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Dr. James McCormick and Hyperbaric Oxygen Chamber
Dr. James McCormick with the hyperbaric oxygen chamber provided by the U.S. Navy

Hyperbaric oxygen treatment will be a bridge to tPA therapy, with hyperbaric oxygen having the ability to stop the FDA 3 hour post stroke time window for safe tPA administration by preserving brain tissue in a safe hyperbaric oxygen stasis. We are proposing to take the first step in designing and building a ground ambulance equipped with a two man hyperbaric oxygen chamber so that once the acute stroke patient is picked up at their home, the FDA 3 hour tPA time clock can be stopped, greatly increasing the range an ambulance can go to get the acute stroke patient to the major medical center stroke center for tPA.

Presently, with the time needed to work up a patient for tPA within the 3 hour window, an ambulance can only travel about 15 minutes or less with the acute stroke patient. As illustrated in the following two figures, a hyperbaric oxygen acute stroke ambulance will greatly expand the geographic area that can be served by a stroke center for the administration of tPA, thus opening up this FDA approved stroke treatment drug to thousands more patients each year.

The present project involves the initial development and testing of an acute stroke treatment two man mobile hyperbaric oxygen chamber equipped ambulance which published scientific clinical trial data indicate will “stop the clock” on the required FDA 3 hour post stroke administration window of the thrombolytic tPA (the only FDA approved stroke treatment drug). This will extend the service area an ambulance can travel to bring acute stroke patients to a major medical center stroke center. This will be a major public health advance extending the FDA approved stroke treatment drug tPA administration to thousands more stroke patients each year. Our published data in the literature (McCormick, Houle, Saltzman, Whaley, and Roy, 2011) suggests that this hyperbaric oxygen treatment in route to the stroke center will be synergistic with tPA increasing efficacy and safety. The hyperbaric chamber is being engineered into a prototype ambulance and safety certified and tested.  This is in preparation for a Phase II Clinical Trial on Acute Stroke Patients. 

Range a Standard Ambulance Can go to get an Acute Stroke Patient and still have time to work the patient up at hospital for tPA within the FDA 3 hour post stroke window compared to increased range of a Hyperbaric Oxygen Chamber Equipped Stroke Treatment Ambulance


 15 Minutes (11 Miles) Standard Ambulance

 standard ambulance range 
Map is by ©2011 Google-Map Data


2 Hours (90 Miles) Hyperbaric Oxygen Acute Stroke Treatment Ambulance

 stroke ambulance range  
Map is by ©2011 Google-Map Data



Hyperbaric Oxygen Revival of Acute Stroke Patients
Excellent to 90 Minutes Post Stroke (100%), Good to 3 Hours Post Stroke (78%).

 Probability of permanent or Partial Transient Improvement of Stroke with Hyperbaric Oxygen
Research Finding of McCormick, Houle, Saltzman, Whaley, and Roy, 2011.




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News Spotlight: U.S. Navy Provides $200,000.00 Hyperbaric Oxygen Chamber, 2008

News Spotlight: U.S. Navy Provides $200,000.00 Hyperbaric Oxygen Chamber, 2008

An innovative ambulance to house a hyperbaric chamber for the improvement of stroke outcomes.

Last Updated: 10-12-2016
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