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Daniel Yohannes, PhD, MBA

Daniel Yohannes, PhD, MBA - Selected Publications

Mazurov, A. A.; Yohannes, D., 2015. Nicotinic Acetylcholine Receptor Modulators. In: Celanire, S., Poli, S. (Eds). Small Molecule Therapeutics for Schizophrenia, vol 13, Top. Med. Chem., Springer, Heidelberg, p. 213-254.  

Toler, S. M.; Yohannes, D.; Lippiello, P. M.; Chancellor, M. B. Anticholinergic therapy for overactive bladder: A nicotinic modality?  Med. Hypotheses 2013, 81, 456-458.  

Mazurov, A.A.; Kombo, D.C.; Akireddy, S.; Murthy, S.; Hauser, T. A.; Jordan, K. G.; Gatto, G. J.; Yohannes, D.  Novel nicotinic acetylcholine receptor agonists containing carbonyl moiety as a hydrogen bond acceptor  Bioorg. Med. Chem.  Lett. 2013, 23, 3927-3934.  

Mazurov, A. A.; Kombo, D. C.; Hauser, T. A.; Miao, L.; Dull, G.; Genus, J. F.; Fedorov, N. B.; Benson, L.; Sidach, S.; Xiao, Y-D.; Hammond, P.; James, J. W.; Miller, C. H.; Yohannes, D. Discovery of (2S,3R)-N-[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a Selective α7 Nicotinic Acetylcholine Receptor Agonist, for the Treatment of Cognitive Disorders J. Med Chem., 2012, 55, 9793-9809.  

Breining, S. R.; Melvin, M.; Bhatti, B. S.; Byrd, G. D.; Kiser, M. N.; Hepler, C. D.; Hooker, D. N.; Zhang, J.; Reynolds, L. A.; Benson, L. R.; Fedorov, N. B.; Sidach, S. S.; Mitchener, J. P.; Lucero, L.R. M.; Lukas, Ronald J.; Whiteaker, P.; Yohannes, D. Structure-Activity Studies of 7-Heteroaryl-3-azabicyclo[3.3.1]non-6-enes: A Novel Class of Highly Potent Nicotinic Receptor Ligands J. Med Chem., 2012, 55, 9929-9945.  

Mazurov, A. A.; Miao, L.; Bhatti, B. S.; Strachan, J-P.; Akireddy, S.; Murthy, S.; Kombo, D.; Xiao, Y-D.; Hammond, P.; Zhang, J.; Hauser, T. A.; Jordan, K. G.; Miller, C. H.; Speake, J. D.; Gatto, G. J.; Yohannes, D. Discovery of 3-(5-Chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a Novel Highly Selective α4β2 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders J. Med Chem., 2012, 55, 9181-9194.  

Hauser, T. A.; Hepler, C. D.; Kombo, D. C.; Grinevich, V. P.; Kiser, M. N.; Hooker, D. N.; Zhang, J.; Mountfort, D.; Selwood, A.; Akireddy, S. R.; Letchworth, S. R.; Yohannes, D. Comparison of acetylcholine receptor interactions of the marine toxins, 13-desmethylspirolide C and gymnodimine Neuropharmacology 2012, 62, 2239-2250.  

Mazurov, A. A; Speake, J. D; Yohannes, D.  Discovery and development of α7 nicotinic acetylcholine receptor modulators  J. Med. Chem. 2011, 54, 7943-7961.  

Grady, S. R.; Drenan, R. M.; Breining, S. R.; Yohannes, D.; Wageman, C. R.; Fedorov, N. B.; McKinney, S.; Whiteaker, P.; Bencherif, M.; Lester, H. A.; Marks, M. J. “Structural differences determine the relative selectivity of nicotinic compounds for native α4β2*-, α6β2*-, α3β4*- and α7-nicotine acetylcholine receptors.” Neuropharmacology 2010, 58, 1054-1066.  

Breining, S. R.; Bencherif, M.; Grady, S. R.; Whiteaker, P.; Marks, M. J.; Wageman, C.R.; Lester, H.A.; Yohannes, D.  “Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the 6* subtype.”  Bioorg. Med. Chem. Lett. 2009, 19, 4359.  

Yohannes, D.; Hansen, C. P.; Akireddy, S. R.; Hauser, T. A.; Kiser, M. N.; Gurnon, N. J.; Day, C. S.; Bhatti, B.; Caldwell, W. S. “First Total Synthesis of (±)-3-Hydroxy-11-norcytisine: Structure Confirmation and Biological Characterization.”  Org. Lett.  2008,  10,  5353.  

Yohannes, D.; Procko, K.; Lebel, L. A.; Fox, C. B.; O'Neill, B. T. “Deconstructing cytisine: The syntheses of (±)-cyfusine and (±)-cyclopropylcyfusine, fused ring analogs of cytisine.” Bioorg. Med. Chem. Lett. 2008, 18, 2316.   

Baldino, C.M.; Caserta, J.; Goetzinger, W.; Harris, M. H.; Hartsough, D.; Yohannes, D.; Yu, L.; Kyranos, J.N. “High-Throughput Medicinal Chemistry for Efficient Drug Discovery” Current Drug Discovery, July 2004, 15.  

Yohannes,D. “Disruption of Protein-Protein Interactions” Ann. Rev. Med. Chem., 2003, 38, 295-303.  

O'Neill, B. T.; Yohannes, D.; Bundesmann, M. W.; Arnold, E. P. “Total Synthesis of (±)-Cytisine”. Organic Letters 2000, 26, 420.

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