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Biostatistics and Bioinformatics Shared Resource

Janet Tooze, Ph.D.


Associate Professor
Department of Biostatistical Sciences
Associate Director
Clinical Trials/Cancer Prevention and Control
Biostatistics and Bioinformatics Shared Resource
Comprehensive Cancer Center
Wake Forest University School of Medicine
Medical Center Blvd.
Winston-Salem, NC 27157
Tel: (336) 716-3833 or (336) 716-0286
Fax: (336)716-6427


Harvard School of Public Health - MPH, Public Health
University of Colorado, Health Sciences Center - PhD, Biometrics
Earlham College, Richmond - BA, Chemistry Postdoctoral Fellowship, National Cancer Institute  

Research Topics

  • Analysis of data with clumping at zero
  • Measurement Error
  • Nutritional epidemiology and surveillance
  • Cancer prevention

Current Research

Dr. Tooze is an Associate Professor in the Department of Biostatistical Sciences, Division of Public Health Sciences, at Wake Forest University. She is a biostatistician with expertise in longitudinal data analysis and nonlinear mixed effects models. She has developed methods for estimating the usual intake of foods and nutrients in a unified framework with applications to nutritional surveillance and epidemiology, termed the “NCI Method,” the foundation of which is a statistical model developed by Dr. Tooze for repeated measures data with excess zeroes.  She developed a SAS macro to fit this model, which has been used by researchers across America and in 13 foreign countries. Dr. Tooze is the Associate Director of the Biostatistics Core of the Comprehensive Cancer Center of Wake Forest University.  In addition, she provides design, analytic support, and subject-matter expertise on other research studies in the areas of nutrition, obesity, aging and cancer control and prevention. 

Selected Publications

  1. Tooze JA, Grunwald GK, Jones RH.  Analysis of repeated measures data with clumping at zero.  Statistical Methods in Medical Research 2002;11(4):341-355. PMID: 12197301.
  2. Tooze JA, Midthune D, Dodd KW, Krebs-Smith SM, Subar AF, Carroll RJ, Kipnis V. A New Statistical Method for Estimating the Distribution of Usual Intake of Episodically Consumed Foods. Journal of the American Dietetics Association 2006;106(10):1575-1587. PMCID: PMC2517157.
  3. Scott LM, Xu X, Veenstra TD, Tooze JA, Wood CE, Register TC, Kock ND And Cline JM. Past oral contraceptive use and current dietary soy isoflavones modify endogenous estrogen metabolism in postmenopausal monkeys (Macaca fascicularis). Cancer Epidemiology, Biomarkers & Prevention. 2008;17(10):2594-602. PMCID: PMC2724961
  4. Akins EJ, Moore ML, Tang S, Willingham MC, Tooze JA, Dubey P. In situ vaccination combined with androgen ablation and regulatory T cell depletion reduces castration-resistant tumor burden in prostate-specific Pten knockout mice. Cancer Research 2010 May 1;70(9):3473-82. PMCID: PMC2866496
  5. Van Ness PH, Charpentier PA, Ip EH, Leng X, Murphy TE, Tooze JA, Allore HG. Gerontologic Biostatistics: The Statistical Challenges of Clinical Research with Older Study Participants. Journal of the American Geriatrics Society 2010;58:1386-1392. PMCID: PMC2918405
  6. Castellino SM, Geiger AM, Mertens AC, Leisenring WM, Tooze JA, Goodman P, Stovall M, Robison LL, Hudson MM.  Morbidity and Mortality in Long-term Survivors of Hodgkin Lymphoma: A report from the Childhood Cancer Survivor Study.  Blood 2011;117:1806-16. PMCID: PMC3056636
  7. Klepin HD, Geiger AM, Tooze JA, Kritchevsky SB, Williamson JD, Ellis LR, Levitan D, Pardee TS, Isom S, Powell BL. The feasibility of inpatient geriatric assessment for older adults receiving induction chemotherapy for acute myelogenous leukemia. Journal of the American Geriatrics Society 2011 59:1837-1846. NIHMS503785
  8. Weaver KE, Danhauer SC, Tooze JA, Blackstock AW, Spangler J, Thomas L, Sutfin EL. Smoking cessation counseling beliefs and behaviors of outpatient oncology providers. The Oncologist  2012;17(3):455-62. PMCID: PMC3316932
  9. Ganz PA, Barry JM, Burke W, Col NF, Corso PS, Dodson E, Hammond ME, Kogan BA, Lynch CF, Newcomer L, Seifter EJ, Tooze JA, Viswanath K, Wessells H. National Institutes of Health State-of-the-Science Conference Statement: Role of Active Surveillance in the Management of Men with Localized Prostate Cancer. Annals of Internal Medicine 2012 Apr 17;156(8):591-595. PMID: 22351514.
  10. Foley KL, Song EY, Klepin H, Geiger A, Tooze J. Screening Colonoscopy Among Colorectal Cancer Survivors Insured by Medicaid. American Journal of Clinical Oncology 2012 Jun;35(3):205-11. PMID: 21358299.
  11. Castellino SM, Tooze JA, Flowers L, Shaw EG, Parsons SK.  Toxicity and efficacy of the acetylcholinesterase (AChe) inhibitor donepezil in childhood brain tumor survivors: A pilot study. Pediatric Blood and Cancer 2012 Sep;59(3):540-7. PMCID: PMC3345166.
  12. Klepin HD, Geiger AM, Tooze JA, Kritchevsky SB, Williamson JD, Pardee TS, Ellis LR, Powell BL. Geriatric assessment predicts survival for older adults receiving induction chemotherapy for acute myelogenous leukemia. Blood 2013 May 23;121(21):4287-94.  PMCID: PMC3663423
  13. Tooze JA, Troiano RP, Carroll RJ, Moshfegh AJ, Freedman LS.  A measurement error model for physical activity level measured by a questionnaire, with application to the NHANES 1999-2006 questionnaire.  American Journal of Epidemiology 2013 Jun 1;177(11):1199-208. PMCID: PMC3664335
  14. Morrell RM, Tooze JA, Harmon MS, Carter AF, Detroye AT, Lesser GJ. An Automated System for Detecting nonadherence in laboratory testing and monitoring for myelosuppression in patients receiving self-administered oral chemotherapy. Journal of Oncology Practice 2013 Sep 1;9(5):e268-71. 
  15. Milliron B, Vitolins MZ, Tooze JA. Usual dietary intake among female breast cancer survivors is not significantly different from women with no cancer history: Results of the National Health and Nutrition Examination, Journal of the Academy of Nutrition and Dietetics 2014 Jun;114(6):932-7.     PMCID: PMC4000572.

Quick Reference

Biostatistics and Bioinformatics Shared Resource
Executive Director
Ralph D'Agostino Jr., PhD


Xiaobo Zhou, PhD

Senior Biostatisticians
Janet Tooze, PhD

Doug Case, PhD

Fang-Chi Hsu, PhD

Senior Bioinformaticians
Carl Langefeld, PhD

Guangxu Jin, PhD

Jing Su, PhD

Scott Isom, MS

Greg Russell, MS

Beverly Levine, PhD

Jeff Chou, PhD

Liang Lui, PhD

Dave McWilliams, PhD

Jian Zhang, PhD

Tina Martin, BSBA


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