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Mei-Chuan Ko, PhD

Mei-Chuan Ko, PhD - Selected Publications

Published Articles in PubMed

NIDA Science Spotlight
Pain relief without risk of addiction or overdose?

Live Science
Scientists deliver opioid-like pain relief without addiction risk

Kiguchi N, Ding H, Peters CM, Kock ND, Kishioka S, Cline JM, Wagner JD, Ko MC. (2017)
Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease 1863(1):274-283. PMID: 27751964

Ding H, Czoty PW, Kiguchi N, Cami-Kobeci G, Sukhtankar DD, Nader MA, Husbands SM, Ko MC. (2016) 
A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates. Proceedings of the National Academy of Sciences of the United States of America 113(37):E5511-E5518. PMID: 27573832
doi: 10.1073/pnas.1605295113

Kiguchi N, Ding H, Ko MC. (2016) 
Central N/OFQ-NOP Receptor System in Pain Modulation. Advances in Pharmacology 75:217-243. PMID: 26920014 

Kiguchi N, Sukhtankar DD, Ding H, Tanaka KI, Kishioka S, Peters CM, Ko MC. (2016)
Spinal functions of B-type natriuretic peptide, gastrin-releasing peptide, and their cognate receptors for regulating itch in mice. Journal of Pharmacology & Experimental Therapeutics 356(3):596-603. PMID: 26669425 

Rizzi A, Sukhtankar DD, Ding H, Hayashida K, Ruzza C, Guerrini R, Calo’ G, Ko MC. (2015)
Spinal antinociceptive effects of the novel NOP receptor agonist PWT2-nociceptin/orphanin FQ in mice and monkeys. British Journal of Pharmacology 172(14):3661-3670. PMID: 25828800 

Lee H, Ko MC. (2015) 
Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates. Scientific Reports 5:11676. PMID: 26119696 

Ding H, Hayashida K, Suto T, Sukhtankar DD, Kimura M, Mendenhall V, Ko MC. (2015)
Supraspinal actions of nociceptin/orphanin FQ, morphine and substance P in regulating pain and itch in non-human primates. British Journal of Pharmacology 172(13):3302-3312. PMID: 25752320 

Ko MC. (2015) 
Neuraxial Opioid-Induced Itch and Its Pharmacological Antagonism. Handbook of Experimental Pharmacology 226: 315-335. PMID: 25861787 

Schröder W. Lambert DG. Ko MC. Koch T. (2014)
Functional plasticity of the N/OFQ-NOP receptor system determines analgesic properties of NOP receptor agonists. British Journal of Pharmacology 171(16):3777-3800. PMID: 24762001 

Sukhtankar DD. Lee H. Rice KC. Ko MC. (2014) 
Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain. Psychopharmacology (Berl) 231(7):1377-1387. PMID: 24217900 

Molinari S. Camarda V. Rizzi A. Marzola G. Salvadori S. Marzola E. Molinari P. McDonald J. Ko MC. Lambert DG. Calo’ G. Guerrini R. (2013) 
[Dmt1]N/OFQ(1-13)-NH2, a potent nociceptin/orphanin FQ and opioid receptor universal agonist. British Journal of Pharmacology 168(1):151-162. PMID: 22827708 

Lin AP. Ko MC. (2013)
The therapeutic potential of nociceptin/orphanin FQ receptor agonists as analgesics without abuse liability. ACS Chemical Neuroscience 4(2):214-224. PMID: 23421672 

Ko MC. Husbands SM. (2013)
Research and Development of Opioid-Related Ligands
(Editors: MC Ko & SM Husbands). ACS Symposium Series, volume 1131, American Chemical Society/ACS Publications, Washington DC, USA (Distributed in print by Oxford University Press, Inc.). ISBN13: 978-0841227828. 
doi: 10.1021/bk-2013-1131

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