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Biostatistics and Bioinformatics Shared Resource

David R. McWilliams, Ph.D.

Center for Public Health Genomics
Bioinformatician IV
Department of Biostatistical Sciences
Division of Public Health Sciences
Wake Forest School of Medicine Medical Center Blvd.
Winston-Salem, NC 27157
Tel: 336-713-1496


University of Tennesse, Knoxville – Ph.D. Proteomics, Bioinformatics

Duke University, Durham, NC – MS, Natural Products Organic Chemistry
Davidson College, Davidson, NC – BS, Chemistry and Biology  

Research Topics

  • Bioinformatic tool development
  • Cancer genomics
  • Proteomics
  • Metagenomics

Current Research

Dr. McWilliams has extensive experience with both laboratory science and informatics, in both industrial and academic settings.  He has bioinformatic experience with lipid, polysaccharide, proteomic and genetic data.  As a consulting scientist he created web-based interfaces to databases and R analysis packages to facilitate use by biologists.  Since his employment in the Department of Biostatistical Sciences he has created automated bioinformatic pipelines for next-generation sequencing data using open-source tools such as Samtools, Picard, GATK, perl and R.

Selected Publications

  1. Bailey JN, Lu L, Chou JW, Xu J, McWilliams DR, Howard TD, Freedman BI, Bowden DW, Langefeld CD, Palmer ND. The Role of Copy Number Variation in African Americans with Type 2 Diabetes-Associated End Stage Renal Disease. J. Mol. Genet. Med. 2013; 7:61. PMCID: PMC3973178.
  2. Chotewutmontri P, Reddick LE, McWilliams DR, Campbell IM, Bruce BD.  Differential transit peptide recognition during preprotein binding and translocation into flowering plant plastids. Plant Cell. 2012;24(7):3040-59. PMCID: PMC3426131.
  3. Liberles DA, Shinozaki K, Bruce BD, Boutry M, Glaser E, Bhushan S, Stahl A, Nilsson S, Lefebvre B, Seki M, Roth C, McWilliams D, Wright SJ.  Catalysis, subcellular localization, expression and evolution of the targeting peptides degrading protease, AtPreP2.  Plant Cell Physiol. 2005 Jun;46(6):985-96K. PMID: 15827031.
  4. Ehrhardt C, Hopkins JB, Maheras JC, and McWilliams, DRMethod for Immobilizing Superabsorbent Polymer and Products Derived Therefrom.  U.S. 5,419,955.
  5. Jeffs, PW, and McWilliams, D. Carbon-13 Nuclear Magnetic Resonance Study of the Biosynthesis of Cycloheximide.  Stereospecific Incorporation of Malonate into the Glutarimide Ring.  J. Am. Chem. Soc. 1981, 103:6185.

Quick Reference

Biostatistics and Bioinformatics Shared Resource
Executive Director
Ralph D'Agostino Jr., PhD


Xiaobo Zhou, PhD

Senior Biostatisticians
Janet Tooze, PhD

Doug Case, PhD

Fang-Chi Hsu, PhD

Senior Bioinformaticians
Carl Langefeld, PhD

Guangxu Jin, PhD

Jing Su, PhD

Scott Isom, MS

Greg Russell, MS

Beverly Levine, PhD

Jeff Chou, PhD

Liang Lui, PhD

Dave McWilliams, PhD

Jian Zhang, PhD

Tina Martin, BSBA


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