):S76.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Yuanyuan Zhang, M.D., Ph.D.

Yuanyuan Zhang, M.D., Ph.D.

Associate Professor, Institute for Regenerative Medicine
Assistant Professor, Institute for Regenerative Medicine
Redox Biology & Medicine Ctr

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