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General Surgery: Hepato-Pancreato-Biliary (HPB) Surgery

Hepato-pancreato-biliary (HPB) surgery consists of the general surgical treatment for benign and malignant diseases of the liver, pancreas, gallbladder, and bile ducts.  These are among the most challenging and complex surgical procedures performed in General Surgery and require a high degree of expertise and skill.

Wake Forest Baptist Health has a dedicated multidisciplinary team committed to the diagnosis and treatment of complex diseases of the liver bile duct, gallbladder and pancreas.  Our team specializes in minimally-invasive approaches including laparoscopic, robotic and endoscopic techniques.   


Quality of Care

This multidisciplinary team effort was a contributing factor in Wake Forest Baptist being recently designated as a National Pancreas Foundation Center for the treatment and care of patients with pancreatic cancer. NPF Centers put emphasis on treating the “whole patient” with a focus on the best possible outcomes and an improved quality of life.

As a designated center, Wake Forest Baptist will seek to advance research and lead the way for heightened awareness and understanding of pancreatic cancer among community physicians, allied health professionals, patients, families and the general public. Read the news release

Meet Our Surgeons

Perry Shen, MD, FACS, Professor of Surgery, Director of HPB Surgery

Russell M. Howerton, MD, FACS, Professor of Surgery, Chief Medical Officier

Clancy J. Clark, MD, FACS, Assistant Professor of Surgery, Associate Program Director General Surgery

Types of Diseases

Liver Tumors – Tumors of the liver can be either primary liver cancers or liver metastases from other sites in the body.  The most common tumor to metastasize to the liver is colorectal cancer.  Another type of tumor that metastasizes to the liver is a neuroendocrine tumor of the gastrointestinal tract.

Pancreas Tumors – Cancers of the pancreatic duct are the most common but patients can develop neuroendocrine tumors of the pancreas as well as cystic tumors that can either be precancerous or malignant upon presentation.

Gallbladder and bile duct Tumors – These types of cancers are relatively rare but when found can require extensive general surgery to treat.


Liver tumors typically present with nonspecific abdominal symptoms and are found with CT or MRI scan of the abdomen.  Sometimes a biopsy may be needed to confirm the diagnosis but often just the imaging and blood work can determine the exact type of liver tumor.

Pancreas, gallbladder, and bile duct tumors can present with painless jaundice or also vague abdominal symptoms.  They also require CT or MRI imaging make the initial diagnosis.  Sometimes other tests such as endoscopy may be needed to make the diagnosis or to relieve bile duct obstruction due to tumor.


The treatment of patients with hepatopancreatobiliary tumors is facilitated by a multidisciplinary conference which meets regularly to discuss new patients and formulate a treatment plan.  Those present include: your general surgeon, medical oncologist, interventional radiologist, and radiation oncologist and people from diagnostic radiology and Nursing.

Liver Tumors – Primary liver cancer can only be cured with resection or liver transplantation.  Metastatic colorectal cancer to the liver can only be cured with complete surgical removal of all disease.  Sometimes ablative therapy (using heat and radio waves destroy tumor cells) is used in conjunction with resection or when the patient’s tumor is not operable with conventional general surgery.  Minimally invasive techniques are also being used to remove liver tumors with smaller incisions and this may help with postoperative recovery and reduce the incidence of wound infection. 

Pancreas Tumors – Surgical removal of pancreatic malignancies is the only chance for cure.  If the tumor is located in the head (figure of pancreas anatomy) of the pancreas a Whipple resection may be necessary with possible blood vessel reconstruction if needed.  For tumors located in the body and tail of the pancreas minimally invasive techniques can be used with similar benefits as in liver surgery.

Gallbladder and bile duct Tumors – Besides liver resection being the treatment of choice for these tumors, often patients may need their bile duct reconstructed by the general surgeon depending on the degree of tumor involvement or if the bile duct is blocked by tumor. 

You can learn more about general surgery specialties or contact your general surgeon online.


Quick Reference

Hepatobiliary Surgery

336-716-0664 Option 1

8 am - 5 pm
Monday - Friday
Clinic Located
Janeway Tower
5th Floor
  • Physician Referral Required
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Last Updated: 11-01-2016
Wake Forest Baptist Ranked among Nation’s ‘Best Hospitals’  25 Years in a Row by U.S. News & World ReportComprehensive Cancer Centers National Designation is Renewed2017-2018 Best DoctorsNursing Magnet StatusJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.

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